LOCUS       NM_053730               4181 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus STAG3 cohesin complex component (Stag3), mRNA.
ACCESSION   NM_053730
VERSION     NM_053730.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4181)
  AUTHORS   Fukuda,T., Fukuda,N., Agostinho,A., Hernandez-Hernandez,A.,
            Kouznetsova,A. and Hoog,C.
  TITLE     STAG3-mediated stabilization of REC8 cohesin complexes promotes
            chromosome synapsis during meiosis
  JOURNAL   EMBO J 33 (11), 1243-1255 (2014)
   PUBMED   24797475
REFERENCE   2  (bases 1 to 4181)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 4181)
  AUTHORS   Llano,E., Herran,Y., Garcia-Tunon,I., Gutierrez-Caballero,C., de
            Alava,E., Barbero,J.L., Schimenti,J., de Rooij,D.G.,
            Sanchez-Martin,M. and Pendas,A.M.
  TITLE     Meiotic cohesin complexes are essential for the formation of the
            axial element in mice
  JOURNAL   J Cell Biol 197 (7), 877-885 (2012)
   PUBMED   22711701
REFERENCE   4  (bases 1 to 4181)
  AUTHORS   Gutierrez-Caballero,C., Herran,Y., Sanchez-Martin,M., Suja,J.A.,
            Barbero,J.L., Llano,E. and Pendas,A.M.
  TITLE     Identification and molecular characterization of the mammalian
            alpha-kleisin RAD21L
  JOURNAL   Cell Cycle 10 (9), 1477-1487 (2011)
   PUBMED   21527826
REFERENCE   5  (bases 1 to 4181)
  AUTHORS   Lee,J. and Hirano,T.
  TITLE     RAD21L, a novel cohesin subunit implicated in linking homologous
            chromosomes in mammalian meiosis
  JOURNAL   J Cell Biol 192 (2), 263-276 (2011)
   PUBMED   21242291
REFERENCE   6  (bases 1 to 4181)
  AUTHORS   Kouznetsova,A., Benavente,R., Pastink,A. and Hoog,C.
  TITLE     Meiosis in mice without a synaptonemal complex
  JOURNAL   PLoS One 6 (12), e28255 (2011)
   PUBMED   22164254
REFERENCE   7  (bases 1 to 4181)
  AUTHORS   Li,X.C. and Schimenti,J.C.
  TITLE     Mouse pachytene checkpoint 2 (trip13) is required for completing
            meiotic recombination but not synapsis
  JOURNAL   PLoS Genet 3 (8), e130 (2007)
   PUBMED   17696610
  REMARK    Erratum:[PLoS Genet. 2007 Sep 7;3(9):e168. Li, Xin [corrected to
            Li, Xin Chenglin]]
REFERENCE   8  (bases 1 to 4181)
  AUTHORS   Kouznetsova,A., Novak,I., Jessberger,R. and Hoog,C.
  TITLE     SYCP2 and SYCP3 are required for cohesin core integrity at
            diplotene but not for centromere cohesion at the first meiotic
            division
  JOURNAL   J Cell Sci 118 (Pt 10), 2271-2278 (2005)
   PUBMED   15870106
REFERENCE   9  (bases 1 to 4181)
  AUTHORS   Bayes,M., Prieto,I., Noguchi,J., Barbero,J.L. and Perez Jurado,L.A.
  TITLE     Evaluation of the Stag3 gene and the synaptonemal complex in a rat
            model (as/as) for male infertility
  JOURNAL   Mol Reprod Dev 60 (3), 414-417 (2001)
   PUBMED   11599053
REFERENCE   10 (bases 1 to 4181)
  AUTHORS   Pezzi,N., Prieto,I., Kremer,L., Perez Jurado,L.A., Valero,C., Del
            Mazo,J., Martinez-A,C. and Barbero,J.L.
  TITLE     STAG3, a novel gene encoding a protein involved in meiotic
            chromosome pairing and location of STAG3-related genes flanking the
            Williams-Beuren syndrome deletion
  JOURNAL   FASEB J 14 (3), 581-592 (2000)
   PUBMED   10698974
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY027880.1.
            
            [WARNING] On Mar 12, 2025 this sequence was replaced by
            NM_053730.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY027880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4181
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..4181
                     /gene="Stag3"
                     /note="STAG3 cohesin complex component"
                     /db_xref="GeneID:114522"
                     /db_xref="RGD:621333"
     exon            1..40
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            41..214
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..3821
                     /gene="Stag3"
                     /note="cohesin subunit SA-3-like; SCC3 homolog 3;
                     stromalin-3; stromal antigen 3"
                     /codon_start=1
                     /product="cohesin subunit SA-3"
                     /protein_id="NP_446182.1"
                     /db_xref="GeneID:114522"
                     /db_xref="RGD:621333"
                     /translation="MPTLWSPSTQHHGSSSGSMSSPLRKSVRCAQMALSPCSSNIQPC
                     DDRDSQGTAEWDSSSTSEDSDFEDSLRRNVRKRAAKRPPKAIPVAKHPKKQSHIVPGG
                     NDKNKSVPPTSDLFDAVKAARSCAQSLVDEWLENYKQDENAGFLELVNFFIRACGCKS
                     TVTPEMFKTMSNSEIIQHLTEEFNEDSGDYPLTAPGPSWKKFQGSFCEFVKTLVCQCQ
                     YSLLFDGFPMDDLISLLIGLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSLHKDNNQ
                     RQYEAERNKGPEQRAPERLESLLEKRKEFQENQEEIEGMMNAIFRGVFVHRYRDILPE
                     IRAVCIEEIGCWMQSYSTSFLNDSYLKYIGWTLHDKHKEVRLKCVKALAGLYSNQELS
                     SRMELFTNRFKDRMVSMVMDRESEVAVEAIRLLTLILKNMEGVLTSADCEKIYSIVYI
                     SNRAMASSAGEFVYWKIFHPECGAKAVSGRERRRSPQAQRTFIYLLLAFFMESEHHDH
                     AAYLVDSLWDCAGSYLKDWESLTSLLLQKDQNLGDMQERMLIEILVSSARQAAEGHPP
                     VGRITGKKSLTAKERKLQAYDKVKLAEHLIPLLPQLLAKFSADAENVAPLLRLLSYFD
                     LNIYCTQRLEKHLELLLQQLQEVVVKHVEPEVLEAAAHALYLLCKPEFTFFSRVDFAR
                     SQLVDLLTDRFQQELDDLMQSSFLDEDEVYSLTATLKRLSAFYNAHDLTRWEISEPCS
                     RLLRKAVDTGEVPHQVILPALTLVYFSILWTVTHISESTSQKQLMSLKKRMVAFCELC
                     QSCLSDVDPEIQEQAFVLLSDLLLIFSPQMVVGGRDFLRPLVFFPEATLQSELASFLM
                     DHVFLQPGELGNGQSQEDHVQIELLHQRRRLLAGFCKLLLYGVLELDAASDVFKHYNK
                     FYEDYGDIIKETLTRARQIDRCQCSRILLLSLKQLYTELIQEQGPQDLTELPAFIEMR
                     DLARRFALSFGPQQLHNRDLVVMLHKEGIKFSLSELPPAGSSREPPNIAFLELLSEFS
                     PRLFHQDKQLLLSYLEKCLQRVSMAPSHPWGPVTTYCHSLHLVENTAEASSQGPPHSK
                     KRCIEVPRRLQEEESSSQGESLQLNSGPTTPTLTSTAVKRRQSPRTVGKRQKGGPGPG
                     PGPGPGPGPGPGPGPGPGPGPELICSQQLSGTQRLKMSSAPCFQIRCDPSGSGLGKQM
                     TRLSLMEEDEEEELRLLDEEWQCGDKLLHSPSSPSEHGLDLLDTTELNMEDF"
     exon            215..311
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            312..431
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            432..528
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            529..605
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            606..810
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            811..962
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1036
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1160
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1259
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1339
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1447
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1562
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1668
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1772
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1865
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1955
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2156
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2227
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2315
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2393
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2486
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2655
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2792
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2894
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3043
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3172
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3330
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..3565
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3667
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3740
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..3812
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
     exon            3813..4163
                     /gene="Stag3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgtgttc atctagaggt cattcttcca agctcaaaca ctggattaac atgcctactc
       61 tgtggtcacc ctccacccag caccatggct cttcctcagg cagtatgtcc tcccctcttc
      121 gaaagtctgt gagatgtgca cagatggcct tgtctccttg ttcttccaac atccaaccct
      181 gtgatgacag agactcccag ggaactgcag aatgggatag ttcctcaact agtgaagaca
      241 gtgactttga agatagctta agaagaaatg tgaggaagag agcagcaaaa cgaccaccca
      301 aagctatccc agtggcaaaa catccgaaga agcagtccca catagtacct ggtgggaatg
      361 acaagaacaa gtcagtgccg ccaaccagtg acctttttga tgctgtgaaa gctgctagaa
      421 gttgtgcgca gtctttggta gatgagtggc tagaaaacta caagcaagat gaaaatgcag
      481 gattcttgga acttgttaat tttttcatcc gagcctgtgg atgtaaaagc actgtcacac
      541 ccgagatgtt caagacaatg tccaactcag agatcatcca gcacctaaca gaagagttta
      601 atgaggactc aggtgactat cccctgacag ctccaggtcc atcctggaag aagttccagg
      661 gaagcttctg tgagtttgtg aagacactag tctgtcagtg ccagtacagc ctcctctttg
      721 acggctttcc aatggatgac cttatctccc tgctcattgg cctctcagat tcccaggtcc
      781 gagcctttcg tcatactagt actttggctg ccatgaagct aatgacttct ctggtaaaag
      841 ttgcactcca gttgagtctg cacaaagaca acaatcaacg tcagtatgag gcagaacgaa
      901 acaaggggcc agagcagagg gcaccagagc ggctcgagag tctgctggag aaacgaaaag
      961 agttccaaga gaatcaagag gagatagagg ggatgatgaa tgccatcttc aggggtgtct
     1021 ttgttcatcg gtacagggac atccttcctg agatccgtgc tgtctgcatc gaggagatcg
     1081 ggtgttggat gcaaagctac agcacctcct ttcttaatga cagctaccta aaatatattg
     1141 gctggaccct gcatgacaag cacaaggaag tccgcctaaa gtgtgtgaag gctctggcag
     1201 ggctgtacag caaccaggag ctgagttcac ggatggagct ctttactaat cgcttcaagg
     1261 accggatggt ttccatggtc atggacagag agagtgaagt agcagtggag gccatcagat
     1321 tgctgaccct tattctgaag aacatggagg gagtactgac tagtgcagat tgtgagaaaa
     1381 tttactccat tgtatacatt tctaatcgtg ccatggcctc ttctgcaggg gaatttgtgt
     1441 actggaagat tttccatcct gaatgtgggg caaaagcagt gagtggcagg gagcgacgcc
     1501 ggagtccaca agcccagagg actttcattt accttttatt ggccttcttt atggagagtg
     1561 agcatcacga ccatgctgct tacctagttg acagcttgtg ggactgtgca gggtcttacc
     1621 tgaaggactg ggagagtctg acaagtctgt tgctgcagaa agaccagaat ctgggtgata
     1681 tgcaagagag aatgttgata gaaatcctgg tgtccagtgc ccggcaagct gcagagggtc
     1741 acccaccagt ggggcgcatc actggaaaga agagtctgac cgccaaagaa cgcaagcttc
     1801 aagcttatga taaggtgaag ctggctgagc acctcatccc cctcttgccc cagctccttg
     1861 ccaagttctc agcagatgca gagaacgttg ctcccttgct ccggctgctc agttactttg
     1921 acctcaacat ttattgcact cagcgcttgg agaagcactt ggagctgctt ctgcaacaac
     1981 tccaggaggt ggtggtgaag cacgtagagc ctgaggtgct tgaggctgca gcacatgccc
     2041 tctatttgct ctgcaagcca gagttcacct tcttcagcag agtggacttc gccagaagcc
     2101 aattagtaga tctgctgact gatagattcc agcaggagct tgacgaccta atgcagtcat
     2161 ccttcctaga tgaggatgag gtatacagtc tgacagccac tctgaagcgt ctctctgcct
     2221 tttacaatgc tcatgacctg actcgctggg agatctctga accatgttct cgactcctcc
     2281 ggaaggctgt agacacagga gaagttcctc accaggtgat tttgccagcc ttgactctgg
     2341 tatatttttc cattctctgg acagtgaccc acatttcaga gtctacttcc caaaagcagc
     2401 tgatgagtct gaagaaaaga atggtagcct tctgtgaact ttgccaaagc tgcctctcag
     2461 acgtggaccc agagatccag gagcaggctt ttgttttatt aagtgacctg cttctcatct
     2521 tcagccccca gatggttgta gggggccggg atttccttag gcctcttgtc ttttttccgg
     2581 aagctactct ccagtcggaa ctagccagct tcctcatgga ccatgtcttt ctccagcctg
     2641 gagaattggg caacggtcaa tcacaggagg atcacgtcca aatagagctt ctgcaccaga
     2701 ggcgccgcct gcttgcagga ttttgtaagc tgttgcttta tggggtattg gaactggatg
     2761 cggcctcaga tgttttcaaa cactacaaca agttctatga agattatggt gacattatca
     2821 aggaaacatt aactcgggcg agacaaattg accgatgtca gtgctctcgg atcctgctcc
     2881 tgagcctaaa gcagctctac acagaactga tacaggagca ggggccccag gacctgacag
     2941 aactgccagc cttcattgag atgagagacc tggcccggag gtttgccttg agctttggac
     3001 cccagcagct ccataacaga gatcttgtgg tcatgctgca caaggaaggc atcaagttct
     3061 cattgtctga gcttcctcct gctggctctt ctcgagagcc cccaaatatt gcattcctgg
     3121 agcttctttc agagttctcc ccccgcctct tccatcagga caaacagcta ctactatcat
     3181 acctggaaaa gtgtctgcag cgtgtctcca tggcacctag ccatccctgg ggtccagtca
     3241 ccacctactg ccactccctc catctagtag agaacacagc agaggccagc tctcaggggc
     3301 ccccccactc caagaagagg tgtattgaag ttccccgcag gcttcaggaa gaagagtctt
     3361 catcccaggg agaaagcctt cagctgaaca gtggccccac aacacctaca ctcacctcca
     3421 cagcagtgaa gagaaggcag tctccgagga cagtaggcaa gaggcaaaaa ggtggaccag
     3481 gaccaggacc aggaccagga ccaggaccag gaccaggacc aggaccagga ccaggaccag
     3541 gaccaggacc agagctgatc tgcagtcagc agctctcagg cacccagagg ttgaaaatgt
     3601 cgagtgcacc gtgtttccag attcgatgtg atccttctgg ctctggcttg ggcaagcaga
     3661 tgacccgact cagccttatg gaagaagatg aggaagaaga gctgagactt ctggatgaag
     3721 aatggcaatg tggagacaag ctacttcata gcccttcttc tcccagtgag catgggctgg
     3781 acctattaga tacaacagag ctgaacatgg aggatttctg atgggactta ggcttctccc
     3841 cttctccact taccacactg caaggccatg agtgagcaaa cgaaggagta aaatgaagca
     3901 ttctttgggt cccagccaag tactttaagg gaatagagaa atggccttat tcaaacctcc
     3961 atttctttct gaagtgggtg ctgtatatag atgctatgag ccctgtgatc cttaattcac
     4021 cctagcttta tgcttttgcc tgtttgaagt ggtgggagtt gggtagggag ctttacctca
     4081 gtattgaagt ttaataaacc ttctgtttga tatctcttcc ccaaacactg ccaagctctc
     4141 aataaacatg ttcacatcag ctaaaaaaaa aaaaaaaaaa a
//
