LOCUS       NM_032612               4102 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus signal transducer and activator of transcription
            1 (Stat1), transcript variant alpha, mRNA.
ACCESSION   NM_032612
VERSION     NM_032612.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4102)
  AUTHORS   Cherqaoui B, Cremazy F, Lauraine M, Shammas G, Said-Nahal R, Mambu
            Mambueni H, Costantino F, Fourmont M, Hulot A, Garchon HJ, Glatigny
            S, Araujo LM and Breban M.
  TITLE     STAT1 deficiency underlies a proinflammatory imprint of naive CD4+
            T cells in spondyloarthritis
  JOURNAL   Front Immunol 14, 1227281 (2023)
   PUBMED   37920469
  REMARK    GeneRIF: STAT1 deficiency underlies a proinflammatory imprint of
            naive CD4[+] T cells in spondyloarthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4102)
  AUTHORS   Liu N, Zhou Q, Wang H, Li Q, Chen Z, Lin Y, Yi L, Jiang S, Chen C
            and Deng Y.
  TITLE     MiRNA-338-3p Inhibits Neuroinflammation in the Corpus Callosum of
            LCV-LPS Rats Via STAT1 Signal Pathway
  JOURNAL   Cell Mol Neurobiol 43 (7), 3669-3692 (2023)
   PUBMED   37479855
  REMARK    GeneRIF: MiRNA-338-3p Inhibits Neuroinflammation in the Corpus
            Callosum of LCV-LPS Rats Via STAT1 Signal Pathway.
REFERENCE   3  (bases 1 to 4102)
  AUTHORS   Peng C, Zhu J, Guo H, Zhao L, Wu F and Liu B.
  TITLE     Long non-coding RNA TLR8-AS1 induces preeclampsia through
            increasing TLR8/STAT1 axis
  JOURNAL   J Hypertens 41 (8), 1245-1257 (2023)
   PUBMED   37199563
  REMARK    GeneRIF: Long non-coding RNA TLR8-AS1 induces preeclampsia through
            increasing TLR8/STAT1 axis.
REFERENCE   4  (bases 1 to 4102)
  AUTHORS   Xu J, Zhang B, Cai J, Peng Q, Hu J, Askar P, Shangguan J, Su W, Zhu
            C, Sun H, Zhou S, Chen G, Yang X and Gu Y.
  TITLE     The transcription factor Stat-1 is essential for Schwann cell
            differentiation, myelination and myelin sheath regeneration
  JOURNAL   Mol Med 29 (1), 79 (2023)
   PUBMED   37365519
  REMARK    GeneRIF: The transcription factor Stat-1 is essential for Schwann
            cell differentiation, myelination and myelin sheath regeneration.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4102)
  AUTHORS   Zhang Y, Jing Z, Cao X, Wei Q, He W, Zhang N, Liu Y, Yuan Q, Zhuang
            Z, Dong Y, Hong Z, Li J, Li P, Zhang L, Wang H and Li W.
  TITLE     SOCS1, the feedback regulator of STAT1/3, inhibits the osteogenic
            differentiation of rat bone marrow mesenchymal stem cells
  JOURNAL   Gene 821, 146190 (2022)
   PUBMED   35124149
  REMARK    GeneRIF: SOCS1, the feedback regulator of STAT1/3, inhibits the
            osteogenic differentiation of rat bone marrow mesenchymal stem
            cells.
REFERENCE   6  (bases 1 to 4102)
  AUTHORS   Kawada N, Uoya M, Seki S, Kuroki T and Kobayashi K.
  TITLE     Regulation by cAMP of STAT1 activation in hepatic stellate cells
  JOURNAL   Biochem Biophys Res Commun 233 (2), 464-469 (1997)
   PUBMED   9144559
REFERENCE   7  (bases 1 to 4102)
  AUTHORS   Cao X, Tay A, Guy GR and Tan YH.
  TITLE     Activation and association of Stat3 with Src in v-Src-transformed
            cell lines
  JOURNAL   Mol Cell Biol 16 (4), 1595-1603 (1996)
   PUBMED   8657134
REFERENCE   8  (bases 1 to 4102)
  AUTHORS   Gupta S, Yan H, Wong LH, Ralph S, Krolewski J and Schindler C.
  TITLE     The SH2 domains of Stat1 and Stat2 mediate multiple interactions in
            the transduction of IFN-alpha signals
  JOURNAL   EMBO J 15 (5), 1075-1084 (1996)
   PUBMED   8605877
REFERENCE   9  (bases 1 to 4102)
  AUTHORS   Fujitani Y, Nakajima K, Kojima H, Nakae K, Takeda T and Hirano T.
  TITLE     Transcriptional activation of the IL-6 response element in the junB
            promoter is mediated by multiple Stat family proteins
  JOURNAL   Biochem Biophys Res Commun 202 (2), 1181-1187 (1994)
   PUBMED   7519422
REFERENCE   10 (bases 1 to 4102)
  AUTHORS   Bany J, Janiak MK and Budzynski W.
  TITLE     Activity of natural killer (NK) cells in the course of experimental
            trichinellosis in mice
  JOURNAL   Wiad Parazytol 38 (3-4), 117-126 (1992)
   PUBMED   1299057
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062079.1, AF205604.1, DY564252.1, CF109416.1, BM386875.1 and
            AA901120.1.
            
            On Sep 17, 2008 this sequence version replaced NM_032612.2.
            
            Transcript Variant: This variant (alpha) represents the longer
            transcript and encodes the longer isoform (alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF205604.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMD00132261,
                                    SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               BC062079.1         1-304
            305-2550            AF205604.1         15-2260
            2551-3243           DY564252.1         13-705
            3244-3582           CF109416.1         655-993
            3583-4084           BM386875.1         19-520              c
            4085-4102           AA901120.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..4102
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..4102
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /note="signal transducer and activator of transcription 1"
                     /db_xref="GeneID:25124"
                     /db_xref="RGD:3771"
     exon            1..101
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            102..287
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            288..418
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..2540
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /note="isoform alpha is encoded by transcript variant
                     alpha; signal transducer and activator of transcription
                     1-alpha/beta"
                     /codon_start=1
                     /product="signal transducer and activator of transcription
                     1-alpha/beta isoform alpha"
                     /protein_id="NP_116001.2"
                     /db_xref="GeneID:25124"
                     /db_xref="RGD:3771"
                     /translation="MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWE
                     HAAYDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMS
                     MIIHNCLKEERKILENAQRFNQAQEGNIQNTVMLDKQKELDSKVRNVKDQVMCIEHEI
                     KTLEDLQDEYDFKCKTSQNRESEANGVAKSDQKQEQLLLHKMFLMLDNKRKEIIHKIR
                     ELLNSIELTQNTLINDELVEWKRRQQSACIGGPPNACLDQLQSWFTIVAESLQQVRQQ
                     LKKLEELEQKFTYEQDPITKNKQVLSDRTFVLFQQLIQSSFVVERQPCMPTHPQRPLV
                     LKTGVQFTVKLRLLVKLQELNYNLKVKVSFDKDVNEKNTVKGFRKFNILGTHTKVMNM
                     EESTNGSLAAEFRHLQLKEQKNAGNRTNEGPLIVTEELHSLSFETQLCQPGLVIDLET
                     TSLPVVVISNVSQLPSGWASILWYNMLVTEPRNLSFFLNPPCAWWSQLSEVLSWQFSS
                     VTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTILELIK
                     KHLLCLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGG
                     EPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYS
                     RPKEAPEPMELDDPKRTGYIKTELISVSEVHPSRLQSTENLLPMSPEEFDEMSKIVGS
                     EFDSMMSAV"
     exon            419..563
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            564..662
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            663..752
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            753..831
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            832..923
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1075
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1234
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1327
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1387
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1417
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1511
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1553
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1637
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1736
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1872
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1922
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2017
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2163
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2349
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2425
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2525
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..4086
                     /gene="Stat1"
                     /gene_synonym="DD6G4-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaagctccc tggagacctc ggggactgcg cccctcagac cctcttggga cgtagctgag
       61 tggcgcaggg agatctgtct agactcgagc tcctgagtgc atcatatcaa cactgttcca
      121 tcctctgagc cgacgccact ccgtgcatgc aacaggcata taacttgctg tgtgtggtgg
      181 tcgcttgtgt tgaaccccca gtctgcaccc ggagacagcc cagtaagtct tcgtggacac
      241 gaaagtattt ggaatctcag ctcttaccgg ctttctaaaa cttaaagagg atgtcgcagt
      301 ggtacgagct tcagcagctg gactccaagt tcctggagca ggtgcaccag ctgtacgatg
      361 acagtttccc catggaaatc agacagtacc tggcccagtg gctagaaaag caagactggg
      421 agcatgctgc ctacgacgtc tcgttcgcca ccatccgctt ccatgacctg ctctcccagc
      481 tggatgacca gtacagccgc ttttctttgg agaataattt cttgttgcag cacaacataa
      541 ggaaaagcaa gcgtaatctc caggataact tccaagaaga tcccgtacag atgtccatga
      601 ttatccacaa ctgtctgaag gaggagagga agattttgga aaacgcccag cgatttaatc
      661 aggcccagga gggaaatatt cagaacaccg tgatgttaga taaacagaag gagctggaca
      721 gtaaagtcag aaatgtgaag gaccaagtca tgtgcataga gcatgaaatc aagaccctag
      781 aagacttaca agatgaatat gactttaaat gcaaaacctc tcagaacaga gaaagcgaag
      841 ccaatggtgt ggcgaagagc gaccagaaac aggaacagct gctgctgcat aagatgttct
      901 taatgcttga caacaagaga aaggagataa ttcacaaaat cagagagctg ctgaactcca
      961 tcgagctcac tcagaacact ctgattaatg atgagcttgt ggagtggaag cgaagacagc
     1021 agagtgcctg cattggggga ccgcccaatg cctgcctgga tcagctgcaa agctggttca
     1081 ccattgttgc agagagcctg cagcaggtcc gtcagcagct taaaaagctg gaggagttgg
     1141 aacagaaatt cacctatgag caggacccta ttacaaaaaa caagcaggtg ttatccgatc
     1201 gcaccttcgt cctcttccag cagctcattc agagctcctt tgtggtggaa cgacagccgt
     1261 gcatgccaac tcaccctcag aggcccctgg tcttgaagac tggggtacag ttcactgtga
     1321 agctgagact gttggtgaaa ttgcaagaac tgaactataa cttgaaagtg aaagtctcat
     1381 ttgacaaaga tgtgaacgag aaaaacacag tgaaaggatt ccggaagttc aacatcttgg
     1441 gtactcacac aaaagtgatg aacatggaag aatccaccaa cggaagtttg gcagctgagt
     1501 tccgacacct gcaactgaag gaacagaaaa atgctgggaa cagaaccaat gagggtcctc
     1561 tcattgtcac cgaagaactt cactctctta gctttgaaac ccagttgtgc cagccaggct
     1621 tggtgattga ccttgagacc acctctcttc ccgtcgtggt gatctccaat gtcagccagc
     1681 tccccagtgg ctgggcttct atcctgtggt acaacatgct ggtgacagag cccaggaatc
     1741 tctccttctt cctgaacccc ccgtgtgcgt ggtggtccca gctctcagag gtgctgagtt
     1801 ggcagttttc gtcagtcacc aagagaggtc tcaacgctga ccagctgagc atgctggggg
     1861 agaagcttct gggccctaat gctggccctg atggtcttat tccatggaca aggttctgta
     1921 aggaaaatat taacgataag aatttctcct tctggccttg gattgacacc atcctagaac
     1981 tcattaagaa gcacctgctt tgcctctgga atgatgggtg catcatgggc tttatcagca
     2041 aggagcgaga acgtgctctg ctcaaggacc agcagcccgg gacgttcctg cttaggttca
     2101 gtgagagctc ccgggaaggg gccatcacat tcacatgggt ggaacggtcc caaaatggag
     2161 gtgaacccga cttccatgct gttgagccct acacgaagaa agaactttca gctgttactt
     2221 tcccagatat tattcgcaat tacaaagtca tggctgctga gaatatacca gagaatcccc
     2281 tgaagtatct gtatcccaat attgacaaag accatgcctt cgggaagtac tactccaggc
     2341 caaaggaagc accagaaccg atggagctcg atgaccctaa gagaactgga tacatcaaga
     2401 ctgagttgat ttctgtgtct gaagtccacc cttctagact tcagagcaca gaaaacctgc
     2461 ttcccatgtc tccagaggag tttgacgaga tgtccaagat agtgggctct gaatttgaca
     2521 gtatgatgag cgcagtataa acacgaattt ctctcttctc tggcgacatt tttcttccca
     2581 tctgtgattc cttcctgcta ctgttccttc atatgctgta tttctaggga aatcaagaaa
     2641 gaacagccca tttgttgaac cctgttgata gcaagtggat atttctctaa ttagaaacct
     2701 gttactctga aggacttcat gcagctcact gaaggtgaaa tggaaagtta cttatgcaaa
     2761 gtggattttg taaacaaaaa acaagagagc cacccacgcc tcaggaccgg agtgtgagtg
     2821 ttgagggagg gtgaggagta ctctagtaat actctgtagt cagtgcctac gtgctgcact
     2881 ggaagatact tacgtgggga gggaccttca tgatgtgggg atacttctgt cctggagata
     2941 catgtcccct ctcctctatg gctgcaagtc ttccactgtc ttacgtatgg catggttcaa
     3001 agtcaacttt agatacaatg atatatcaga ctggagtggg catccttcat cagagtggga
     3061 aggaaacagt cgtgttcctt aatgcagctt ctgcattggc cgtgttaatc ttaaggcttg
     3121 gttgctctct tcaggattag ctttgttggt ggctatggct gaacaaaact aaacaccagt
     3181 agaagtagga acattttcat gagtactctc ttcagtctgt actccaccaa gctaaacggt
     3241 ttttgctgtc tttttggtca ttggttgaat aaaattgtct ttgcacatct atcaaggggg
     3301 ctaactttct taaggcaaaa tttttttttt agttgaaatt acagatgtag gtaaacccag
     3361 cagtttaact catgttcttt aatgggctga ttttattgtt tttagctggt tgtcttaatt
     3421 agccataatc ttggaaaaag cagtaactat ttgaatcatt agccaaatat gagtatcaga
     3481 taattttaaa acactccctg taaattcact gaaaactact gttagcaatg aatgtgtttt
     3541 tctgataact agtcacaaat ggttgcaagg tctgtcctgt gttttgtcac ccttttgagg
     3601 ggtgatgttc tgtggtacga acacagcctg gtggttctgg tctcaggttg gtcttctggg
     3661 cagctttcac aggctgccgt ccacgaaggt acagctagag tgttgtccca taatcctttg
     3721 ttttactttg gtgaagatca atccacctta caacccaagt gcaaggtgtg taccacagtt
     3781 acgtgtgcat cacagttacg tgtccaccac agttacgtgt gcaccacagt tacgtgtgca
     3841 cagcccttag tgttgcaggg aagcagaggc ctcctctctt ttcatgtcaa aatgaaatga
     3901 ccaggaaaca aaacatttaa aaaatattgt ttctaaattc tgagagctaa ccattgctta
     3961 cattgttgtc tgttgaaaca gtttgttaca atttcattcc gttgaactag ctgagacttt
     4021 aagaaatgtt aaaattgtgt tagtttccta ctattatgta atataaagat atatgtaaag
     4081 tgtctaaaaa aaaaaaaaaa aa
//
