LOCUS       NM_053436               3073 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus staufen double-stranded RNA binding protein 1
            (Stau1), transcript variant 1, mRNA.
ACCESSION   NM_053436
VERSION     NM_053436.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3073)
  AUTHORS   Lee K, Yoo KS, Park YS and Kim HK.
  TITLE     Activity of Arhgef4 is modulated through Staufen1 in neurons
  JOURNAL   Neurosci Lett 756, 135962 (2021)
   PUBMED   34022264
  REMARK    GeneRIF: Activity of Arhgef4 is modulated through Staufen1 in
            neurons.
REFERENCE   2  (bases 1 to 3073)
  AUTHORS   Xue Y, Guo Y, Luo S, Zhou W, Xiang J, Zhu Y, Xiang Z and Shen J.
  TITLE     Aberrantly Methylated-Differentially Expressed Genes Identify Novel
            Atherosclerosis Risk Subtypes
  JOURNAL   Front Genet 11, 569572 (2020)
   PUBMED   33381146
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3073)
  AUTHORS   Blackham SL and McGarvey MJ.
  TITLE     A host cell RNA-binding protein, Staufen1, has a role in hepatitis
            C virus replication before virus assembly
  JOURNAL   J Gen Virol 94 (Pt 11), 2429-2436 (2013)
   PUBMED   23907398
REFERENCE   4  (bases 1 to 3073)
  AUTHORS   Ghoujal B, Milev MP, Ajamian L, Abel K and Mouland AJ.
  TITLE     ESCRT-II's involvement in HIV-1 genomic RNA trafficking and
            assembly
  JOURNAL   Biol Cell 104 (12), 706-721 (2012)
   PUBMED   22978549
REFERENCE   5  (bases 1 to 3073)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 3073)
  AUTHORS   Villace P, Marion RM and Ortin J.
  TITLE     The composition of Staufen-containing RNA granules from human cells
            indicates their role in the regulated transport and translation of
            messenger RNAs
  JOURNAL   Nucleic Acids Res 32 (8), 2411-2420 (2004)
   PUBMED   15121898
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3073)
  AUTHORS   Macchi P, Kroening S, Palacios IM, Baldassa S, Grunewald B,
            Ambrosino C, Goetze B, Lupas A, St Johnston D and Kiebler M.
  TITLE     Barentsz, a new component of the Staufen-containing
            ribonucleoprotein particles in mammalian cells, interacts with
            Staufen in an RNA-dependent manner
  JOURNAL   J Neurosci 23 (13), 5778-5788 (2003)
   PUBMED   12843282
REFERENCE   8  (bases 1 to 3073)
  AUTHORS   Monshausen M, Rehbein M, Richter D and Kindler S.
  TITLE     The RNA-binding protein Staufen from rat brain interacts with
            protein phosphatase-1
  JOURNAL   J Neurochem 81 (3), 557-564 (2002)
   PUBMED   12065664
REFERENCE   9  (bases 1 to 3073)
  AUTHORS   Monshausen M, Putz U, Rehbein M, Schweizer M, DesGroseillers L,
            Kuhl D, Richter D and Kindler S.
  TITLE     Two rat brain staufen isoforms differentially bind RNA
  JOURNAL   J Neurochem 76 (1), 155-165 (2001)
   PUBMED   11145988
REFERENCE   10 (bases 1 to 3073)
  AUTHORS   Kiebler MA, Hemraj I, Verkade P, Kohrmann M, Fortes P, Marion RM,
            Ortin J and Dotti CG.
  TITLE     The mammalian staufen protein localizes to the somatodendritic
            domain of cultured hippocampal neurons: implications for its
            involvement in mRNA transport
  JOURNAL   J Neurosci 19 (1), 288-297 (1999)
   PUBMED   9870958
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN932990.1, AF227200.1 and BC081755.1.
            
            On Oct 12, 2007 this sequence version replaced NM_053436.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF227200.1, SRR8487227.63913.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-584               DN932990.1         30-613
            585-1243            AF227200.1         572-1230
            1244-3073           BC081755.1         1184-3013
FEATURES             Location/Qualifiers
     source          1..3073
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3073
                     /gene="Stau1"
                     /gene_synonym="Stau"
                     /note="staufen double-stranded RNA binding protein 1"
                     /db_xref="GeneID:84496"
                     /db_xref="RGD:621778"
     exon            1..180
                     /gene="Stau1"
                     /gene_synonym="Stau"
                     /inference="alignment:Splign:2.1.0"
     exon            181..319
                     /gene="Stau1"
                     /gene_synonym="Stau"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1727
                     /gene="Stau1"
                     /gene_synonym="Stau"
                     /note="isoform 1 is encoded by transcript variant 1;
                     staufen RNA binding protein homolog 1; double-stranded
                     RNA-binding protein Staufen homolog 1"
                     /codon_start=1
                     /product="double-stranded RNA-binding protein Staufen
                     homolog 1 isoform 1"
                     /protein_id="NP_445888.1"
                     /db_xref="GeneID:84496"
                     /db_xref="RGD:621778"
                     /translation="MYKPVDPHSRMQSTYSYGMRGGAYPPRYFYPFPVPPLLYQVELS
                     VGGQQFNGKGKMRPPVKHDATARALRTLQSEPLPERLEVNGRESEEENLNKSEISQVF
                     EIALKRNLPVNFESFPLTQVARESGPPHMKNFVTRVSVGEFVGEGEGKSKKISKKNAA
                     RAVLEQLRRLPPLPAVERVKPRIKKKSQPTCKLQTAPDYGQGMNPISRLAQIQQAKKE
                     KEPEYMLLTERGLPRRREFVMQVKVGHHTAEGAGTNKKVAKRNAAENMLEILGFKVPQ
                     AQPAKPALKSEEKTPVKKPGDGRKVTFFEPSPGDENGTSNKEDEFRMPYLSHQQLPAG
                     ILPMVPEVAQAVGVSQGHHTKDFARAAPNPAKATVTAMIARELLYGGTSPTAETILKS
                     NISSGHVPHGPRTRPSEQLYYLSRAQGFQVEYKDFPKNNKNECVSLINCSSQPPLVSH
                     GIGKDVESCHDMAALNILKLLSELDQQSTEMPRTGNGPVSACGRC"
     exon            320..485
                     /gene="Stau1"
                     /gene_synonym="Stau"
                     /inference="alignment:Splign:2.1.0"
     exon            486..584
                     /gene="Stau1"
                     /gene_synonym="Stau"
                     /inference="alignment:Splign:2.1.0"
     exon            585..815
                     /gene="Stau1"
                     /gene_synonym="Stau"
                     /inference="alignment:Splign:2.1.0"
     exon            816..959
                     /gene="Stau1"
                     /gene_synonym="Stau"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1106
                     /gene="Stau1"
                     /gene_synonym="Stau"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1182
                     /gene="Stau1"
                     /gene_synonym="Stau"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1502
                     /gene="Stau1"
                     /gene_synonym="Stau"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1625
                     /gene="Stau1"
                     /gene_synonym="Stau"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1711
                     /gene="Stau1"
                     /gene_synonym="Stau"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..3073
                     /gene="Stau1"
                     /gene_synonym="Stau"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgcgtctg tgtgcgctcc cccttcttct gacccccggc ccggcggcgc ccgccttctc
       61 cgcagccact ccgtctcttc cctcccccgg tctttttttc ctcgccctct tcttttgctt
      121 ttcttcctcg ccgccgccca ataccgccgg ccccgggacg agctctgggg aagcagccag
      181 aaagtatagc ttctaccatt gagctcaatg cactgtgcgt gaaactggaa agaaaaccaa
      241 tgtataagcc cgtggacccc cactctcgga tgcagtccac ctacagctat ggcatgcgtg
      301 gaggtgccta tccccccaga tacttttacc catttccagt tccaccgtta ctctaccaag
      361 ttgagctctc cgtgggagga cagcagttta atgggaaggg aaagatgaga ccacctgtga
      421 aacatgatgc cactgcccga gccctgagga ctctgcagag tgagccccta ccagagaggc
      481 tagaggtaaa tggaagagaa tcagaagaag aaaaccttaa taaatcagaa ataagccaag
      541 tgtttgagat tgcgctgaag cggaatttgc ctgtgaattt tgagtctttc cctctgacac
      601 aggtggcccg ggagagtggc ccgccacaca tgaagaactt tgtgaccagg gtttcagttg
      661 gggagtttgt aggggaagga gaagggaaaa gcaagaagat ctccaagaag aatgcggcaa
      721 gggccgtgct ggagcagcta aggaggctgc cacctctacc tgctgtggag cgagtgaagc
      781 ccagaatcaa gaagaaaagt cagcccacct gcaagctaca gactgccccc gactatggcc
      841 aagggatgaa tcctattagc agactggcac agatccagca ggcaaaaaag gagaaggagc
      901 cggagtacat gctccttaca gaacgaggtc ttccacgtcg cagggagttt gtgatgcagg
      961 tgaaggttgg gcatcacacc gcagaaggag caggtaccaa taagaaggtg gccaagcgca
     1021 atgctgctga gaacatgctg gagatcctgg ggttcaaagt cccccaggcg cagcctgcca
     1081 agccagcact caaatcagaa gagaagactc cagtaaagaa accaggagat ggaaggaaag
     1141 taacattttt tgaacctagc cctggggatg aaaatggaac cagtaataaa gaggatgagt
     1201 tcaggatgcc ctatcttagc catcagcagc tgccagccgg gatcctcccc atggtgccag
     1261 aggttgccca ggctgtcggg gttagtcaag gacaccatac caaagatttc gccagggcag
     1321 ctccaaatcc tgccaaggcc acggtaactg ccatgatagc ccgagaattg ttgtacgggg
     1381 gcacctcgcc cacagccgag accattttaa agagtaacat ctcttcagga catgtacccc
     1441 atggacctcg cacaagaccc tctgagcaac tgtactacct ttccagagcc cagggattcc
     1501 aggttgaata caaagacttc cccaagaaca acaagaacga gtgtgtatct ctcatcaact
     1561 gctcttcaca gccacctctc gtcagccatg gcatcggcaa ggatgtggag tcctgtcatg
     1621 atatggctgc actgaacatc ttaaagctgc tgtctgagtt ggaccaacag agcacagaga
     1681 tgccaaggac aggaaacgga ccagtttcag cgtgcgggag gtgctgaacc tattctggcc
     1741 atgaaccatt ataaaaccca acatatatac cgaaaatact gagaactgct ttgaaaattt
     1801 ggaatttctg ataactccag tgggccaaga catggtggat aaaaaaatgt ggcaaagaag
     1861 aaaaggaact gcaggtggtg gccttggttg ggctgggctg ctggtgacgc tgtgctccgc
     1921 catccaccag gagaccagca gctccagtgt ctccagcttt tatttttgcc tcgtgacaga
     1981 gaaacggaga gcgtggccaa ctctcacgct ggcttcttca gattctttgg aaaaccggga
     2041 cagccacacc agagaggcct tacagcggcc ccggagctaa acgcaccaga gaaaaaccag
     2101 tgcttcctac atgactgacg caactctgcc acacgtagca cccaccgtaa ccactgcttt
     2161 ctcttcaaca gtgatggatg cctgttagtt ccattattcc ctttggttga gatgacacta
     2221 tgtaattttc atttcagttt ctcagttgca tctacttacc tagcagttta gaaactagtc
     2281 tgagacagat gctatccagc tatgtaactg gcaaagacca cagccctgtt tggtgatgca
     2341 ttctgtgcct ctggctcggc tggcagttct ggacttaacc acaagaatcc ttgactccca
     2401 accccttgta taaattggac agcttaggac ttttaaactt taggagatca aaagatttgg
     2461 tcctttttaa ctttattttt aagcagcata cttaaaagtg agcctgacct ttaccagtta
     2521 taacagattg tcaacgggag aggttgtcac ccattgtaac agattgccag tgggaggtca
     2581 cttgagggag tattgctcaa ggtggctttt tctacacact acaggacatt acctgtgggc
     2641 ccagaagact atgggctggt gtccctggag ggcccaatac agtcaatccc agcctccacg
     2701 tagggaaggg cgacaggttt cctggtgctg tgctagtgtg cacagaggca ggaaggtctg
     2761 ccggcctggt gtggagcatt gtggctctga gtgcaaccct gctgctccca ctcggggttt
     2821 agctggacct tttcacccat ggaatataag gaaacttagt ctttgtcacc aataaatgag
     2881 aatactaaat tttttttgtt aatttatttt caaatgtcac tacttctaga tcaatctcct
     2941 tctggttcat ccccttcccc accttttttt aaaagaagag aatatttgta atgcttgtga
     3001 ttctgtctgg gcaaaaatct gaagatctaa aatctcttta tattaaacta ttgatcaata
     3061 aacagctact aag
//
