LOCUS       NM_001105750            3392 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus stromal interaction molecule 2 (Stim2), mRNA.
ACCESSION   NM_001105750 XM_001053661 XM_223454
VERSION     NM_001105750.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3392)
  AUTHORS   Luo,R., Gourrierec,P.L., Antigny,F., Bedouet,K., Domenichini,S.,
            Gomez,A.M., Benitah,J.P. and Sabourin,J.
  TITLE     STIM2 variants regulate Orai1/TRPC1/TRPC4-mediated store-operated
            Ca2+ entry and mitochondrial Ca2+ homeostasis in cardiomyocytes
  JOURNAL   Cell Calcium 119, 102871 (2024)
   PUBMED   38537434
  REMARK    GeneRIF: STIM2 variants regulate Orai1/TRPC1/TRPC4-mediated
            store-operated Ca[2+] entry and mitochondrial Ca[2+] homeostasis in
            cardiomyocytes.
REFERENCE   2  (bases 1 to 3392)
  AUTHORS   Iranipour,N., Babaei-Balderlou,F., Maleki,A., Moslemi,M. and
            Khodagholi,F.
  TITLE     STIM1, STIM2, and PDI Participate in Cellular Fate Decisions in Low
            Energy Availability Induced by 3-NP in Male Rats
  JOURNAL   Neurotox Res 39 (5), 1459-1469 (2021)
   PUBMED   34173958
  REMARK    GeneRIF: STIM1, STIM2, and PDI Participate in Cellular Fate
            Decisions in Low Energy Availability Induced by 3-NP in Male Rats.
REFERENCE   3  (bases 1 to 3392)
  AUTHORS   Gruszczynska-Biegala,J., Strucinska,K., Maciag,F., Majewski,L.,
            Sladowska,M. and Kuznicki,J.
  TITLE     STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent
            Calcium Levels in Cortical Neurons
  JOURNAL   Cells 9 (1), 160 (2020)
   PUBMED   31936514
  REMARK    GeneRIF: STIM Protein-NMDA2 Receptor Interaction Decreases
            NMDA-Dependent Calcium Levels in Cortical Neurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3392)
  AUTHORS   Kuang,X.L., Liu,Y., Chang,Y., Zhou,J., Zhang,H., Li,Y., Qu,J. and
            Wu,S.
  TITLE     Inhibition of store-operated calcium entry by sub-lethal levels of
            proteasome inhibition is associated with STIM1/STIM2 degradation
  JOURNAL   Cell Calcium 59 (4), 172-180 (2016)
   PUBMED   26960935
  REMARK    GeneRIF: conclude that sub-lethal levels of proteasome inhibition
            reduce store-operated calcium entry and promote autophagy-mediated
            degradation of STIM1/2
REFERENCE   5  (bases 1 to 3392)
  AUTHORS   Garcia-Alvarez,G., Lu,B., Yap,K.A., Wong,L.C., Thevathasan,J.V.,
            Lim,L., Ji,F., Tan,K.W., Mancuso,J.J., Tang,W., Poon,S.Y.,
            Augustine,G.J. and Fivaz,M.
  TITLE     STIM2 regulates PKA-dependent phosphorylation and trafficking of
            AMPARs
  JOURNAL   Mol Biol Cell 26 (6), 1141-1159 (2015)
   PUBMED   25609091
  REMARK    GeneRIF: STIM2 promotes cAMP-dependent surface delivery of GluA1
            through combined effects on exocytosis and endocytosis.
REFERENCE   6  (bases 1 to 3392)
  AUTHORS   Zheng,L., Stathopulos,P.B., Li,G.Y. and Ikura,M.
  TITLE     Biophysical characterization of the EF-hand and SAM domain
            containing Ca2+ sensory region of STIM1 and STIM2
  JOURNAL   Biochem Biophys Res Commun 369 (1), 240-246 (2008)
   PUBMED   18166150
REFERENCE   7  (bases 1 to 3392)
  AUTHORS   Parvez,S., Beck,A., Peinelt,C., Soboloff,J., Lis,A.,
            Monteilh-Zoller,M., Gill,D.L., Fleig,A. and Penner,R.
  TITLE     STIM2 protein mediates distinct store-dependent and
            store-independent modes of CRAC channel activation
  JOURNAL   FASEB J 22 (3), 752-761 (2008)
   PUBMED   17905723
REFERENCE   8  (bases 1 to 3392)
  AUTHORS   Brandman,O., Liou,J., Park,W.S. and Meyer,T.
  TITLE     STIM2 is a feedback regulator that stabilizes basal cytosolic and
            endoplasmic reticulum Ca2+ levels
  JOURNAL   Cell 131 (7), 1327-1339 (2007)
   PUBMED   18160041
REFERENCE   9  (bases 1 to 3392)
  AUTHORS   Soboloff,J., Spassova,M.A., Hewavitharana,T., He,L.P., Xu,W.,
            Johnstone,L.S., Dziadek,M.A. and Gill,D.L.
  TITLE     STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry
  JOURNAL   Curr Biol 16 (14), 1465-1470 (2006)
   PUBMED   16860747
REFERENCE   10 (bases 1 to 3392)
  AUTHORS   Williams,R.T., Manji,S.S., Parker,N.J., Hancock,M.S., Van
            Stekelenburg,L., Eid,J.P., Senior,P.V., Kazenwadel,J.S.,
            Shandala,T., Saint,R., Smith,P.J. and Dziadek,M.A.
  TITLE     Identification and characterization of the STIM (stromal
            interaction molecule) gene family: coding for a novel class of
            transmembrane proteins
  JOURNAL   Biochem J 357 (Pt 3), 673-685 (2001)
   PUBMED   11463338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            [WARNING] On Jan 17, 2025 this sequence was replaced by
            NM_001105750.3.
            
            On May 31, 2013 this sequence version replaced NM_001105750.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. There are no full-length
            transcripts supporting this RefSeq in rat; however, it is predicted
            based on partial transcript alignments and on full-length
            transcript support from the mouse (GeneID: 116873, AK173183.1) and
            human (GeneID: 57620, AF328905.1) homologs.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.57042.1,
                                           SRR22582416.1055802.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-364               JAXUCZ010000014.1  61216717-61217080   c
            365-495             JAXUCZ010000014.1  61165619-61165749   c
            496-610             JAXUCZ010000014.1  61137197-61137311   c
            611-722             JAXUCZ010000014.1  61109122-61109233   c
            723-838             JAXUCZ010000014.1  61108483-61108598   c
            839-1016            JAXUCZ010000014.1  61106576-61106753   c
            1017-1194           JAXUCZ010000014.1  61105746-61105923   c
            1195-1362           JAXUCZ010000014.1  61101249-61101416   c
            1363-1463           JAXUCZ010000014.1  61100483-61100583   c
            1464-1702           JAXUCZ010000014.1  61100006-61100244   c
            1703-1967           JAXUCZ010000014.1  61095328-61095592   c
            1968-3392           JAXUCZ010000014.1  61091550-61092974   c
FEATURES             Location/Qualifiers
     source          1..3392
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q11"
     gene            1..3392
                     /gene="Stim2"
                     /note="stromal interaction molecule 2"
                     /db_xref="GeneID:117087"
                     /db_xref="RGD:1304641"
     exon            1..364
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..2445
                     /gene="Stim2"
                     /codon_start=1
                     /product="stromal interaction molecule 2 precursor"
                     /protein_id="NP_001099220.2"
                     /db_xref="GeneID:117087"
                     /db_xref="RGD:1304641"
                     /translation="MLLFGLLVAGVADGCDLVPRHLRGRRASGSAGAAASPSAAAAGE
                     RQALLTDPCMSLSPPCFTEEDRFSLEALQTIHKQMDDDKDGGIEVDESDEFIREDMKY
                     KDATNKHSHLHREDKHITVEDLWKQWKTSEVHNWTLEDTLQWLIEFVELPQYEKNFRD
                     NNVKGTTLPRIAVHETSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHNWMKDF
                     ILTISIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEEN
                     RTVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKK
                     AEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRS
                     TVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSG
                     LPSLTSSLYSDHSWVVMPRVSIPPYPIAGGVDDLDEDTPPIVSQFPGTVAKPAGSLAR
                     SSSLCRSRRSIVPSSPQSQRAQLPAHAPLAAHPRHPHHPQHSLPSPDPDILSVSSCPA
                     LYRNEEEEEAIYFTAEKQWEVPDTASECDSLNSSIGRKQSPPSSLEIYQTLSSRKISR
                     DELSLEDSSRGDSPVTADVSRGSPECVGLTETKSMIFSPASRVYNGILEKSCSMHQLS
                     SGIPVPNPRHTSCSLAGSDSKPVQEASSVSRVGSIPHDLCHNGEKSKKPSKIKSLFKK
                     KSK"
     exon            365..495
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..610
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            611..722
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            723..838
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1016
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1194
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1362
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1463
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1702
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1967
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..3392
                     /gene="Stim2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaataaccgg aaccaatgaa cgcggcgggg tgccgagctc cgcgggccgc cggtgaaggg
       61 agcgggctag cacccggcgg gagtctgctt ccgaggcgac ggggccccgg acagctggcg
      121 gcgagcgagt gcccggcggc tcctgtgagc gctcctcccg ccgcggcacc cggccgggcc
      181 ttgggccgcc cttcccgacg gcgctgggca gcaatgctgc tcttcgggct gttggtggcc
      241 ggcgtggcgg acggatgcga cctggtgccc cggcacctcc gcgggcggcg cgcgtcgggg
      301 tcggccggag cggctgcgtc tccttcggct gcggctgccg gcgagcgcca ggcgctgctg
      361 acagatccct gtatgtctct gagtccacca tgcttcactg aagaagacag gttcagtctg
      421 gaagcacttc agacaataca taaacagatg gacgacgaca aggatggtgg gatagaagtg
      481 gacgagagtg atgagtttat cagagaagat atgaaatata aagatgctac gaataaacac
      541 agtcatctgc acagagaaga taagcacata actgttgagg acttgtggaa acagtggaag
      601 acatcagaag ttcacaattg gacgcttgag gataccctgc agtggttgat agaatttgtt
      661 gaactcccac aatacgagaa gaattttagg gataataatg tgaaaggaac aacacttccc
      721 aggatagcag ttcatgaaac ttcatttatg atttcccagt tgaaaatcag tgaccggagt
      781 cacagacaga aacttcaact caaagcactg gatgtggttt tgtttgggcc tctgacacgc
      841 ccacctcata attggatgaa ggattttatt ctcacaattt ccatagtaat tggcgttgga
      901 ggttgttggt ttgcttatac acaaaataag acatcaaagg aacatgttgc aaagatgatg
      961 aaagacttag aaagcctaca aaccgcagag cagagcctca tggacttaca ggagagactt
     1021 gaaaaggcac aggaagaaaa cagaactgtt gctgtcgaaa agcaaaatct ggaacgaaag
     1081 atgatggatg aaatcaacta cgccaaggag gaggcctgcc ggctgcggga gctgagggag
     1141 ggcgcagagt gtgagctgag caggcgccag tatgcggagc aggagctgga gcaggtccgc
     1201 atggctctaa aaaaggctga aaaggagttt gaactgagaa gcagctggtc tgtccctgat
     1261 gcactgcaga aatggcttca gctaacacac gaggttgaag tacagtacta taatattaag
     1321 aggcagaatg ccgagatgca gctagccatc gctaaggacg aggcagaaaa aattaaaaag
     1381 aaaagaagca cagtctttgg gaccctgcat gttgcacaca gctcctccct ggatgaagta
     1441 gaccacaaga ttctggaagc caagaaagca ctctctgagc tgacgacatg tttgcgagaa
     1501 cggctttttc gctggcagca gattgagaag atctgtggct ttcagatagc tcacaactct
     1561 ggcctcccca gtctcacctc ctctctgtac tctgaccaca gctgggtggt gatgcctaga
     1621 gtctccattc caccttaccc tattgcggga ggagtcgatg acctggatga agatacaccc
     1681 ccaatagtgt cacagtttcc agggaccgtg gctaagcctg ctgggtcttt agccagaagc
     1741 agtagtttat gccgctctcg tcgaagcatt gtgccatcct ccccacagtc tcagcgagct
     1801 cagcttcctg cacatgctcc tctggcagcc caccctcggc accctcacca tccccagcac
     1861 tcattacctt ccccagatcc agacattctc tctgtgtcaa gttgccctgc tctgtatcgg
     1921 aacgaagaag aggaggaggc tatctacttc actgctgaga aacaatggga ggtaccagac
     1981 acagcttcag aatgtgactc cttaaactct tccattggga gaaaacagtc tcctccttca
     2041 agccttgaga tataccaaac attgtcttct cgaaaaatat caagagacga gctttccctg
     2101 gaggactctt ccagggggga ctcacccgtg acagcagatg tctcccgggg ctcccctgag
     2161 tgtgtgggcc tgacggaaac caagagcatg atcttcagcc ctgcgagcag agtgtacaac
     2221 ggcatcctgg agaagtcctg cagcatgcac cagctctcta gtggcatccc ggtgcctaat
     2281 cctcgacaca cgtcctgctc cttggctggc agtgacagca agccagttca ggaagcctcc
     2341 agcgtttcca gagtaggcag catcccgcac gacctttgtc ataatggtga gaaaagcaaa
     2401 aagccatcaa aaatcaaaag ccttttcaag aagaagtcca agtgactcgg ctgatgagat
     2461 ggaattccat tcaagaggca tctgtaaact tttatctccc accctccact ccgtttttat
     2521 tttaatttta ggaatgtaac tccattgggg ctttccagac tcgatgccat agtggaaatg
     2581 tccttaaggg caactgtccg ctgtctgctt aaactgacta cgccatcagt ccatctagtc
     2641 aggcattacc gaaaagtcat cgggaggagg cagtttacag ttatttccgc ctatttattt
     2701 ctgcattgat gttagtgatg tatacacagc attctgtcga aagccgctat ggacttacaa
     2761 gctttaatgg actgtaagcc agcatgggct tgcacaattt tcttgtttac cagaatatct
     2821 tcttatcttt ccacagagct gtttccatca tggactaaat aacttaaaag aagtaaaact
     2881 gattgcacta ttgttttcca gaccgggaaa ccaatctctg caagtaaaac tgtatagttt
     2941 ataaaatgac tgtggacagg ggactgtttt cacttttaga taaaatgggt ttttaagtag
     3001 aaactagggt ttctaattga ctcgatttct ggaaatgaaa acccacactt ttattatggg
     3061 atgcttcctc aaatgcattt attattatta taaagtttca agtcctgctg taaagaccat
     3121 gttgttttgt tttccccagg gctttcactg tgatttactg cactgcaggc tgtatgataa
     3181 aatataaata atgtaaagac agaaggctct tgattccttg tacaagtgga agagttaaga
     3241 cttgatcgaa ggacttaaaa cattcacatg cttaaactga ggttgggggt gtggggattc
     3301 aggcacttgt ttacagactt tgaataaatg caaagaattt atggtttgtg aaaaatttgt
     3361 actgtggaaa agataataaa ttggagacat ta
//
