LOCUS       NM_133314               2739 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus STEAP3 metalloreductase (Steap3), mRNA.
ACCESSION   NM_133314
VERSION     NM_133314.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2739)
  AUTHORS   Sun,C., Peng,S., Lv,Z., Guo,T. and Zhang,L.
  TITLE     Research of STEAP3 interaction with Rab7A and RACK1 to modulate the
            MAPK and JAK/STAT signaling in Osteoarthritis
  JOURNAL   Int Immunopharmacol 124 (Pt B), 111034 (2023)
   PUBMED   37820423
  REMARK    GeneRIF: Research of STEAP3 interaction with Rab7A and RACK1 to
            modulate the MAPK and JAK/STAT signaling in Osteoarthritis.
REFERENCE   2  (bases 1 to 2739)
  AUTHORS   Lane,D.J., Merlot,A.M., Huang,M.L., Bae,D.H., Jansson,P.J.,
            Sahni,S., Kalinowski,D.S. and Richardson,D.R.
  TITLE     Cellular iron uptake, trafficking and metabolism: Key molecules and
            mechanisms and their roles in disease
  JOURNAL   Biochim Biophys Acta 1853 (5), 1130-1144 (2015)
   PUBMED   25661197
  REMARK    Review article
REFERENCE   3  (bases 1 to 2739)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2739)
  AUTHORS   Wan,C., Fu,J., Wang,Y., Miao,S., Song,W. and Wang,L.
  TITLE     Exosome-related multi-pass transmembrane protein TSAP6 is a target
            of rhomboid protease RHBDD1-induced proteolysis
  JOURNAL   PLoS One 7 (5), e37452 (2012)
   PUBMED   22624035
REFERENCE   5  (bases 1 to 2739)
  AUTHORS   Lambe,T., Simpson,R.J., Dawson,S., Bouriez-Jones,T.,
            Crockford,T.L., Lepherd,M., Latunde-Dada,G.O., Robinson,H.,
            Raja,K.B., Campagna,D.R., Villarreal,G. Jr., Ellory,J.C.,
            Goodnow,C.C., Fleming,M.D., McKie,A.T. and Cornall,R.J.
  TITLE     Identification of a Steap3 endosomal targeting motif essential for
            normal iron metabolism
  JOURNAL   Blood 113 (8), 1805-1808 (2009)
   PUBMED   18955558
REFERENCE   6  (bases 1 to 2739)
  AUTHORS   Sendamarai,A.K., Ohgami,R.S., Fleming,M.D. and Lawrence,C.M.
  TITLE     Structure of the membrane proximal oxidoreductase domain of human
            Steap3, the dominant ferrireductase of the erythroid transferrin
            cycle
  JOURNAL   Proc Natl Acad Sci U S A 105 (21), 7410-7415 (2008)
   PUBMED   18495927
REFERENCE   7  (bases 1 to 2739)
  AUTHORS   Ohgami,R.S., Campagna,D.R., McDonald,A. and Fleming,M.D.
  TITLE     The Steap proteins are metalloreductases
  JOURNAL   Blood 108 (4), 1388-1394 (2006)
   PUBMED   16609065
REFERENCE   8  (bases 1 to 2739)
  AUTHORS   Ohgami,R.S., Campagna,D.R., Greer,E.L., Antiochos,B., McDonald,A.,
            Chen,J., Sharp,J.J., Fujiwara,Y., Barker,J.E. and Fleming,M.D.
  TITLE     Identification of a ferrireductase required for efficient
            transferrin-dependent iron uptake in erythroid cells
  JOURNAL   Nat Genet 37 (11), 1264-1269 (2005)
   PUBMED   16227996
REFERENCE   9  (bases 1 to 2739)
  AUTHORS   Amzallag,N., Passer,B.J., Allanic,D., Segura,E., Thery,C., Goud,B.,
            Amson,R. and Telerman,A.
  TITLE     TSAP6 facilitates the secretion of translationally controlled tumor
            protein/histamine-releasing factor via a nonclassical pathway
  JOURNAL   J Biol Chem 279 (44), 46104-46112 (2004)
   PUBMED   15319436
REFERENCE   10 (bases 1 to 2739)
  AUTHORS   Steiner,M.S., Zhang,X., Wang,Y. and Lu,Y.
  TITLE     Growth inhibition of prostate cancer by an adenovirus expressing a
            novel tumor suppressor gene, pHyde
  JOURNAL   Cancer Res 60 (16), 4419-4425 (2000)
   PUBMED   10969787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Dec 1, 2020 this sequence version replaced NM_133314.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085696.1, SRR26360194.766751.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                JAXUCZ010000013.1  33944291-33944356   c
            67-566              JAXUCZ010000013.1  33921099-33921598   c
            567-1094            JAXUCZ010000013.1  33918798-33919325   c
            1095-1259           JAXUCZ010000013.1  33912760-33912924   c
            1260-2739           JAXUCZ010000013.1  33904710-33906189   c
FEATURES             Location/Qualifiers
     source          1..2739
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q11"
     gene            1..2739
                     /gene="Steap3"
                     /note="STEAP3 metalloreductase"
                     /db_xref="GeneID:170824"
                     /db_xref="RGD:708552"
     exon            1..66
                     /gene="Steap3"
                     /inference="alignment:Splign:2.1.0"
     exon            67..566
                     /gene="Steap3"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1541
                     /gene="Steap3"
                     /note="pHyde; six-transmembrane epithelial antigen of
                     prostate 3; tumor suppressor pHyde; STEAP family member 3,
                     metalloreductase"
                     /codon_start=1
                     /product="metalloreductase STEAP3"
                     /protein_id="NP_579848.2"
                     /db_xref="GeneID:170824"
                     /db_xref="RGD:708552"
                     /translation="MSGEMDKPLISRRLVDSDGSLAEVPKEAPKVGILGSGDFARSLA
                     TRLVGSGFSVVVGSRNPKRTAGLFPSLAQVTFQEEAVSSPEVIFVAVFREHYSSLCSL
                     ADQLAGKILVDVSNPTEKERLQHRQSNAEYLASLFPACTVVKAFNVISAWALQAGPRD
                     GNRQVLICGDQLEAKHTVSEMARAMGFTPLDMGSLASAREVEAIPLRLLPSWKVPTLL
                     ALGLFVCFYAYNFIRDVLQPYIRKDENKFYKMPLSVVNTTLPCVAYVLLSLVYLPGVL
                     AAALQLRRGTKYQRFPDWLDHWLQHRKQIGLLSFFFAMLHALYSFCLPLRRSHRYDLV
                     NLAVKQVLANKSRLWVEEEVWRMEIYLSLGVLALGMLSLLAVTSIPSIANSLNWKEFS
                     FVQSTLGFVALMLSTMHTLTYGWTRAFEENHYKFYLPPTFTLTLLLPCVIILAKGLFL
                     LPCLSHRLTKIRRGWERDGAVKFMLPAGHTQGEKTSHV"
     exon            567..1094
                     /gene="Steap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1259
                     /gene="Steap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..2739
                     /gene="Steap3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgagccac cgcctcctcc cgcgacctgc agctgccaag gctcctccaa gcggccagct
       61 gccgaggcac tgtgatgtcc ggggagatgg acaaaccgct catcagtcgc cgcttggtgg
      121 acagtgatgg cagtctggct gaggtcccca aggaggctcc caaagtgggc atcctgggca
      181 gcggggattt tgcccggtcc ctggccacac gcctggtggg ctctggcttc agtgtggtgg
      241 tgggaagccg taaccccaaa cgcactgccg gcctcttccc ctccttagcc caagtgactt
      301 tccaggagga ggccgtgagc tctccagagg tcatctttgt ggccgtgttc cgggagcact
      361 actcctcact gtgcagtctt gctgaccagt tggctggcaa gatcctagtg gatgtaagca
      421 accccacgga gaaggagcgt cttcagcacc gccagtcgaa cgccgagtac ctggcctccc
      481 tcttccctgc ctgcactgtg gtcaaggcct tcaacgtcat ctctgcatgg gccctacagg
      541 ctggcccaag ggatgggaac aggcaggtgc tcatctgcgg tgaccagctg gaagccaagc
      601 acaccgtctc agagatggcg cgcgccatgg gtttcacccc actggacatg ggatccctgg
      661 cctcagcgag ggaggtagag gccatacccc tgcgcctcct tccatcctgg aaggtgccca
      721 ccctcctggc cctggggctc tttgtgtgct tctatgccta caacttcatc cgggacgttc
      781 tacagccgta catccggaaa gatgagaaca agttctacaa gatgcccctg tctgtggtca
      841 acaccacgct accctgtgtg gcttatgtgc tgctgtccct ggtttacctg cctggtgtgc
      901 tggcagctgc ccttcagctg aggaggggga ccaagtacca gcgcttccca gactggctgg
      961 accattggct gcagcaccgc aagcagatcg ggctactcag cttcttcttc gccatgctgc
     1021 acgctctcta cagcttctgc ctgccgctgc gccgctccca ccgctatgat ctggtcaacc
     1081 tggctgtgaa gcaggtcctg gccaacaaga gccgcctctg ggttgaggaa gaagtctggc
     1141 ggatggagat atacctgtcc ctgggtgtgc tggctctggg catgctgtca ctgctggcgg
     1201 ttacctcgat cccttccatt gcaaactcac tcaactggaa ggagttcagc tttgtgcagt
     1261 ccacgctggg cttcgtggcc ctgatgctga gcacaatgca caccctcacc tacggctgga
     1321 cccgtgcttt tgaggaaaac cactacaagt tctacctgcc acccacattc acgctcacgc
     1381 tgctcctgcc ctgtgtcatc atcctggcca agggcctctt cctcctgccc tgcctcagcc
     1441 acagactcac caagatccgc aggggctggg agagggatgg tgccgtcaag ttcatgctgc
     1501 ccgctggcca cacacagggg gagaaaacaa gccacgtgtg aggccctgga aatggagaca
     1561 ggcacagctt gtgggggccc tgggctgggt tcgggtctct tttctgggat ggtatatgcg
     1621 tgggtggccg aggtctgaat ttctgggatg caggtgtatg ccaagatact cagaatggcg
     1681 taccacacat gcgataagta ctcacatata tttcatatat aataggattt actattattc
     1741 ttacttagtt aaaaaaaata gtgggtcctt atatttcaat ttatgcaggg tccctatatt
     1801 tcaacttgag catttcagag caaatgccac acattaaaca gcagatccca cccttgtggt
     1861 agctgcagag acagacagac acttctggta tgagagagac tgtattttgt tggattctac
     1921 ctttaatccc cgttctctac gttccctgtt agccacatct taacgttggt gcagagctgg
     1981 gacaagagct ggctctggtg cagcctcccc catcccaggg ctaggaaaca agcctctgat
     2041 gaacagaggg accaggtctg gaccctcctg ctcccgcttc cctgggctcg agtggggagg
     2101 ctcagcggga tcccccgaaa tctgtgcagg agttttcaca ggtctgtcct ttcttccggg
     2161 agcggtctga agcggcccca tctgatccta gctgagccga gattgttccc cactccctga
     2221 aagtccagag tcaccgtgga gcctgcaaat tgctccttct gcgaaggtgt gaagtcaccg
     2281 tctcaccaga gccattaacg aacctgatct tcagaagaag cataattgtt tcccctccat
     2341 taagttggtg gtgaccctct ttaaaccact gtgccttctc gcctttccca tcactaattt
     2401 gggcatctcc atggagtgga ctcttgtcgg ggcagttcag gggggaggga agcattagag
     2461 attgtggaga ataaccatcg aagcctccct tggatgttcc caggcctgcc ttcattaaat
     2521 tggtccctaa tgagaatgac agggacccct gttgcctgta ggcagagaac cagccttctg
     2581 agcacccagg aaacacagtg gccccacgcc cttcaggggg gtcccacgtc ccctttccca
     2641 tgcttttgcc tccctccctc ccggttacaa tcaaccataa aagtctgcaa atattgtttt
     2701 ttgaattctt aaagagacca catcctttgt tattaccaa
//
