LOCUS       NM_001106629            1200 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus STEAP family member 1 (Steap1), mRNA.
ACCESSION   NM_001106629 XM_001067555 XM_216315
VERSION     NM_001106629.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1200)
  AUTHORS   Gomes,I.M., Santos,C.R., Socorro,S. and Maia,C.J.
  TITLE     Six transmembrane epithelial antigen of the prostate 1 is
            down-regulated by sex hormones in prostate cells
  JOURNAL   Prostate 73 (6), 605-613 (2013)
   PUBMED   23060075
  REMARK    GeneRIF: STEAP1 is down-regulated by dihydrotestosterone and
            estradiols in LNCaP cells and in rat prostate.
REFERENCE   2  (bases 1 to 1200)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 1200)
  AUTHORS   Ohgami,R.S., Campagna,D.R., McDonald,A. and Fleming,M.D.
  TITLE     The Steap proteins are metalloreductases
  JOURNAL   Blood 108 (4), 1388-1394 (2006)
   PUBMED   16609065
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474013.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001067555.1, XM_216315.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220333.1, FQ220437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     gene            1..1200
                     /gene="Steap1"
                     /gene_synonym="Steap"
                     /note="STEAP family member 1"
                     /db_xref="GeneID:297738"
                     /db_xref="RGD:1311543"
     exon            1..61
                     /gene="Steap1"
                     /gene_synonym="Steap"
                     /inference="alignment:Splign:2.1.0"
     exon            62..173
                     /gene="Steap1"
                     /gene_synonym="Steap"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1109
                     /gene="Steap1"
                     /gene_synonym="Steap"
                     /note="metalloreductase STEAP1; six transmembrane
                     epithelial antigen of the prostate 1"
                     /codon_start=1
                     /product="STEAP1 protein"
                     /protein_id="NP_001100099.1"
                     /db_xref="GeneID:297738"
                     /db_xref="RGD:1311543"
                     /translation="MEISKNITNPEELWKMKPKGNLEDDSYSTKDTGETSMLKRPVLS
                     PLPHTVHVDAFDCPTELQHTQELFPNWQLPIKVAAVLSSLTFLYTLLREIIYPLVASR
                     EQYFYKIPILVVNKVLPMVSITLLALVYLPGEIAAVVQLRNGTKYKKFPPWLDRWMLA
                     RKQFGLLSFFFAVLHAIYSLSYPMRRSYRYKLLNWAYKQVQQSKEDAWVEHDVWRMEI
                     YVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTVHASIFAWNK
                     WVDISQFVWYMPPTFMIAVFLPTVVLICKIVLCLPCLRKKILKIRCGWEDVRKVNRTE
                     MACRL"
     exon            174..686
                     /gene="Steap1"
                     /gene_synonym="Steap"
                     /inference="alignment:Splign:2.1.0"
     exon            687..851
                     /gene="Steap1"
                     /gene_synonym="Steap"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1200
                     /gene="Steap1"
                     /gene_synonym="Steap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgtggga ctgggagtcc gggcagcgag cccctcgccg tcgggtccca cgaagaaact
       61 ggtggctgaa gccatattct gcagcattca tggagatcag taaaaatatt acgaacccag
      121 aagaactttg gaaaatgaag cctaagggga acctggaaga tgacagttac tcgactaagg
      181 acaccggaga gacaagcatg ctgaaaagac cggtgctctc gcctttgccg cacacggtcc
      241 acgtcgacgc cttcgactgc cccacggagc tccagcacac gcaggaactc tttccaaact
      301 ggcaattgcc aattaaagtt gccgccgtcc tatcgtctct caccttcctg tacactcttc
      361 tgagggaaat catttaccca ttagtcgctt cccgcgaaca gtatttttat aagatcccga
      421 tcctggtcgt taacaaagtc ttgccaatgg tctccattac cctcttggca ttggtttatc
      481 tgccaggaga gatagcggca gttgtgcagc ttcgcaatgg gaccaagtac aagaagttcc
      541 caccctggtt agacagatgg atgctggcga ggaaacaatt tgggctcctc agcttcttct
      601 ttgcagttct gcacgccatt tacagtctct cgtacccaat gagacggtcc tacagataca
      661 agctgctcaa ctgggcttac aaacaggttc aacaaagcaa agaagatgcc tgggttgagc
      721 atgatgtctg gagaatggag atttatgtgt ccctggggat tgtgggactg gccatcttgg
      781 ctctcttggc tgtgacatct atcccatctg tgagcgactc tttaacctgg agagaatttc
      841 actatattca gagcaaactg ggaattgtct ctcttcttct gggcacggta cacgcttcga
      901 tttttgcctg gaataaatgg gtagatatca gtcagtttgt ctggtacatg cctccgactt
      961 tcatgatagc tgttttcctt ccaactgttg ttctgatctg taaaattgta ctttgcctgc
     1021 cctgcctgag gaagaagata ctgaagatta gatgtggttg ggaagatgtc cgcaaagtta
     1081 acaggactga gatggcctgc aggttgtaga actactgttt gcacataatt gcttaatacc
     1141 gatgtcttat aaacatttca aacctgtgtc tgttaataaa atgaatactt ctggatcatt
//
