LOCUS       NM_001108069            3119 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus serine/threonine kinase 11 (Stk11), mRNA.
ACCESSION   NM_001108069 XM_001076821 XM_234900
VERSION     NM_001108069.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3119)
  AUTHORS   Liu,Y. and Xu,Y.J.
  TITLE     LKB1 and CRMP1 cooperatively promote the repair of the sciatic
            nerve injury
  JOURNAL   Dev Neurobiol 84 (1), 18-31 (2024)
   PUBMED   38105470
  REMARK    GeneRIF: LKB1 and CRMP1 cooperatively promote the repair of the
            sciatic nerve injury.
REFERENCE   2  (bases 1 to 3119)
  AUTHORS   Zheng,Y., Tao,Y., Zhan,X. and Wu,Q.
  TITLE     Nuclear receptor 4A1 (NR4A1) silencing protects hepatocyte against
            hypoxia-reperfusion injury in vitro by activating liver kinase B1
            (LKB1)/AMP-activated protein kinase (AMPK) signaling
  JOURNAL   Bioengineered 13 (4), 8349-8359 (2022)
   PUBMED   35311465
  REMARK    GeneRIF: Nuclear receptor 4A1 (NR4A1) silencing protects hepatocyte
            against hypoxia-reperfusion injury in vitro by activating liver
            kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) signaling.
REFERENCE   3  (bases 1 to 3119)
  AUTHORS   Cui,C., Fan,J., Zeng,Q., Cai,J., Chen,Y., Chen,Z., Wang,W.,
            Li,S.Y., Cui,Q., Yang,J., Tang,C., Xu,G., Cai,J. and Geng,B.
  TITLE     CD4+ T-Cell Endogenous Cystathionine gamma Lyase-Hydrogen Sulfide
            Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote
            T Regulatory Cell Differentiation and Proliferation
  JOURNAL   Circulation 142 (18), 1752-1769 (2020)
   PUBMED   32900241
  REMARK    GeneRIF: CD4(+) T-Cell Endogenous Cystathionine gamma
            Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating
            Liver Kinase B1 to Promote T Regulatory Cell Differentiation and
            Proliferation.
REFERENCE   4  (bases 1 to 3119)
  AUTHORS   Ming,Y., Yin,Y. and Sun,Z.
  TITLE     Interaction of Nuclear Receptor Subfamily 4 Group A Member 1
            (Nr4a1) and Liver Linase B1 (LKB1) Mitigates Type 2 Diabetes
            Mellitus by Activating Monophosphate-Activated Protein Kinase
            (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B
            (NF-kappaB) Activation
  JOURNAL   Med Sci Monit 26, e920278 (2020)
   PUBMED   31939452
  REMARK    GeneRIF: Interaction of Nuclear Receptor Subfamily 4 Group A Member
            1 (Nr4a1) and Liver Linase B1 (LKB1) Mitigates Type 2 Diabetes
            Mellitus by Activating Monophosphate-Activated Protein Kinase
            (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B
            (NF-kappaB) Activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3119)
  AUTHORS   Wen,J., Xu,B., Sun,Y., Lian,M., Li,Y., Lin,Y., Chen,D., Diao,Y.,
            Almoiliqy,M. and Wang,L.
  TITLE     Paeoniflorin protects against intestinal ischemia/reperfusion by
            activating LKB1/AMPK and promoting autophagy
  JOURNAL   Pharmacol Res 146, 104308 (2019)
   PUBMED   31181335
  REMARK    GeneRIF: Paeoniflorin mitigated the intestinal I/R-impaired
            autophagy flux by activating LKB1/AMPK signaling pathway.
REFERENCE   6  (bases 1 to 3119)
  AUTHORS   Ylikorkala,A., Rossi,D.J., Korsisaari,N., Luukko,K., Alitalo,K.,
            Henkemeyer,M. and Makela,T.P.
  TITLE     Vascular abnormalities and deregulation of VEGF in Lkb1-deficient
            mice
  JOURNAL   Science 293 (5533), 1323-1326 (2001)
   PUBMED   11509733
REFERENCE   7  (bases 1 to 3119)
  AUTHORS   Sapkota,G.P., Kieloch,A., Lizcano,J.M., Lain,S., Arthur,J.S.,
            Williams,M.R., Morrice,N., Deak,M. and Alessi,D.R.
  TITLE     Phosphorylation of the protein kinase mutated in Peutz-Jeghers
            cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and
            cAMP-dependent protein kinase, but not its farnesylation at
            Cys(433), is essential for LKB1 to suppress cell vrowth
  JOURNAL   J Biol Chem 276 (22), 19469-19482 (2001)
   PUBMED   11297520
REFERENCE   8  (bases 1 to 3119)
  AUTHORS   Karuman,P., Gozani,O., Odze,R.D., Zhou,X.C., Zhu,H., Shaw,R.,
            Brien,T.P., Bozzuto,C.D., Ooi,D., Cantley,L.C. and Yuan,J.
  TITLE     The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent
            cell death
  JOURNAL   Mol Cell 7 (6), 1307-1319 (2001)
   PUBMED   11430832
REFERENCE   9  (bases 1 to 3119)
  AUTHORS   Smith,D.P., Spicer,J., Smith,A., Swift,S. and Ashworth,A.
  TITLE     The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear
            protein kinase
  JOURNAL   Hum Mol Genet 8 (8), 1479-1485 (1999)
   PUBMED   10400995
REFERENCE   10 (bases 1 to 3119)
  AUTHORS   Nishioka,Y., Kobayashi,K., Sagae,S., Sugimura,M., Ishioka,S.,
            Nagata,M., Terasawa,K., Tokino,T. and Kudo,R.
  TITLE     Mutational analysis of STK11 gene in ovarian carcinomas
  JOURNAL   Jpn J Cancer Res 90 (6), 629-632 (1999)
   PUBMED   10429654
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000177.1.
            
            [WARNING] On Mar 31, 2024 this sequence was replaced by
            NM_001108069.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001108069.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1112              JACYVU010000177.1  4749152-4750263     c
            1113-1196           JACYVU010000177.1  4739959-4740042     c
            1197-1286           JACYVU010000177.1  4739224-4739313     c
            1287-1419           JACYVU010000177.1  4738653-4738785     c
            1420-1556           JACYVU010000177.1  4738449-4738585     c
            1557-1684           JACYVU010000177.1  4738039-4738166     c
            1685-1742           JACYVU010000177.1  4737686-4737743     c
            1743-1939           JACYVU010000177.1  4736660-4736856     c
            1940-2146           JACYVU010000177.1  4734671-4734877     c
            2147-3119           JACYVU010000177.1  4733501-4734473     c
FEATURES             Location/Qualifiers
     source          1..3119
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3119
                     /gene="Stk11"
                     /gene_synonym="Lkb1"
                     /note="serine/threonine kinase 11"
                     /db_xref="GeneID:314621"
                     /db_xref="RGD:1308653"
     exon            1..1112
                     /gene="Stk11"
                     /gene_synonym="Lkb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             823..2133
                     /gene="Stk11"
                     /gene_synonym="Lkb1"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase LKB1;
                     serine/threonine-protein kinase 11; liver kinase B1
                     homolog"
                     /codon_start=1
                     /product="serine/threonine-protein kinase STK11"
                     /protein_id="NP_001101539.1"
                     /db_xref="GeneID:314621"
                     /db_xref="RGD:1308653"
                     /translation="MDVADPQPLGLFPEGELMSVGMDTFIHRIDSTEVIYQPRRKRAK
                     LIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLL
                     RRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFRQL
                     IDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPA
                     FQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGRGDFTIPC
                     DCAPPLSDLLRGMLEYEPAKRFSIRQIRQHSWFRKKHPLAEALVPIPPSPDTKDRWRS
                     MTVVPYLEDLHGRAEEEEDEDLFDIEDGIIYTQDFTVPGQVLEEEVGQNGQSHSLPKA
                     VCVNGTEPQLSSKVKPEGRPGAANPARKVCSSNKIRRLSACKQQ"
     exon            1113..1196
                     /gene="Stk11"
                     /gene_synonym="Lkb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1286
                     /gene="Stk11"
                     /gene_synonym="Lkb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1419
                     /gene="Stk11"
                     /gene_synonym="Lkb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1556
                     /gene="Stk11"
                     /gene_synonym="Lkb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1684
                     /gene="Stk11"
                     /gene_synonym="Lkb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1742
                     /gene="Stk11"
                     /gene_synonym="Lkb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1939
                     /gene="Stk11"
                     /gene_synonym="Lkb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2146
                     /gene="Stk11"
                     /gene_synonym="Lkb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..3119
                     /gene="Stk11"
                     /gene_synonym="Lkb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgcggcg cagggcggta aacaagatgg cggcggcgtg tcggtctagg aaaggggagg
       61 cggctcacag cgcccgcgag tgaggcgcga gcctccgagg gcggtgtcgg cgtggagttt
      121 tctctcgcgg acagcatctt tctgcctgaa gttcgactcc cccctcgccg ctccggcctc
      181 ctgcctgtca cgcggcggct aggcggcgag ggggacgcgc cgccccgggt ggttttctcc
      241 ccccattggt cccccgaaga tttcctgtcc cgacttcgtg cccgcgactt gtgggtgtcc
      301 cgcgtccggg tggagtttgc gcaccgagaa gtcgtggaac taagggaact aaggggccgc
      361 gcgcggcgtc ggcgcgggcc ggacatggac ggagcggacc gtcctcgacg cggccgcctg
      421 ggcccctgag cgcggggccc aagtggcgac catgacctag cggcccgcgc gccgcgacgg
      481 cggaccgtcg cctccgtcgg aagcagcgtc cccggggacc cgaattaggg ggacgcgagg
      541 gttggggggg ctcattgctt tttttttttt tattcttatt ttcatttttt ttctccctga
      601 gcacctagaa gaaaagggga aaatcaaaag tgaagaattg gcgcccagga aacggacgtg
      661 gacccggttg tggggaccgg gagggttgtg gaggtcgttc cttccccccc ccccattcct
      721 ttttttcccc ttcttgaaca tttggaagaa gcgggtgggg gaaatttgaa cttgaaaaga
      781 attggcgctc ccgaagggga cgaggacaaa gagtgggcca ggatggacgt ggctgacccc
      841 cagccgttgg gcctgttccc cgagggcgag ctaatgtcgg tgggcatgga caccttcatc
      901 caccgcatcg actccaccga ggtgatctac cagccgcgcc gcaagcgcgc caagctcatc
      961 ggcaagtacc tgatggggga cctgctcggg gagggctcgt acggcaaggt gaaggaggtg
     1021 ctggactccg agaccttatg ccgcagggcg gtcaagatcc tcaagaagaa aaagctgcgc
     1081 aggatcccca atggcgaggc caacgtcaag aaggagatcc agctgctgcg gcggctgcgg
     1141 catcggaatg tgatccagct tgtggatgtg ctgtacaatg aggagaagca gaagatgtat
     1201 atggtgatgg agtactgcgt gtgtggcatg caggagatgc tggacagtgt gccagagaag
     1261 cgcttccccg tgtgccaagc tcatgggtac ttccgccagc tgattgacgg cctggagtac
     1321 ctacacagcc agggcattgt tcacaaggac atcaagccgg gcaacctgct cctcaccacc
     1381 aatggcacac tcaagatctc cgacctcggt gttgccgagg ccttgcaccc tttcgctgtg
     1441 gatgacacct gccggaccag ccagggctcc ccagccttcc agcctccaga gattgccaat
     1501 ggactggaca ccttttcagg tttcaaggtg gacatctggt cagctggggt cacactctac
     1561 aacatcacca cgggcctgta cccatttgag ggggacaata tctacaagct ctttgagaac
     1621 atcgggagag gggacttcac catcccttgt gactgcgctc caccactctc tgacctactc
     1681 cgagggatgt tggagtacga gccagccaag aggttctcca tccgacagat tagacagcac
     1741 agctggttcc ggaagaaaca cccgctggcc gaggctcttg tgcctatccc cccaagtcca
     1801 gacactaagg accgctggcg cagcatgacc gtagtgccct acctggagga cctgcatggc
     1861 cgtgcagagg aggaggagga cgaggacttg tttgacattg aggacggcat catctatacc
     1921 caggacttca cagtgcctgg acaggtcctg gaagaggaag tgggtcagaa tggacagagc
     1981 cacagcctgc ccaaggctgt ttgtgtgaat ggcacagagc cccagctcag cagcaaggtg
     2041 aagccagaag gccggcctgg cgctgccaac cctgcacgca aggtgtgctc cagcaacaag
     2101 atccgccggc tctcggcctg caagcagcag tgactgaggc ctacagtgtg tcgccaggat
     2161 ctttgggcag gtgtcccggc aatactgatt ccgggcctgt ctgtccacat acttctggac
     2221 attggagccg agggcagacc tgccacccca gaagcacttt atgtcgagac cactggtcgg
     2281 cctcgcctgc atgccgccct gcgagcctcg ctgtctttgg gttggttttt tttttccttt
     2341 tttttttttt tttttttttt ttttttaaat aaaacaggag gatttgagct gtggctatga
     2401 ggatgtttgg aaatagggag caggcggggc acagggtggc ctgcagagaa aacccagagc
     2461 gaacaaatat gcagagacat ttatgatcaa ccagacaaca cgaccaacca cagggcgcag
     2521 ggcagggagt gggcaggcac tcatggcgag gctgcccaat cttttggcaa taaataaagc
     2581 ttgggaaact tgaagctgcc accgggctgt tctgtctctg tgtttaaagc ccaaagctcg
     2641 tggggaggga tgggacaggc tggagcctgt gcacatgcag agagcgagca ggcgcagtcg
     2701 gttattgctc agagaggaaa ggtacagttg ctacaaagtg cataccatgg acaggggaaa
     2761 ggattaagga tctggggcgc gtgttcctct ctgatcctca gtgccccgca gtcacttccc
     2821 ctccagtagg ttcacgcatg cagtggcact gccagcacgt gctcacgagt gtggaggttc
     2881 ggctgatcct ggagggaggc tgcacgcgca cctcagaacc tgctccaccc gcatctgtgg
     2941 ccagaggctg ggtgccgggg gtcaaccgta tatggacttg agaatccaag atcttcatcc
     3001 tccctgcagc tgagcctggg tccggaggcc ttgtgcatcc ggaggcccac tgcaccctgc
     3061 taagtgcccg aggggacact ccttgtacac acttgggatt tgggccgcgt acccatgca
//
