LOCUS       NM_019206               5153 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus serine/threonine kinase 10 (Stk10), mRNA.
ACCESSION   NM_019206 XM_001064952 XM_001065000 XM_577078
VERSION     NM_019206.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5153)
  AUTHORS   Hong,H., Xu,G., Bao,G., Zhang,J., Chen,C., Chen,J., Wu,C.,
            Jiang,J., Huang,J., Huang,H. and Cui,Z.
  TITLE     VIRMA promotes neuron apoptosis via inducing m6A methylation of
            STK10 in spinal cord injury animal models
  JOURNAL   CNS Neurosci Ther 30 (3), e14453 (2024)
   PUBMED   37721438
  REMARK    GeneRIF: VIRMA promotes neuron apoptosis via inducing m6A
            methylation of STK10 in spinal cord injury animal models.
REFERENCE   2  (bases 1 to 5153)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 5153)
  AUTHORS   Belkina,N.V., Liu,Y., Hao,J.J., Karasuyama,H. and Shaw,S.
  TITLE     LOK is a major ERM kinase in resting lymphocytes and regulates
            cytoskeletal rearrangement through ERM phosphorylation
  JOURNAL   Proc Natl Acad Sci U S A 106 (12), 4707-4712 (2009)
   PUBMED   19255442
REFERENCE   4  (bases 1 to 5153)
  AUTHORS   Pike,A.C., Rellos,P., Niesen,F.H., Turnbull,A., Oliver,A.W.,
            Parker,S.A., Turk,B.E., Pearl,L.H. and Knapp,S.
  TITLE     Activation segment dimerization: a mechanism for kinase
            autophosphorylation of non-consensus sites
  JOURNAL   EMBO J 27 (4), 704-714 (2008)
   PUBMED   18239682
REFERENCE   5  (bases 1 to 5153)
  AUTHORS   Walter,S.A., Cutler,R.E. Jr., Martinez,R., Gishizky,M. and
            Hill,R.J.
  TITLE     Stk10, a new member of the polo-like kinase kinase family highly
            expressed in hematopoietic tissue
  JOURNAL   J Biol Chem 278 (20), 18221-18228 (2003)
   PUBMED   12639966
REFERENCE   6  (bases 1 to 5153)
  AUTHORS   Endo,J., Toyama-Sorimachi,N., Taya,C., Kuramochi-Miyagawa,S.,
            Nagata,K., Kuida,K., Takashi,T., Yonekawa,H., Yoshizawa,Y.,
            Miyasaka,N. and Karasuyama,H.
  TITLE     Deficiency of a STE20/PAK family kinase LOK leads to the
            acceleration of LFA-1 clustering and cell adhesion of activated
            lymphocytes
  JOURNAL   FEBS Lett 468 (2-3), 234-238 (2000)
   PUBMED   10692593
REFERENCE   7  (bases 1 to 5153)
  AUTHORS   Schaar,D.G., Varia,M.R., Elkabes,S., Ramakrishnan,L., Dreyfus,C.F.
            and Black,I.B.
  TITLE     The identification of a novel cDNA preferentially expressed in the
            olfactory-limbic system of the adult rat
  JOURNAL   Brain Res 721 (1-2), 217-228 (1996)
   PUBMED   8793103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Dec 16, 2009 this sequence version replaced
            XM_001065000.1, XM_001064952.1, XM_577078.2, NM_019206.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000010.1  17622164-17622425
            263-427             JAXUCZ010000010.1  17644706-17644870
            428-476             JAXUCZ010000010.1  17666071-17666119
            477-626             JAXUCZ010000010.1  17669189-17669338
            627-699             JAXUCZ010000010.1  17678359-17678431
            700-894             JAXUCZ010000010.1  17679434-17679628
            895-976             JAXUCZ010000010.1  17680052-17680133
            977-1150            JAXUCZ010000010.1  17686370-17686543
            1151-1699           JAXUCZ010000010.1  17687578-17688126
            1700-1830           JAXUCZ010000010.1  17690462-17690592
            1831-1954           JAXUCZ010000010.1  17693358-17693481
            1955-2137           JAXUCZ010000010.1  17694255-17694437
            2138-2148           JAXUCZ010000010.1  17696751-17696761
            2149-2187           JAXUCZ010000010.1  17697686-17697724
            2188-2227           JAXUCZ010000010.1  17699306-17699345
            2228-2357           JAXUCZ010000010.1  17705446-17705575
            2358-2482           JAXUCZ010000010.1  17706234-17706358
            2483-2671           JAXUCZ010000010.1  17707313-17707501
            2672-2797           JAXUCZ010000010.1  17708005-17708130
            2798-2911           JAXUCZ010000010.1  17709854-17709967
            2912-5153           JAXUCZ010000010.1  17714096-17716337
FEATURES             Location/Qualifiers
     source          1..5153
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..5153
                     /gene="Stk10"
                     /note="serine/threonine kinase 10"
                     /db_xref="GeneID:29398"
                     /db_xref="RGD:3779"
     exon            1..262
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..3049
                     /gene="Stk10"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 10"
                     /protein_id="NP_062079.2"
                     /db_xref="GeneID:29398"
                     /db_xref="RGD:3779"
                     /translation="MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNDVWEILGELGD
                     GAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYY
                     DGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHGKRIIHRDLKA
                     GNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCETMKDAPYDYKA
                     DIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSTEFRDFLKIALD
                     KNPETRPSAAQLLQHPFVSTVTSNKALRELVAEAKAEVMEEIEDGKEDGREDGREDGE
                     EEDGDEKDAVSAVPPPVNHTQDSSANGTQPSLNSDKLLQDSSTPLPPSQPQEPVNGPC
                     NQPSGDGSPQNTSPADEVSKNDNGLKVPVPLRKSRPLSVDARIQVTEEKQITDQAENP
                     SSAASKPPKVNQSRPNSSALETLGVETLANGGLELPGSVTPNHSKRASDCSNLSTSES
                     MDYGTSLSADLSLNKETGSLSLKGSKLHNKTLKRTRRFVVDGVEVSITTSKIISEDEK
                     KDEEMRFLRRQELRELRLLQKEEHRNQTQLSTKHELQLEQMHRRFEQEINAKKKFYDV
                     ELENLERQQKQQVEKMEQDHSVRRREEAKRIRLEQDRDYARFQEQLKQMKKEVKLTVE
                     RLARNSRNSSSFQEQTEHPQAARRRDRDFVAKQKEDLELAMKKLTAENRREICDKERD
                     CLNKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHDLLRKHEKEREQMQ
                     RYNQRMMEQLKVRQQQEKARLPKIQRSDGKTRMAMYKKSLHINGAGSASEQREKVKQF
                     SQQEEKRQKAERLQQQQKHENQMRDMVAQCESNMNELQQLQNEKCHLLVEHETQKLKA
                     LDESHNQSLKEWRDKLRPRKKALEEDLNQKKREQEMFFRLSEEAETRPTTPNRASKFF
                     PYSSGDAS"
     exon            263..427
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            428..476
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            477..626
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            627..699
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            700..894
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            895..976
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1150
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1699
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1830
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1954
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2137
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2148
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2187
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2227
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2357
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2482
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            2483..2671
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2797
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2911
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..5153
                     /gene="Stk10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttccggca gctccctgcc gccacgggcg cactcggccg gtgctgcgct gcggggaggg
       61 cggctctccg aagccgcgcg tcctgtcgtc gcgctcctga tccaccatgg ctttcgccaa
      121 ttttcgccgc atcttgcggt tatccacctt cgagaagaga aagtcccgtg aatacgagca
      181 tgtccgcagg gacctggacc ccaacgacgt atgggagatc ctgggcgagc tgggagacgg
      241 cgccttcggc aaagtctaca aggccaaaaa caaggagacg ggcgccctgg cagcagccaa
      301 agtcattgag actaagagcg aggaggagct ggaggactac atcgtggaga tcgagatcct
      361 cgccacctgc gaccacccat atatcgtgaa gctcctgggg gcctattact atgacgggaa
      421 actatggatc atgattgagt tctgccctgg gggagctgtg gatgccatca tgctagagct
      481 ggatcgaggc ctcactgagc cccagattca ggtcgtttgc cgccagatgt tggaggctct
      541 caacttcctg cacggcaaga gaatcatcca ccgcgacctg aaagctggca acgtgcttat
      601 gaccctggag ggggacatca ggctggctga ttttggagta tctgccaaga atctgaaaac
      661 tctgcaaaag cgagattcct tcataggaac gccttactgg atggcccctg aggtggtgct
      721 gtgtgaaacc atgaaggacg ccccctatga ctacaaggct gacatctggt ccctgggcat
      781 cacgctgatc gagatggcgc agattgagcc cccacaccat gagctcaacc ccatgcgggt
      841 cctgctcaag atcgccaagt cggaccctcc caccctgctc acaccctcca agtggtccac
      901 ggagttccga gactttctga agatagcctt ggataagaac ccagaaaccc ggcccagtgc
      961 tgcgcagctg ctgcagcatc ccttcgtcag tacagtcacc agtaataagg cccttcggga
     1021 gctggtggct gaggcgaagg ctgaggtgat ggaggagatc gaggacggca aggaggacgg
     1081 cagggaggac ggcagggagg atggagaaga ggaggatgga gacgagaagg atgctgtgag
     1141 tgctgttccg cccccagtca accacactca ggactcctct gccaatggaa ctcagccaag
     1201 cctcaactct gacaagcttc tccaggattc ttctaccccc ctgcctccca gccagcctca
     1261 ggagcctgtg aacgggccct gtaaccaacc ctcaggggat ggatcccccc agaacaccag
     1321 ccctgcagat gaggtctcca agaatgacaa tggcttaaag gtacctgttc ccctccggaa
     1381 gtcccggcca ttgtccgtgg atgccagaat tcaggtgacc gaagagaaac aaatcactga
     1441 ccaggctgag aaccccagtt ctgcagccag caaacccccg aaggtcaacc agagccgacc
     1501 taacagcagc gccctggaga ctttgggtgt cgagactctg gccaatggag gcctggagct
     1561 ccctggctct gtaactccaa accattctaa gagggcgtcg gactgtagca acctgtctac
     1621 ctcagagagc atggactacg gcacctcctt gtctgctgac ctgtcattga acaaagagac
     1681 gggctcattg tctctcaagg gctcaaaact gcacaacaag accctgaaga ggacccgccg
     1741 gtttgtggtg gacggtgtgg aggtgagcat caccacctcc aagatcatca gcgaagacga
     1801 gaagaaagac gaggagatga ggtttctcag gcgccaggaa ctccgagagc ttcggctcct
     1861 gcagaaagaa gagcatcgga accagacgca gctgagcacc aagcacgagc tgcagctgga
     1921 gcagatgcac agacgatttg aacaagaaat caacgccaag aagaaattct atgacgtgga
     1981 gctagagaac ctggagcggc agcagaagca gcaggtggag aagatggagc aggaccacag
     2041 cgtgcgtcgc agagaggagg ccaagcggat ccgcctggag caggatcgag actacgccag
     2101 gttccaagag cagctcaagc agatgaagaa ggaggtgaag ctgactgtcg agaggttggc
     2161 tagaaatagt agaaatagtt cttccttcca ggaacagact gagcatcctc aggcagctag
     2221 gaggagggac cgagactttg tagccaagca gaaggaagac ctggagctgg ccatgaagaa
     2281 gctcacggca gaaaacaggc gtgagatctg tgacaaggaa cgtgattgcc ttaacaagaa
     2341 gcaggagctc ctccgagacc gagaggcagc cctgtgggag atggaggagc accagttaca
     2401 ggagagacat cagctggtga agcagcagct taaggaccag tacttcctgc agcggcatga
     2461 cctgctgcgc aagcacgaga aggagcggga gcagatgcag cgctacaacc agcgtatgat
     2521 ggagcagctg aaggtcagac agcagcagga gaaggcgcgg ctacccaaga tccagaggag
     2581 tgacggcaag acccgcatgg ccatgtacaa gaagagcctg cacatcaatg gtgcgggcag
     2641 tgcctccgag cagcgggaga aggtcaagca gttctcccag caggaagaga agaggcagaa
     2701 ggcggagagg ctgcagcagc agcagaaaca cgagaaccag atgcgagaca tggtggcaca
     2761 gtgcgagagc aacatgaacg agctgcagca gctgcagaat gaaaagtgtc atctgttagt
     2821 ggagcatgaa acccagaagc tgaaggccct ggacgagagc cataaccaga gcctgaagga
     2881 atggcgagac aagcttcggc cacgcaaaaa ggccctggaa gaggatttga accagaagaa
     2941 gcgggaacag gaaatgttct tcagactaag tgaggaggca gagaccagac ccaccacacc
     3001 caacagagcc agcaagttct tcccctacag ctctggggat gcttcctaac acacacatgc
     3061 ctgggctgcg gtgcggcagt acagccacca gggccaccaa ccctctacaa acaagtgact
     3121 caggacctct tcctcttgct tctgtgccag ctccaactac ccagcacccc agttgcccac
     3181 agcaccaccc cagtgcttct gatggatgac ctcatcccaa ctcagattcc catcacctgg
     3241 aagtgacctg ggctgttggg gtccgggacc gagcgggatg ggcgtacccc tcctgtttgc
     3301 caaaacacca gctctactgt ctgtgggcac aagcgctact gatgacatca ccacgaaccc
     3361 atccttattg tgatccttgt ggttttttct tctccttcag taattcctca cagtgttgga
     3421 aaacatccct cagagccatt ttgcttctca gcagccagct ctcaggggtg tccccattac
     3481 cctgcttcgc acagctgact ttgtgctcga tgagacgctg tgtatgtggg ggtagggagt
     3541 ggggaaaggg aggccagaaa tgttcattct gctggtttct gacattttat gccatctcat
     3601 tttgcctctc cctgtctctc acacacacac acacacacac acacacacac acacacacac
     3661 acacacaatg caaacacaca acttggccct cctgaacctg atcgtaggac acggagtaca
     3721 gagcatgtca ggtggagcag ctgctggggc atgctgagtg ctggccccaa agcccagaga
     3781 aggcacaggc tgtactgcag cctgcctgcc actcgtttgg ctgcacacag gatcctgtgt
     3841 tcaggggtaa actcccctcc acacttgtct tctgctgcct agcgcatgcc aatctcgccc
     3901 ttgcccagtt gtcggcaagt actggggaag gctcctgacc tttgaccttt gccccagtcc
     3961 tgcactggag tcccactgta catttccact aagccggaca gtcctttgga cttctctgtt
     4021 taggaagaga tgcttcccac ccctgggaac atgccgagct caggaaaatg ccaagcctcg
     4081 tgcctgggcc tttgggttgc tcaggtagcc tcccaagatg ctgcgcccca taggctaccc
     4141 tgcccagaaa agcagctggt cggcccagcc ggcgttcgct gatagcgcct tagggctcag
     4201 ttaaagcaca ggtaaatggc tggctgcttt gtataccctc cttttagaca gcatcacccc
     4261 agggattagg atgggatggg tgggggcggg gcacccaggc agtggagtct gggagtggct
     4321 gagacctcag cagtatttcc ccatcactgc cccatgctga gacaaccttc taggacgttt
     4381 cctcagatgc tgactgggtg cttgggaggg gagtgggcta gtaaaacaaa ataggaaaac
     4441 aggtcttggg actcccagat cttgtgtgca gtaaggaagt tcacagagcc ccaggaaggc
     4501 gatagttctc agggtagcga gcgtcagctt gctttcaggc cgcacactga ggagtcttga
     4561 ggaacagttg acttctttct tactggtgca tgggggctgg gaaacacaag ttgtcagagt
     4621 gcagctgtgg gactcagaga tgggaagtgg gcaaggccac gccctgcagg gctctaccat
     4681 tgtttacaat gtacttggct gcattcgggg gtggggggaa cttgacagtg gctattaggc
     4741 aaaatgccgg ttttgtggtt caggtaacag tctttgacca ctccctgacg tcattcgtac
     4801 tgtcctcctt cttgttgctt ccacacttag tcccacctga gctctggtac ctctgctgtg
     4861 ccttttttga gtggggtcta gccttgtctt ccagcctcat aatttaacct aagtgcaatg
     4921 cctgccaccg acaaaggccc gtgaagtatt cctcatgtcc tgtgctaacg ttttctgtat
     4981 aggaacaggc agaaatgtct ttagcaccgc ggatataact aacttatatt tcccttcacg
     5041 aaggatagaa gtaacgggtg tgtcatttcc aacggtcatg tataattttt gtaaactgtt
     5101 ctctgcaaac aaaaaaaatg taaatatgct tctaataaaa taataaggta att
//
