LOCUS       NM_001107800            5229 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus serine/threonine kinase 4 (Stk4), mRNA.
ACCESSION   NM_001107800 XM_001070199 XM_230833
VERSION     NM_001107800.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5229)
  AUTHORS   Huang,W., Wu,D., Cai,C., Yao,H., Tian,Z., Yang,Y., Pang,M., Rong,L.
            and Liu,B.
  TITLE     Inhibition of MST1 ameliorates neuronal apoptosis via
            GSK3beta/beta-TrCP/NRF2 pathway in spinal cord injury accompanied
            by diabetes
  JOURNAL   Redox Biol 71, 103104 (2024)
   PUBMED   38430683
  REMARK    GeneRIF: Inhibition of MST1 ameliorates neuronal apoptosis via
            GSK3beta/beta-TrCP/NRF2 pathway in spinal cord injury accompanied
            by diabetes.
REFERENCE   2  (bases 1 to 5229)
  AUTHORS   Ren,Y., Wang,X., Liang,H. and Ma,Y.
  TITLE     Differentially expressed microRNAs during the differentiation of
            muscle-derived stem cells into insulin-producing cells, a promoting
            role of microRNA-708-5p/STK4 axis
  JOURNAL   PLoS One 17 (4), e0266609 (2022)
   PUBMED   35395037
  REMARK    GeneRIF: Differentially expressed microRNAs during the
            differentiation of muscle-derived stem cells into insulin-producing
            cells, a promoting role of microRNA-708-5p/STK4 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5229)
  AUTHORS   Mardi,A., Biglar,A., Nejatbakhsh,R. and Abdanipour,A.
  TITLE     Valproic Acid Ameliorates Locomotor Function in the Rat Model of
            Contusion via Alteration of Mst1, Bcl-2, and Nrf2 Gene Expression
  JOURNAL   Iran Biomed J 25 (4), 303-307 (2021)
   PUBMED   34217161
  REMARK    GeneRIF: Valproic Acid Ameliorates Locomotor Function in the Rat
            Model of Contusion via Alteration of Mst1, Bcl-2, and Nrf2 Gene
            Expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5229)
  AUTHORS   Su,D., Li,Y., Guan,L., Li,Q., Shi,C., Ma,X. and Song,Y.
  TITLE     Elevated MST1 leads to apoptosis via depletion of YAP1 in
            cardiomyocytes exposed to high glucose
  JOURNAL   Mol Med 27 (1), 13 (2021)
   PUBMED   33568044
  REMARK    GeneRIF: Elevated MST1 leads to apoptosis via depletion of YAP1 in
            cardiomyocytes exposed to high glucose.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5229)
  AUTHORS   Hu,Y.H., Sun,J., Zhang,J., Hua,F.Z., Liu,Q. and Liang,Y.P.
  TITLE     Long non-coding RNA ROR sponges miR-138 to aggravate
            hypoxia/reoxygenation-induced cardiomyocyte apoptosis via
            upregulating Mst1
  JOURNAL   Exp Mol Pathol 114, 104430 (2020)
   PUBMED   32240614
  REMARK    GeneRIF: Long non-coding RNA ROR sponges miR-138 to aggravate
            hypoxia/reoxygenation-induced cardiomyocyte apoptosis via
            upregulating Mst1.
REFERENCE   6  (bases 1 to 5229)
  AUTHORS   Lee,K.K. and Yonehara,S.
  TITLE     Phosphorylation and dimerization regulate nucleocytoplasmic
            shuttling of mammalian STE20-like kinase (MST)
  JOURNAL   J Biol Chem 277 (14), 12351-12358 (2002)
   PUBMED   11805089
REFERENCE   7  (bases 1 to 5229)
  AUTHORS   Lee,K.K., Ohyama,T., Yajima,N., Tsubuki,S. and Yonehara,S.
  TITLE     MST, a physiological caspase substrate, highly sensitizes apoptosis
            both upstream and downstream of caspase activation
  JOURNAL   J Biol Chem 276 (22), 19276-19285 (2001)
   PUBMED   11278283
REFERENCE   8  (bases 1 to 5229)
  AUTHORS   Graves,J.D., Gotoh,Y., Draves,K.E., Ambrose,D., Han,D.K.,
            Wright,M., Chernoff,J., Clark,E.A. and Krebs,E.G.
  TITLE     Caspase-mediated activation and induction of apoptosis by the
            mammalian Ste20-like kinase Mst1
  JOURNAL   EMBO J 17 (8), 2224-2234 (1998)
   PUBMED   9545236
REFERENCE   9  (bases 1 to 5229)
  AUTHORS   Creasy,C.L., Ambrose,D.M. and Chernoff,J.
  TITLE     The Ste20-like protein kinase, Mst1, dimerizes and contains an
            inhibitory domain
  JOURNAL   J Biol Chem 271 (35), 21049-21053 (1996)
   PUBMED   8702870
REFERENCE   10 (bases 1 to 5229)
  AUTHORS   Creasy,C.L. and Chernoff,J.
  TITLE     Cloning and characterization of a member of the MST subfamily of
            Ste20-like kinases
  JOURNAL   Gene 167 (1-2), 303-306 (1995)
   PUBMED   8566796
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474005.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001070199.1, XM_230833.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132269 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5229
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..5229
                     /gene="Stk4"
                     /note="serine/threonine kinase 4"
                     /db_xref="GeneID:311622"
                     /db_xref="RGD:1312035"
     exon            1..88
                     /gene="Stk4"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1517
                     /gene="Stk4"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 4"
                     /protein_id="NP_001101270.1"
                     /db_xref="GeneID:311622"
                     /db_xref="RGD:1312035"
                     /translation="METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSV
                     YKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVM
                     EYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTE
                     GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMA
                     EGKPPYADIHPMRAIFMIPTNPPPTFRKPEVWSDNFMDFVKQCLVKSPEQRATATQLL
                     QHPFVKSAKGAAILRDLINEAMDVKLKRQEAQQRAVDQDDDENSEEDEMDSGTMVRAA
                     GDDMGTVRVASTMSGGANTMIEHGDTLPSQLGTMVINTEDEEEEGTMKRRDETMQPAK
                     PSFLEYFEQKEKENQINSFGKNVSGSLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLSA
                     LDPMMEQEMEEIRQKYRSKRQPILDAIEAKKRRQQNF"
     exon            89..169
                     /gene="Stk4"
                     /inference="alignment:Splign:2.1.0"
     exon            170..298
                     /gene="Stk4"
                     /inference="alignment:Splign:2.1.0"
     exon            299..413
                     /gene="Stk4"
                     /inference="alignment:Splign:2.1.0"
     exon            414..578
                     /gene="Stk4"
                     /inference="alignment:Splign:2.1.0"
     exon            579..746
                     /gene="Stk4"
                     /inference="alignment:Splign:2.1.0"
     exon            747..884
                     /gene="Stk4"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1013
                     /gene="Stk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1200
                     /gene="Stk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1358
                     /gene="Stk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..5229
                     /gene="Stk4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctcccag aggatggagc attgaggcag tctgggcggc tgctggcagc gccatggaga
       61 ccgtgcaact gaggaaccca ccgcgcaggc agctgaaaaa gttggatgaa gatagtttaa
      121 ctaaacagcc agaagaagtg tttgatgtct tagagaaact tggagaaggg tcttatggca
      181 gcgtgtacaa ggcgattcac aaagagaccg gccagattgt cgccatcaag caggtgcccg
      241 tggagtcgga cctgcaggag ataatcaagg aaatctcgat aatgcagcag tgtgacagcc
      301 cacatgtcgt caaatactat ggcagctact ttaagaacac ggacctgtgg attgttatgg
      361 agtactgtgg ggctggttct gtatccgata ttattcggct ccgaaacaag acgttaacag
      421 aagatgaaat agctacaata ttacaatcaa ctcttaaagg attagaatac cttcatttta
      481 tgagaaaaat acaccgagat atcaaggcgg gaaatatttt gctaaacaca gaaggccatg
      541 caaagcttgc agactttgga gtcgcaggcc aacttacaga taccatggca aagaggaata
      601 cagtgatagg gacaccgttt tggatggctc ctgaagttat tcaggaaatc gggtacaact
      661 gtgtggcaga catctggtct ctgggaatca cggccataga aatggctgaa ggaaagcccc
      721 catacgctga catccatcca atgagggcaa tattcatgat tcctacaaac cctcctccca
      781 cattccgtaa gcccgaggtg tggtcggaca acttcatgga tttcgtgaag cagtgtctgg
      841 taaaaagccc ggagcagaga gccacagcca ctcagctcct ccagcacccg tttgttaaga
      901 gcgccaaggg agcggccata ctgcgagact taattaacga ggccatggac gtgaaactga
      961 agcgccagga agcccagcag cgggcagtgg accaggacga cgatgagaac tcagaggagg
     1021 atgaaatgga ctctggcacg atggttcgag ctgcgggtga tgacatgggc actgtccgag
     1081 tagccagcac gatgagcggc ggagccaata ctatgattga gcacggtgac acattgccat
     1141 cccagctggg taccatggtg atcaacacgg aggatgagga agaggaagga accatgaaaa
     1201 ggagagatga gaccatgcag cctgcaaaac cgtcttttct tgaatacttt gaacaaaaag
     1261 aaaaggaaaa tcagatcaac agctttggca agaatgtatc tggctctctg aagaattctt
     1321 cagattggaa aatacctcag gatggagact acgagtttct gaagagctgg actgtggagg
     1381 accttcagaa gcggctctct gccctcgacc ccatgatgga gcaggaaatg gaagagatcc
     1441 ggcagaaata ccgctccaag cggcagccaa tcctggatgc catcgaagcc aagaagagga
     1501 ggcaacagaa cttctgatga caccagccca gcctttggtg gcttctgggt tgctagactc
     1561 gtgtctgtta gccagcactt ctgctctgtc atttatccac agcacctttg tgaactcagg
     1621 aatgcacgcc agtgggaagg gctactcgac agtcattgtg ccatttggtg tgagcattta
     1681 caccagcaag gtgtatcttg aagggtttgt attggtgctt ttaactcaga aatttagacc
     1741 ccaggagcag agactcctag ttcagtgaca gctgggacat tttttttttt ttttacattg
     1801 tttcttttgt tttcctccta gtaatagctt ttggttgctc gccctggaat actttttaaa
     1861 aatctataaa tatgcatata tataaattat aaatagaccc cccactccgt gtgggggtat
     1921 ctctgtacag gtacagtttc aaacactttg cctctttcct gtgagattat ggtactgtgc
     1981 agcaagagag cagaggacac tgggagactt agcttgtcac tgaatcccag gagtcagcgt
     2041 catctgttac agagctgcat ggagaaatta gtcttgggat ggatgtgcta ccacagtgac
     2101 aagcctcgtg tggtcaccac tggtctccaa agctgtcggt ggccgggaaa aagcctggag
     2161 aacttgagtt ggctccttga gtcccaggag aagcctttgc tctcccaacg cctttcatgc
     2221 atccccaccc tcccagctgc ctgcagtcac acctcagatc ctgcccagtg ccttaagagg
     2281 agacacatct gtgaaaggac aggcaaccaa gaactctcca gcaaacaggg ccctcagcag
     2341 tccaaaaacc tcgctgttga tggggactca cacacggcat tcattccttc gatacagggt
     2401 aaagggcact gctttcatgg tccacattca aatacgtgat tgtttatttt atttttttca
     2461 ctcactgtgg aggctgtgac aagggtaaat taatgccaga ctgaggctca ctcagaatgg
     2521 cagagctgga agggcctgtg gcagtcattg ggtccgacct tgtattgtcc cagtgggaaa
     2581 atgagactta gaggagaggt gactttgtca atgtcacaaa tcaagttaga agcagggatg
     2641 agaattcaga gcctttgttc tgggccactg gaccaagaac ctcttcactg agaatgaaga
     2701 attgtagacc aggttggccc aggaacccct gctcgctctt tgcctctttg gtacccaagc
     2761 tgctgtggaa aggctcccca gggcagccat gtcattctgt ctcagcatac cagcggtgtc
     2821 ttacggtgtc tcccagctac agacaggcac tcacgaaagg cctgcagcgg ggtggagggc
     2881 tttgcaaaga cagttacaga gtcatctctg cgcccttagc tcaaaactgc agccagaagg
     2941 aactgggaag gcagttgcct tttatttctt cccctttcgt ccctctgatg gggctgcacc
     3001 tgaggacacg gaaactcgac tcctttaatt gcctttgctc cctaactgga gagtcgataa
     3061 aaaggcaggg gatgttctgt tctgtgacca gactctgttc tttgcagtta aagcaagctt
     3121 taaaaaatgc aagaggcagc tggtctgcag gacgcagcca gcaaagcaac tgtgcaacag
     3181 agaggattag aggaccgttt gaggatcttg ctgggatgat aaatggtggc cagcactctg
     3241 ggtagcaggc ggcaggcact gagcaaggtg ttctacagat tcatcggggt cccctgtgct
     3301 cgctaactaa gttctttctc atatgatgaa attgagtttg aaagattcct ccccacgaca
     3361 ccgtggatct ggatgccttg gcatcctgtc aggctagcag tcccagaaat cgggaagtcc
     3421 aaaacgctta gaatgaagtg accgcggctt ctcaccaagt gtaagtggta tttttttttt
     3481 tttttttttg gttctttttt tcggagctgg ggaccgaacc cagggccttg cacttcctag
     3541 gcaagcgctc taccactgag ctaaatcccc aaccccaagt ggtatttttt ttttaaaggt
     3601 tagaaaccag atgaattaat agtcctgtcc cccagtcaaa ttaatagtcc tgtaccccaa
     3661 tcaagaaagt ttttaaaaac ccaaaacagg gaggacatgc gtaacatttg ctatgcttac
     3721 ttggtaaccc agcctcagct ctttcctctt gaagaaaaag gatttgggct ttgccagaca
     3781 gaagggaaaa gcccatgact cccttctgaa gcaaggtggg agtaccagaa agtggttctc
     3841 ctgtgagcct ccatccgagt ctgtggttgc aagtgtgtct gtgaagccct ttgccagaag
     3901 ccagttgttt gaggtccctg gtgaggagca tgcgatgttc agtgacagtc aggggagcaa
     3961 accactcttc ccctgaggac cgagtcccag gaagcttcac ttccctggag cctgagccct
     4021 tgagactctg gccagcctct ctgctccaag acgctgaggc ctacacctaa attttctttt
     4081 caacaaacaa acctcatgct ctcttaaaag ttttgtagtt ttgctcccat tcataaattt
     4141 gaagcacatt tccaatttta tttcctttat atatttttta ttttatagaa gattttatat
     4201 ataagatttt atactcccca gtagattaga caagaatttg acaggctggg agtgagaaag
     4261 atggttgggt tgtgtggatg aacaggggca gcaatcgaag cctcaggagt tgagtcttac
     4321 actgtagagt agaacctggc aacgccagaa acttccttta ccatttaaaa ctcaatagcc
     4381 ctgtctaatg tcaggaagga gaaggatggc gctgtaggcc ctgcagattc tcagagccgt
     4441 aataacagag tattatgaac agcttcatgc tgatacactc accagctaaa gtgaagtgga
     4501 cggataccca gaaaatgtca aaggaactaa gcttactcag agacaaaatg ggcagtcgca
     4561 acagccccca gcccctttcc taccagaact cggtagctct gagagacacg gatatctctt
     4621 ccttcaaagg atctgacact ctggtagcaa ctgttcctca aggtcatgcc agcagagtgt
     4681 gacagagtct tactccactg tccttcccag catacctttt ggtccctaaa gactgccatt
     4741 cttcatcttg gaggaaattg ttcccactca aaccacaccc ctcacctcac cgttctcagc
     4801 cttttctaag gaccgtgttt gtatttttat ttggatgaca cgcatcgttt ttggaatcca
     4861 tgctctctgt gtttagacgg gaggtctctt ccaccagcct gcactcagac caacttggaa
     4921 agaaaaaaaa atctgaaatg ctgttgctga tgtacaattt aaaaagaaaa tgtgaagttt
     4981 gtagctttaa tcttttgtaa caaaaactaa ttaacactgg cttcagtgct gaccggaaat
     5041 gctattttgt aaggtttggc tgtaaataat agagctcagc tgtttgtata tgtgtgaaac
     5101 atagcttcct ccactgccgt gttcttttaa cttgaggtac ctcctgtgtg cgtttatgtt
     5161 agagttgtcc cccctcaccc ctcccccaac acctgtcacc cttgcgttaa ataaactgtc
     5221 ctttagacc
//
