LOCUS       NM_138531               1735 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus Stam binding protein (Stambp), mRNA.
ACCESSION   NM_138531
VERSION     NM_138531.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1735)
  AUTHORS   Herrera,G., Silvero,C. MJ, Becerra,M.C., Lasaga,M. and
            Scimonelli,T.
  TITLE     Modulatory role of alpha-MSH in hippocampal-dependent memory
            impairment, synaptic plasticity changes, oxidative stress, and
            astrocyte reactivity induced by short-term high-fat diet intake
  JOURNAL   Neuropharmacology 239, 109688 (2023)
   PUBMED   37591460
  REMARK    GeneRIF: Modulatory role of alpha-MSH in hippocampal-dependent
            memory impairment, synaptic plasticity changes, oxidative stress,
            and astrocyte reactivity induced by short-term high-fat diet
            intake.
REFERENCE   2  (bases 1 to 1735)
  AUTHORS   McDonell,L.M., Mirzaa,G.M., Alcantara,D., Schwartzentruber,J.,
            Carter,M.T., Lee,L.J., Clericuzio,C.L., Graham,J.M. Jr.,
            Morris-Rosendahl,D.J., Polster,T., Acsadi,G., Townshend,S.,
            Williams,S., Halbert,A., Isidor,B., David,A., Smyser,C.D.,
            Paciorkowski,A.R., Willing,M., Woulfe,J., Das,S., Beaulieu,C.L.,
            Marcadier,J., Geraghty,M.T., Frey,B.J., Majewski,J., Bulman,D.E.,
            Dobyns,W.B., O'Driscoll,M. and Boycott,K.M.
  CONSRTM   FORGE Canada Consortium
  TITLE     Mutations in STAMBP, encoding a deubiquitinating enzyme, cause
            microcephaly-capillary malformation syndrome
  JOURNAL   Nat Genet 45 (5), 556-562 (2013)
   PUBMED   23542699
REFERENCE   3  (bases 1 to 1735)
  AUTHORS   Suzuki,S., Tamai,K., Watanabe,M., Kyuuma,M., Ono,M., Sugamura,K.
            and Tanaka,N.
  TITLE     AMSH is required to degrade ubiquitinated proteins in the central
            nervous system
  JOURNAL   Biochem Biophys Res Commun 408 (4), 582-588 (2011)
   PUBMED   21531206
REFERENCE   4  (bases 1 to 1735)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1735)
  AUTHORS   Lata,S., Roessle,M., Solomons,J., Jamin,M., Gottlinger,H.G.,
            Svergun,D.I. and Weissenhorn,W.
  TITLE     Structural basis for autoinhibition of ESCRT-III CHMP3
  JOURNAL   J Mol Biol 378 (4), 818-827 (2008)
   PUBMED   18395747
REFERENCE   6  (bases 1 to 1735)
  AUTHORS   Mukai,A., Mizuno,E., Kobayashi,K., Matsumoto,M., Nakayama,K.I.,
            Kitamura,N. and Komada,M.
  TITLE     Dynamic regulation of ubiquitylation and deubiquitylation at the
            central spindle during cytokinesis
  JOURNAL   J Cell Sci 121 (Pt 8), 1325-1333 (2008)
   PUBMED   18388320
REFERENCE   7  (bases 1 to 1735)
  AUTHORS   Ishii,N., Owada,Y., Yamada,M., Miura,S., Murata,K., Asao,H.,
            Kondo,H. and Sugamura,K.
  TITLE     Loss of neurons in the hippocampus and cerebral cortex of
            AMSH-deficient mice
  JOURNAL   Mol Cell Biol 21 (24), 8626-8637 (2001)
   PUBMED   11713295
REFERENCE   8  (bases 1 to 1735)
  AUTHORS   Itoh,F., Asao,H., Sugamura,K., Heldin,C.H., ten Dijke,P. and
            Itoh,S.
  TITLE     Promoting bone morphogenetic protein signaling through negative
            regulation of inhibitory Smads
  JOURNAL   EMBO J 20 (15), 4132-4142 (2001)
   PUBMED   11483516
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061711.1.
            
            On Feb 9, 2004 this sequence version replaced NM_138531.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061711.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1735
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1735
                     /gene="Stambp"
                     /gene_synonym="Amsh"
                     /note="Stam binding protein"
                     /db_xref="GeneID:171565"
                     /db_xref="RGD:619963"
     exon            1..41
                     /gene="Stambp"
                     /gene_synonym="Amsh"
                     /inference="alignment:Splign:2.1.0"
     exon            42..212
                     /gene="Stambp"
                     /gene_synonym="Amsh"
                     /inference="alignment:Splign:2.1.0"
     exon            213..429
                     /gene="Stambp"
                     /gene_synonym="Amsh"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1501
                     /gene="Stambp"
                     /gene_synonym="Amsh"
                     /EC_number="3.1.2.15"
                     /note="associated molecule with the SH3 domain of STAM"
                     /codon_start=1
                     /product="STAM-binding protein"
                     /protein_id="NP_612540.1"
                     /db_xref="GeneID:171565"
                     /db_xref="RGD:619963"
                     /translation="MSDHADVSLPPQDRVRILSQLGSAVELNEDIPPRRYFRSGVEII
                     RMASIYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAIIPEKKDAVKKLKNVAFPK
                     AEELKTELLKRYTKEYEQYKERKKKEEEELARNIAIQQELEKEKQRVAQQKQKQLEQE
                     QFHAFEKMIQKQELEKERLKIVQEFGKVDPGPCGPLLPDLEKPCVDVAPSSPFSPTQT
                     SDCNTTLRPAKPPVVDRSLKPGALSVIENVPTIEGLRHIVVPRNLCSEFLQLASANTA
                     KGIETCGVLCGKLMRNEFTITHVLIPRQNGGPDYCHTENEEEIFFMQDDLGLLTLGWI
                     HTHPTQTAFLSSVDLHTHCSYQMMLPESIAIVCSPKFQETGFFKLTDYGLQEISTCRQ
                     KGFHPHGRDPPLFCDCSHVTVKDRIVTITDLR"
     exon            430..505
                     /gene="Stambp"
                     /gene_synonym="Amsh"
                     /inference="alignment:Splign:2.1.0"
     exon            506..601
                     /gene="Stambp"
                     /gene_synonym="Amsh"
                     /inference="alignment:Splign:2.1.0"
     exon            602..968
                     /gene="Stambp"
                     /gene_synonym="Amsh"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1093
                     /gene="Stambp"
                     /gene_synonym="Amsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1231
                     /gene="Stambp"
                     /gene_synonym="Amsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1344
                     /gene="Stambp"
                     /gene_synonym="Amsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1444
                     /gene="Stambp"
                     /gene_synonym="Amsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1713
                     /gene="Stambp"
                     /gene_synonym="Amsh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgacgtttc cggaagctcc gactgtcatc cttcaggaaa ggtcagaaga gggcaccaga
       61 cctgattata gatggttgtg agccaccatg tggttgctgg gaattgaact caggacctct
      121 ggaagagcag actgtgctct taacctctga gccatctctc cagcccctca ccaggcagtc
      181 ttcatgaggg tgcagtgaac acactctgcc agaactcatc ggtccaatgt ctgaccatgc
      241 agatgtgagc ctcccacccc aagaccgggt gaggattctg tcgcaactcg gtagtgcagt
      301 tgagttaaat gaagacattc cgccccgtcg ctactttcgt tccggtgttg agatcatccg
      361 catggcatcc atttactctg aagaaggcaa cattgaacat gcctttatcc tctacaacaa
      421 gtacatcacg ctgtttattg aaaaacttcc aaaacaccga gactacaaat cggccatcat
      481 tcccgagaag aaagacgcgg tcaagaaatt aaagaatgtc gctttcccta aagcggaaga
      541 gctgaagaca gaactcttga agagatacac caaagagtat gagcagtata aggagcgaaa
      601 gaagaaggaa gaagaggaac ttgcccgaaa tatcgccatc cagcaagaac tggaaaaaga
      661 aaagcagaga gttgcacagc agaagcagaa gcagctcgag caggagcagt tccatgcctt
      721 tgagaagatg atccagaagc aggagctaga gaaagagcgg ctaaaaattg ttcaagagtt
      781 cgggaaggta gaccctggcc cgtgcgggcc tctgctccct gatctggaaa agccctgtgt
      841 agatgtggcc cccagttcac ctttctcgcc cacgcagact tcagactgta acacaaccct
      901 gaggccagct aagccacctg tggtggacag gtccctcaaa cctggagcat taagcgtcat
      961 agaaaatgtt cccaccattg aaggcctgcg ccacattgtg gtgccccgca atctgtgctc
     1021 agaatttctc cagcttgcca gcgccaacac tgccaaaggc atcgagacct gtggagtcct
     1081 ctgtggaaaa ctgatgagaa atgaattcac aatcacacat gttctcatcc ccagacaaaa
     1141 tggtgggcct gattattgcc acacagagaa tgaagaagaa attttcttta tgcaggatga
     1201 tcttggactc ctcactcttg gctggatcca cacccatcca acccaaacgg cctttctgtc
     1261 cagtgtggat ctgcacacgc actgctccta ccaaatgatg ttaccagagt ccatagcaat
     1321 tgtctgctcc cccaagttcc aggagactgg attctttaaa ttaactgact atggccttca
     1381 agagatttca acctgccggc agaaaggctt tcacccccat ggcagagacc caccgctgtt
     1441 ctgtgactgc agccatgtca ctgtcaaaga cagaattgtg acgatcacag accttcgata
     1501 aatctcagtc atgaaccagg aggtggccca ctgggtaaac acacttgcca ccaagcccaa
     1561 cagcccaagt tctattgctg ggatcccccc aagttgtcct ctaacctcca tttgtgtact
     1621 gtggtatgtg tgtacccaca tatacacaca cagacacaga cacacacaca tattaattaa
     1681 tttaaaacaa ataaatgtaa attacaaaaa gaaaaaaaaa aaaaaaaaaa aaaaa
//
