LOCUS       NM_133392               2159 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus serine/threonine kinase 17b (Stk17b), mRNA.
ACCESSION   NM_133392
VERSION     NM_133392.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2159)
  AUTHORS   Kuwahara,H., Nishizaki,M. and Kanazawa,H.
  TITLE     Nuclear localization signal and phosphorylation of Serine350
            specify intracellular localization of DRAK2
  JOURNAL   J Biochem 143 (3), 349-358 (2008)
   PUBMED   18084041
  REMARK    GeneRIF: These results suggest that phosphorylation of Ser350 plays
            an essential role in regulating translocation of DRAK2 to the
            nucleus from the cytoplasm, possibly by affecting the activity of
            the nuclear localization signal.
REFERENCE   2  (bases 1 to 2159)
  AUTHORS   Kuwahara,H., Kamei,J., Nakamura,N., Matsumoto,M., Inoue,H. and
            Kanazawa,H.
  TITLE     The apoptosis-inducing protein kinase DRAK2 is inhibited in a
            calcium-dependent manner by the calcium-binding protein CHP
  JOURNAL   J Biochem 134 (2), 245-250 (2003)
   PUBMED   12966074
REFERENCE   3  (bases 1 to 2159)
  AUTHORS   Matsumoto,M., Miyake,Y., Nagita,M., Inoue,H., Shitakubo,D.,
            Takemoto,K., Ohtsuka,C., Murakami,H., Nakamura,N. and Kanazawa,H.
  TITLE     A serine/threonine kinase which causes apoptosis-like cell death
            interacts with a calcineurin B-like protein capable of binding
            Na(+)/H(+) exchanger
  JOURNAL   J Biochem 130 (2), 217-225 (2001)
   PUBMED   11481038
REFERENCE   4  (bases 1 to 2159)
  AUTHORS   Sanjo,H., Kawai,T. and Akira,S.
  TITLE     DRAKs, novel serine/threonine kinases related to death-associated
            protein kinase that trigger apoptosis
  JOURNAL   J Biol Chem 273 (44), 29066-29071 (1998)
   PUBMED   9786912
REFERENCE   5  (bases 1 to 2159)
  AUTHORS   Praloran,V. and Bartocci,A.
  TITLE     CFU-C in Agar
  JOURNAL   Methods Mol Biol 5, 323-330 (1990)
   PUBMED   21374135
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB070349.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB070349.1, SRR8487227.145907.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2159
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..2159
                     /gene="Stk17b"
                     /gene_synonym="Drak2"
                     /note="serine/threonine kinase 17b"
                     /db_xref="GeneID:170904"
                     /db_xref="RGD:620457"
     exon            1..124
                     /gene="Stk17b"
                     /gene_synonym="Drak2"
                     /inference="alignment:Splign:2.1.0"
     exon            125..289
                     /gene="Stk17b"
                     /gene_synonym="Drak2"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1283
                     /gene="Stk17b"
                     /gene_synonym="Drak2"
                     /EC_number="2.7.11.1"
                     /note="DAP kinase-related apoptosis-inducing protein
                     kinase 2; serine/threonine kinase 17b
                     (apoptosis-inducing); death-associated protein
                     kinase-related 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 17B"
                     /protein_id="NP_596883.1"
                     /db_xref="GeneID:170904"
                     /db_xref="RGD:620457"
                     /translation="MSRRRFDCRSISGLLTTTPQTPMKTENFNNFYTLTPKELGRGKF
                     AVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELARSCPHVINLHEVYET
                     ATEIILVLEYAAGGEIFNLCLPELAEMVSENDVIRLIKQILEGVHYLHQNNIVHLDLK
                     PQNILLSSIYPLGDIKIVDFGMSRKIGNASELREIMGTPEYLAPEILNYDPITTATDM
                     WNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEEMFSSVSQLATDFIQSLLVK
                     NPEKRPTAESCLSHSWLQQWDFGSLFHPEETSESSQTQDLSLRSSEDKTPKSCNGSCG
                     DREDKENIPEDDSLLSKRFRFDDSLPSPHELVPDLFC"
     exon            290..502
                     /gene="Stk17b"
                     /gene_synonym="Drak2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..647
                     /gene="Stk17b"
                     /gene_synonym="Drak2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..774
                     /gene="Stk17b"
                     /gene_synonym="Drak2"
                     /inference="alignment:Splign:2.1.0"
     exon            775..823
                     /gene="Stk17b"
                     /gene_synonym="Drak2"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1003
                     /gene="Stk17b"
                     /gene_synonym="Drak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..2159
                     /gene="Stk17b"
                     /gene_synonym="Drak2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgctgca cttttcaaac ctcaactgta agaagcgtcg gtcagcgtct gtgcggtcgc
       61 cgccgggagt ctcctcatag gggtctggct gacggcgacc agccgctgtg gggaagagtg
      121 cgaggtgaaa gtcagtgcct agagaagcag gcctggtagt catcaacatg tctcggagga
      181 gatttgattg ccgaagtatc tcgggcttgc taactacaac ccctcaaacg ccgatgaaaa
      241 cagagaattt taataatttc tatacgctta ccccgaaaga acttgggaga ggaaaatttg
      301 cagtagttag acagtgtata tcaaagtcaa ctggacagga gtatgctgcc aaattcctga
      361 agaagaggag aagagggcag gactgccggg cagagattct gcacgagata gcggtgctgg
      421 agctggccag gtcttgtccc cacgtgatta atctgcacga ggtctatgaa acggcaacgg
      481 aaatcatttt ggtgttagaa tatgctgcag gtggagaaat tttcaacctg tgtttacctg
      541 agttggctga aatggtgtct gaaaatgatg ttatccgact cattaaacaa atacttgaag
      601 gagttcatta tctacatcag aataacattg ttcatcttga tttaaagcca cagaatatac
      661 ttttgagcag tatataccca cttggggaca taaaaattgt agattttgga atgtctcgaa
      721 aaattgggaa tgcaagtgag cttcgggaaa tcatgggaac gcctgaatac ttagctccag
      781 aaatcctcaa ctatgatccc attaccacag caacagatat gtggaatatt ggcataatag
      841 catatatgtt gttgactcat acatcaccat ttgtaggaga agataaccaa gaaacatatc
      901 tgaatatttc tcaagtgaat gtagattatt cagaagaaat gttttcatca gtttcacaac
      961 tggccacaga cttcatccag agccttctag taaagaatcc agagaaaaga ccaacagcag
     1021 aatcctgcct ttcccactca tggctgcagc agtgggactt tggaagcttg tttcatcctg
     1081 aggaaacttc agagtcctct caaactcagg atctgagcct caggtcctct gaagataaga
     1141 cccccaagtc ctgtaatgga agctgtggag accgagagga caaggagaac atccctgagg
     1201 atgacagctt actttctaaa agatttcgat tcgatgactc cttgcccagc ccccacgaac
     1261 tcgttccaga tttgttctgt tagcatttct ctctgtcatt catctggact gacttggaaa
     1321 tttgaaatct tctctggtgt cagattgtgt ttgtagcttc atatataata tgtttatatt
     1381 ataagtgcac ttttgcttag aagaacttaa ggaacagttc aaatgctagc cttctattag
     1441 ctagcatatc atttcctgtc ctgaaattgt tttatagaga aaaatattta aatatatgac
     1501 aaaactgtaa attttgcatg tgagttcata tgcaactgaa agaattcaag ttcaggtgaa
     1561 gttataaaat gggttatgtt atgtttagta aatattgaac aaaatgaaaa aataggaatt
     1621 tagtaggtcc tctctaaggt aagccctata ccagaaccct attagcagag aattttgttt
     1681 ggctgtcaag ggtaaaccac aatatatact gctttataca tactccagag atattttata
     1741 actgaaaatg cttcccagtt accaatagct tgaaattgta cgattctttc tgtgccatgt
     1801 gctctgtgag aaggcacagt caaccagagc aggggaaacc agattggtcc aggctgtttc
     1861 tctgtaaact gacatcattt ccaactcaca tatcttgcac atgcatccta tttcagatct
     1921 agtaagatct ggaagacgga tatgcatggt atgcaaataa aagaggactt catcctctag
     1981 aattgttaga gtagaggaga attggggagt agcaaatgtg ttctaatttc agtcagacat
     2041 attcataaag ggaaatgtta agtccaggca gctgactgag tgttgggtgt ctaagtctca
     2101 ggatgcaagc ccatcgttta gagcataggc acttctggag ttcttgtgtg aaattttag
//
