LOCUS       NM_031123               2463 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus stanniocalcin 1 (Stc1), mRNA.
ACCESSION   NM_031123
VERSION     NM_031123.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2463)
  AUTHORS   Bonfante,S., Joaquim,L., Fileti,M.E., Giustina,A.D., de Souza
            Goldim,M.P., Danielski,L.G., Cittadin,E., De Carli,R.J., de
            Farias,B.X., Engel,N.A., da Rosa,N., Fortunato,J.J., Giridharan,V.,
            Scaini,G., Rezin,G.T., Generoso,J., de Bitencourt,R.M., Terra,S.,
            Barichello,T. and Petronilho,F.
  TITLE     Stanniocalcin 1 Inhibits the Inflammatory Response in Microglia and
            Protects Against Sepsis-Associated Encephalopathy
  JOURNAL   Neurotox Res 39 (2), 119-132 (2021)
   PUBMED   33025358
  REMARK    GeneRIF: Stanniocalcin 1 Inhibits the Inflammatory Response in
            Microglia and Protects Against Sepsis-Associated Encephalopathy.
REFERENCE   2  (bases 1 to 2463)
  AUTHORS   Dalvin,L.A., Hartnett,M.E., Bretz,C.A., Hann,C.R., Cui,R.Z.,
            Marmorstein,A.D., Sheikh-Hamad,D., Fautsch,M.P. and Roddy,G.W.
  TITLE     Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy
            Severity
  JOURNAL   Curr Eye Res 45 (1), 46-51 (2020)
   PUBMED   31314602
  REMARK    GeneRIF: Stanniocalcin-1 is a Modifier of Oxygen-Induced
            Retinopathy Severity.
REFERENCE   3  (bases 1 to 2463)
  AUTHORS   Schein,V., Kucharski,L.C., Guerreiro,P.M., Martins,T.L.,
            Morgado,I., Power,D.M., Canario,A.V. and da Silva,R.S.
  TITLE     Stanniocalcin 1 effects on the renal gluconeogenesis pathway in rat
            and fish
  JOURNAL   Mol Cell Endocrinol 414, 1-8 (2015)
   PUBMED   26187698
  REMARK    GeneRIF: Results show that STC1 have an important role in the
            carbohydrate metabolism regulation, in particular gluconeogenesis
            from glutamine in the kidney, across the vertebrates.
REFERENCE   4  (bases 1 to 2463)
  AUTHORS   Ito,Y., Zemans,R., Correll,K., Yang,I.V., Ahmad,A., Gao,B. and
            Mason,R.J.
  TITLE     Stanniocalcin-1 is induced by hypoxia inducible factor in rat
            alveolar epithelial cells
  JOURNAL   Biochem Biophys Res Commun 452 (4), 1091-1097 (2014)
   PUBMED   25251473
  REMARK    GeneRIF: In this study, we have found that several HIF target genes
            including STC1 are upregulated in AECs by a submerged condition,
            that STC1 is regulated by hypoxia and HIF.
REFERENCE   5  (bases 1 to 2463)
  AUTHORS   Law,A.Y., Hebert,R.L., Nasrallah,R., Langenbach,R., Wong,C.K. and
            Wagner,G.F.
  TITLE     Cyclooxygenase-2 mediates induction of the renal stanniocalcin-1
            gene by arginine vasopressin
  JOURNAL   Mol Cell Endocrinol 381 (1-2), 210-219 (2013)
   PUBMED   23877023
  REMARK    GeneRIF: AVP-mediated elevations in STC-1 gene expression are
            wholly dependent on functional COX-2 activity.
REFERENCE   6  (bases 1 to 2463)
  AUTHORS   Paciga,M., Watson,A.J., DiMattia,G.E. and Wagner,G.F.
  TITLE     Ovarian stanniocalcin is structurally unique in mammals and its
            production and release are regulated through the luteinizing
            hormone receptor
  JOURNAL   Endocrinology 143 (10), 3925-3934 (2002)
   PUBMED   12239104
REFERENCE   7  (bases 1 to 2463)
  AUTHORS   Stasko,S.E. and Wagner,G.F.
  TITLE     Stanniocalcin gene expression during mouse urogenital development:
            a possible role in mesenchymal-epithelial signalling
  JOURNAL   Dev Dyn 220 (1), 49-59 (2001)
   PUBMED   11146507
REFERENCE   8  (bases 1 to 2463)
  AUTHORS   Ookata,K., Tojo,A., Onozato,M.L., Kashiwagi,M., Honda,S. and
            Hirose,S.
  TITLE     Distribution of stanniocalcin 1 in rat kidney and its regulation by
            vitamin D3
  JOURNAL   Exp Nephrol 9 (6), 428-435 (2001)
   PUBMED   11702003
REFERENCE   9  (bases 1 to 2463)
  AUTHORS   Tanuma,J., Shisa,H., Hiai,H., Higashi,S., Yamada,Y., Kamoto,T.,
            Hirayama,Y., Matsuuchi,H. and Kitano,M.
  TITLE     Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced
            tongue carcinogenesis in the rat
  JOURNAL   Cancer Res 58 (8), 1660-1664 (1998)
   PUBMED   9563479
REFERENCE   10 (bases 1 to 2463)
  AUTHORS   Olsen,H.S., Cepeda,M.A., Zhang,Q.Q., Rosen,C.A., Vozzolo,B.L. and
            Wagner,G.F.
  TITLE     Human stanniocalcin: a possible hormonal regulator of mineral
            metabolism
  JOURNAL   Proc Natl Acad Sci U S A 93 (5), 1792-1796 (1996)
   PUBMED   8700837
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078803.1.
            
            On Aug 8, 2004 this sequence version replaced NM_031123.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078803.1, U62667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2463
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..2463
                     /gene="Stc1"
                     /note="stanniocalcin 1"
                     /db_xref="GeneID:81801"
                     /db_xref="RGD:621776"
     exon            1..375
                     /gene="Stc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1001
                     /gene="Stc1"
                     /note="STC-1"
                     /codon_start=1
                     /product="stanniocalcin-1 precursor"
                     /protein_id="NP_112385.1"
                     /db_xref="GeneID:81801"
                     /db_xref="RGD:621776"
                     /translation="MLQNSAVILALVISAAAAHEAEQNDSVSPRKSRVAAQNSAEVVR
                     CLNSALQVGCGAFACLENSTCDTDGMYDICKSFLYSAAKFDTQGKAFVKESLKCIANG
                     ITSKVFLAIRRCSTFQRMIAEVQEDCYSKLNVCSIAKRNPEAITEVIQLPNHFSNRYY
                     NRLVRSLLECDEDTVSTIRDSLMEKIGPNMASLFHILQTDHCAQTHPRADFNRRRTNE
                     PQKLKVLLRNLRGEGDSPSHIKRTSQENA"
     exon            376..518
                     /gene="Stc1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..730
                     /gene="Stc1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..2445
                     /gene="Stc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcagcag cagcagcagc agcaacaaca acagcagcag tagcagcagc agcagcagca
       61 gcagcagcag cagcagcagc agcagccacc gccgccgctt gccagccagc cacacagcca
      121 cacaaaaatt cctcctcaaa tcctcaccta agctttcagt atatccagat ccacatcttc
      181 actcaagccg ggagagggaa agaggaaagg gggggaggaa aaaaaaagcc aacaacttag
      241 cggaaacttc tcagagaatg ctccaaaact cagcagtgat tctggcgctg gtcatcagtg
      301 ctgctgcagc tcacgaggcg gaacagaatg attctgtgag ccccagaaaa tcccgggtgg
      361 cggctcaaaa ttcagctgaa gtggtccgct gcctcaacag tgccctacag gttggctgtg
      421 gggcttttgc atgcctggaa aactccacat gtgacacaga tgggatgtac gacatttgta
      481 aatccttctt gtacagtgct gctaaatttg acactcaggg aaaagcattt gtcaaagaga
      541 gcttaaagtg catcgccaat gggatcacct ccaaggtctt ccttgccatt cggaggtgtt
      601 ctactttcca gaggatgatc gccgaggtgc aggaggactg ctacagcaag ctcaatgttt
      661 gcagcattgc caagcgcaac ccggaagcca tcactgaagt catacagctg cccaatcact
      721 tctccaacag atactacaac agacttgtcc gaagccttct ggaatgtgat gaagatacgg
      781 tcagcacaat cagagacagc ctgatggaga agatcgggcc caacatggcc agcctcttcc
      841 atatcctgca gacagaccac tgtgcccaga cacaccccag agctgacttc aataggaggc
      901 gcacaaatga gccacagaag ctgaaagtcc tcctcaggaa cctccgaggt gagggggatt
      961 ctccctcaca catcaaacgc acctcccaag agaatgcgta agcagggaga ggtattcaca
     1021 gcctcaccaa actaatagcg ttttaggggt gtttacacac caactttgag tgtactgtgc
     1081 ctggtttgat ttttttttaa gtagtaccta ttttctatcc ccccttaaag aaaactgcat
     1141 gaaactaagc ttccatgatc aatatcccaa tattctgcaa tgacagcatt cttagcaata
     1201 gaatacatgt ggtcattctg cctcttctgg agagagaatg taccctcttc catcccccct
     1261 ctctctcaat tctttttcaa gatccccatc tactctctgc aaacacaaaa cattcatgta
     1321 actgcccagt cattgtaatc tgaagatgta ggtcccttta gaatggtcac ccagtagagt
     1381 tagccaatac aaaacaactt tatttaaatg catgtcttaa atgctcataa atatgttaaa
     1441 tggaattcgt gttatgaatc tgtgctggcc atggacgaat atgaatgtca tgtttgaatt
     1501 cttgatctct aatgagtctt atggtctcaa tcctccaatg tctaacttcc tttctgacat
     1561 atttaccaaa ttgctcaaac ctggttctcc aaccagattt tgagccagca tcttcttgca
     1621 tctaatgaaa aacaaaaagc taacatcttt atgtactgta actgctcaga gctttaaaag
     1681 tatctttaac aattgtctta aaaacagaga atcttaaggt ctaactgtgg aatataaata
     1741 gctgaaaact attgtactgt acataaattc cagaggactc tgcttaacag agcagtctat
     1801 aataacttta ttgcatatag atttagtttt gtaccttagc tttattttcc ttttcctggg
     1861 aatggaataa ctatctcact tccagatatc cgcgttcatg ctccttgtgg ccttttttat
     1921 aactaagggg gtagaagtag ttttaactca acatcagaac ttaagatggg cctatacttg
     1981 ataggaaaac ccaacaggtt atctgaagga ccccaggtga gatatcaatc tcccagccca
     2041 gctcaaccca gaggctacat ttgacttaga tgtatcctga aacagctctg tcacagccaa
     2101 ctgggaatta caggaatcaa agagatcatc cctctgggct ttgatcactt agtgtgacaa
     2161 ggcctactat ccccttggaa gtggcagttc ttggctcatt gccttccatc aatgcctggc
     2221 actctggtaa atgatggaat gggatattgt tccactaagc caatcaggaa tgagtcaatc
     2281 agcctttggg tctttagtcc tgggaacttg ggcttaaggg ggtataaata accctgggct
     2341 gtccagcctt aatagactcc tcttacatct tttgtcctgt aacacgctgc ctgccaaagt
     2401 agtcctggca gctggaccat ctctgtagga tcttaaaaaa aaaaaaaaaa aaaaaaaaaa
     2461 aaa
//
