LOCUS       NM_031735               2603 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus serine/threonine kinase 3 (Stk3), mRNA.
ACCESSION   NM_031735
VERSION     NM_031735.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2603)
  AUTHORS   Moon,S., Lee,O.H., Lee,S., Lee,J., Park,H., Park,M., Chang,E.M.,
            Park,K.H. and Choi,Y.
  TITLE     STK3/4 Expression Is Regulated in Uterine Endometrial Cells during
            the Estrous Cycle
  JOURNAL   Cells 8 (12), 1643 (2019)
   PUBMED   31847471
  REMARK    GeneRIF: STK3/4 Expression Is Regulated in Uterine Endometrial
            Cells during the Estrous Cycle.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2603)
  AUTHORS   Kwan,J., Sczaniecka,A., Heidary Arash,E., Nguyen,L., Chen,C.C.,
            Ratkovic,S., Klezovitch,O., Attisano,L., McNeill,H., Emili,A. and
            Vasioukhin,V.
  TITLE     DLG5 connects cell polarity and Hippo signaling protein networks by
            linking PAR-1 with MST1/2
  JOURNAL   Genes Dev 30 (24), 2696-2709 (2016)
   PUBMED   28087714
REFERENCE   3  (bases 1 to 2603)
  AUTHORS   Du,X., Dong,Y., Shi,H., Li,J., Kong,S., Shi,D., Sun,L.V., Xu,T.,
            Deng,K. and Tao,W.
  TITLE     Mst1 and mst2 are essential regulators of trophoblast
            differentiation and placenta morphogenesis
  JOURNAL   PLoS One 9 (3), e90701 (2014)
   PUBMED   24595170
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2603)
  AUTHORS   Ni,L., Li,S., Yu,J., Min,J., Brautigam,C.A., Tomchick,D.R., Pan,D.
            and Luo,X.
  TITLE     Structural basis for autoactivation of human Mst2 kinase and its
            regulation by RASSF5
  JOURNAL   Structure 21 (10), 1757-1768 (2013)
   PUBMED   23972470
REFERENCE   5  (bases 1 to 2603)
  AUTHORS   Park,B.H., Kim,D.S., Won,G.W., Jeon,H.J., Oh,B.C., Lee,Y., Kim,E.G.
            and Lee,Y.H.
  TITLE     Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte
            differentiation by activation of PPARgamma
  JOURNAL   PLoS One 7 (1), e30983 (2012)
   PUBMED   22292086
  REMARK    Erratum:[PLoS One. 2015 Mar 18;10(3):e0119098. doi:
            10.1371/journal.pone.0119098.. PMID: 25785583]
REFERENCE   6  (bases 1 to 2603)
  AUTHORS   Deng,Y., Pang,A. and Wang,J.H.
  TITLE     Regulation of mammalian STE20-like kinase 2 (MST2) by protein
            phosphorylation/dephosphorylation and proteolysis
  JOURNAL   J Biol Chem 278 (14), 11760-11767 (2003)
   PUBMED   12554736
REFERENCE   7  (bases 1 to 2603)
  AUTHORS   Lee,K.K. and Yonehara,S.
  TITLE     Phosphorylation and dimerization regulate nucleocytoplasmic
            shuttling of mammalian STE20-like kinase (MST)
  JOURNAL   J Biol Chem 277 (14), 12351-12358 (2002)
   PUBMED   11805089
REFERENCE   8  (bases 1 to 2603)
  AUTHORS   Lee,K.K., Ohyama,T., Yajima,N., Tsubuki,S. and Yonehara,S.
  TITLE     MST, a physiological caspase substrate, highly sensitizes apoptosis
            both upstream and downstream of caspase activation
  JOURNAL   J Biol Chem 276 (22), 19276-19285 (2001)
   PUBMED   11278283
REFERENCE   9  (bases 1 to 2603)
  AUTHORS   Aurisicchio,L., Di Lauro,R. and Zannini,M.
  TITLE     Identification of the thyroid transcription factor-1 as a target
            for rat MST2 kinase
  JOURNAL   J Biol Chem 273 (3), 1477-1482 (1998)
   PUBMED   9430685
REFERENCE   10 (bases 1 to 2603)
  AUTHORS   Creasy,C.L. and Chernoff,J.
  TITLE     Cloning and characterization of a member of the MST subfamily of
            Ste20-like kinases
  JOURNAL   Gene 167 (1-2), 303-306 (1995)
   PUBMED   8566796
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031735.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ001529.1, BC161844.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               JAXUCZ010000007.1  68208182-68208287   c
            107-187             JAXUCZ010000007.1  68173377-68173457   c
            188-316             JAXUCZ010000007.1  68171228-68171356   c
            317-431             JAXUCZ010000007.1  68157874-68157988   c
            432-596             JAXUCZ010000007.1  68133159-68133323   c
            597-764             JAXUCZ010000007.1  68132610-68132777   c
            765-902             JAXUCZ010000007.1  68067799-68067936   c
            903-1028            JAXUCZ010000007.1  68050654-68050779   c
            1029-1221           JAXUCZ010000007.1  68017531-68017723   c
            1222-1397           JAXUCZ010000007.1  68004353-68004528   c
            1398-2603           JAXUCZ010000007.1  67938378-67939583   c
FEATURES             Location/Qualifiers
     source          1..2603
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2603
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /note="serine/threonine kinase 3"
                     /db_xref="GeneID:65189"
                     /db_xref="RGD:68412"
     exon            1..106
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1556
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /EC_number="2.7.11.1"
                     /note="MST-2; STE20-like kinase MST2; mammalian STE20-like
                     protein kinase 2; serine/threonine kinase 3 (STE20
                     homolog, yeast)"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 3"
                     /protein_id="NP_113923.2"
                     /db_xref="GeneID:65189"
                     /db_xref="RGD:68412"
                     /translation="MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKA
                     IHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYC
                     GAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHA
                     KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGK
                     PPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHP
                     FIKNAKPVSILRELITEGMEIKAKRHEEQQRELEDEEENSDEDELDSHTMVKTSSEGV
                     GTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPS
                     FMDYFDKQDFKNKSHENCDQSMREPCPMSNNVFPDNWRVPQDGDFDFLKNLSLEELQM
                     RLKALDPMMEREIEELHQRYSAKRQPILDAMDAKKRRQQNF"
     exon            107..187
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /inference="alignment:Splign:2.1.0"
     exon            188..316
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /inference="alignment:Splign:2.1.0"
     exon            317..431
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..596
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..764
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..902
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1028
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1221
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1397
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..2603
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcggccggc tgctcccagg ctcctttcct tcctacggcc ttcacggtcc attcggtccc
       61 tctttctgcc accggccgcc atggagcagc cgccggcgcc caagagtaag ctaaaaaagc
      121 tgagtgaaga cagtttgact aagcagcctg aagaggtctt tgatgttttg gagaagcttg
      181 gagaagggtc ttatggaagt gtttttaaag caatacataa ggaatctggt caagttgttg
      241 caattaagca agtacctgtt gagtcagatc ttcaggaaat aatcaaagaa atttccataa
      301 tgcaacaatg tgacagccct tacgtggtga agtactatgg cagttacttt aagaacacag
      361 acctctggat tgttatggag tactgtggag ccgggtccgt ttcagacata attagattac
      421 gaaacaagac attaacggaa gatgaaattg caactattct aaaatccacg ttgaaaggat
      481 tagaatattt gcattttatg aggaaaatac acagagatat aaaagctggg aatattctcc
      541 tcaatacaga aggacatgca aagcttgcag attttggagt ggctggccag ttaacagaca
      601 cgatggcaaa acgcaatact gtaataggaa ccccgttttg gatggctccc gaggtaattc
      661 aagaaatagg ttacaactgt gtggctgaca tctggtccct tggcattacg tctatagaaa
      721 tggcagaagg aaaacctcct tatgctgata tacatccaat gagggctatt tttatgattc
      781 ctacaaaccc accaccaaca ttcaggaaac ctgagctctg gtctgacgac ttcacggatt
      841 ttgtgaagaa gtgcttggtg aagagtcctg agcagagggc cactgccacc cagctgttac
      901 agcatccttt catcaagaat gcgaagcccg tgtcgatatt gagagagctg atcacggaag
      961 gcatggaaat caaggccaag cggcatgagg agcagcagcg agagctggag gacgaggagg
     1021 aaaactcgga tgaagatgag ctggattcgc acactatggt gaagactagt tcagaaggtg
     1081 tgggcacaat gcgggccacc agcacgatga gtgaaggggc ccagaccatg attgaacaca
     1141 acagcaccat gctagagtcg gacctgggga ccatggtgat aaacagtgag gatgaagagg
     1201 aggaagacgg aaccatgaaa agaaatgcaa cgtcacccca agtacaaaga ccttctttca
     1261 tggactactt tgataagcag gacttcaaga acaagagtca tgaaaattgt gatcagagca
     1321 tgcgtgagcc atgccctatg tcaaacaatg tttttcctga caactggaga gttcctcaag
     1381 atggagactt tgatttttta aaaaatctaa gtttagaaga actacagatg cggctaaaag
     1441 cactggaccc catgatggaa cgagaaatag aagaactgca tcaaagatac agtgcgaaaa
     1501 gacagcccat cctggatgcc atggatgcca aaaagaggag gcagcagaat ttctgaccag
     1561 atcccttctg tctctgtgtg accagagacc aaggaacaca ggaattgaag gaactgtaat
     1621 actttttaat ccctaaaatg tatactctac aattttttta gaagtcaaaa atgatggtac
     1681 acacctagat aaatttccca aaagcaaact ttgcagttgt gtcctcgatg acgtcggttt
     1741 aaacggatga gaacaataca catgcgcacc tctctctctg ccagccgtta cctgcaacag
     1801 aaccaacctg cgactgaagc cgcctgtgga gccggagtcc agcgccattg ctttgggctc
     1861 acagcactgc agggcttgtg ttgccctgat cttccttcct gtggagaagc ctatttattg
     1921 accccctagg tagacttatt tatttatgca gctttttttt tttggagggg ggggttctaa
     1981 agaaaagatc aggatagttt tggtgaatgt ccagacacat cacagattgt aacactcaac
     2041 caaattgtac actaagcagg gagctatggg tgtattcctt tatctccagt aaaaataaag
     2101 ccataatgtc cacatggacc agacaatttt ataagtgtta attcttgatt ttgatattgg
     2161 tacaaataaa actatatata cataggtcaa aaagagttat acagtgtaaa accaaagaaa
     2221 tcaatgaatt tttgcaccaa aaaagtgtgg gaaatatttt taaagacatg aaacccaaga
     2281 agacagtgca gtcgttaatg tttcctttat tggtctgtag taacttcaag ttcattctat
     2341 gggacatgct tctgtcacag ggcttttgtt gacttcattc atctcctggg aattggtaag
     2401 catcatgtat ctgacaataa agcagtaata tgtttatact aaaactgtgt gtccttaggg
     2461 cctaaaaaat gaaagcatta gaaaaaggct cctttctgag aagcattagc atttgtgtaa
     2521 ttgacctggg accagtcatt tcctgcacta cacagggcca ttttgatatc gtgttctttt
     2581 atgtgttaat tactatgtgt gca
//
