LOCUS       NM_001007627            1297 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus StAR-related lipid transfer domain containing 6
            (Stard6), mRNA.
ACCESSION   NM_001007627 XM_214545
VERSION     NM_001007627.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1297)
  AUTHORS   Chang IY, Ohn T, Jeon YJ, Lee KH, Kim JW, Kim IY and Yoon SP.
  TITLE     A comparison of the steroidogenic acute regulatory protein-related
            lipid transfer (START) domain-containing 6 on the brain and testes
            between young and aged rats
  JOURNAL   Acta Histochem 116 (4), 551-558 (2014)
   PUBMED   24360190
  REMARK    GeneRIF: StarD6 might also play a role for neurosteroidogenesis in
            the hippocampus of aged rats
REFERENCE   2  (bases 1 to 1297)
  AUTHORS   Chang IY, Kim JH, Cho KW and Yoon SP.
  TITLE     Acute responses of DNA repair proteins and StarD6 in rat
            hippocampus after domoic acid-induced excitotoxicity
  JOURNAL   Acta Histochem 115 (3), 234-239 (2013)
   PUBMED   22883302
  REMARK    GeneRIF: The StarD6 may not be closely related with DNA repair
            proteins in the hippocampus after domoic acid-induced
            excitotoxicity, although the activities of these proteins might be
            positively affected by excitotoxic stimuli.
REFERENCE   3  (bases 1 to 1297)
  AUTHORS   Chang IY, Ohn T, Ko GS, Yoon Y, Kim JW and Yoon SP.
  TITLE     Immunolocalization of steroidogenic acute regulatory
            protein-related lipid transfer (START) domain-containing proteins
            in the developing cerebellum of normal and hypothyroid rats
  JOURNAL   J Chem Neuroanat 43 (1), 28-33 (2012)
   PUBMED   22024186
  REMARK    GeneRIF: These results suggest that StarD6 may affect the
            development of Purkinje cells during the first and second postnatal
            weeks, a known period of thyroid hormone action.
REFERENCE   4  (bases 1 to 1297)
  AUTHORS   Chang IY, Jeon YJ, Jung SM, Jang YH, Ahn JB, Park KS and Yoon SP.
  TITLE     Does the StarD6 mark the same as the StAR in the nervous system?
  JOURNAL   J Chem Neuroanat 40 (3), 239-242 (2010)
   PUBMED   20609383
  REMARK    GeneRIF: morphological aspects of StarD6 were significantly
            different from those of StAR in cultured glial and neuronal cells,
            as well as the distribution in the normal and epileptic rat
            hippocampus
REFERENCE   5  (bases 1 to 1297)
  AUTHORS   Chang IY, Kim JK, Lee SM, Kim JN, Soh J, Kim JW and Yoon SP.
  TITLE     The changed immunoreactivity of StarD6 after pilocarpine-induced
            epilepsy
  JOURNAL   Neuroreport 20 (10), 963-967 (2009)
   PUBMED   19434006
  REMARK    GeneRIF: StarD6 might have nuclear roles and contribute to
            subsequent formation of neuroprotective steroids after excitotoxic
            brain injury.
REFERENCE   6  (bases 1 to 1297)
  AUTHORS   Chang IY, Kim JH, Hwang G, Song PI, Song RJ, Kim JW and Yoon SP.
  TITLE     Immunohistochemical detection of StarD6 in the rat nervous system
  JOURNAL   Neuroreport 18 (15), 1615-1619 (2007)
   PUBMED   17885612
  REMARK    GeneRIF: StarD6 might play an important role in lipid sensing of
            the nervous system
REFERENCE   7  (bases 1 to 1297)
  AUTHORS   Chang IY, Shin SY, Kim JW, Yu JM, Kim JS, Song PI and Yoon SP.
  TITLE     The changed immunolocalization of START-domain-containing 6
            (StarD6) during the development of testes in rat perinatal
            hypothyroidism
  JOURNAL   Acta Histochem 109 (4), 315-321 (2007)
   PUBMED   17462719
  REMARK    GeneRIF: StarD6 may play a pivotal role, not only in the
            spermatogenesis of normal rats, but also in the steroidogenesis of
            Leydig cells under perinatal hypothyroidism
REFERENCE   8  (bases 1 to 1297)
  AUTHORS   Gomes C, Oh SD, Kim JW, Chun SY, Lee K, Kwon HB and Soh J.
  TITLE     Expression of the putative sterol binding protein Stard6 gene is
            male germ cell specific
  JOURNAL   Biol Reprod 72 (3), 651-658 (2005)
   PUBMED   15564601
  REMARK    GeneRIF: In situ hybridization showed Stard6 mRNA expression to be
            germ cell-specific and expressed only during the maturation stages
            of round and elongated spermatids of adult rat testis.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078976.1.
            
            On Nov 29, 2004 this sequence version replaced XM_214545.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078976.1, AY555189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132301, SAMD00132307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1297
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1297
                     /gene="Stard6"
                     /note="StAR-related lipid transfer domain containing 6"
                     /db_xref="GeneID:291527"
                     /db_xref="RGD:1359639"
     exon            1..149
                     /gene="Stard6"
                     /inference="alignment:Splign:2.1.0"
     exon            150..227
                     /gene="Stard6"
                     /inference="alignment:Splign:2.1.0"
     exon            228..321
                     /gene="Stard6"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..915
                     /gene="Stard6"
                     /note="START domain containing protein 6; STAR-related
                     lipid transfer (START) domain containing protein 6;
                     StAR-related lipid transfer (START) domain containing 6"
                     /codon_start=1
                     /product="stAR-related lipid transfer protein 6"
                     /protein_id="NP_001007628.1"
                     /db_xref="GeneID:291527"
                     /db_xref="RGD:1359639"
                     /translation="MDYKAIAQQSAEQVLAYNQDLSGWKVVKTSKKVTVSSKASKLFQ
                     GNLYRIEGVIPELPAHLSDFLYKSEHRVSWDKSLKAFNMIHKIDSDTLICHTITQSFA
                     MGSISPRDFIDLVHIKHQDGNMDIISTRSVEFPGYPPTSHYIRGYNHPSGYVCSPLKE
                     NPAYSKLVVFVQTEMKGKLLASVIEKSMPSNLVSFFLNVKDGLKIHKAPIPALRSHHS
                     MHSAVHKKK"
     exon            322..371
                     /gene="Stard6"
                     /inference="alignment:Splign:2.1.0"
     exon            372..498
                     /gene="Stard6"
                     /inference="alignment:Splign:2.1.0"
     exon            499..616
                     /gene="Stard6"
                     /inference="alignment:Splign:2.1.0"
     exon            617..710
                     /gene="Stard6"
                     /inference="alignment:Splign:2.1.0"
     exon            711..1270
                     /gene="Stard6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaagtggga aaaatcaagt tgcaaccaag tgctttgtca aaagaaggtg ccatctcaac
       61 aatggtctgg cttccactga cccaatggct gaagacaccc ttggctttca tctgaataca
      121 ttctagttca tccaatgttg catcatcagg ttaacagaga tggagatctc caggatttgg
      181 agaccagtaa caatgggcac taaaattctg gactagattt gagaaaggta gatggactat
      241 aaggcaatcg cccaacaatc tgctgaacaa gttttagctt acaatcaaga cctgtctggc
      301 tggaaagtcg ttaaaacttc aaaaaaggta actgtttcca gcaaggcctc taaactattc
      361 caaggaaacc tataccgtat tgaaggagta attccagaat taccagctca cctctctgat
      421 ttcctctaca aatctgaaca cagagtttca tgggataaat ctttgaaagc attcaacatg
      481 atacacaaga ttgattcgga tacacttata tgccacacca tcacacagag ttttgccatg
      541 ggctcaattt ccccgagaga ctttatcgac ttagtacaca tcaagcacca ggacgggaat
      601 atggacatta tcagtactag gagtgtggag ttcccaggat accctcccac gtcacattat
      661 atccgtggct ataaccatcc ctccggctat gtgtgctccc ctctcaagga aaacccagca
      721 tattccaagc tagtggtgtt tgtccagaca gaaatgaaag gaaaattgct tgcctcagta
      781 attgagaagt ctatgccttc caacttagta agcttcttcc tcaatgtgaa agacggccta
      841 aagatacaca aagccccaat cccagcactt cgttcacatc acagtatgca ctccgctgta
      901 cacaaaaaga aataaagcta tgctgccatt aaaccagaga tctcagacgg cacaaactac
      961 tactagtgta agtgtagttt gttactgcag actgctccta agtcggtatg aataaacctg
     1021 tcacacgcct ctagacatta accttgtaca cactacttaa aatactttgt caaggggcta
     1081 gagagatggc tcagcagtta agagcactga ctgctcttcc taaggttctg agttcaattc
     1141 ccagcaacca catggtggct cacaaccatc tgtaatggga tttgatattt gatgccctct
     1201 tctggtgtgt atgaagaaga cagctacagt gtactcataa attaaaaata aataaatctt
     1261 taaaaaagaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
