LOCUS       NM_001044265            3112 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus STEAP4 metalloreductase (Steap4), mRNA.
ACCESSION   NM_001044265 XM_001067033 XM_575346
VERSION     NM_001044265.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3112)
  AUTHORS   Song,F.Q., Song,M., Ma,W.X., Gao,Z., Ti,Y., Zhang,X., Hu,B.A.,
            Zhong,M., Zhang,W. and Yu,Y.
  TITLE     Overexpressing STAMP2 attenuates diabetic renal injuries via
            upregulating autophagy in diabetic rats
  JOURNAL   Biochem Biophys Res Commun 579, 47-53 (2021)
   PUBMED   34583195
  REMARK    GeneRIF: Overexpressing STAMP2 attenuates diabetic renal injuries
            via upregulating autophagy in diabetic rats.
REFERENCE   2  (bases 1 to 3112)
  AUTHORS   Oosterheert,W., van Bezouwen,L.S., Rodenburg,R.N.P., Granneman,J.,
            Forster,F., Mattevi,A. and Gros,P.
  TITLE     Cryo-EM structures of human STEAP4 reveal mechanism of iron(III)
            reduction
  JOURNAL   Nat Commun 9 (1), 4337 (2018)
   PUBMED   30337524
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3112)
  AUTHORS   Gauss,G.H., Kleven,M.D., Sendamarai,A.K., Fleming,M.D. and
            Lawrence,C.M.
  TITLE     The crystal structure of six-transmembrane epithelial antigen of
            the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel
            interdomain flavin-binding site
  JOURNAL   J Biol Chem 288 (28), 20668-20682 (2013)
   PUBMED   23733181
  REMARK    GeneRIF: Data suggest that Steap4 utilizes an interdomain
            flavin-binding site to shuttle electrons between the oxidoreductase
            and transmembrane domains.
REFERENCE   4  (bases 1 to 3112)
  AUTHORS   Ohgami,R.S., Campagna,D.R., McDonald,A. and Fleming,M.D.
  TITLE     The Steap proteins are metalloreductases
  JOURNAL   Blood 108 (4), 1388-1394 (2006)
   PUBMED   16609065
REFERENCE   5  (bases 1 to 3112)
  AUTHORS   Moldes,M., Lasnier,F., Gauthereau,X., Klein,C., Pairault,J.,
            Feve,B. and Chambaut-Guerin,A.M.
  TITLE     Tumor necrosis factor-alpha-induced adipose-related protein
            (TIARP), a cell-surface protein that is highly induced by tumor
            necrosis factor-alpha and adipose conversion
  JOURNAL   J Biol Chem 276 (36), 33938-33946 (2001)
   PUBMED   11443137
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097353.1.
            
            On or before Aug 24, 2006 this sequence version replaced
            XM_575346.2, XM_001067033.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097353.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3112
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q12"
     gene            1..3112
                     /gene="Steap4"
                     /note="STEAP4 metalloreductase"
                     /db_xref="GeneID:499991"
                     /db_xref="RGD:1560331"
     exon            1..126
                     /gene="Steap4"
                     /inference="alignment:Splign:2.1.0"
     exon            127..584
                     /gene="Steap4"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1541
                     /gene="Steap4"
                     /EC_number="1.16.1.9"
                     /note="six-transmembrane epithelial antigen of prostate 4;
                     Ab1-219; STEAP family member 4"
                     /codon_start=1
                     /product="metalloreductase STEAP4"
                     /protein_id="NP_001037730.1"
                     /db_xref="GeneID:499991"
                     /db_xref="RGD:1560331"
                     /translation="MEKTCADEFPLTVDSSEKQGVVCIFGTGDFGKSLGLKMLQCGYS
                     VVFGSRNPQVSSLLPRGAEVLCYSEAASRSDVIVLAVHREHYDFLAELADSLKGRVLI
                     DVSNNQKMNQYPESNAEYLAQLVPGAHVVKAFNTISAWALQSGTLDASRQVFVCGNDS
                     KAKDRVMDIARTLGLTPLDQGSLVAAKEIENYPLQLFPMWRFPFYLSSGLCVFFFVYC
                     AIREVIYPYVTGKTDSTYRLVVSIPNRVFPITALTLLALVYLPGILAAILQLYRGTKY
                     RRFPNWLDHWMLCRKQLGLVALGFAFLHAIYTLVIPIRYYVRWRLRNATITQALTNKD
                     SPFSSSTAWLSDSYLALGILGFFLFLLLGITSLPSVSNMVNWREFRFVQSKLGYLTLV
                     LCTAHTLVYGGKRFLSPSILIWSLPSAYILALIIPCTVLVMKFILIMPCIDKTLTRIR
                     QGWERKSKYAQSTLNGKSDI"
     exon            585..1112
                     /gene="Steap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1277
                     /gene="Steap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..3086
                     /gene="Steap4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttaaaggcg agagcctgga gccgtcgcag agcacaggct gcctacctca ctctacaaag
       61 ctaaagggca gagcccacca gcagctgcgt gcgccagacc aacggccctc cggggacctc
      121 ccgcagtaat ggagaagacg tgtgcagatg agtttcctct gactgtggat tcctcagaaa
      181 agcaaggcgt tgtctgcatt ttcggaacag gggatttcgg gaaatcattg gggttgaaaa
      241 tgcttcagtg tggctattct gttgttttcg ggagtcgaaa cccccaggta tccagccttc
      301 tgcccagggg agcagaggtc ctgtgctact cagaagcagc atcgaggtct gacgtcatag
      361 tcctggccgt gcacagagag cattatgatt tcctcgcaga attagctgat tctctcaaag
      421 gaagagtatt gatagatgtc agtaacaacc aaaaaatgaa tcagtatcca gaatcaaacg
      481 ccgagtacct tgctcagctg gtaccaggag cccacgtggt caaggcattt aacaccatct
      541 cagcctgggc tctccagtca ggaacactag atgcaagtcg gcaggtgttt gtctgtggaa
      601 atgacagcaa agccaaggac agagtgatgg acattgctcg cactcttggg ctcactccac
      661 tggatcaagg atctctcgtg gcagccaagg aaattgaaaa ctaccctctg caactatttc
      721 ccatgtggag gttccctttc tacttgtcct ctgggctgtg cgtcttcttc tttgtgtact
      781 gcgctatacg ggaagtgata tacccctacg tgactgggaa gacagatagt acgtaccgcc
      841 tggttgtttc catcccgaat cgtgtctttc ctataacagc acttaccctg ctggcgttgg
      901 tgtacctccc tggtattctc gccgccattt tgcagctcta ccgaggcaca aagtaccgcc
      961 gattcccaaa ctggcttgac cattggatgc tttgcagaaa gcaactgggc ttggtagctc
     1021 tgggatttgc cttccttcac gccatctaca cccttgtgat tcctattcgt tactacgtac
     1081 gatggaggct gagaaacgcg accattactc aggccctaac taataaagac agcccattca
     1141 gttcctctac tgcctggctc agtgattcct atctggccct gggaattctg ggattttttc
     1201 tgtttcttct cttgggaatc acttccttgc catcagtaag caacatggtc aactggagag
     1261 agttccggtt tgtccagtcc aaactgggtt atctgaccct ggtcttgtgc acagcccaca
     1321 ctttggtgta tggtggaaag agattcctca gcccttcaat tctaatatgg agccttcctt
     1381 cagcctatat tctggcgctc atcatcccct gcacagtgtt ggtgatgaag tttatcctca
     1441 tcatgccgtg catagacaag accctcacgc gcatccgcca gggctgggaa aggaagtcaa
     1501 aatatgcaca atcaacactg aacggaaaat cggatattta aaatacggtt gaatttgctg
     1561 ggatttctgt actacctgta gtgagcgttt agagcataac gtgtccagtt acaaaaaagc
     1621 aatttcttgc gtcgtggtcc taagttcatc atcacggaag gacatgttgc ctgactctga
     1681 aagacgacca gaatagcaag ggagcactgg ttacctgagt catgtgatga ctcacctcag
     1741 gcctccctca cttcctttcc cagaaacccc agagatgcca ccatgattag atttacagtt
     1801 tcgtactgcg aagcttcttg atttgggcaa cgtgcctgac ttttgaagag ctccggaaga
     1861 gtgtgtgcaa cttccttctc taattcaagg gctgttgtaa gtgaaaaaac aacactgtgg
     1921 tcatgctaaa gattttgctt ggcttgccca tactgatctg ggggtattca gggtttggct
     1981 gtagtgctga gctcaaacct agagccttat acatgagcta catacacccc agtcctgcca
     2041 tagtgagtat gtagtcatgt gtacccctta attttgcttt ctaccaatat ggatagtatg
     2101 gggaagtatt ttatactgca acaaaaatat aacaattggt ttgaagtaac cgttctttgg
     2161 atatatgaaa tgctatgtaa ttgtcacaag atccttcctc tataagggac ggcttgaggg
     2221 gaggtggggt aagagttgag ctatcctaag tcgagggaag atggggaaag agtggaagat
     2281 ccattggggt tttcaagtgc cataagcaga gaagggttga taacggcctt gtacagaaat
     2341 gtcaaataac ccagaatttt agctagtaag taagcagata caatagagtt tcactatgcc
     2401 gtttggtatc atttaggggt cgtggtgtgt ttcctgcatt atacatttca gatactgtcc
     2461 agtattaagc atctgtgaaa ttaacttcta gtataaacat gtagcttcca taatctgtct
     2521 ttgttatcat tgtaaatggt gcagttaaag ggaatcatct gaaatcgtcg gtgcgaggag
     2581 aagatagctc agagaattgt gggacgctgg gaagaggcga gcggcagtga atcggaagca
     2641 accggctctg gcttccggtg tggatagtgt ctttcccaag gtgaccttca gcaggctgaa
     2701 cacccctagc tccagcttgg agctaaaagg agattttttg cataatcttc ccacgtgtca
     2761 ctgaaataag gaaaaggcat cgggtttgat atttttctgc ctaatccaca aaggctgttt
     2821 tatttttcat tttgctaact tttatatcac acatcgcgta cacgatatca tacattacac
     2881 acaatacagg gatttttatg caaagctctt atgtaacaca gacatttatt tttactattg
     2941 ccctaataga tcacgcagac catattcagt tttcactaag aggacagttg aggtaatgtc
     3001 tttgtactaa caaaatattt ctgtattttc aattatttcc ttggaatatt ttccaagagt
     3061 taataaaatt aaagagtatt tgataaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
