LOCUS       NM_001012226            3007 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus signal transducer and activator of transcription
            4 (Stat4), mRNA.
ACCESSION   NM_001012226 XM_346046
VERSION     NM_001012226.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3007)
  AUTHORS   He,M., Yu,Y., Ning,S., Han,J. and Guo,Z.
  TITLE     Effects of STAT4 on myocardial ischemia-reperfusion injury and the
            underlying mechanisms
  JOURNAL   Mol Med Rep 30 (5) (2024)
   PUBMED   39239743
  REMARK    GeneRIF: Effects of STAT4 on myocardial ischemia-reperfusion injury
            and the underlying mechanisms.
REFERENCE   2  (bases 1 to 3007)
  AUTHORS   He,M., Li,M. and Guo,Z.
  TITLE     STAT4 regulates cardiomyocyte apoptosis in rat models of diabetic
            cardiomyopathy
  JOURNAL   Acta Histochem 124 (4), 151872 (2022)
   PUBMED   35367814
  REMARK    GeneRIF: STAT4 regulates cardiomyocyte apoptosis in rat models of
            diabetic cardiomyopathy.
REFERENCE   3  (bases 1 to 3007)
  AUTHORS   Xue,Y.L., Zhang,S.X., Zheng,C.F., Li,Y.F., Zhang,L.H., Hao,Y.F.,
            Wang,S. and Li,X.W.
  TITLE     Silencing of STAT4 Protects Against Autoimmune Myocarditis by
            Regulating Th1/Th2 Immune Response via Inactivation of the
            NF-kappaB Pathway in Rats
  JOURNAL   Inflammation 42 (4), 1179-1189 (2019)
   PUBMED   30848408
  REMARK    GeneRIF: silencing of STAT4 could hinder the progression of
            autoimmune myocarditis by balancing the expression of Th1/Th2
            inflammatory cytokines via the NF-kappaB pathway.
REFERENCE   4  (bases 1 to 3007)
  AUTHORS   Li,X., Chen,H., Cai,Y., Zhang,P. and Chen,Z.
  TITLE     Association of STAT4 and PTPN22 polymorphisms and their
            interactions with type-1 autoimmune hepatitis susceptibility in
            Chinese Han children
  JOURNAL   Oncotarget 8 (37), 60933-60940 (2017)
   PUBMED   28977835
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3007)
  AUTHORS   Zheng,L. and Zhou,H.
  TITLE     [Single nucleotide polymorphism of STAT4 rs7574865 is associated
            with the susceptibility of primary biliary cirrhosis in Han
            population of partial regions of Jiangsu province]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 33 (4), 521-525 (2017)
   PUBMED   28395724
REFERENCE   6  (bases 1 to 3007)
  AUTHORS   Poltorak,A., Merlin,T., Nielsen,P.J., Sandra,O., Smirnova,I.,
            Schupp,I., Boehm,T., Galanos,C. and Freudenberg,M.A.
  TITLE     A point mutation in the IL-12R beta 2 gene underlies the IL-12
            unresponsiveness of Lps-defective C57BL/10ScCr mice
  JOURNAL   J Immunol 167 (4), 2106-2111 (2001)
   PUBMED   11489994
REFERENCE   7  (bases 1 to 3007)
  AUTHORS   Matsukawa,A., Kaplan,M.H., Hogaboam,C.M., Lukacs,N.W. and
            Kunkel,S.L.
  TITLE     Pivotal role of signal transducer and activator of transcription
            (Stat)4 and Stat6 in the innate immune response during sepsis
  JOURNAL   J Exp Med 193 (6), 679-688 (2001)
   PUBMED   11257135
REFERENCE   8  (bases 1 to 3007)
  AUTHORS   Jee,Y., Kim,G., Tanuma,N. and Matsumoto,Y.
  TITLE     STAT expression and localization in the central nervous system
            during autoimmune encephalomyelitis in Lewis rats
  JOURNAL   J Neuroimmunol 114 (1-2), 40-47 (2001)
   PUBMED   11240014
REFERENCE   9  (bases 1 to 3007)
  AUTHORS   Holz,A., Bot,A., Coon,B., Wolfe,T., Grusby,M.J. and von
            Herrath,M.G.
  TITLE     Disruption of the STAT4 signaling pathway protects from autoimmune
            diabetes while retaining antiviral immune competence
  JOURNAL   J Immunol 163 (10), 5374-5382 (1999)
   PUBMED   10553062
REFERENCE   10 (bases 1 to 3007)
  AUTHORS   Stamm,L.M., Satoskar,A.A., Ghosh,S.K., David,J.R. and Satoskar,A.R.
  TITLE     STAT-4 mediated IL-12 signaling pathway is critical for the
            development of protective immunity in cutaneous leishmaniasis
  JOURNAL   Eur J Immunol 29 (8), 2524-2529 (1999)
   PUBMED   10458767
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081938.1.
            
            On Feb 11, 2005 this sequence version replaced XM_346046.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3007
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..3007
                     /gene="Stat4"
                     /note="signal transducer and activator of transcription 4"
                     /db_xref="GeneID:367264"
                     /db_xref="RGD:1305747"
     exon            1..472
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            473..601
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     CDS             474..2720
                     /gene="Stat4"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     4"
                     /protein_id="NP_001012226.1"
                     /db_xref="GeneID:367264"
                     /db_xref="RGD:1305747"
                     /translation="MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIETQDWE
                     VASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVA
                     VVISNCLREERRILAAANMPIQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQD
                     TKYLEDLQDEFDYRYKTIQTMDQGDKNSILVNQEVLTLQEMLNNLDFKRKEALSKMTQ
                     IVNETDLLMNSMLLEELQDWKKRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRQQL
                     EKLQEQSTKMTYEGDPIPAQRVHLLERATFLIYNLFKNSFVVERQPCMPTHPQRPMVL
                     KTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTHIKAMSSEESSN
                     GSLSVEFRHLQPKEMKCSTGSKGNEGCHMVTEELHSITFETQICLYGLTINLETSSLP
                     VVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYVGR
                     GLNSDQLNMLAEKLTVQSNYSDGHLTWAKFCKEHLPGKTFTFWTWLEAILDLIKKHIL
                     PLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDQSENGEVRFHS
                     VEPYNKARLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEV
                     SRPTERGDKGYVPSVFIPISTIRSDSTEPQSPSDLLPMSPSAYAVLRENLSPTTIETA
                     MNSPYSAE"
     exon            602..746
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            747..845
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            846..938
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1017
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1103
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1255
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1414
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1507
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1567
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1585
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1679
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1724
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1808
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1907
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2043
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2093
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2188
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2325
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2517
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2584
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2693
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2982
                     /gene="Stat4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggaaaggg cagacactgg gaaccttcac aggagttggc ccaaacctga gtaaggctgt
       61 cctctcataa gagagcagac cctgctggag gttggtgtgt tgatcctggt tccctggtct
      121 ctctttccag aaaaagtggg gttgtgtctg aggaaaacag ggattctagt ccttcagtgt
      181 gtacgcttta ctctgcactc ttgggccatc tgcatttata agagtggtta ctagggatgg
      241 gggcggtgct ctgcaaaggg ggatccagct gcctttgtaa agcgtttcta gaatagagtg
      301 ggtaggaact gactaaagtc ccagggactc aaacactgac gcacaggaaa gcctcaagtg
      361 ggtggagaaa tgcaaatccc ctagtggcat ggcgtcagca gctgtggacc ctgaaggccg
      421 attctgactt tggacttgag cagtgccact gcctggacgg agagagagcc agcatgtctc
      481 agtggaatca agtccaacaa ttagaaatca agtttttgga gcaagtagat cagttctatg
      541 atgacaactt tcctatggaa atccggcatc tgctggccca gtggattgag actcaagact
      601 gggaagtagc ttctaacaat gaaactatgg caacaattct ccttcaaaac ttattaatac
      661 aattggatga acagttaggt cgggtttcca aagagaaaaa cctgctattg attcacaatc
      721 taaagagaat taggaaagtt cttcagggaa agtttcacgg aaatccaatg catgtagctg
      781 tggtcatttc aaattgctta agggaagaga ggagaatact ggctgcggcc aacatgccta
      841 tccagggacc tctggagaaa tctttacaga gctcttcagt ttcagaaaga cagagaaatg
      901 tggaacacaa agtggctgcc attaaaaaca gtgtgcagat gacagaacaa gacaccaaat
      961 acttagaaga tctgcaagat gagtttgact acaggtataa aacaattcag acaatggatc
     1021 agggtgacaa gaacagtatc ctggtgaacc aggaagtttt gacattgcaa gaaatgctta
     1081 ataacctgga ctttaaaaga aaggaagcac tcagtaagat gacacagata gtgaatgaga
     1141 cagacctgct catgaacagc atgctgctag aagagctgca ggactggaag aagcggcaac
     1201 agatcgcctg cattggtggc ccgctccaca acgggttgga ccagcttcag aactgcttta
     1261 ccctactggc agagagtctt ttccaactta gacagcaact ggagaaatta caggagcaat
     1321 ctaccaaaat gacgtacgaa ggggatccca tccctgctca aagagttcac ctgctggaga
     1381 gagcgacctt cctcatctac aaccttttta agaattcatt tgtggtcgag cgacagccat
     1441 gcatgccaac acaccctcag aggccgatgg tacttaaaac cctcattcag ttcactgtaa
     1501 aattgagatt actaataaaa ttgccagaac tgaactatca ggtgaaagtg aaggcatcca
     1561 ttgacaagaa tgtctcaact ctaagcaata gaagatttgt gctctgtgga actcacatca
     1621 aagctatgtc cagtgaggaa tcttccaatg ggagcctctc agtggagttt agacatttgc
     1681 aaccgaagga gatgaagtgc agcactggga gtaaaggaaa cgagggctgc cacatggtga
     1741 cggaagagct gcactccata acctttgaga cccagatctg cctctatggc ctcaccatta
     1801 acctagagac cagctcatta cctgtggtga tgatttctaa tgtcagccaa ctccctaatg
     1861 catgggcgtc catcatttgg tacaatgtgt caaccaacga ctcccagaac ttggttttct
     1921 ttaacaaccc tccatctgtt accttgggcc aactcctgga agtgatgagc tggcagtttt
     1981 catcctacgt cggtcgtggc cttaattcag accagctcaa catgctggca gagaagctca
     2041 cagttcagtc taactacagt gatggtcacc tcacctgggc caagttctgc aaggaacatt
     2101 tgcctggcaa aacgtttacc ttctggacct ggcttgaagc aatattggac ctaattaaaa
     2161 aacacattct tcccctctgg attgatgggt acatcatggg ctttgttagc aaagagaagg
     2221 aacggcttct gctcaaagat aaaatgcctg ggacattttt gttaagattc agtgagagcc
     2281 atcttggagg gataaccttc acctgggtgg accaatctga aaatggagaa gtgagattcc
     2341 actccgtgga accctacaac aaagcgcggc tatcagctct gccattcgct gacattcttc
     2401 gagactacaa ggttatcatg gctgaaaaca tccccgaaaa ccctctgaag tacctctacc
     2461 ctgacattcc caaagacaaa gcctttggca aacactacag ctcccagccg tgcgaagttt
     2521 caagaccgac agaacggggc gacaagggtt atgtcccctc tgtttttata cccatttcaa
     2581 caatccgaag tgattccacg gagccacagt ctccttcaga ccttctcccc atgtcaccaa
     2641 gtgcatatgc tgtgctgaga gaaaacctga gcccaacgac aattgagact gcaatgaatt
     2701 ccccgtattc tgctgaatga taaatcaact cttcaaagaa ggaagcagag gaaactagag
     2761 actgttcttt accatagatc acaatttatt tcttcagctt tgtaaatacc ggtttctaga
     2821 aaatgatagg aagttcgaag ctctcttctc acttggtgcc actcccagcc tggagtgctg
     2881 tgattaaaat gctaaaggaa acaagctcca gataaacttg caagaaaaga cagctttaag
     2941 aaaccagtgt tggtaacaat ataacagagg actccttcta aaaaaaaaaa aaaaaaaaaa
     3001 aaaaaaa
//
