LOCUS       NM_001127494            1350 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus serine/threonine kinase 24 (Stk24), mRNA.
ACCESSION   NM_001127494 XM_001078875 XM_341377
VERSION     NM_001127494.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Lu,T.J., Chan,C.H., Ling,P., Chao,Y.M., Bao,B.Y., Chiang,C.Y.,
            Lee,T.H., Weng,Y.P., Kan,W.C. and Lu,T.L.
  TITLE     MST3 (mammalian Ste20-like protein kinase 3), a novel gene involved
            in ion homeostasis and renal regulation of blood pressure in
            spontaneous hypertensive rats
  JOURNAL   Int Urol Nephrol 50 (12), 2299-2307 (2018)
   PUBMED   30328087
  REMARK    GeneRIF: This is the first study reporting that MST3, a Ste20-like
            kinase, exerts a conserved regulatory role in sodium homeostasis
            after high-salt diet and in the development of hypertension.
REFERENCE   2  (bases 1 to 1350)
  AUTHORS   Mardakheh,F.K., Self,A. and Marshall,C.J.
  TITLE     RHO binding to FAM65A regulates Golgi reorientation during cell
            migration
  JOURNAL   J Cell Sci 129 (24), 4466-4479 (2016)
   PUBMED   27807006
REFERENCE   3  (bases 1 to 1350)
  AUTHORS   Zhang,Y., Hu,H., Tian,T., Zhang,L., Zhao,D., Wu,Q., Chang,Y.,
            Wang,Q., Zhou,S., Feng,G. and Huang,F.
  TITLE     Mst3b promotes spinal cord neuronal regeneration by promoting
            growth cone branching out in spinal cord injury rats
  JOURNAL   Mol Neurobiol 51 (3), 1144-1157 (2015)
   PUBMED   24990316
  REMARK    GeneRIF: Mst3b was identified as a powerful regulator for promoting
            spinal cord injury recovery.
REFERENCE   4  (bases 1 to 1350)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1350)
  AUTHORS   Fidalgo,M., Guerrero,A., Fraile,M., Iglesias,C., Pombo,C.M. and
            Zalvide,J.
  TITLE     Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates
            phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin
            by mammalian Ste20-4 to protect cells from oxidative stress
  JOURNAL   J Biol Chem 287 (14), 11556-11565 (2012)
   PUBMED   22291017
REFERENCE   6  (bases 1 to 1350)
  AUTHORS   Voss,K., Stahl,S., Schleider,E., Ullrich,S., Nickel,J.,
            Mueller,T.D. and Felbor,U.
  TITLE     CCM3 interacts with CCM2 indicating common pathogenesis for
            cerebral cavernous malformations
  JOURNAL   Neurogenetics 8 (4), 249-256 (2007)
   PUBMED   17657516
REFERENCE   7  (bases 1 to 1350)
  AUTHORS   Lu,T.J., Lai,W.Y., Huang,C.Y., Hsieh,W.J., Yu,J.S., Hsieh,Y.J.,
            Chang,W.T., Leu,T.H., Chang,W.C., Chuang,W.J., Tang,M.J.,
            Chen,T.Y., Lu,T.L. and Lai,M.D.
  TITLE     Inhibition of cell migration by autophosphorylated mammalian
            sterile 20-like kinase 3 (MST3) involves paxillin and
            protein-tyrosine phosphatase-PEST
  JOURNAL   J Biol Chem 281 (50), 38405-38417 (2006)
   PUBMED   17046825
REFERENCE   8  (bases 1 to 1350)
  AUTHORS   Irwin,N., Li,Y.M., O'Toole,J.E. and Benowitz,L.I.
  TITLE     Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon
            outgrowth
  JOURNAL   Proc Natl Acad Sci U S A 103 (48), 18320-18325 (2006)
   PUBMED   17114295
  REMARK    GeneRIF: Mst3b, a neuron-specific homolog of the yeast kinase
            Ste20, is critical for axon outgrowth. Mst3b is activated in
            response to trophic factors, and suppressing its expression
REFERENCE   9  (bases 1 to 1350)
  AUTHORS   Stegert,M.R., Hergovich,A., Tamaskovic,R., Bichsel,S.J. and
            Hemmings,B.A.
  TITLE     Regulation of NDR protein kinase by hydrophobic motif
            phosphorylation mediated by the mammalian Ste20-like kinase MST3
  JOURNAL   Mol Cell Biol 25 (24), 11019-11029 (2005)
   PUBMED   16314523
REFERENCE   10 (bases 1 to 1350)
  AUTHORS   Huang,C.Y., Wu,Y.M., Hsu,C.Y., Lee,W.S., Lai,M.D., Lu,T.J.,
            Huang,C.L., Leu,T.H., Shih,H.M., Fang,H.I., Robinson,D.R.,
            Kung,H.J. and Yuan,C.J.
  TITLE     Caspase activation of mammalian sterile 20-like kinase 3 (Mst3).
            Nuclear translocation and induction of apoptosis
  JOURNAL   J Biol Chem 277 (37), 34367-34374 (2002)
   PUBMED   12107159
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EU371958.1.
            
            On or before May 22, 2008 this sequence version replaced
            XM_341377.3, XM_001078875.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU371958.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24"
     gene            1..1350
                     /gene="Stk24"
                     /gene_synonym="MST-3; Mst3b; RGD1561742"
                     /note="serine/threonine kinase 24"
                     /db_xref="GeneID:361092"
                     /db_xref="RGD:1561742"
     CDS             1..1296
                     /gene="Stk24"
                     /gene_synonym="MST-3; Mst3b; RGD1561742"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine kinase 24 (STE20 homolog, yeast);
                     STE20-like kinase MST3; mammalian STE20-like protein
                     kinase 3"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 24"
                     /protein_id="NP_001120966.1"
                     /db_xref="GeneID:361092"
                     /db_xref="RGD:1561742"
                     /translation="MAHSPVQSGLPGMQTLKADPEELFTKLEKIGKGSFGEVFKGIDN
                     RTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYL
                     GGGSALDLLEPGPLDEIQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKL
                     ADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPP
                     HSELHPMKVLFLIPKNNPPTLEGSYSRPLKEFVEACLNKEPSFRPTAKELLKHKFIIR
                     NAKKTSYLTELIDRYKRWKAEQSHEDSSSEDSDVETDSQASGGSDSGDWIFTIREKDP
                     KNLENGTLQPSDLERNKMKDFPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEEL
                     RGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGGASAH"
     exon            1..42
                     /gene="Stk24"
                     /gene_synonym="MST-3; Mst3b; RGD1561742"
                     /inference="alignment:Splign:2.1.0"
     exon            43..273
                     /gene="Stk24"
                     /gene_synonym="MST-3; Mst3b; RGD1561742"
                     /inference="alignment:Splign:2.1.0"
     exon            274..330
                     /gene="Stk24"
                     /gene_synonym="MST-3; Mst3b; RGD1561742"
                     /inference="alignment:Splign:2.1.0"
     exon            331..439
                     /gene="Stk24"
                     /gene_synonym="MST-3; Mst3b; RGD1561742"
                     /inference="alignment:Splign:2.1.0"
     exon            440..597
                     /gene="Stk24"
                     /gene_synonym="MST-3; Mst3b; RGD1561742"
                     /inference="alignment:Splign:2.1.0"
     exon            598..783
                     /gene="Stk24"
                     /gene_synonym="MST-3; Mst3b; RGD1561742"
                     /inference="alignment:Splign:2.1.0"
     exon            784..929
                     /gene="Stk24"
                     /gene_synonym="MST-3; Mst3b; RGD1561742"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1053
                     /gene="Stk24"
                     /gene_synonym="MST-3; Mst3b; RGD1561742"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1122
                     /gene="Stk24"
                     /gene_synonym="MST-3; Mst3b; RGD1561742"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1259
                     /gene="Stk24"
                     /gene_synonym="MST-3; Mst3b; RGD1561742"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1350
                     /gene="Stk24"
                     /gene_synonym="MST-3; Mst3b; RGD1561742"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcccact ccccggtgca gtcgggcctg ccgggcatgc agaccctgaa agcagaccca
       61 gaagagcttt ttaccaagct ggagaaaatt ggaaagggct cctttggtga ggtgttcaaa
      121 ggcatcgaca atcggactca gaaagtggtt gccataaaaa tcattgatct ggaagaagcg
      181 gaggacgaga tagaggacat tcaacaagag atcacagtgc tgagccagtg tgacagtccg
      241 tacgtcacca agtattatgg atcctatctc aaggatacta aattatggat aatcatggag
      301 tatctcggtg gaggctctgc cctggatctg ttagaacctg gccctttaga tgaaattcag
      361 attgcaacca ttctacgaga gattctgaaa ggacttgatt atctacactc agagaagaaa
      421 atccacagag atattaaagc ggccaatgtt ctgctctctg aacatggaga ggtgaagctg
      481 gctgactttg gagtggctgg ccagctgacg gatacccaga taaaaaggaa caccttcgtg
      541 ggcactccct tctggatggc gcctgaggtc atcaagcagt cagcctacga ctcaaaggcg
      601 gacatctggt ccctcggcat cacagccata gaactggcca aaggcgagcc gccacattct
      661 gagctgcacc ccatgaaggt gctgttcctt atcccaaaga acaaccctcc cacgctggag
      721 ggcagctaca gcagacccct caaggagttc gtggaggcct gcctgaacaa ggagcccagc
      781 ttcaggccca ctgctaagga gttattgaag cacaaattta taatccgcaa tgcaaagaaa
      841 acgtcctacc tgactgagct catcgacagg tacaagaggt ggaaggcgga gcagagtcac
      901 gaggactcca gctcggagga ctcagatgtg gagacagata gccaggcgtc tggaggcagc
      961 gactctgggg actggatctt taccatccgg gagaaagacc ccaagaatct ggagaacgga
     1021 actcttcagc cctcagattt ggaaagaaat aagatgaaag acttcccaaa gaggcccttc
     1081 tctcagtgct tgtccacaat catttctcct ctgtttgcgg agctgaaaga gaagagccag
     1141 gcgtgtggag ggaacttggg gtcaatagaa gagcttcggg gagccatcta cttggcggaa
     1201 gaggcctgcc ctgggatctc cgacaccatg gtggcacagc ttgtacaacg gctgcagaga
     1261 tattctctga gcggtggagg agcctcagcg cactgaaagc ccatggcgtc ctggttggtt
     1321 tttcctttct tcttcatctt ccttcttttt
//
