LOCUS       NM_001398991            3344 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus serine/threonine kinase 38 (Stk38), mRNA.
ACCESSION   NM_001398991 XM_006256140
VERSION     NM_001398991.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3344)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3344)
  AUTHORS   Ultanir,S.K., Hertz,N.T., Li,G., Ge,W.P., Burlingame,A.L.,
            Pleasure,S.J., Shokat,K.M., Jan,L.Y. and Jan,Y.N.
  TITLE     Chemical genetic identification of NDR1/2 kinase substrates AAK1
            and Rabin8 Uncovers their roles in dendrite arborization and spine
            development
  JOURNAL   Neuron 73 (6), 1127-1142 (2012)
   PUBMED   22445341
REFERENCE   3  (bases 1 to 3344)
  AUTHORS   Enomoto,A., Kido,N., Ito,M., Morita,A., Matsumoto,Y., Takamatsu,N.,
            Hosoi,Y. and Miyagawa,K.
  TITLE     Negative regulation of MEKK1/2 signaling by serine-threonine kinase
            38 (STK38)
  JOURNAL   Oncogene 27 (13), 1930-1938 (2008)
   PUBMED   17906693
REFERENCE   4  (bases 1 to 3344)
  AUTHORS   Tamaskovic,R., Bichsel,S.J., Rogniaux,H., Stegert,M.R. and
            Hemmings,B.A.
  TITLE     Mechanism of Ca2+-mediated regulation of NDR protein kinase through
            autophosphorylation and phosphorylation by an upstream kinase
  JOURNAL   J Biol Chem 278 (9), 6710-6718 (2003)
   PUBMED   12493777
REFERENCE   5  (bases 1 to 3344)
  AUTHORS   Millward,T., Cron,P. and Hemmings,B.A.
  TITLE     Molecular cloning and characterization of a conserved nuclear
            serine(threonine) protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 92 (11), 5022-5026 (1995)
   PUBMED   7761441
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Dec 29, 2021 this sequence version replaced XM_006256140.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216844.1, FQ217790.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               JAXUCZ010000020.1  7069197-7069439     c
            244-379             JAXUCZ010000020.1  7063342-7063477     c
            380-431             JAXUCZ010000020.1  7057401-7057452     c
            432-554             JAXUCZ010000020.1  7056189-7056311     c
            555-638             JAXUCZ010000020.1  7053288-7053371     c
            639-762             JAXUCZ010000020.1  7048314-7048437     c
            763-917             JAXUCZ010000020.1  7046300-7046454     c
            918-1020            JAXUCZ010000020.1  7043933-7044035     c
            1021-1082           JAXUCZ010000020.1  7042520-7042581     c
            1083-1200           JAXUCZ010000020.1  7040770-7040887     c
            1201-1324           JAXUCZ010000020.1  7039579-7039702     c
            1325-1420           JAXUCZ010000020.1  7039328-7039423     c
            1421-1515           JAXUCZ010000020.1  7038151-7038245     c
            1516-3344           JAXUCZ010000020.1  7035923-7037751     c
FEATURES             Location/Qualifiers
     source          1..3344
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..3344
                     /gene="Stk38"
                     /note="serine/threonine kinase 38"
                     /db_xref="GeneID:361813"
                     /db_xref="RGD:1309455"
     exon            1..243
                     /gene="Stk38"
                     /inference="alignment:Splign:2.1.0"
     exon            244..379
                     /gene="Stk38"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1646
                     /gene="Stk38"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 38"
                     /protein_id="NP_001385920.1"
                     /db_xref="GeneID:361813"
                     /db_xref="RGD:1309455"
                     /translation="MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMR
                     QKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGE
                     VRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVRMFYSFQDKL
                     NLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNL
                     LLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRR
                     QLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKV
                     MNWKETLTFPPEVPVSEKAKGLILRFCCEWEHRIGAPGVEEIKSNPFFEGVDWEHIRE
                     RPAAISIEIKSIDDTSNFDEFPESDILKPTVTTSNHPETDYKSKDWVFINYTYKRFEG
                     LTARGAIPSYMKAAK"
     exon            380..431
                     /gene="Stk38"
                     /inference="alignment:Splign:2.1.0"
     exon            432..554
                     /gene="Stk38"
                     /inference="alignment:Splign:2.1.0"
     exon            555..638
                     /gene="Stk38"
                     /inference="alignment:Splign:2.1.0"
     exon            639..762
                     /gene="Stk38"
                     /inference="alignment:Splign:2.1.0"
     exon            763..917
                     /gene="Stk38"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1020
                     /gene="Stk38"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1082
                     /gene="Stk38"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1200
                     /gene="Stk38"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1324
                     /gene="Stk38"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1420
                     /gene="Stk38"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1515
                     /gene="Stk38"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..3344
                     /gene="Stk38"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtcggcc gcaacggccc ctctctccac agtctgaggg ggtaaccggg gagccttggc
       61 ccctccgcgc tgccgtcttt tccggcagtt ggggttcttc ctgttgtcct ctcccgtcac
      121 ggctcggcag ccgcgctccc tcggcgtccc cggcgcggcg cggtcgctct cgagccgccc
      181 gctcgtcgcg tctgtgccgt ctctgtcgcc gccggccccg tgcttccctc ccccctgggt
      241 ctgttgccat ggcaatgaca ggatctacac cttgctcatc catgagtaat catacgaagg
      301 agagggtgac aatgaccaaa gtgacactgg agaattttta tagcaacctt atcgctcaac
      361 atgaagaacg agaaatgagg cagaagaaat tagagaaggt gatggaagaa gaaggcctga
      421 aagacgagga gaaacgactc agaagatctg cacatgctcg gaaggaaacg gagtttcttc
      481 gattaaagag aacaaggctt ggactggaag attttgagtc tttaaaagtc ataggccgag
      541 gagcatttgg tgaggtgcgg cttgtccaga agaaagacac agggcacgtg tatgcgatga
      601 aaatcctgcg caaagcagac atgctggaga aggagcaggt tggccacatc cgtgcggagc
      661 gtgacattct agtggaggca gacagtttgt gggttgtgag aatgttctat agttttcagg
      721 ataagctaaa cctctaccta atcatggagt tcctgcctgg aggggacatg atgactttat
      781 tgatgaagaa agatactctg acagaagagg agactcagtt ctacatagca gagacagtgt
      841 tagccataga ctccattcac cagctggggt tcatccacag agatatcaag ccagacaacc
      901 ttctcttgga cagcaagggc catgtgaaac tttccgactt tggcctttgc acaggcttga
      961 aaaaagccca caggactgag ttttatagga acctgaacca cagcctgccc agtgatttca
     1021 cttttcagaa tatgaattct aaaaggaaag cagagacctg gaaaagaaac agacgccagc
     1081 tcgccttctc tacagtgggc acccctgact acattgctcc ggaggtgttc atgcagacag
     1141 ggtacaacaa gctctgcgat tggtggtccc tcggggtgat catgtatgag atgctcatcg
     1201 gctacccacc attctgctcc gagacccctc aagagacgta caagaaggtg atgaactgga
     1261 aggaaacttt gacctttccc ccggaagttc ctgtctccga gaaagccaag ggcctgattc
     1321 tgaggttctg ctgtgaatgg gaacatagaa tcggagcccc tggagtcgag gaaataaaaa
     1381 gtaacccctt ctttgaaggt gttgactggg agcatatcag ggagagacca gctgccatat
     1441 ctattgaaat caagagcatc gatgatacct caaacttcga tgagttcccg gagtctgata
     1501 tcctgaagcc cacagtgacc acaagtaacc accctgagac ggactacaag agtaaagact
     1561 gggtcttcat caattacaca tacaagcgct tcgagggcct gacagccagg ggcgccatac
     1621 cttcctacat gaaggcggcc aagtagagct gtgcaggagc cctggagggc agagttctct
     1681 gagcaacgtt ggttttcctc gtgcgctctt gaaagaactt ccaagaattt ggtagaacca
     1741 ttactgcgtc ctagtcaagt ctctgagatg tgattgtgag tggccattcc tccgtaatgc
     1801 accgagaagc agctgagagg acagataagc gtttctccgt cagccatagc agccgcttgc
     1861 ttcttctgaa gccccacgag ccagtttggt aggtggtgta cggagaactt gattttccca
     1921 agttcatcag aatggaggga agaccagccg tccaccgtgc cgagctcaca cacaccgagt
     1981 acagccaatg cctgtgctgt gtgccacctg ccaagcccac caagtatttt tctctttata
     2041 gctgaaaatt ctgtagttaa agaaataagg caataatgaa agtcctcgtg aacagcccag
     2101 tgtggcagag gagcgagctc catctccccc gcctcggccg gtgcaaatgg cttgcacagc
     2161 cttcattcgt ggtgcacttt acctatggta ccagggcaga gaccctgacc cactgacctg
     2221 tcttccctcc gaaagactac gctgcgcttc tgttgatggg agaggtacca gtgcgatcct
     2281 tgatcttaca aagcccacaa caccactggg cactgccaag gagtttggac cctgtggaca
     2341 accctcactc tgtctccacg gctgtctgac gtgaccttga ggcacatggg cctcccagca
     2401 agcaataccc gcggatgctg ccagagcagc ctgacctgag gagcagggag aacccgctgg
     2461 agctcaggcg ctgccgtgcg ggatcccaca gcctccttgg agtcaaggca ggtccagccc
     2521 gctgagtcct tgagctcatt cctcaatcca tggtgcaaac gtgtttgtct tagcatttct
     2581 ctagcccaac tttagccatt ttgccttgga atcatgatta caaaattttc ctttgcagat
     2641 gccttcccgg ggcattcttg tccctccacc cacaagggtg gcctgcagct tgggccgaac
     2701 tggcctctgc tgtggtgttc tctcctgaga aacactgaat ttagcacaaa gtgccttctc
     2761 tgtcacggct gctgccacct ttaggagact tttgctgtgt cagaaaaatg tggaggttcc
     2821 atattaatgc attactagag tttggtttta agtgtcggta actgttaaag cattatttgc
     2881 acctgtgtgg taacttgcag tgtcattggc caagctacaa ctgggatcgg ctctctgcta
     2941 gtcctgagat tgtgaaggtc agtttggtcc cagctcagcc attcagagaa cagaatataa
     3001 gacttaaaat tgtaagcaaa actgctttga gttttcatgt cttagatgaa gaaaaaggaa
     3061 tgttagggaa gtcttaactc tgggttaagg gtgattgatg ttcgctcctt aatcctccat
     3121 tcagaacctg ctaatgcgaa ggagatagag gtgcctgtgc gtggctctgt gctctctgtg
     3181 ttcatgagca gttgaggtcc tgatccctgt gtttgcagag tgtgtggtga gcatgggaga
     3241 agtagttgaa tagtggtagt ccgcgtggtg ggggatggtt cgttttgggg ggaaatgttc
     3301 acattttaac tattcaactt ttgaataaac tgtgaaaata ataa
//
