LOCUS       NM_022230                910 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus stanniocalcin 2 (Stc2), mRNA.
ACCESSION   NM_022230
VERSION     NM_022230.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 910)
  AUTHORS   Wang,T., Dai,L., Shen,S., Yang,Y., Yang,M., Yang,X., Qiu,Y. and
            Wang,W.
  TITLE     Comprehensive Molecular Analyses of a Macrophage-Related Gene
            Signature With Regard to Prognosis, Immune Features, and Biomarkers
            for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and
            the LASSO Algorithm
  JOURNAL   Front Immunol 13, 843408 (2022)
   PUBMED   35693827
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 910)
  AUTHORS   Jiang,J., Westberg,J.A. and Andersson,L.C.
  TITLE     Stanniocalcin 2, forms a complex with heme oxygenase 1, binds hemin
            and is a heat shock protein
  JOURNAL   Biochem Biophys Res Commun 421 (2), 274-279 (2012)
   PUBMED   22503972
REFERENCE   3  (bases 1 to 910)
  AUTHORS   Takei,Y., Yamamoto,H., Sato,T., Otani,A., Kozai,M., Masuda,M.,
            Taketani,Y., Muto-Sato,K., Lanske,B. and Takeda,E.
  TITLE     Stanniocalcin 2 is associated with ectopic calcification in
            alpha-klotho mutant mice and inhibits hyperphosphatemia-induced
            calcification in aortic vascular smooth muscle cells
  JOURNAL   Bone 50 (4), 998-1005 (2012)
   PUBMED   22285620
REFERENCE   4  (bases 1 to 910)
  AUTHORS   Zeiger,W., Ito,D., Swetlik,C., Oh-hora,M., Villereal,M.L. and
            Thinakaran,G.
  TITLE     Stanniocalcin 2 is a negative modulator of store-operated calcium
            entry
  JOURNAL   Mol Cell Biol 31 (18), 3710-3722 (2011)
   PUBMED   21746875
REFERENCE   5  (bases 1 to 910)
  AUTHORS   Lee,H.J., Lee,Y.J., Kang,C.M., Bae,S., Jeoung,D., Jang,J.J.,
            Lee,S.S., Cho,C.K. and Lee,Y.S.
  TITLE     Differential gene signatures in rat mammary tumors induced by DMBA
            and those induced by fractionated gamma radiation
  JOURNAL   Radiat Res 170 (5), 579-590 (2008)
   PUBMED   18959458
REFERENCE   6  (bases 1 to 910)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   7  (bases 1 to 910)
  AUTHORS   Luo,C.W., Pisarska,M.D. and Hsueh,A.J.
  TITLE     Identification of a stanniocalcin paralog, stanniocalcin-2, in fish
            and the paracrine actions of stanniocalcin-2 in the mammalian ovary
  JOURNAL   Endocrinology 146 (1), 469-476 (2005)
   PUBMED   15486227
REFERENCE   8  (bases 1 to 910)
  AUTHORS   Ito,D., Walker,J.R., Thompson,C.S., Moroz,I., Lin,W.,
            Veselits,M.L., Hakim,A.M., Fienberg,A.A. and Thinakaran,G.
  TITLE     Characterization of stanniocalcin 2, a novel target of the
            mammalian unfolded protein response with cytoprotective properties
  JOURNAL   Mol Cell Biol 24 (21), 9456-9469 (2004)
   PUBMED   15485913
  REMARK    GeneRIF: induced STC2 expression is an essential feature of
            survival component of the unfolded-protein response
REFERENCE   9  (bases 1 to 910)
  AUTHORS   Honda,S., Kashiwagi,M., Ookata,K., Tojo,A. and Hirose,S.
  TITLE     Regulation by 1alpha,25-dihydroxyvitamin D(3) of expression of
            stanniocalcin messages in the rat kidney and ovary
  JOURNAL   FEBS Lett 459 (1), 119-122 (1999)
   PUBMED   10508929
REFERENCE   10 (bases 1 to 910)
  AUTHORS   Ishibashi,K., Miyamoto,K., Taketani,Y., Morita,K., Takeda,E.,
            Sasaki,S. and Imai,M.
  TITLE     Molecular cloning of a second human stanniocalcin homologue (STC2)
  JOURNAL   Biochem Biophys Res Commun 250 (2), 252-258 (1998)
   PUBMED   9753616
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB030707.1.
            
            On Feb 21, 2013 this sequence version replaced NM_022230.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB030707.1, FQ127219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-910               AB030707.1         1-910
FEATURES             Location/Qualifiers
     source          1..910
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..910
                     /gene="Stc2"
                     /note="stanniocalcin 2"
                     /db_xref="GeneID:63878"
                     /db_xref="RGD:621777"
     exon            1..163
                     /gene="Stc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..903
                     /gene="Stc2"
                     /note="STC-2"
                     /codon_start=1
                     /product="stanniocalcin-2 precursor"
                     /protein_id="NP_071566.1"
                     /db_xref="GeneID:63878"
                     /db_xref="RGD:621777"
                     /translation="MCAERLGQFVTLALVFATLDPARGTDSTNPPEGPQDRGSQQKGR
                     LSLQNTAEIQHCLVNAGDVGCGVFECFENNSCEIQGLHGICMTFLHNAGKFDAQGKSF
                     IKDALRCKAHALRHKFGCISRKCPAIREMVYQLQRECYLKHDLCSAAQENVVVIVEMI
                     HFKDLLLHEPYVDLVNLLLTCGEDVREAVTRSVQAQCEQSWGGLCSILSFCTSNIQRP
                     PTAAPEHQPLADRAQLSRPYHRDTDHHLTANRGAKGERGSKSHLHAHARGGAGGQSAQ
                     GPSGSSEWEDEQSEYSDIRR"
     exon            164..306
                     /gene="Stc2"
                     /inference="alignment:Splign:2.1.0"
     exon            307..518
                     /gene="Stc2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..910
                     /gene="Stc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataccaagaa ccatgtgtgc ggagcggctg ggccagttcg tgaccctggc tttggtgttt
       61 gccaccttgg accctgcgcg agggacggac tccacgaacc ctccggaagg tccccaagac
      121 aggggctccc agcagaaagg ccgcctgtcc ctgcagaaca cagcggagat ccagcactgt
      181 ttggtcaacg ccggggacgt ggggtgtggt gtgtttgagt gcttcgagaa caactcttgt
      241 gaaatccagg gcttacatgg gatttgcatg acgtttctgc acaacgctgg aaaatttgat
      301 gcccagggca agtcattcat caaggatgcc ctgaggtgca aggcccatgc cctgcggcat
      361 aaatttggct gcatcagcag gaagtgtccg gcaattaggg aaatggttta ccagttgcag
      421 agggaatgct atctcaagca cgacctgtgc tcggcagcgc aggagaacgt cgtcgtgatt
      481 gtggagatga ttcatttcaa ggatctcctg ctgcatgaac cctacgtgga ccttgtaaac
      541 ctgctgctga cctgtgggga agacgtgagg gaggcggtca cccgaagcgt ccaggctcag
      601 tgtgaacaga gctggggagg cctctgctcc atcctgagtt tctgcacctc caacatacag
      661 agacccccta ccgcagcccc ggagcatcag cccctggcag acagggccca gctctccaga
      721 ccttaccacc gggacaccga ccaccaccta acagccaaca gaggtgccaa gggtgagcga
      781 gggagcaaaa gccacctgca tgcccatgct cgaggcggag caggtggcca gagtgcccaa
      841 ggaccctctg gaagcagtga gtgggaagac gaacagtctg agtattccga catccggagg
      901 tgaaatgaaa
//
