LOCUS       NM_001007149            2981 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus staufen double-stranded RNA binding protein 2
            (Stau2), transcript variant 1, mRNA.
ACCESSION   NM_001007149
VERSION     NM_001007149.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2981)
  AUTHORS   Fernandez-Moya,S.M., Ehses,J., Bauer,K.E., Schieweck,R.,
            Chakrabarti,A.M., Lee,F.C.Y., Illig,C., Luscombe,N.M., Harner,M.,
            Ule,J. and Kiebler,M.A.
  TITLE     RGS4 RNA Secondary Structure Mediates Staufen2 RNP Assembly in
            Neurons
  JOURNAL   Int J Mol Sci 22 (23), 13021 (2021)
   PUBMED   34884825
  REMARK    GeneRIF: RGS4 RNA Secondary Structure Mediates Staufen2 RNP
            Assembly in Neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2981)
  AUTHORS   Berger,S.M., Fernandez-Lamo,I., Schonig,K., Fernandez Moya,S.M.,
            Ehses,J., Schieweck,R., Clementi,S., Enkel,T., Grothe,S., von
            Bohlen Und Halbach,O., Segura,I., Delgado-Garcia,J.M., Gruart,A.,
            Kiebler,M.A. and Bartsch,D.
  TITLE     Forebrain-specific, conditional silencing of Staufen2 alters
            synaptic plasticity, learning, and memory in rats
  JOURNAL   Genome Biol 18 (1), 222 (2017)
   PUBMED   29149906
  REMARK    GeneRIF: RBP Stau2 plays an important role in the regulation of
            specific aspects of hippocampal synaptic plasticity and learning
            and memory.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2981)
  AUTHORS   Sharangdhar,T., Sugimoto,Y., Heraud-Farlow,J., Fernandez-Moya,S.M.,
            Ehses,J., Ruiz de Los Mozos,I., Ule,J. and Kiebler,M.A.
  TITLE     A retained intron in the 3'-UTR of Calm3 mRNA mediates its
            Staufen2- and activity-dependent localization to neuronal dendrites
  JOURNAL   EMBO Rep 18 (10), 1762-1774 (2017)
   PUBMED   28765142
  REMARK    GeneRIF: results identify the retained intron as a critical element
            in recruiting Stau2, which then allows for the localization of
            Calm3L mRNA to distal dendrites
REFERENCE   4  (bases 1 to 2981)
  AUTHORS   Graber,T.E., Freemantle,E., Anadolu,M.N., Hebert-Seropian,S.,
            MacAdam,R.L., Shin,U., Hoang,H.D., Alain,T., Lacaille,J.C. and
            Sossin,W.S.
  TITLE     UPF1 Governs Synaptic Plasticity through Association with a STAU2
            RNA Granule
  JOURNAL   J Neurosci 37 (38), 9116-9131 (2017)
   PUBMED   28821679
  REMARK    GeneRIF: Here, we describe a new role for the ATP-dependent
            helicase UPF1 and its interaction with the RNA localization protein
            STAU2 in mediating mGluR-LTD through the regulation of mRNA
            translation complexes stalled at the level of elongation and/or
            termination.
            Erratum:[J Neurosci. 2017 Oct 18;37(42):10253. doi:
            10.1523/JNEUROSCI.2761-17.2017.. PMID: 31305598]
REFERENCE   5  (bases 1 to 2981)
  AUTHORS   Heraud-Farlow,J.E., Sharangdhar,T., Li,X., Pfeifer,P., Tauber,S.,
            Orozco,D., Hormann,A., Thomas,S., Bakosova,A., Farlow,A.R.,
            Edbauer,D., Lipshitz,H.D., Morris,Q.D., Bilban,M., Doyle,M. and
            Kiebler,M.A.
  TITLE     Staufen2 regulates neuronal target RNAs
  JOURNAL   Cell Rep 5 (6), 1511-1518 (2013)
   PUBMED   24360961
  REMARK    GeneRIF: Stau2 stabilizes expression of Rgs4 mRNA via its 3' UTR in
            hippocampal neurons.
REFERENCE   6  (bases 1 to 2981)
  AUTHORS   Thomas,M.G., Martinez Tosar,L.J., Loschi,M., Pasquini,J.M.,
            Correale,J., Kindler,S. and Boccaccio,G.L.
  TITLE     Staufen recruitment into stress granules does not affect early mRNA
            transport in oligodendrocytes
  JOURNAL   Mol Biol Cell 16 (1), 405-420 (2005)
   PUBMED   15525674
  REMARK    GeneRIF: Staufen 1 and Staufen 2 are novel and ubiquitous stress
            granules components that are involved in repositioning of most
            polysomal mRNAs, but not of recently synthesized transcripts,
            during the stress response
REFERENCE   7  (bases 1 to 2981)
  AUTHORS   Miki,T. and Yoneda,Y.
  TITLE     Alternative splicing of Staufen2 creates the nuclear export signal
            for CRM1 (Exportin 1)
  JOURNAL   J Biol Chem 279 (46), 47473-47479 (2004)
   PUBMED   15364930
  REMARK    GeneRIF: Data show that an isoform of Staufen2, Stau2(59), is
            exported from the nucleus by two distinct pathways, one of which is
            RNA-binding domain 3-mediated and the other of which is CRM1
            (exportin 1)-dependent.
REFERENCE   8  (bases 1 to 2981)
  AUTHORS   Mallardo,M., Deitinghoff,A., Muller,J., Goetze,B., Macchi,P.,
            Peters,C. and Kiebler,M.A.
  TITLE     Isolation and characterization of Staufen-containing
            ribonucleoprotein particles from rat brain
  JOURNAL   Proc Natl Acad Sci U S A 100 (4), 2100-2105 (2003)
   PUBMED   12592035
REFERENCE   9  (bases 1 to 2981)
  AUTHORS   Duchaine,T.F., Hemraj,I., Furic,L., Deitinghoff,A., Kiebler,M.A.
            and DesGroseillers,L.
  TITLE     Staufen2 isoforms localize to the somatodendritic domain of neurons
            and interact with different organelles
  JOURNAL   J Cell Sci 115 (Pt 16), 3285-3295 (2002)
   PUBMED   12140260
REFERENCE   10 (bases 1 to 2981)
  AUTHORS   Tang,S.J., Meulemans,D., Vazquez,L., Colaco,N. and Schuman,E.
  TITLE     A role for a rat homolog of staufen in the transport of RNA to
            neuronal dendrites
  JOURNAL   Neuron 32 (3), 463-475 (2001)
   PUBMED   11709157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 2, 2021 this sequence version replaced NM_001007149.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF483620.1, SRR26643289.14599.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               JAXUCZ010000005.1  7624019-7624170
            153-219             JAXUCZ010000005.1  7632311-7632377
            220-350             JAXUCZ010000005.1  7650905-7651035
            351-510             JAXUCZ010000005.1  7671841-7672000
            511-646             JAXUCZ010000005.1  7682634-7682769
            647-806             JAXUCZ010000005.1  7719325-7719484
            807-914             JAXUCZ010000005.1  7722906-7723013
            915-1127            JAXUCZ010000005.1  7725339-7725551
            1128-1265           JAXUCZ010000005.1  7732118-7732255
            1266-1397           JAXUCZ010000005.1  7736859-7736990
            1398-1458           JAXUCZ010000005.1  7741558-7741618
            1459-1769           JAXUCZ010000005.1  7770449-7770759
            1770-1858           JAXUCZ010000005.1  7865886-7865974
            1859-2981           JAXUCZ010000005.1  7867081-7868203
FEATURES             Location/Qualifiers
     source          1..2981
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..2981
                     /gene="Stau2"
                     /note="staufen double-stranded RNA binding protein 2"
                     /db_xref="GeneID:171500"
                     /db_xref="RGD:621479"
     exon            1..152
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            153..219
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            220..350
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1952
                     /gene="Stau2"
                     /note="isoform LL (A) is encoded by transcript variant 1;
                     double-stranded RNA-binding protein Staufen homolog 2;
                     r-staufen protein; staufen, RNA binding protein, homolog
                     2"
                     /codon_start=1
                     /product="double-stranded RNA-binding protein Staufen
                     homolog 2 isoform LL (A)"
                     /protein_id="NP_001007150.2"
                     /db_xref="GeneID:171500"
                     /db_xref="RGD:621479"
                     /translation="MANPKEKTPMCLVNELARFHSIQPQYKLLNESGPAHSKMFSVQL
                     SLGEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNG
                     LAMKRGEPAIYRPLDPKPFPNYRANYNFRGMYNQRYHCPMPKIFYVQLTVGNNEFFGE
                     GKTRQAARHNAAMKALQALQNEPIPEKSPQNGESGKEMDDDKDANKSEISLVFEIALK
                     RNMPVSFEVIKESGPPHMKSFVTRVSVGEFSAEGEGNSKKLSKKRAATTVLQELKKLP
                     PLPVIEKPKLFFKKRPKTIIKAGPEYGQGMNPISRLAQIQQARKEKEPDYVLLSERGM
                     PRRREFVMQVKVGNEVATGTGPNKKIAKKNAAEAMLLQLGYKASTSLQDQLDKTGENK
                     GWSGPKPGFPEPANNTPKGILHLSPDVYQEMEASRHRVTSGTTLGYLSPKDMNQPSSS
                     FFSVESPSPTSSAPAARELLMNGTSPAAEAIGLKGSSPTPPCSSVQPSKQLEYLARIQ
                     GFQAALSALKQFSEQGLESIDGVVNVENGSLEKQAKHLREKADNNQANPGSITQDCKK
                     SKSVI"
     exon            351..510
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            511..646
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            647..806
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            807..914
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1127
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1265
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1397
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1458
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1769
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1858
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2981
                     /gene="Stau2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggagggcg cggcgggagc gcagggcggc tggcagagga ggggggcggg ggccgaggag
       61 ggagccggcg gcgtcggcgg cggcagagcg gggtcatttc tcgggagcgc tcgccaatgt
      121 ggagccgtct gccgggcgtc cgtggcccgc agttttttgg agctgtgagg gatacagaag
      181 tttgatcaat attgtcttaa catgcttcag ataaatcagc ttttctccac gataaaatgg
      241 caaatcccaa agagaaaact ccaatgtgtc tggtaaatga gttagcccgt ttccatagca
      301 tccaacccca gtataaactt ctgaatgaaa gcgggcctgc tcattcgaag atgttttcgg
      361 tgcagctgag tctgggtgag cagacatggg aatccgaagg gagcagtata aagaaggccc
      421 aacaggctgt tgcaaataaa gctttgactg aatctacgct tcccaaaccc gttcagaaac
      481 cacccaaaag taatgtcaat aataacccag gcagtataac tccgactgtg gaactgaatg
      541 ggcttgctat gaaaagggga gagcctgcca tctacaggcc gttagaccca aagccattcc
      601 caaattatag agctaattac aacttccggg gcatgtacaa ccagagatat cattgcccaa
      661 tgcccaagat cttttatgtt cagttgactg taggaaataa tgaattcttt ggcgaaggga
      721 agactcggca agctgccaga cacaatgctg cgatgaaagc tcttcaagcc ctacagaatg
      781 agccaattcc agaaaagtct cctcagaatg gtgaatcagg aaaagaaatg gatgacgata
      841 aagatgcaaa taaatctgaa ataagcttag tgtttgaaat tgcgctgaag agaaatatgc
      901 ccgtcagttt tgaggttatt aaagaaagtg gaccaccaca tatgaagagt tttgttaccc
      961 gggtgtcagt gggagaattt tctgcagaag gagagggaaa tagcaaaaag ctctccaaga
     1021 agcgtgcagc aaccacggtc ttacaggagc ttaagaaact cccacctctt cctgtgatag
     1081 agaagccaaa actatttttt aaaaaacgcc ctaaaacaat aataaaggct ggacccgagt
     1141 atggtcaagg aatgaacccc attagccgcc tggctcaaat ccagcaggcc agaaaggaaa
     1201 aggagcctga ttacgtttta ctttcagaac gtggaatgcc tcgccgtcga gagtttgtaa
     1261 tgcaggtcaa ggtaggcaat gaagttgcga ctggaacagg acctaataaa aagatagcca
     1321 agaaaaatgc tgcagaagct atgctgttac agctcggcta taaagcgtcc actagtcttc
     1381 aggatcagct cgacaagacc ggggaaaaca aaggatggag tggtccaaag cctggatttc
     1441 cggaaccagc gaataacact ccaaaaggaa ttcttcatct ttctcctgat gtttatcaag
     1501 agatggaagc cagccgccac agagtgacct ctggcacaac tctaggctac ttatcaccca
     1561 aagatatgaa ccaaccttca agctccttct tcagtgtaga gtctccctca ccgactagtt
     1621 cagccccagc tgccagggaa ctcctaatga atggaacatc tcctgctgct gaagccatag
     1681 gtttaaaagg aagttctcct actccccctt gttcttcagt acagccttca aaacaactgg
     1741 aatatttagc aaggattcaa ggctttcagg cagccttaag tgccttgaaa cagttttctg
     1801 aacaaggact ggaatcaatt gatggggtgg tgaatgttga aaacggctct cttgaaaaac
     1861 aagccaagca tctgcgggag aaagcggaca ataaccaggc aaacccaggc tccatcactc
     1921 aggactgcaa gaaatcaaag tcggtcatct agcagctccc agaacccatg gctgccactg
     1981 cgtccatata aagctgtcag cacgcacgag ggtgtctgtg ttctaggaaa cgaatgacta
     2041 ataccattat ctgagtctga tgtgaagaca acactattct aacccaggag acaatgtaca
     2101 tggtactgct tattcaactg ggggaaaata aaactttgag catttccctt ggaacttgag
     2161 atcagatcat aactcatttg cccagaggca gcagaaatct gatccactac tggagtttaa
     2221 aaataacaat taatgaaaag tgttagaaac aaggctgcag ttttaaaatg actcacacag
     2281 aagttgggtt tggttctgtc cttacagttg ctttgtcgtg gagattgtgg tgttatactc
     2341 tctcttgttt gaaataatgc ttgacaattc agaaattaac caatgatgtg ctgtggaatg
     2401 tgatgcttgt cttcatatag tctcacagtt tctcttttta ttcagatatt tgtaaccttc
     2461 ttcttgcaca gacacacaca cacacacata cacacacaca tatacacaca catattactt
     2521 taaggtgcat agcacaaaga tgtatgcaaa taacttttaa atcaggtcag ataactgatt
     2581 taaatataaa taactaggaa ccagtagttt ccatatattt caggactttt aaaaagacaa
     2641 aatgaaacaa aactgaacag ttgtgggttt tgcgctatgg gatgccatca gccatcgagg
     2701 aggcgtcttg cctctgacca tcaatccaag agtctactct gtcgtggaaa ttgtgcccac
     2761 ccccatctgt gtgttgtaac cactcactgt ttgcatcgag tgtctttagt aaatgcctct
     2821 ggactcggga cagtgagtag gatcgagtag gatcaaatag atactgtaca tggtggggaa
     2881 tggaaagcct gtgggagaag cttctagcca accgcgctct ggaccagcat gttggaatcc
     2941 agcgtggggc aaatgcagta aagatttggt ctgtttctgt a
//
