LOCUS       NM_001173986            5031 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus serine/threonine kinase 36 (Stk36), mRNA.
ACCESSION   NM_001173986 XM_001058046 XM_217435
VERSION     NM_001173986.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5031)
  AUTHORS   Vogel,P., Read,R.W., Hansen,G.M., Payne,B.J., Small,D., Sands,A.T.
            and Zambrowicz,B.P.
  TITLE     Congenital hydrocephalus in genetically engineered mice
  JOURNAL   Vet Pathol 49 (1), 166-181 (2012)
   PUBMED   21746835
REFERENCE   2  (bases 1 to 5031)
  AUTHORS   Wilson,C.W., Nguyen,C.T., Chen,M.H., Yang,J.H., Gacayan,R.,
            Huang,J., Chen,J.N. and Chuang,P.T.
  TITLE     Fused has evolved divergent roles in vertebrate Hedgehog signalling
            and motile ciliogenesis
  JOURNAL   Nature 459 (7243), 98-102 (2009)
   PUBMED   19305393
REFERENCE   3  (bases 1 to 5031)
  AUTHORS   Maloveryan,A., Finta,C., Osterlund,T. and Kogerman,P.
  TITLE     A possible role of mouse Fused (STK36) in Hedgehog signaling and
            Gli transcription factor regulation
  JOURNAL   J Cell Commun Signal 1 (3-4), 165-173 (2007)
   PUBMED   18600476
REFERENCE   4  (bases 1 to 5031)
  AUTHORS   Merchant,M., Evangelista,M., Luoh,S.M., Frantz,G.D., Chalasani,S.,
            Carano,R.A., van Hoy,M., Ramirez,J., Ogasawara,A.K.,
            McFarland,L.M., Filvaroff,E.H., French,D.M. and de Sauvage,F.J.
  TITLE     Loss of the serine/threonine kinase fused results in postnatal
            growth defects and lethality due to progressive hydrocephalus
  JOURNAL   Mol Cell Biol 25 (16), 7054-7068 (2005)
   PUBMED   16055717
REFERENCE   5  (bases 1 to 5031)
  AUTHORS   Murone,M., Luoh,S.M., Stone,D., Li,W., Gurney,A., Armanini,M.,
            Grey,C., Rosenthal,A. and de Sauvage,F.J.
  TITLE     Gli regulation by the opposing activities of fused and suppressor
            of fused
  JOURNAL   Nat Cell Biol 2 (5), 310-312 (2000)
   PUBMED   10806483
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_217435.5, XM_001058046.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.51136.1,
                                           SRR26360181.2542497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               JAXUCZ010000009.1  83626032-83626200
            170-342             JAXUCZ010000009.1  83626606-83626778
            343-483             JAXUCZ010000009.1  83627729-83627869
            484-561             JAXUCZ010000009.1  83627982-83628059
            562-692             JAXUCZ010000009.1  83630608-83630738
            693-942             JAXUCZ010000009.1  83631373-83631622
            943-1036            JAXUCZ010000009.1  83633058-83633151
            1037-1206           JAXUCZ010000009.1  83633392-83633561
            1207-1394           JAXUCZ010000009.1  83633701-83633888
            1395-1494           JAXUCZ010000009.1  83634680-83634779
            1495-1638           JAXUCZ010000009.1  83637008-83637151
            1639-1818           JAXUCZ010000009.1  83639564-83639743
            1819-1916           JAXUCZ010000009.1  83640595-83640692
            1917-2022           JAXUCZ010000009.1  83641192-83641297
            2023-2173           JAXUCZ010000009.1  83642856-83643006
            2174-2301           JAXUCZ010000009.1  83643381-83643508
            2302-2406           JAXUCZ010000009.1  83643908-83644012
            2407-2505           JAXUCZ010000009.1  83644669-83644767
            2506-2594           JAXUCZ010000009.1  83644862-83644950
            2595-2658           JAXUCZ010000009.1  83645203-83645266
            2659-2769           JAXUCZ010000009.1  83645425-83645535
            2770-2844           JAXUCZ010000009.1  83647464-83647538
            2845-3016           JAXUCZ010000009.1  83648747-83648918
            3017-3164           JAXUCZ010000009.1  83649075-83649222
            3165-3312           JAXUCZ010000009.1  83649410-83649557
            3313-4059           JAXUCZ010000009.1  83650085-83650831
            4060-5031           JAXUCZ010000009.1  83651814-83652785
FEATURES             Location/Qualifiers
     source          1..5031
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..5031
                     /gene="Stk36"
                     /note="serine/threonine kinase 36"
                     /db_xref="GeneID:301516"
                     /db_xref="RGD:1307318"
     exon            1..169
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            170..342
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..4203
                     /gene="Stk36"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine kinase 36 (fused homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 36"
                     /protein_id="NP_001167457.1"
                     /db_xref="GeneID:301516"
                     /db_xref="RGD:1307318"
                     /translation="MEKYHVLEMIGEGSFGRVYKGRKKYSAQVVALKFIPKLGRSEKE
                     LRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEEQV
                     QAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSI
                     KGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVR
                     WPSTITSCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGRVTIITEPAGSNLGTPFTSR
                     LPPELQVLKDEQAHRLAPKGNQSRILRQACKRMAEEAKQKEDQNTGSTLDQEARLSKV
                     TPSTAPVPGLKATPQESSLLAGLLASEMKNNWEDWGAGEAPPTPRENHITLECEQAFP
                     ELRPETMGRRSTDAVDPENEEPDSDDEWQRLLETMEPVPVQLKSPLTLLCNPDFCQHI
                     QSQLRGTGEQILKGVLDGASHLLPALRILSSLLSSCSDSVLLYSFCQEVGLPELPLSL
                     LRYSQESSSIQQQPWYGAFLRELVAVVQAYFSCTFNLERSQTGDSLQVFEEAASLFLD
                     LLGKLLAQPDDSEPTFRRDSLMCFAVLCEAVDGNSRAISKAFYASLLTTQRAVLDGLL
                     HGLTVPQLPFHTPPGAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKEQV
                     SWHLANQLTEDSSQLRPSLISGLRHHILCLHLLKVLYSCCYISERLCHILGQEPLALE
                     SLLMLVQGKVKVADWEESTEVALYLLSLLVFRLQDLPSGMEKLGSEVATLFTHSHIVS
                     LVNAAACLLGQLGQQGVTFDLQPREWIAAAAHALSAPAEVRLTPPCSCGFYDGLLVLL
                     LQLLTQGKPGLIRDVAGSEVWTILWHRFSMALRLSEEVSAQEDDLSLSSPPSLEPDWT
                     LISPQGMAALLSLAMAIFTQEPQLCLSHLSQHGSVLMLTLKHLLSPSFLHRLSQAPQG
                     SEFLPVVVLSVCKLLCFPFALDVDADLLGGILADLRASEVAVYLLQVCCHHLPLFQAE
                     LPIGLLTRLALMDPTSLKQFVNTVATSSRAIISFLSVVLLCDQPLMVSDLLSLLTHTT
                     RILSPSHLSFIQELLSGSDESYRPLRSLLGHSENAVRVRTYRLLGHLLQHSMALRGAL
                     QSQSGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDAQ
                     DAIRRNAASALGNLGPEGLGKELLKCQVPQRLLEMACGDPQPTVKEAALIALRSLRQE
                     PCIHQVLVSLGASEKLTLLSLGHQLLPSSNSRPTSARHCRKLIHLLRPTHST"
     exon            343..483
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            484..561
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            562..692
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            693..942
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1036
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1206
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1394
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1494
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1638
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1818
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1916
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2022
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2173
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2301
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2406
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2505
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2594
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2658
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2769
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2844
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..3016
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3164
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3312
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..4059
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..5031
                     /gene="Stk36"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaagctgg cgccgtttct aggcaactgc agactctaga tcctttgtgg ggtctgctag
       61 ccaagcgaca gaagtgccct agaaagtgct aatgggcggt tcgcatctgt cacacacctc
      121 tgagagcttt gtcctctaaa cttctgacca gttccaggga gtaaaactgg cctcccagat
      181 gtgtggaacc atccctggat ctatagctct ttgtcaccgt cttctttctg ccttctgaga
      241 gaccctgaaa cccttgccat ggaaaagtac cacgttttgg agatgattgg agaaggctct
      301 tttgggagag tgtataaggg ccggaaaaaa tacagtgctc aggtggtggc cttgaagttc
      361 atccccaaac tggggcgctc agagaaagag ctgaggaatc tgcaacgaga gattgaaatc
      421 atgcggggtc tgtggcatcc caacattgtg catatgcttg acagcttcga gactgacaag
      481 gaggtggtgg tggtgacaga ctatgctgag ggagagctct ttcagattct ggaagatgat
      541 ggaaaacttc ctgaagagca ggttcaggcc atcgccgccc agttggtgtc agccctgtac
      601 tatctgcatt cccaccgcat cctacaccga gacatgaaac ctcagaacat tcttctcgcc
      661 aagggcggtg gcatcaaact ctgtgacttt ggatttgccc gagctatgag caccaacacc
      721 atggtgctga cctcaatcaa aggcacaccg ctctatatgt ctccagaact ggtggaggag
      781 cgaccatatg accacacggc agacctctgg tctgtaggct gcatcctgta tgagctggct
      841 gtaggcacac ctcccttcta caccaccagc atctttcaac tggttagcct cattctcaag
      901 gaccctgtgc gctggccctc caccattact tcctgcttca agaacttctt gcaggggctg
      961 ctcactaagg acccccggca gcgtctgtcc tggccagacc tcttacatca cccctttatt
     1021 gccggccgtg tcaccataat aaccgaacca gcaggctcca acttgggcac cccatttact
     1081 agtcgcctac ccccagaact tcaggtccta aaagatgaac aggcccatcg actggcaccc
     1141 aagggtaacc agtcccgcat cctgcgccag gcctgtaaac gcatggctga agaagccaag
     1201 cagaaggaag accaaaatac aggatccacc cttgatcaag aagctaggct cagcaaggtg
     1261 acacccagca cagcccctgt gcctggtcta aaggccactc ctcaggagtc aagcctcttg
     1321 gctggcttac tggcttcaga aatgaagaac aactgggaag actggggggc tggagaagca
     1381 ccccctacac ctcgggaaaa ccacatcacc ttggagtgtg aacaagcctt ccctgagctg
     1441 aggccagaga cgatgggtcg gcggagcacc gatgcagtgg atcctgaaaa cgaggagcca
     1501 gacagtgatg acgagtggca acgcttactc gagactatgg agccagtgcc tgtgcagctg
     1561 aagtcccccc tcaccctgct gtgtaatcct gacttctgcc agcatatcca gagtcagctg
     1621 cgcgggactg gcgagcagat cctgaaaggc gtcctggatg gtgcttccca cctccttcct
     1681 gcactccgca tcctgagcag tctcctgtcc agctgcagtg actctgtgct cttgtattcc
     1741 ttctgccagg aggtgggact gcccgagctg cctctcagtc ttcttaggta cagccaggag
     1801 agcagcagta tccagcagca accttggtac ggggccttct tacgggaact ggtggctgtg
     1861 gttcaggcct acttttcatg caccttcaat ctggagagga gccagacagg tgacagccta
     1921 caggtgtttg aggaggctgc cagcctcttt ttggacttgt tggggaagct gttggcccaa
     1981 ccagatgatt ccgagccgac atttcgaagg gatagcctca tgtgctttgc tgtcttgtgt
     2041 gaggctgtgg atgggaacag ccgggccatc tccaaagcct tttatgccag cttgttgacc
     2101 acacagcgtg ctgtgttgga cgggctcctt cacggcctaa cggttccaca actccctttc
     2161 cacacaccac caggagcccc acaagtgagc cagccactgc gggagcagag tgaagatgta
     2221 cccggagcca tctcttctgc cctggcagcc atgtgcactg cccctgtggg gttgcccagc
     2281 tgttgggacg ccaaggagca ggtctcttgg catttggcca accagctaac cgaggacagc
     2341 agccaactga ggccatccct catctctggt ctgcggcacc atatcctatg cctccacctt
     2401 ctcaaggttc tctactcctg ctgctatatt agtgagcgcc tgtgccatat tctgggacaa
     2461 gagcctctgg ccttggagtc gctgctcatg ttagtccagg gcaaggtgaa agtagcagac
     2521 tgggaagagt ccactgaggt ggcactttac ctcctgtccc ttcttgtctt tcggctccaa
     2581 gatctacctt cagggatgga gaagctgggc agtgaggtcg ctactctctt cacccactca
     2641 cacatcgtct ctcttgtgaa tgcagcagcc tgtctcttag gacagcttgg tcagcaaggg
     2701 gtgacctttg acctccagcc ccgggaatgg atagctgcag ctgcacatgc cttgtctgcc
     2761 cctgcagagg tccggctgac tccaccgtgt agttgtggct tctatgatgg cctcctcgtt
     2821 cttctgcttc agctccttac acaggggaag cctggcctga tcagggacgt ggcaggttca
     2881 gaggtgtgga ccattctgtg gcaccgcttt tccatggctc tgagactatc tgaggaggtg
     2941 tctgcccagg aagatgacct gtcactatca agtccaccca gcctagagcc agactggaca
     3001 ctgatttcac cccaaggcat ggcagccttg ctgagcctgg caatggccat cttcacccag
     3061 gagccccagt tatgcctgag ccacctgtcc cagcatggca gtgtcctcat gctgaccctg
     3121 aagcacctgc tttcacccag cttcttgcac cgcctgagcc aggcgcctca ggggtctgag
     3181 tttctccccg ttgtggtgct ctctgtgtgc aagctgctct gcttcccctt cgccctggat
     3241 gtggatgctg acctcctcgg aggcatcttg gctgacctca gggcctcaga agttgcagtc
     3301 tacctgctgc aggtctgctg ccaccacctt ccattgttcc aagcagagct gcccattggc
     3361 ctccttacac gcctggccct catggatccc acctctctca agcagtttgt gaacacagta
     3421 gccacctctt ctagagccat catctcattc ctctctgttg ttctcctgtg tgaccaaccc
     3481 ctcatggtct ctgacctcct gtccctgctg acacacacaa cccggattct atcccccagc
     3541 cacttgtcct ttatccagga gctcctgtct ggctctgatg aatcctatcg gccactgcgc
     3601 agcctcctag gccactcaga gaatgctgtg cgggtccgta cttacaggct cctgggacat
     3661 ttattacaac acagcatggc cctacgtggg gcactacaga gccagtcagg actgctcaac
     3721 cttctgctgc tagggcttgg agacaaggac cctgccgtgc gacgcagtgc cagctttgct
     3781 gtgggcaatg cagcctacca ggctggtccc ttgggacctg ccttggcagc tgcagtgccc
     3841 agtatgaccc agctgctggg agatgctcag gatgctatcc ggcgcaatgc tgcatcagct
     3901 ctaggcaatc tgggacctga aggattgggc aaggagctat taaagtgcca agtaccccag
     3961 cggctcctag aaatggcgtg tggagaccct caaccaactg tcaaagaggc tgcccttatt
     4021 gccctccgga gcctccgaca ggagccctgt attcatcagg tgctggtgtc gctgggtgcc
     4081 agtgagaaat taaccttgct gtctttgggg catcagttac tgccaagcag caatagcagg
     4141 cctacctctg ccagacactg caggaagctt atccacctcc tgaggccgac ccacagcaca
     4201 tgaccccgat gcctggggtc ccctccagcc gtcactatcc tactgttgca aatcttcctt
     4261 tttctcctac ccaagcttct aactcagcca agagctgaag cgactgagaa agagtgctaa
     4321 gctgccgact cccctgcaag tgagaaacta gaagagattt tattaaagct ccttcctccc
     4381 tagattcata atgacttgaa tcagtaaact ccatcactgt tggtgccaga gaaaatccct
     4441 tttgtctaca tgcggggatc tctcttccag taatgagccc ttaaccccag gaccatgcca
     4501 tccacccagg ccttaggaaa aaaccacctc taccttgctg gacctcctcc tttctggatc
     4561 tcctgtaatc tgccttgctg tttttgcctt aagtacactg gtctctattt cagctgtctc
     4621 ccatggggat aaatgtcatc acccctgttg ttgaggggtt cctcagccct tagcccactt
     4681 tccttccacg agtggtttgt gtgtgtgtat aatgtatatt tccatatata tgtgtgtgtg
     4741 tacatatgta tatatttata tgatatatac acacatatat aagttgttta taaacactta
     4801 gtgaaaattg tgcctcaccc taactgaagc tcccaaggta aggtgttggg aggcttgggc
     4861 ccttttctaa cttctctgac actggaagcc ctgtaccctg ttcacacaag atcttggttt
     4921 agagaattgt ttataccttt caaggtaagg ccagtggaac tgatacagag aagagtgggg
     4981 ataaacaggt aaatcaaggt actgtgagaa tacagtcatt ttaacattta a
//
