LOCUS       NM_001109122            2040 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus stimulator of interferon response cGAMP
            interactor 1 (Sting1), mRNA.
ACCESSION   NM_001109122 XM_001062602 XM_574124
VERSION     NM_001109122.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2040)
  AUTHORS   Mou,L., Sun,D., Qu,J., Tan,X., Wang,S., Zeng,Q. and Liu,C.
  TITLE     GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP
            facilitates iodoacetic acid-mediated testosterone decline
  JOURNAL   J Hazard Mater 476, 135101 (2024)
   PUBMED   39002476
  REMARK    GeneRIF: GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP
            facilitates iodoacetic acid-mediated testosterone decline.
REFERENCE   2  (bases 1 to 2040)
  AUTHORS   Fan,C., Du,J., Yu,Z., Wang,J., Yao,L., Ji,Z., He,W., Deng,Y.,
            Geng,D., Wu,X. and Mao,H.
  TITLE     Inhibition of MAGL attenuates Intervertebral Disc Degeneration by
            Delaying nucleus pulposus senescence through STING
  JOURNAL   Int Immunopharmacol 131, 111904 (2024)
   PUBMED   38518595
  REMARK    GeneRIF: Inhibition of MAGL attenuates Intervertebral Disc
            Degeneration by Delaying nucleus pulposus senescence through STING.
REFERENCE   3  (bases 1 to 2040)
  AUTHORS   Chen,Z., Chen,C., Yang,X., Zhou,Y., Cao,X., Han,C., Zhou,T.,
            Zhao,J. and Qin,A.
  TITLE     Dysfunction of STING Autophagy Degradation in Senescent Nucleus
            Pulposus Cells Accelerates Intervertebral Disc Degeneration
  JOURNAL   Int J Biol Sci 20 (7), 2370-2387 (2024)
   PUBMED   38725841
  REMARK    GeneRIF: Dysfunction of STING Autophagy Degradation in Senescent
            Nucleus Pulposus Cells Accelerates Intervertebral Disc
            Degeneration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2040)
  AUTHORS   Zhu,S., Chen,Q., Sun,J., Du,W., Chen,Z., Yu,M., Tao,J., Zhou,Y.,
            Zhao,Y. and Zhang,Q.
  TITLE     The cGAS-STING pathway promotes endometriosis by up-regulating
            autophagy
  JOURNAL   Int Immunopharmacol 117, 109644 (2023)
   PUBMED   36878046
  REMARK    GeneRIF: The cGAS-STING pathway promotes endometriosis by
            up-regulating autophagy.
REFERENCE   5  (bases 1 to 2040)
  AUTHORS   Wu,W., Zhang,X., Wang,S., Li,T., Hao,Q., Li,S., Yao,W. and Sun,R.
  TITLE     Pharmacological inhibition of the cGAS-STING signaling pathway
            suppresses microglial M1-polarization in the spinal cord and
            attenuates neuropathic pain
  JOURNAL   Neuropharmacology 217, 109206 (2022)
   PUBMED   35926582
  REMARK    GeneRIF: Pharmacological inhibition of the cGAS-STING signaling
            pathway suppresses microglial M1-polarization in the spinal cord
            and attenuates neuropathic pain.
REFERENCE   6  (bases 1 to 2040)
  AUTHORS   Tsuchida,T., Zou,J., Saitoh,T., Kumar,H., Abe,T., Matsuura,Y.,
            Kawai,T. and Akira,S.
  TITLE     The ubiquitin ligase TRIM56 regulates innate immune responses to
            intracellular double-stranded DNA
  JOURNAL   Immunity 33 (5), 765-776 (2010)
   PUBMED   21074459
REFERENCE   7  (bases 1 to 2040)
  AUTHORS   Saitoh,T., Fujita,N., Hayashi,T., Takahara,K., Satoh,T., Lee,H.,
            Matsunaga,K., Kageyama,S., Omori,H., Noda,T., Yamamoto,N.,
            Kawai,T., Ishii,K., Takeuchi,O., Yoshimori,T. and Akira,S.
  TITLE     Atg9a controls dsDNA-driven dynamic translocation of STING and the
            innate immune response
  JOURNAL   Proc Natl Acad Sci U S A 106 (49), 20842-20846 (2009)
   PUBMED   19926846
REFERENCE   8  (bases 1 to 2040)
  AUTHORS   Ishikawa,H., Ma,Z. and Barber,G.N.
  TITLE     STING regulates intracellular DNA-mediated, type I
            interferon-dependent innate immunity
  JOURNAL   Nature 461 (7265), 788-792 (2009)
   PUBMED   19776740
REFERENCE   9  (bases 1 to 2040)
  AUTHORS   Sun,W., Li,Y., Chen,L., Chen,H., You,F., Zhou,X., Zhou,Y., Zhai,Z.,
            Chen,D. and Jiang,Z.
  TITLE     ERIS, an endoplasmic reticulum IFN stimulator, activates innate
            immune signaling through dimerization
  JOURNAL   Proc Natl Acad Sci U S A 106 (21), 8653-8658 (2009)
   PUBMED   19433799
REFERENCE   10 (bases 1 to 2040)
  AUTHORS   Zhong,B., Yang,Y., Li,S., Wang,Y.Y., Li,Y., Diao,F., Lei,C., He,X.,
            Zhang,L., Tien,P. and Shu,H.B.
  TITLE     The adaptor protein MITA links virus-sensing receptors to IRF3
            transcription factor activation
  JOURNAL   Immunity 29 (4), 538-550 (2008)
   PUBMED   18818105
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473974.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001062602.1, XM_574124.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: JN587497.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMD00132261,
                                    SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2040
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..2040
                     /gene="Sting1"
                     /gene_synonym="RGD1562552; rSTING; Tmem173"
                     /note="stimulator of interferon response cGAMP interactor
                     1"
                     /db_xref="GeneID:498840"
                     /db_xref="RGD:1562552"
     exon            1..264
                     /gene="Sting1"
                     /gene_synonym="RGD1562552; rSTING; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     exon            265..356
                     /gene="Sting1"
                     /gene_synonym="RGD1562552; rSTING; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..1496
                     /gene="Sting1"
                     /gene_synonym="RGD1562552; rSTING; Tmem173"
                     /note="mitochondrial transmembrane protein 173"
                     /codon_start=1
                     /product="stimulator of interferon genes protein"
                     /protein_id="NP_001102592.1"
                     /db_xref="GeneID:498840"
                     /db_xref="RGD:1562552"
                     /translation="MPYSNLHPSIPRPRSYRFKLAAFVLLVGSLMSLWMTGEPPSHTL
                     HYLALHVASQQLGLLLKKLCCLAEELCHVQSRYQGSYWKAVRACVGSPICFMALILLS
                     FYFYCSLENTSDLRLAWHLGILVLSKSLSMTLDLQSLAPAEVSAVCEEKNFNVAHGLA
                     WSYYIGYLKLILPGLQARIRMFNQLHNNMLSGAGSRRLYILFPLDCGVPDDLSVADPN
                     IRFRDMLPQQNTDRAGVKNRAYSNSVYELLENGQPAGACILEYATPLQTLFAMSQDGK
                     AGFSREDRLEQAKLFCRTLEEILADVPESRNHCRLIVYQESEEGNSFSLSQEVLRHIR
                     QEEKEEVTMSGPPTSVAPRPSLLSQEPRLLISGMEQPLPLRTDLI"
     exon            357..583
                     /gene="Sting1"
                     /gene_synonym="RGD1562552; rSTING; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     exon            584..767
                     /gene="Sting1"
                     /gene_synonym="RGD1562552; rSTING; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     exon            768..876
                     /gene="Sting1"
                     /gene_synonym="RGD1562552; rSTING; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1115
                     /gene="Sting1"
                     /gene_synonym="RGD1562552; rSTING; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1302
                     /gene="Sting1"
                     /gene_synonym="RGD1562552; rSTING; Tmem173"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..2040
                     /gene="Sting1"
                     /gene_synonym="RGD1562552; rSTING; Tmem173"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcctggg cttctactaa attcttagct tagagcccga gatttcagga agtagagtgt
       61 gctgtttacc ctctcaatct ctcctgtgca atcctccctc ctgatgtcct agggatagat
      121 agtggagggt ttgggggcat cttgaaatcc tgtggggggc cctgtcactt tgggtccttg
      181 tgtgagtcct gcctggtgtc tactgcagcg tgttgcatcc cacggacctt tagaggaatc
      241 cggagtgcgg ggctgtgact gctgtctgcc ctttgagagg ccacttgccg gtcgctacgg
      301 aagggttctt catagtctct ccagttccag gaacacttcg gtctaggaag cagaagatgc
      361 catactccaa cctgcatcca tccatcccac ggcccagaag ttaccgcttc aaactggcag
      421 ccttcgtctt gctggtgggc agcctgatga gcctttggat gacaggggaa ccaccaagtc
      481 acactctgca ttacctagca cttcacgtag cctcgcagca acttggatta ctgttgaaaa
      541 agctctgctg tctggctgaa gagttgtgcc atgtccagtc caggtaccag ggcagctact
      601 ggaaggctgt gcgcgcctgc gtggggagtc ccatctgctt tatggccctg atcctactgt
      661 cattttattt ctactgctcc ctcgaaaata cttctgacct gcgccttgct tggcatcttg
      721 gcatcctggt cctttcaaag tccctaagca tgaccctgga ccttcagagc ttggccccag
      781 cagaagtctc tgcggtctgt gaagaaaaga acttcaatgt tgcccatgga ctggcctggt
      841 cgtactacat tgggtacctg aagctgatct tgccaggact gcaggcccgg atccggatgt
      901 tcaatcagct acacaacaac atgctctcgg gtgcggggag ccggcggctg tatatcctct
      961 tcccattgga ctgtggggtg cctgatgatc tgagtgtggc tgaccccaat attcgattcc
     1021 gagatatgct gccccagcaa aacacagacc gtgctggcgt caagaatcgg gcttattcca
     1081 acagtgtcta tgaacttctg gagaatgggc agccggcagg tgcctgtatc ctggagtacg
     1141 ccaccccctt gcagaccttg tttgccatgt cacaggatgg caaagctggc ttcagtcggg
     1201 aggaccggct tgagcaggcc aaactcttct gtcggacact tgaggaaatt ctggctgatg
     1261 tccctgagtc tcgaaaccac tgccgcctca ttgtctacca agaatccgaa gagggaaaca
     1321 gtttctcgct gtctcaggag gtgctccggc acattcggca agaagaaaag gaggaagtta
     1381 ccatgagtgg ccccccgacc tcagtggcac ctcgtccctc cctactgtcc caagagccga
     1441 gacttctcat cagtggcatg gagcagcctc tcccactccg cacggacctc atctgaggca
     1501 tgagacagcc ttgcctgggt cccagtgacc cttcagcctc ttgactgggc tcccctttaa
     1561 tggctggggg cctcatagag acttcacatc tccagatgag tcccacattc ccgggcaagc
     1621 cacttcacct ctctgagcct cagcctgccc cactccaaag gccatcataa ggtattccct
     1681 gcccactcag ggtttttgtg aagacaatac atgtagaagt ttggtgtcaa tgcctggtaa
     1741 acttgagaga taggccaagt atttcccatg atgatcagca ttctccactc tctgttgact
     1801 tgtgtgggtt gttccagcag acctctgacc cagcttctgg tcatgtgtgt tcaacgggag
     1861 cctcagtaga tggagagagg gagaaggaac atgtgttctg taggcagtca cagtgggccg
     1921 ccctgccagg ctgtcttctc agtaaacata tttattctca ggtttctaga atggtctctt
     1981 ctccttgccc cagcactggt atttgtgtga cactggagta cttactgtct gtggtctctt
//
