LOCUS       NM_022380               2670 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus signal transducer and activator of transcription
            5B (Stat5b), mRNA.
ACCESSION   NM_022380
VERSION     NM_022380.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2670)
  AUTHORS   Guo,L., Fang,T., Jiang,Y. and Liu,D.
  TITLE     Identification of immune checkpoint inhibitors and biomarkers among
            STAT family in stomach adenocarcinoma
  JOURNAL   Am J Transl Res 12 (9), 4977-4997 (2020)
   PUBMED   33042401
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2670)
  AUTHORS   Wang,X., Liao,X., Yu,T., Gong,Y., Zhang,L., Huang,J., Yang,C.,
            Han,C., Yu,L., Zhu,G., Qin,W., Liu,Z., Zhou,X., Liu,J., Han,Q. and
            Peng,T.
  TITLE     Analysis of clinical significance and prospective molecular
            mechanism of main elements of the JAK/STAT pathway in
            hepatocellular carcinoma
  JOURNAL   Int J Oncol 55 (4), 805-822 (2019)
   PUBMED   31485610
REFERENCE   3  (bases 1 to 2670)
  AUTHORS   Oberley,C.C., Bilger,A. and Drinkwater,N.R.
  TITLE     Genetic background determines if Stat5b suppresses or enhances
            murine hepatocarcinogenesis
  JOURNAL   Mol Carcinog 54 (10), 959-970 (2015)
   PUBMED   24838184
REFERENCE   4  (bases 1 to 2670)
  AUTHORS   Pastuszak-Lewandoska,D., Domanska,D., Czarnecka,K.H., Kordiak,J.,
            Migdalska-Sek,M., Nawrot,E., Kiszalkiewicz,J., Antczak,A.,
            Gorski,P. and Brzezianska,E.
  TITLE     Expression of STAT5, COX-2 and PIAS3 in correlation with NSCLC
            histhopathological features
  JOURNAL   PLoS One 9 (8), e104265 (2014)
   PUBMED   25137041
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2670)
  AUTHORS   Fernando,J., Faber,T.W., Pullen,N.A., Falanga,Y.T., Kolawole,E.M.,
            Oskeritzian,C.A., Barnstein,B.O., Bandara,G., Li,G., Schwartz,L.B.,
            Spiegel,S., Straus,D.B., Conrad,D.H., Bunting,K.D. and Ryan,J.J.
  TITLE     Genotype-dependent effects of TGF-beta1 on mast cell function:
            targeting the Stat5 pathway
  JOURNAL   J Immunol 191 (9), 4505-4513 (2013)
   PUBMED   24068671
REFERENCE   6  (bases 1 to 2670)
  AUTHORS   Yiu,G.K. and Hecht,N.B.
  TITLE     Novel testis-specific protein-DNA interactions activate
            transcription of the mouse protamine 2 gene during spermatogenesis
  JOURNAL   J Biol Chem 272 (43), 26926-26933 (1997)
   PUBMED   9341127
REFERENCE   7  (bases 1 to 2670)
  AUTHORS   Gebert,C.A., Park,S.H. and Waxman,D.J.
  TITLE     Regulation of signal transducer and activator of transcription
            (STAT) 5b activation by the temporal pattern of growth hormone
            stimulation
  JOURNAL   Mol Endocrinol 11 (4), 400-414 (1997)
   PUBMED   9092792
REFERENCE   8  (bases 1 to 2670)
  AUTHORS   Yi,W., Kim,S.O., Jiang,J., Park,S.H., Kraft,A.S., Waxman,D.J. and
            Frank,S.J.
  TITLE     Growth hormone receptor cytoplasmic domain differentially promotes
            tyrosine phosphorylation of signal transducers and activators of
            transcription 5b and 3 by activated JAK2 kinase
  JOURNAL   Mol Endocrinol 10 (11), 1425-1443 (1996)
   PUBMED   8923468
REFERENCE   9  (bases 1 to 2670)
  AUTHORS   Ripperger,J.A., Fritz,S., Richter,K., Hocke,G.M., Lottspeich,F. and
            Fey,G.H.
  TITLE     Transcription factors Stat3 and Stat5b are present in rat liver
            nuclei late in an acute phase response and bind interleukin-6
            response elements
  JOURNAL   J Biol Chem 270 (50), 29998-30006 (1995)
   PUBMED   8530402
REFERENCE   10 (bases 1 to 2670)
  AUTHORS   Venge,P., Zetterstrom,O., Dahl,R., Roxin,L.E. and Olsson,I.
  TITLE     Low levels of eosinophil cationic proteins in patients with asthma
  JOURNAL   Lancet 2 (8034), 373-375 (1977)
   PUBMED   70587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 2, 2021 this sequence version replaced NM_022380.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X97541.1, SRR26643429.39037.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                JAXUCZ010000010.1  86275854-86275952   c
            100-237             JAXUCZ010000010.1  86233280-86233417   c
            238-394             JAXUCZ010000010.1  86229446-86229602   c
            395-484             JAXUCZ010000010.1  86226869-86226958   c
            485-659             JAXUCZ010000010.1  86225225-86225399   c
            660-790             JAXUCZ010000010.1  86222529-86222659   c
            791-942             JAXUCZ010000010.1  86222165-86222316   c
            943-1098            JAXUCZ010000010.1  86221575-86221730   c
            1099-1278           JAXUCZ010000010.1  86221010-86221189   c
            1279-1366           JAXUCZ010000010.1  86220560-86220647   c
            1367-1489           JAXUCZ010000010.1  86220359-86220481   c
            1490-1582           JAXUCZ010000010.1  86218097-86218189   c
            1583-1789           JAXUCZ010000010.1  86214485-86214691   c
            1790-1884           JAXUCZ010000010.1  86212864-86212958   c
            1885-2015           JAXUCZ010000010.1  86212564-86212694   c
            2016-2186           JAXUCZ010000010.1  86211436-86211606   c
            2187-2238           JAXUCZ010000010.1  86208468-86208519   c
            2239-2343           JAXUCZ010000010.1  86208109-86208213   c
            2344-2670           JAXUCZ010000010.1  86207293-86207619   c
FEATURES             Location/Qualifiers
     source          1..2670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2670
                     /gene="Stat5b"
                     /note="signal transducer and activator of transcription
                     5B"
                     /db_xref="GeneID:25126"
                     /db_xref="RGD:3774"
     exon            1..99
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            100..237
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2470
                     /gene="Stat5b"
                     /note="Signal transducer and activator of transcription
                     5a"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     5B"
                     /protein_id="NP_071775.1"
                     /db_xref="GeneID:25126"
                     /db_xref="RGD:3774"
                     /translation="MAMWIQAQQLQGDALHQMQALYGQHFPIEVRHYLSQWIESQAWD
                     SIDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCP
                     MELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLITQDTES
                     ELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLNPQERMSRETALQQKQVSLETWLQRE
                     AQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQ
                     SWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFII
                     EKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDY
                     SGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFDSQFSV
                     GGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLC
                     EALNMKFKAEVQSNRGLTKENLVFLAQKLFNSSSNHLEDYNSMSVSWSQFNRENLPGR
                     NYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEI
                     GGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKY
                     YTPVPCEPATAKAADGYVKPQIKQVVPEFVNASADAGSGATYMDQAPSPVVCPQAHYN
                     MYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS"
     exon            238..394
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            395..484
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            485..659
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            660..790
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            791..942
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1098
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1278
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1366
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1489
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1582
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1789
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1884
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2015
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2186
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2238
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2343
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2670
                     /gene="Stat5b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgacgacgcg cggaggtcct gcactgggag ggagcaagcg ggcgcgcgag agagcgtgcg
       61 gggccggaaa gaccgctggc tctggtgggg cagaacgagg ttgtaagcca tggcaatgtg
      121 gatacaggct cagcagctcc agggcgatgc ccttcatcag atgcaggcct tgtacggcca
      181 gcatttcccc atcgaggtgc gacattattt atcccagtgg atcgaaagtc aagcctggga
      241 ctcaatagat cttgataatc cacaggagaa cattaaggcc acccagctcc tggagggcct
      301 ggtgcaggag ctgcagaaga aggcagaaca ccaggtgggg gaagatgggt ttttgctgaa
      361 gatcaagctg gggcactatg ccacgcagct ccagaacacg tatgaccgct gccccatgga
      421 gctggtgcgc tgtatccggc acattctata caatgaacag aggctggtcc gagaagccaa
      481 caacggaagc tctccggctg gaagtcttgc tgacgccatg tcccagaagc accttcagat
      541 caaccaaacg tttgaggagc tgcgtctgat cacacaggac acggagagcg agctgaagaa
      601 gctgcagcag acccaagagt acttcatcat ccagtaccag gagagcctgc ggatccaagc
      661 tcagtttgcc cagctggccc aactgaaccc ccaggagcgc atgagcaggg agacagccct
      721 ccagcagaag caagtgtccc tggagacctg gctgcagcga gaggcacaga cactgcagca
      781 gtaccgcgtg gagctggctg aaaagcacca gaagaccctg cagctgctga ggaagcagca
      841 gaccatcatc ctggacgacg agctgatcca gtggaagcgg cgacagcaac tggccgggaa
      901 tgggggtcct cctgagggca gcctggatgt gctgcagtcc tggtgtgaga agctggccga
      961 gatcatctgg cagaaccggc agcagatccg cagggctgag cacctgtgcc agcagctgcc
     1021 catcccaggc cccgtggagg agatgctggc cgaggtcaac gccaccatca cagacatcat
     1081 ctcagccctg gtcaccagca cgttcatcat cgagaagcag cctcctcagg tcctgaagac
     1141 ccagaccaag ttcgcggcca ccgtgcgcct gctggtgggc gggaagctga acgtgcacat
     1201 gaaccctccg caggtgaagg cgaccatcat cagcgagcag caggccaagt ccctgctcaa
     1261 gaacgagaac acccgcaatg attatagcgg cgagatcctg aacaactgct gcgtcatgga
     1321 gtaccaccag gccacaggca ccctcagcgc ccacttcaga aacatgtccc tgaaacgaat
     1381 caagaggtct gaccgccgtg gtgcagagtc ggtcacggaa gagaagttca caatcttgtt
     1441 tgactcacag ttcagtgttg gtggaaatga gctggtcttt caagtcaaga ccttgtcgct
     1501 cccggtggtg gtgatcgttc acggcagcca ggacaacaat gcgacggcta ctgtcctctg
     1561 ggacaacgcc tttgcagagc ctggcagggt gccatttgcc gtgcctgaca aggtgctgtg
     1621 gccgcagctg tgtgaggcgc tcaacatgaa gttcaaggct gaggtgcaga gcaaccgggg
     1681 cttgaccaag gagaacctcg tgttcctggc acagaaactg ttcaacagca gcagcaacca
     1741 cctcgaggac tacaacagca tgtccgtgtc ctggtcccag ttcaaccggg agaatctgcc
     1801 aggacggaat tacactttct ggcagtggtt tgacggtgtg atggaggtgt taaagaaaca
     1861 tctcaagcct cactggaacg atggggccat cttgggtttc gtgaacaagc agcaggccca
     1921 cgacctgctc atcaacaagc cagatgggac cttcctgctg cgcttcagcg actcggaaat
     1981 cgggggcatc accattgctt ggaagtttga ctcccaggag agaatgtttt ggaatctgat
     2041 gccttttacc acaagagact tctctatccg gtccctcgct gaccgcctgg gggacctgaa
     2101 ttacctcata tacgtgtttc ctgatcggcc aaaggatgaa gtatattcta agtactacac
     2161 accagtcccg tgtgagcccg ccaccgcgaa agcagctgac ggatacgtga agccgcagat
     2221 caagcaagtg gtccccgagt ttgtcaatgc ttctgcagat gcagggagcg gcgccaccta
     2281 catggaccag gctccttccc cagtggtgtg ccctcaggct cactataaca tgtacccaca
     2341 gaatcccgac tctgtcctcg ataccgatgg ggatttcgat ctggaagaca cgatggacgt
     2401 ggcacggcgt gtggaagagc tcttaggccg gcccatggac agtcagtgga tccctcacgc
     2461 gcagtcatga ccagacctca ccgcctgcag cttcactgtc ctcctggagg acccttcctg
     2521 tggatgtttt aattccatga atcgcttctc tttggaaaca atattcgtaa tgtgaagtgt
     2581 taatactagt cgtgacttta gtgtctctgt gcatagtggc actagtgaag ggagtgtgcg
     2641 tgagtgtgag tgtgtgagtt tgcacgttgt
//
