LOCUS       NM_001044250            2635 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus signal transducer and activator of transcription
            6 (Stat6), mRNA.
ACCESSION   NM_001044250 XM_001057138 XM_001057192 XM_343223
VERSION     NM_001044250.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2635)
  AUTHORS   Blackler,G., Lai-Zhao,Y., Klapak,J., Philpott,H.T., Pitchers,K.K.,
            Maher,A.R., Fiset,B., Walsh,L.A., Gillies,E.R. and Appleton,C.T.
  TITLE     Targeting STAT6-mediated synovial macrophage activation improves
            pain in experimental knee osteoarthritis
  JOURNAL   Arthritis Res Ther 26 (1), 73 (2024)
   PUBMED   38509602
  REMARK    GeneRIF: Targeting STAT6-mediated synovial macrophage activation
            improves pain in experimental knee osteoarthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2635)
  AUTHORS   Zhong,Y.M., Zhang,L.L., Lu,W.T., Shang,Y.N. and Zhou,H.Y.
  TITLE     Moxibustion regulates the polarization of macrophages through the
            IL-4/STAT6 pathway in rheumatoid arthritis
  JOURNAL   Cytokine 152, 155835 (2022)
   PUBMED   35240467
  REMARK    GeneRIF: Moxibustion regulates the polarization of macrophages
            through the IL-4/STAT6 pathway in rheumatoid arthritis.
            Review article
            Erratum:[Cytokine. 2022 Jun;154:155893. PMID: 35484060]
REFERENCE   3  (bases 1 to 2635)
  AUTHORS   Guo,L., Fang,T., Jiang,Y. and Liu,D.
  TITLE     Identification of immune checkpoint inhibitors and biomarkers among
            STAT family in stomach adenocarcinoma
  JOURNAL   Am J Transl Res 12 (9), 4977-4997 (2020)
   PUBMED   33042401
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2635)
  AUTHORS   Zhang,J., Zhao,D., Na,N., Li,H., Miao,B., Hong,L. and Huang,Z.
  TITLE     Renoprotective effect of erythropoietin via modulation of the
            STAT6/MAPK/NF-kappaB pathway in ischemia/reperfusion injury after
            renal transplantation
  JOURNAL   Int J Mol Med 41 (1), 25-32 (2018)
   PUBMED   29115389
  REMARK    GeneRIF: the results of the present study demonstrated that EPO
            exerted a protective effect in renal IRI via the
            STAT6/MAPK/NF-kappaB pathway. This protective effect of EPO may
            improve reperfusion tolerance in ischemic kidneys and benefit
            transplant recipients.
REFERENCE   5  (bases 1 to 2635)
  AUTHORS   Qiu,Y., Nguyen,K.D., Odegaard,J.I., Cui,X., Tian,X., Locksley,R.M.,
            Palmiter,R.D. and Chawla,A.
  TITLE     Eosinophils and type 2 cytokine signaling in macrophages
            orchestrate development of functional beige fat
  JOURNAL   Cell 157 (6), 1292-1308 (2014)
   PUBMED   24906148
REFERENCE   6  (bases 1 to 2635)
  AUTHORS   Harris,M.B., Chang,C.C., Berton,M.T., Danial,N.N., Zhang,J.,
            Kuehner,D., Ye,B.H., Kvatyuk,M., Pandolfi,P.P., Cattoretti,G.,
            Dalla-Favera,R. and Rothman,P.B.
  TITLE     Transcriptional repression of Stat6-dependent interleukin-4-induced
            genes by BCL-6: specific regulation of iepsilon transcription and
            immunoglobulin E switching
  JOURNAL   Mol Cell Biol 19 (10), 7264-7275 (1999)
   PUBMED   10490661
REFERENCE   7  (bases 1 to 2635)
  AUTHORS   Ong,C.J., Ip,S., Teh,S.J., Wong,C., Jirik,F.R., Grusby,M.J. and
            Teh,H.S.
  TITLE     A role for T helper 2 cells in mediating skin fibrosis in
            tight-skin mice
  JOURNAL   Cell Immunol 196 (1), 60-68 (1999)
   PUBMED   10486156
REFERENCE   8  (bases 1 to 2635)
  AUTHORS   Dent,A.L., Doherty,T.M., Paul,W.E., Sher,A. and Staudt,L.M.
  TITLE     BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent
            pathway that controls susceptibility to infection by Leishmania
            major
  JOURNAL   J Immunol 163 (4), 2098-2103 (1999)
   PUBMED   10438949
REFERENCE   9  (bases 1 to 2635)
  AUTHORS   Dent,A.L., Shaffer,A.L., Yu,X., Allman,D. and Staudt,L.M.
  TITLE     Control of inflammation, cytokine expression, and germinal center
            formation by BCL-6
  JOURNAL   Science 276 (5312), 589-592 (1997)
   PUBMED   9110977
REFERENCE   10 (bases 1 to 2635)
  AUTHORS   Kotanides,H. and Reich,N.C.
  TITLE     Interleukin-4-induced STAT6 recognizes and activates a target site
            in the promoter of the interleukin-4 receptor gene
  JOURNAL   J Biol Chem 271 (41), 25555-25561 (1996)
   PUBMED   8810328
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ462201.1.
            
            On or before Aug 28, 2006 this sequence version replaced
            XM_343223.3, XM_001057138.1, XM_001057192.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ462201.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2635
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2635
                     /gene="Stat6"
                     /note="signal transducer and activator of transcription 6"
                     /db_xref="GeneID:362896"
                     /db_xref="RGD:1309063"
     exon            1..61
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            62..199
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2609
                     /gene="Stat6"
                     /note="signal transducer and transcription activator 6;
                     signal transducer and activator of transcription 6,
                     interleukin-4 induced"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     6"
                     /protein_id="NP_001037715.1"
                     /db_xref="GeneID:362896"
                     /db_xref="RGD:1309063"
                     /translation="MSLWSLVSKMSPEKLQRLYVDFPQHLRHLLAEWLENQPWEFLVG
                     SDAFCYNMASALLSATVQRLQASAGEQGKGSSLLQHISTLESIYQRDPLKLVATIRQI
                     LQGEKKAVIEEFHHLPGPFHRKQEELKFTTALGRLQHRVRETRILRESLQQGTKTAQV
                     SLKNLIDPPANGTGPSEDLATMLQGTVGDLEATQALVLKRIQIWKRQQQLAGNGTPFE
                     ESLAGLQERCESLVEIYSQLQQEIGAASGELEPKTRASLISRLDEVLRTLVTSSFLVE
                     KQPPQVLKTQTKFQAGVRFLLGLQFLGTSAKPPLVRADMVTEKQARELSLPQGSGAGV
                     ESTGEIMNNTVPLENSVPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSF
                     MLGPNKHLIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEK
                     MCETLNLKFMAEVGTSRGLLPEHFLFLAQKIFNDNSLSIEAFQHRCVSWSQFNKEILL
                     GRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDS
                     EIGGITIAHVIRGQDGSSQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEA
                     FRSHYKPEQMGKDGRGYVSTTIKMTVERDQPLPTPEPQMPAMVAPYDLGMAPDASMQL
                     SSDMVYPPQSHSIHSFQSIPLEESMSVLPPFQEPHLQMPPTMSQISMPFDQPHPQGLL
                     QCQSQEHAVSSPEPLLCSDVTMAEDSCLTQPVQGFPQGTWVSEGMYPPLMPPTEQDLT
                     KLLLEGQGEGGGSIGTQPLLQPSSYGQSGISMSHLDLRTNPSW"
     exon            200..338
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            339..422
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            423..561
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            562..614
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            615..763
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            764..895
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1084
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1172
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1295
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1388
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1595
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1690
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1827
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1974
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2038
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2143
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2227
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2293
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2422
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2635
                     /gene="Stat6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacccatgg gcttggtagt gcccgctgag agagggagaa gatagcagcg gggctgccga
       61 ggcaccctgc gatatcccag atcatgtctc tgtggagtct agtttccaag atgtccccag
      121 aaaaactgca acggctctat gttgactttc cacaacacct gcggcatctt ctggccgaat
      181 ggctggagaa tcagccctgg gagttcctgg ttggttcaga tgctttctgt tacaacatgg
      241 ctagtgccct actttctgcc actgtccagc gtcttcaggc ctctgcagga gagcagggga
      301 aaggaagcag cctcttgcag cacatcagca ccttggagag catctatcag agggaccccc
      361 tgaagctggt ggccaccatc agacaaatac ttcaagggga gaaaaaagct gttatagaag
      421 agttccacca cctgccaggg cccttccatc gaaagcagga agaactcaag tttactacag
      481 ccctgggcag gcttcagcac cgagtaaggg agaccaggat tctccgagaa tctctgcagc
      541 aggggaccaa gactgcgcaa gtgtctctga agaacttgat agaccctcct gccaatggca
      601 ctggtccaag tgaggatctg gccacgatgc tgcaggggac tgtgggggac ttggaggcca
      661 cccaggctct agtgctgaaa aggattcaga tttggaagcg gcaacagcag ctggcaggga
      721 atggcacacc ctttgaggag agcctggcag ggctgcagga gaggtgtgaa agcctggtgg
      781 aaatttattc ccagctgcag caggagattg gagcagccag tggggagctt gagcccaaga
      841 cccgggcatc gctcataagc cgtctggatg aagtcctgcg aacccttgtg accagctctt
      901 tcctggtgga gaagcagccc ccacaggttc tgaagacaca gactaagttt caggctgggg
      961 ttcgattcct actgggtctg cagttcctag ggacctcagc caagcctcca ctggtcagag
     1021 ctgacatggt gacagagaaa caggccagag aactaagcct gccccagggg tctggggctg
     1081 gagtggagag cacaggagag atcatgaaca atactgtacc tctggagaac agtgttcctg
     1141 ggaactgctg ctctgccctc ttcaagaacc tgctcctgaa gaaaatcaag cgctgtgagc
     1201 ggaagggtac agagtctgtc accgaagaga agtgcgctgt gctcttctct acgagcttca
     1261 tgctgggccc caacaaacac ctcatccagc ttcaggccct gtctctgccc ttggtggtca
     1321 tcgttcatgg caaccaagac aacaatgcca aagctaccat cctgtgggat aatgccttct
     1381 ctgagatgga ccgagtgccc tttgtggtag ctgagcgagt gccctgggag aaaatgtgtg
     1441 aaactctgaa cctcaagttt atggctgagg tggggaccag ccggggactg ctaccagaac
     1501 acttcctgtt cctggcccag aagatcttca atgacaacag ccttagcata gaggcctttc
     1561 agcaccgctg tgtgtcttgg tcacagttca acaaggagat tctactgggc cgaggcttca
     1621 ctttttggca gtggtttgat ggtgtcctgg acctcactaa acgctgtctt cggagctact
     1681 ggtcagatcg gctgatcatc ggctttatca gtaagcaata tgtcactagc cttctcctca
     1741 acgagccaga tggaaccttc ctcctccgct ttagcgactc tgagattggg ggcatcacca
     1801 ttgcccatgt catccggggt caggatggct cctcacagat agagaacatc cagccgtttt
     1861 ctgccaaaga cctatccatt cgctcactgg gggaccgaat ccgagatctt gctcaattaa
     1921 aaaacctcta ccccaagaaa cccaaggatg aggcttttcg gagccactat aagccggaac
     1981 agatgggaaa ggacgggagg ggttatgtct caactactat caagatgact gtggaaaggg
     2041 accagcccct tcctactcca gagccccaga tgcctgccat ggtggcccct tatgatcttg
     2101 gaatggcccc tgatgcttcc atgcaactca gctcagatat ggtgtatcct ccacagtctc
     2161 attccatcca ctcatttcag agcatccccc tagaagagtc catgagtgta ctgccaccct
     2221 ttcaggagcc tcacctccaa atgcccccca ccatgagcca gataagcatg ccctttgacc
     2281 agcctcatcc ccagggcctg ctccagtgcc agtcccagga gcatgcggtg tccagccctg
     2341 aacccttgct gtgttcagat gtcactatgg cggaagacag ctgcctaact cagcctgtgc
     2401 aaggtttccc ccagggcacc tgggtcagcg aaggcatgta ccctcccctg atgcctccca
     2461 ctgaacagga cctcaccaag cttctcctag agggccaagg ggaaggtgga ggatccatag
     2521 ggactcagcc cctcctgcaa ccatcttctt atgggcaatc ggggatctca atgtcccacc
     2581 tggacctaag gaccaacccc agttggtgat cccaactgga gaagcccaga gacag
//
