LOCUS       NM_001011905            3464 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus signal transducer and activator of transcription
            2 (Stat2), mRNA.
ACCESSION   NM_001011905 XM_222301
VERSION     NM_001011905.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3464)
  AUTHORS   Le-Trilling,V.T.K., Banchenko,S., Paydar,D., Leipe,P.M.,
            Binting,L., Lauer,S., Graziadei,A., Klingen,R., Gotthold,C.,
            Burger,J., Bracht,T., Sitek,B., Jan Lebbink,R., Malyshkina,A.,
            Mielke,T., Rappsilber,J., Spahn,C.M., Voigt,S., Trilling,M. and
            Schwefel,D.
  TITLE     Structural mechanism of CRL4-instructed STAT2 degradation via a
            novel cytomegaloviral DCAF receptor
  JOURNAL   EMBO J 42 (5), e112351 (2023)
   PUBMED   36762436
  REMARK    GeneRIF: Structural mechanism of CRL4-instructed STAT2 degradation
            via a novel cytomegaloviral DCAF receptor.
REFERENCE   2  (bases 1 to 3464)
  AUTHORS   Wang,Y., Song,Q., Huang,W., Lin,Y., Wang,X., Wang,C., Willard,B.,
            Zhao,C., Nan,J., Holvey-Bates,E., Wang,Z., Taylor,D., Yang,J. and
            Stark,G.R.
  TITLE     A virus-induced conformational switch of STAT1-STAT2 dimers boosts
            antiviral defenses
  JOURNAL   Cell Res 31 (2), 206-218 (2021)
   PUBMED   32759968
REFERENCE   3  (bases 1 to 3464)
  AUTHORS   Elsaesser,H.J., Mohtashami,M., Osokine,I., Snell,L.M.,
            Cunningham,C.R., Boukhaled,G.M., McGavern,D.B.,
            Zuniga-Pflucker,J.C. and Brooks,D.G.
  TITLE     Chronic virus infection drives CD8 T cell-mediated thymic
            destruction and impaired negative selection
  JOURNAL   Proc Natl Acad Sci U S A 117 (10), 5420-5429 (2020)
   PUBMED   32094187
REFERENCE   4  (bases 1 to 3464)
  AUTHORS   Miorin,L., Laurent-Rolle,M., Pisanelli,G., Co,P.H., Albrecht,R.A.,
            Garcia-Sastre,A. and Morrison,J.
  TITLE     Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus
            Tropism
  JOURNAL   J Virol 93 (14), e00151-19 (2019)
   PUBMED   31043530
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3464)
  AUTHORS   Song,H., Tan,G., Yang,Y., Cui,A., Li,H., Li,T., Wu,Z., Yang,M.,
            Lv,G., Chi,X., Niu,J., Zhu,K., Crispe,I.N., Su,L. and Tu,Z.
  TITLE     Hepatitis B Virus-Induced Imbalance of Inflammatory and Antiviral
            Signaling by Differential Phosphorylation of STAT1 in Human
            Monocytes
  JOURNAL   J Immunol 202 (8), 2266-2275 (2019)
   PUBMED   30842274
REFERENCE   6  (bases 1 to 3464)
  AUTHORS   Murray,P.J.
  TITLE     The JAK-STAT signaling pathway: input and output integration
  JOURNAL   J Immunol 178 (5), 2623-2629 (2007)
   PUBMED   17312100
  REMARK    Review article
REFERENCE   7  (bases 1 to 3464)
  AUTHORS   Hahm,B., Trifilo,M.J., Zuniga,E.I. and Oldstone,M.B.
  TITLE     Viruses evade the immune system through type I interferon-mediated
            STAT2-dependent, but STAT1-independent, signaling
  JOURNAL   Immunity 22 (2), 247-257 (2005)
   PUBMED   15723812
REFERENCE   8  (bases 1 to 3464)
  AUTHORS   Zhang,S.S., Wei,J.Y., Li,C., Barnstable,C.J. and Fu,X.Y.
  TITLE     Expression and activation of STAT proteins during mouse retina
            development
  JOURNAL   Exp Eye Res 76 (4), 421-431 (2003)
   PUBMED   12634107
REFERENCE   9  (bases 1 to 3464)
  AUTHORS   Kisseleva,T., Bhattacharya,S., Braunstein,J. and Schindler,C.W.
  TITLE     Signaling through the JAK/STAT pathway, recent advances and future
            challenges
  JOURNAL   Gene 285 (1-2), 1-24 (2002)
   PUBMED   12039028
  REMARK    Review article
REFERENCE   10 (bases 1 to 3464)
  AUTHORS   Gupta,S., Yan,H., Wong,L.H., Ralph,S., Krolewski,J. and
            Schindler,C.
  TITLE     The SH2 domains of Stat1 and Stat2 mediate multiple interactions in
            the transduction of IFN-alpha signals
  JOURNAL   EMBO J 15 (5), 1075-1084 (1996)
   PUBMED   8605877
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083867.1.
            
            On Feb 11, 2005 this sequence version replaced XM_222301.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132272, SAMD00132273
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3464
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3464
                     /gene="Stat2"
                     /note="signal transducer and activator of transcription 2"
                     /db_xref="GeneID:288774"
                     /db_xref="RGD:1311649"
     exon            1..122
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            123..260
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..2658
                     /gene="Stat2"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     2"
                     /protein_id="NP_001011905.1"
                     /db_xref="GeneID:288774"
                     /db_xref="RGD:1311649"
                     /translation="MAQWEMLQNLDSPFLDQLHELYSQSLLPMDVRQHLAAWIEDQNW
                     REAVLGSDHSKANMLYFNILDQLNQWDHYSLDSDYLLLQHNLRKFNRDIQMFPNGPTQ
                     LAEMIFNLLLEEKRILNQAQRAQEMQPRPAPEAAGESQQQLEIETRILDLQTAVEALV
                     RSIRQLKDVQDVFSFRYTVLNHKKTSSLDPHQSQQRQLVQTTANELDRMRKEVLDISK
                     ALVGRLTTLVDLLLPKLDEWKAQQQKSCIGAPAPELQLDQLEQWLTAGAKVLFHLRQL
                     LKQLKDMSLMLRYEGDMFGQGVDLQNAQVTELLQRLLQRSFVVETQPCMPQTLHRPLI
                     LKTGSKFTVRTRLLVRLQEGNESLKAEVSIDRNSELPGFRKFNILTSNQKSLTPEEGQ
                     RQGLIWDFGFLTLVEQRSVGAGKGSNKGPLPVTEELHIISAMVEYVYQGLKMKLQTDT
                     LPVVIISNMNQLSIAWASILWFNMLSSTPKDQQFFCKVPKAPWSLLGPALSWQFSSYI
                     GRGLDPEQLGMLRNKLFGKNCKTEDALLSWADFSKRESPPGKIPFWTWLDKILELVHD
                     HLKDLWNDGRIMGFVSRSEERRLLKKMVSGTFLLRFSETSEGGITCSWVEHQDDDKVL
                     IYSVQPYTKEVLQSLPLTEIIRHYQVLAEENAPENPLRFLYPRVPRDEAFGCYYQEKV
                     NLEERRKYLKHRLIVISNRQADELQQPLELKQDPESLELDAELMSVMELARDLELQSM
                     LQVGLDLGVEPKPDPTLSPAPQILLEPDPARALNQLLPEPDLPQDLQQLNTGEMEIFR
                     NNINIDDVMPYGDPVLAGQSIIEEAYRSCPSHFDVDGPLIPSED"
     exon            261..411
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..507
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..600
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            601..676
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..762
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..914
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1073
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1166
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1226
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1244
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1338
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1386
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1470
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1569
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1705
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1758
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1853
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1990
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2173
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2231
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2515
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..3434
                     /gene="Stat2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccgctca cggtctgggt ccgccagagt cgggagtggg tgggaaacgg gtccttgagc
       61 cacttgaagg attggaagtt gaaacgggag cactggaagg agcggcactt taccctcaga
      121 agagtccaaa tggcgcagtg ggagatgttg cagaaccttg acagtccatt tctggaccag
      181 ttgcatgagc tctactcaca aagcctcctg ccaatggacg tccgacagca cttggctgcc
      241 tggattgaag accagaactg gagggaagct gtactaggca gtgatcattc caaggccaac
      301 atgctatact tcaacatcct ggaccagctg aaccagtggg accactacag cttggactcc
      361 gactaccttt tattacagca taacttgcga aaattcaatc gggacattca gatgtttccc
      421 aatggcccta cccagttggc tgagatgatc ttcaatcttc tcctggaaga gaaaaggatt
      481 ctgaatcagg cccaaagagc tcaagagatg cagcccaggc cagcccctga agcggcaggg
      541 gagagccagc agcagcttga gattgaaaca agaatcctgg atttacagac tgctgtggag
      601 gcgctggtga gatccatcag gcagctgaag gatgtgcagg atgtcttcag cttcagatac
      661 acagttctca atcacaagaa gacatcgtct ttggaccccc atcagagcca acagcggcag
      721 cttgtgcaga caacagccaa tgaactggac agaatgagaa aggaggtgct ggacatctcc
      781 aaagccctgg ttggacgatt aaccaccctg gtcgacctgt tgctgccaaa gctggatgag
      841 tggaaggctc agcagcagaa gtcctgcatt ggagccccag cacccgagct gcagctggat
      901 cagctggaac agtggttgac agctggagca aaggtcttgt tccaccttcg gcagctactg
      961 aagcaactga aggatatgag tcttatgctt cgttatgagg gtgacatgtt tggccaaggg
     1021 gtggacctgc agaatgccca agtcacggag ttacttcagc gtctgctcca aaggtccttt
     1081 gtagtggaaa cccagccctg catgccccag actctccatc gacccctcat cctgaagact
     1141 gggagcaagt tcactgtccg aacaagactg ctggtgagac tccaggaagg caatgaatca
     1201 ctcaaagcag aagtctccat tgacaggaat tcagagttgc caggcttccg gaagttcaac
     1261 attctgacct caaaccagaa gtccttgacc cctgaggaag gccagagaca aggcttaatt
     1321 tgggacttcg gcttcttgac gctggtggag cagcgctcag tgggcgcagg aaagggcagc
     1381 aacaaggggc cgctgcctgt gacagaggag ctacacatca tcagcgccat ggtggagtac
     1441 gtttaccagg gtctgaagat gaagctgcag acggacactc tccctgtggt gattatctct
     1501 aacatgaacc aactctccat tgcctgggcc tccattctct ggttcaacat gctcagctca
     1561 actcccaagg accagcagtt cttctgcaaa gttccgaaag ctccgtggag tttgctgggg
     1621 cctgcactca gttggcagtt ctcctcctac atcggccgag gcctcgatcc tgagcagctg
     1681 ggcatgctga gaaacaagct gttcggaaag aactgcaaga cagaggatgc actgttgtcc
     1741 tgggcagact tcagcaagcg agagagcccc cctggcaaga tccctttctg gacctggctg
     1801 gacaaaattc tggagctggt acatgaccac ctgaaggatc tctggaatga tgggcgcatc
     1861 atgggctttg tgagccggag cgaggaacgc cgactactga agaagatggt gtcgggcacc
     1921 ttcctgctgc gcttcagtga gacttctgaa gggggcatta cctgctcttg ggtggagcac
     1981 caggatgatg ataaagtcct catctactct gtgcagccct acaccaagga agtgctacag
     2041 tcactcccac tgacagaaat catccgccac taccaggttc tcgccgaaga gaatgctcct
     2101 gagaacccac tccgcttcct ctatccccgc gtccctcggg acgaagcctt tgggtgttac
     2161 taccaggaaa aagttaactt ggaagaacgg aggaaatacc tgaaacatag actcatcgtg
     2221 atctctaaca gacaggcgga cgagctgcag cagcctctgg agcttaaaca ggatccagag
     2281 tccttagagc tggatgcaga gctcatgtca gtgatggagt tggcacgaga cctggagctg
     2341 cagtcaatgc tgcaggtggg gctggacctg ggcgtagagc cgaaaccaga tcccacactg
     2401 agtccagccc cacaaatcct gctggagcca gacccagcac gtgcattgaa tcagctgttg
     2461 ccagagccgg atttgcctca ggacctgcag cagctgaaca caggggagat ggaaatcttc
     2521 agaaacaaca taaatattga tgacgtcatg ccctacggtg acccagtgtt ggctggccag
     2581 agcatcatag aggaggctta caggtcctgc cccagccatt ttgacgtgga tggacccttg
     2641 attccttctg aagactaaga gctttgtttc tgttttgtcc cttctaactc ccaaatcagg
     2701 atgttgcttc cagcagtggg aaaagaggcc ttgtgagcag ggttagcata ggctctggag
     2761 taagaggtag aagcatagca tgctttctaa ggtacaccac agggtcagaa cagacactgg
     2821 ccatagccct tctaggaccc tgaggctgcc tgccatgctg ggagacacag gggtcttaag
     2881 ggcaggtcag gacatttggg aggtccttag agggtctgag gcagtggtgt ctttccagta
     2941 tggaacgatt ttaatgtttt gataattggc taagttggta tgaagcaaca ttgggccttg
     3001 gtggggagct catggatgga attctgtcct tccttcatcg ctatcctggg acctgtcaaa
     3061 cccagaacct tgcccatggt aggcaaccac agtggcactg agccataccc aactgagttc
     3121 ttcagttctc tcttccggtt atctcaggtc tcctcccttc actcctgact ccagttctaa
     3181 atccttctct tcctgtagag actgagggct atctgcttca gttggccatg tgaagcagac
     3241 tactgctagc agccccttgc catgctcaac ccccacaaag tgaccctgac actctagtga
     3301 aggcgtgacg ctttgctgcc ttagactgtc ccgtctctac ctcccccagc gcctgagaga
     3361 atcactcctg gagctttgaa cggtttctga gcccttgggc attgcttctc ataataaata
     3421 tttgatagag ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
