LOCUS       NM_001108496            3839 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus stromal interaction molecule 1 (Stim1), mRNA.
ACCESSION   NM_001108496 XM_001069624 XM_341896
VERSION     NM_001108496.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3839)
  AUTHORS   Ohara,H., Takeuchi,F., Kato,N. and Nabika,T.
  TITLE     Genotypes of Stim1 and the proximal region on chromosome 1 exert
            opposite effects on stroke susceptibility in stroke-prone
            spontaneously hypertensive rat
  JOURNAL   J Hypertens 42 (1), 118-128 (2024)
   PUBMED   37711097
  REMARK    GeneRIF: Genotypes of Stim1 and the proximal region on chromosome 1
            exert opposite effects on stroke susceptibility in stroke-prone
            spontaneously hypertensive rat.
REFERENCE   2  (bases 1 to 3839)
  AUTHORS   Zhang,S. and Zang,W.
  TITLE     The Role and Mechanism of STIM1/Orai1-Regulated Ca2+ Influx in
            Myocardial Hypertrophy in Type 2 Diabetes Mellitus
  JOURNAL   Ann Clin Lab Sci 54 (1), 17-25 (2024)
   PUBMED   38514055
  REMARK    GeneRIF: The Role and Mechanism of STIM1/Orai1-Regulated Ca[2+]
            Influx in Myocardial Hypertrophy in Type 2 Diabetes Mellitus.
REFERENCE   3  (bases 1 to 3839)
  AUTHORS   Tedeschi,V., Sisalli,M.J., Pannaccione,A., Piccialli,I.,
            Molinaro,P., Annunziato,L. and Secondo,A.
  TITLE     Na+/Ca2+ exchanger isoform 1 (NCX1) and canonical transient
            receptor potential channel 6 (TRPC6) are recruited by STIM1 to
            mediate Store-Operated Calcium Entry in primary cortical neurons
  JOURNAL   Cell Calcium 101, 102525 (2022)
   PUBMED   34995919
  REMARK    GeneRIF: Na(+)/Ca(2+) exchanger isoform 1 (NCX1) and canonical
            transient receptor potential channel 6 (TRPC6) are recruited by
            STIM1 to mediate Store-Operated Calcium Entry in primary cortical
            neurons.
REFERENCE   4  (bases 1 to 3839)
  AUTHORS   Gammons,J., Halpage,J. and Mancarella,S.
  TITLE     Mapping the Proximity Interaction Network of STIM1 Reveals New
            Mechanisms of Cytoskeletal Regulation
  JOURNAL   Cells 10 (10), 2701 (2021)
   PUBMED   34685680
  REMARK    GeneRIF: Mapping the Proximity Interaction Network of STIM1 Reveals
            New Mechanisms of Cytoskeletal Regulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3839)
  AUTHORS   Iranipour,N., Babaei-Balderlou,F., Maleki,A., Moslemi,M. and
            Khodagholi,F.
  TITLE     STIM1, STIM2, and PDI Participate in Cellular Fate Decisions in Low
            Energy Availability Induced by 3-NP in Male Rats
  JOURNAL   Neurotox Res 39 (5), 1459-1469 (2021)
   PUBMED   34173958
  REMARK    GeneRIF: STIM1, STIM2, and PDI Participate in Cellular Fate
            Decisions in Low Energy Availability Induced by 3-NP in Male Rats.
REFERENCE   6  (bases 1 to 3839)
  AUTHORS   Takahashi,Y., Murakami,M., Watanabe,H., Hasegawa,H., Ohba,T.,
            Munehisa,Y., Nobori,K., Ono,K., Iijima,T. and Ito,H.
  TITLE     Essential role of the N-terminus of murine Orai1 in store-operated
            Ca2+ entry
  JOURNAL   Biochem Biophys Res Commun 356 (1), 45-52 (2007)
   PUBMED   17343823
REFERENCE   7  (bases 1 to 3839)
  AUTHORS   Ong,H.L., Cheng,K.T., Liu,X., Bandyopadhyay,B.C., Paria,B.C.,
            Soboloff,J., Pani,B., Gwack,Y., Srikanth,S., Singh,B.B., Gill,D.L.
            and Ambudkar,I.S.
  TITLE     Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved
            in store-operated calcium influx. Evidence for similarities in
            store-operated and calcium release-activated calcium channel
            components
  JOURNAL   J Biol Chem 282 (12), 9105-9116 (2007)
   PUBMED   17224452
  REMARK    GeneRIF: dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is
            involved in activation of SOC channel in response to internal Ca2+
            store depletion
            Erratum:[J Biol Chem. 2007 Sep 14;282(37):27556. Gill, Donald
            [corrected to Gill, Donald L]]
REFERENCE   8  (bases 1 to 3839)
  AUTHORS   Soboloff,J., Spassova,M.A., Tang,X.D., Hewavitharana,T., Xu,W. and
            Gill,D.L.
  TITLE     Orai1 and STIM reconstitute store-operated calcium channel function
  JOURNAL   J Biol Chem 281 (30), 20661-20665 (2006)
   PUBMED   16766533
  REMARK    GeneRIF: suppression of store-operated channels function by Orai1
            overexpression likely reflects a required stoichiometry between
            STIM1 and Orai1
REFERENCE   9  (bases 1 to 3839)
  AUTHORS   Zhang,S.L., Yu,Y., Roos,J., Kozak,J.A., Deerinck,T.J.,
            Ellisman,M.H., Stauderman,K.A. and Cahalan,M.D.
  TITLE     STIM1 is a Ca2+ sensor that activates CRAC channels and migrates
            from the Ca2+ store to the plasma membrane
  JOURNAL   Nature 437 (7060), 902-905 (2005)
   PUBMED   16208375
  REMARK    GeneRIF: proposal that STIM1 functions as the missing link between
            Ca2+ store depletion and store-operated calcium influx, serving as
            a Ca2+ sensor that translocates upon store depletion to the plasma
            membrane to activate CRAC channels
REFERENCE   10 (bases 1 to 3839)
  AUTHORS   Liou,J., Kim,M.L., Heo,W.D., Jones,J.T., Myers,J.W., Ferrell,J.E.
            Jr. and Meyer,T.
  TITLE     STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered
            Ca2+ influx
  JOURNAL   Curr Biol 15 (13), 1235-1241 (2005)
   PUBMED   16005298
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473956.2.
            
            On May 23, 2008 this sequence version replaced NM_001108496.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3839
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3839
                     /gene="Stim1"
                     /note="stromal interaction molecule 1"
                     /db_xref="GeneID:361618"
                     /db_xref="RGD:1306831"
     exon            1..515
                     /gene="Stim1"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..2434
                     /gene="Stim1"
                     /codon_start=1
                     /product="stromal interaction molecule 1 precursor"
                     /protein_id="NP_001101966.2"
                     /db_xref="GeneID:361618"
                     /db_xref="RGD:1306831"
                     /translation="MDVCARLALWLLWGLLLHQGQSLSHSHSEKNTGASSGATSEEST
                     EAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDVEESDEFLREDLNYHDPT
                     VKHSTFHGEDKLISVEDLWKAWKASEVYNWTVDEVIQWLITYVELPQYEETFRKLQLT
                     GHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVV
                     SIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVE
                     VEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKE
                     LESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAERQLLVAKEGAEKIKKKRNTLFG
                     TFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSL
                     VAALNIDPSWMGSTRPNPAHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQH
                     GLGSQRDLTHSDSESSLHTSDRQRVAPKPPQMGRAADEALNATSSNGSHRLIEGVHPG
                     SLVEKLPDSPALAKKTILALNHGLDKAHSLMELNPSVPPGGSPLLDSSHSHSPSSPDP
                     DTPSPVGDSRALQGSRNTRIPHLAGKKAMAEEDNGSIGEETDSSPGRKKFPLKIFKKP
                     LKK"
     exon            516..646
                     /gene="Stim1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..761
                     /gene="Stim1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..873
                     /gene="Stim1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..989
                     /gene="Stim1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1167
                     /gene="Stim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1345
                     /gene="Stim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1513
                     /gene="Stim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1614
                     /gene="Stim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1850
                     /gene="Stim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1917
                     /gene="Stim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..3839
                     /gene="Stim1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccctcccc cacctccgtg cgggcgggag attctgcccg cctcctcccg caggggtgca
       61 gcaagctgcg gagctgacag cggccccgca gccaccctgc tcaaactctc cggaagcagc
      121 tagagctcag gccgccgccg ccgcagcttc ggcggaccca cagttggacc ggagactccg
      181 atccttctgc gtccaaactt ggggcacttg accttcggtt gtcgaaggag gtaagcccgc
      241 aggtggctgg acagctgcgg cgacgccgcg agggcatctt gctttggaac cgtcgtctgc
      301 actccccgac tctgggattt gcttctggga tccaaaggtg tctacagcag gcgcatgttg
      361 accgagacct tccgtcatgg atgtgtgcgc tcgtcttgcc ctgtggcttc tttgggggct
      421 ccttctgcat cagggccaga gtctcagcca tagtcacagt gagaagaata caggagctag
      481 ctcgggggcg acttctgaag agtctaccga agcagagttt tgccggattg acaagcccct
      541 gtgccacagt gaagatgaga agctcagctt tgaggccgtc cgcaacatcc acaagctgat
      601 ggatgatgat gccaatggtg atgtggatgt ggaagaaagt gatgagttcc taagggaaga
      661 cctcaattac catgacccta cagtgaaaca cagcaccttc catggtgagg acaagcttat
      721 cagcgtggag gacctatgga aggcatggaa ggcatcagaa gtgtataact ggaccgtgga
      781 tgaggtgata cagtggctga ttacgtatgt ggagctgcca cagtatgagg agactttccg
      841 gaagttgcag cttactggcc atgccatgcc aaggctagct gtaacaaaca ccaccatgac
      901 agggactgtc ctgaagatga cagaccggag ccacaggcag aagctgcagc tgaaggctct
      961 ggacacagtg ctgttcgggc ctcctctctt gactcgccac aatcacctga aggacttcat
     1021 gctggtggta tctatcgtga ttggtgtggg tggctgctgg tttgcctata tccagaaccg
     1081 ttactctaag gagcacatga agaaaatgat gaaggatctg gaaggattgc accgagctga
     1141 gcagagtctg catgaccttc aggaaaggct gcacaaggcc caggaggagc accgaacagt
     1201 ggaagtagag aaggtccacc tggagaagaa gctgcgtgac gagatcaatc ttgccaagca
     1261 ggaagctcag cggctgaagg agctgaggga gggtaccgag aatgagagga gccgccaaaa
     1321 atatgctgag gaagagctgg agcaggttcg ggaggctttg aggaaagcag agaaggagct
     1381 ggaatcacac agctcctggt atgctcctga ggccctgcag aagtggctgc agctgacaca
     1441 tgaggtggag gtgcagtact acaacatcaa gaagcaaaat gcagagaggc agctgctggt
     1501 ggccaaggag ggggctgaga aaataaaaaa gaagagaaac acgctttttg gtaccttcca
     1561 tgtggcccac agctcgtccc tggatgacgt ggatcataaa atcttaactg ctaagcaggc
     1621 actgagtgag gtgacagcag ccctgaggga gcgcctgcac cggtggcagc agatcgagat
     1681 cctctgtggt ttccagattg tcaataaccc tggcatccac tccttggtgg ccgcgctcaa
     1741 catagatccc agctggatgg gcagtacccg ccctaaccct gcccacttca tcatgactga
     1801 cgatgtggat gacatggatg aggagatcgt gtcgcccttg tccatgcagt cccccagcct
     1861 gcagagcagt gtccggcagc gcctgacgga gccacagcat ggcctgggat ctcagaggga
     1921 tttgacccat tccgattcgg agtcctccct ccacacgagt gaccgccagc gtgtggcccc
     1981 caagcctcct cagatgggcc gtgctgcaga tgaggctctc aatgccacgt cttccaatgg
     2041 tagccatcgg ctgattgagg gggtccatcc aggatctctg gtggagaaac tgcctgacag
     2101 ccctgctctg gccaagaaga caatcctggc gctgaaccat ggcctagata aggcccacag
     2161 cctgatggag ctgaacccct cagtcccacc tggtggctcc ccacttttgg attcttccca
     2221 ttctcatagc cccagctccc cagacccaga cacaccatct ccagttgggg acagccgagc
     2281 cctgcagggt agccgaaaca cacgaattcc ccacttggct ggcaagaagg ctatggctga
     2341 ggaggataat ggctctattg gtgaggagac agactctagt ccaggcagga agaagtttcc
     2401 cctcaaaatt tttaagaagc ctcttaagaa gtaggcagaa tagggtggta gtattgacac
     2461 agcctgtcct tccctggggc ttctgccttc acttcccttc ctttttttga gatatctggc
     2521 ccctagagtg ggccatggag gggctggccc aagggcctgg gcactgtaca tacctgccct
     2581 gctcatcctt ggtccttcat cattatttat taactgaccg ccatggcctg cctgccctga
     2641 aatccttcca accacgggct gctgctgtca catcctctcc acttcagtgc atgtcttagt
     2701 tgctgttccc tcaatcccac tccacttttg gggtccagct tctgtctctg ctgtcccagt
     2761 ttagaggttt ggtttttgtt tctgtctcct gctttcaggc tcctctctcc cattactccc
     2821 ccatgttcct agcagttgtg gggaagatag gaggagtaac ttctgacacc tgtacctcag
     2881 atctattcat actgctcaca atcattctgc ttaccccaga ctgggccaag gtcctaatct
     2941 ctggggattg ttctatggaa ggtggtggac cggagggaac ctcaccctgg agctcatttg
     3001 gatctccagg gctccattca gacagtggaa ccaactccca gggaacagat cagcagagtt
     3061 tcgaagagag accaggcttg tgactgtggg aaagacttct ctgagttgga ggatgagtag
     3121 atgccaaagc tgtgggctcc gaggcagttg ccatttccct cttgccctgc ccacatctgc
     3181 cttcctctta cctctgctcc cctatattgt aggagtgggt ctcttaagag gtgctgccct
     3241 gaagctcctc aagcatcagt actcctgggg ctcaggacaa ctggctcccc tggctatggg
     3301 agccacagtc atgacacggg gctcttgtgg agccctagac aaggatgttg tatctgaacc
     3361 aaaagacaaa cggttttaaa gtaaaaaaat aaaaacaaaa gaaataaatc tcctgaattt
     3421 cccaagtgcc tgcacagcat cctccccttg tcagactcca ttttcgtgta ctgcatagcc
     3481 tgggccacag gctccaaaca gacacagttg gtttggggaa ggggtggaga aggaagatgg
     3541 tatatgtgcg tgaagctgct gtgtgaccac ttctcccccc tgacgcctcc cctcttccag
     3601 acaactctct cctttacctg gttttgctat ggctgtaaag atattttccc tctgccccat
     3661 tctgtcatgc ctttaccctg agttcctaat ttgggcctgg gttgggtgca gctggggctg
     3721 gtcttaggtg ggtgctaggc tctagactgc ctcggtgccc cctggacacc ctcacatggg
     3781 tttttctgtg ttattttcat aagattcttt gaagtccaat aaagcatgta ggagatttt
//
