LOCUS       NM_001173507            6122 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus STAG2 cohesin complex component (Stag2), mRNA.
ACCESSION   NM_001173507 XM_001059059 XM_002727666 XM_002727667 XM_002730173
            XM_002730174 XM_233108
VERSION     NM_001173507.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6122)
  AUTHORS   Mullegama,S.V., Klein,S.D., Mulatinho,M.V., Senaratne,T.N.,
            Singh,K., Nguyen,D.C., Gallant,N.M., Strom,S.P., Ghahremani,S.,
            Rao,N.P. and Martinez-Agosto,J.A.
  CONSRTM   UCLA Clinical Genomics Center
  TITLE     De novo loss-of-function variants in STAG2 are associated with
            developmental delay, microcephaly, and congenital anomalies
  JOURNAL   Am J Med Genet A 173 (5), 1319-1327 (2017)
   PUBMED   28296084
REFERENCE   2  (bases 1 to 6122)
  AUTHORS   Soardi,F.C., Machado-Silva,A., Linhares,N.D., Zheng,G., Qu,Q.,
            Pena,H.B., Martins,T.M.M., Vieira,H.G.S., Pereira,N.B.,
            Melo-Minardi,R.C., Gomes,C.C., Gomez,R.S., Gomes,D.A.,
            Pires,D.E.V., Ascher,D.B., Yu,H. and Pena,S.D.J.
  TITLE     Familial STAG2 germline mutation defines a new human cohesinopathy
  JOURNAL   NPJ Genom Med 2, 7 (2017)
   PUBMED   29263825
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6122)
  AUTHORS   Remeseiro,S., Cuadrado,A., Kawauchi,S., Calof,A.L., Lander,A.D. and
            Losada,A.
  TITLE     Reduction of Nipbl impairs cohesin loading locally and affects
            transcription but not cohesion-dependent functions in a mouse model
            of Cornelia de Lange Syndrome
  JOURNAL   Biochim Biophys Acta 1832 (12), 2097-2102 (2013)
   PUBMED   23920377
REFERENCE   4  (bases 1 to 6122)
  AUTHORS   Liu,H., Rankin,S. and Yu,H.
  TITLE     Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects
            sororin and centromeric cohesion during mitosis
  JOURNAL   Nat Cell Biol 15 (1), 40-49 (2013)
   PUBMED   23242214
  REMARK    Erratum:[Nat Cell Biol. 2013 Feb;15(2):229]
REFERENCE   5  (bases 1 to 6122)
  AUTHORS   Faure,A.J., Schmidt,D., Watt,S., Schwalie,P.C., Wilson,M.D., Xu,H.,
            Ramsay,R.G., Odom,D.T. and Flicek,P.
  TITLE     Cohesin regulates tissue-specific expression by stabilizing highly
            occupied cis-regulatory modules
  JOURNAL   Genome Res 22 (11), 2163-2175 (2012)
   PUBMED   22780989
REFERENCE   6  (bases 1 to 6122)
  AUTHORS   Kagey,M.H., Newman,J.J., Bilodeau,S., Zhan,Y., Orlando,D.A., van
            Berkum,N.L., Ebmeier,C.C., Goossens,J., Rahl,P.B., Levine,S.S.,
            Taatjes,D.J., Dekker,J. and Young,R.A.
  TITLE     Mediator and cohesin connect gene expression and chromatin
            architecture
  JOURNAL   Nature 467 (7314), 430-435 (2010)
   PUBMED   20720539
  REMARK    Erratum:[Nature. 2011 Apr 14;472(7342):247]
REFERENCE   7  (bases 1 to 6122)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 6122)
  AUTHORS   Watrin,E., Schleiffer,A., Tanaka,K., Eisenhaber,F., Nasmyth,K. and
            Peters,J.M.
  TITLE     Human Scc4 is required for cohesin binding to chromatin,
            sister-chromatid cohesion, and mitotic progression
  JOURNAL   Curr Biol 16 (9), 863-874 (2006)
   PUBMED   16682347
REFERENCE   9  (bases 1 to 6122)
  AUTHORS   Strachan,T.
  TITLE     Cornelia de Lange Syndrome and the link between chromosomal
            function, DNA repair and developmental gene regulation
  JOURNAL   Curr Opin Genet Dev 15 (3), 258-264 (2005)
   PUBMED   15917200
  REMARK    Review article
REFERENCE   10 (bases 1 to 6122)
  AUTHORS   Gregson,H.C., Schmiesing,J.A., Kim,J.S., Kobayashi,T., Zhou,S. and
            Yokomori,K.
  TITLE     A potential role for human cohesin in mitotic spindle aster
            assembly
  JOURNAL   J Biol Chem 276 (50), 47575-47582 (2001)
   PUBMED   11590136
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            [WARNING] On Oct 18, 2024 this sequence was replaced by
            NM_001173507.2.
            
            On or before May 13, 2010 this sequence version replaced
            XM_002727666.1, XM_002727667.1, XM_001059059.2, XM_233108.5,
            XM_002730173.1, XM_002730174.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.66142.1,
                                           SRR26643299.68713.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               JAXUCZ010000021.1  125840401-125840761
            362-500             JAXUCZ010000021.1  125896964-125897102
            501-579             JAXUCZ010000021.1  125899935-125900013
            580-744             JAXUCZ010000021.1  125904929-125905093
            745-841             JAXUCZ010000021.1  125912560-125912656
            842-918             JAXUCZ010000021.1  125916730-125916806
            919-1123            JAXUCZ010000021.1  125917969-125918173
            1124-1275           JAXUCZ010000021.1  125919494-125919645
            1276-1349           JAXUCZ010000021.1  125921221-125921294
            1350-1473           JAXUCZ010000021.1  125922536-125922659
            1474-1572           JAXUCZ010000021.1  125923438-125923536
            1573-1652           JAXUCZ010000021.1  125923622-125923701
            1653-1760           JAXUCZ010000021.1  125928190-125928297
            1761-1872           JAXUCZ010000021.1  125928962-125929073
            1873-1990           JAXUCZ010000021.1  125930816-125930933
            1991-2094           JAXUCZ010000021.1  125931648-125931751
            2095-2187           JAXUCZ010000021.1  125940261-125940353
            2188-2277           JAXUCZ010000021.1  125940471-125940560
            2278-2481           JAXUCZ010000021.1  125941154-125941357
            2482-2552           JAXUCZ010000021.1  125943244-125943314
            2553-2640           JAXUCZ010000021.1  125943532-125943619
            2641-2721           JAXUCZ010000021.1  125943722-125943802
            2722-2814           JAXUCZ010000021.1  125945088-125945180
            2815-2989           JAXUCZ010000021.1  125945724-125945898
            2990-3129           JAXUCZ010000021.1  125949831-125949970
            3130-3231           JAXUCZ010000021.1  125950974-125951075
            3232-3380           JAXUCZ010000021.1  125953085-125953233
            3381-3509           JAXUCZ010000021.1  125954680-125954808
            3510-3733           JAXUCZ010000021.1  125957198-125957421
            3734-3923           JAXUCZ010000021.1  125960453-125960642
            3924-4050           JAXUCZ010000021.1  125963743-125963869
            4051-4128           JAXUCZ010000021.1  125965365-125965442
            4129-6122           JAXUCZ010000021.1  125969216-125971209
FEATURES             Location/Qualifiers
     source          1..6122
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq35"
     gene            1..6122
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /note="STAG2 cohesin complex component"
                     /db_xref="GeneID:313304"
                     /db_xref="RGD:1562042"
     exon            1..361
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            362..500
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..4152
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /note="stromal antigen 2"
                     /codon_start=1
                     /product="cohesin subunit SA-2"
                     /protein_id="NP_001166978.1"
                     /db_xref="GeneID:313304"
                     /db_xref="RGD:1562042"
                     /translation="MIAAPEIPTDFNLLQESETHFSSDTDFEDIEGKNQKQGKGKTCK
                     KGKKGPAEKGKSGNGGGKPPSGPNRMNGHHQQNGVENMMLFEVVKMGKSAMQSVVDDW
                     IESYKHDRDIALLDLINFFIQCSGCKGVVTAEMFRHMQNSEIIRKMTEEFDEDSGDYP
                     LTMAGPQWKKFKSSFCEFIGVLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHT
                     STLAAMKLMTALVNVALNLSINMDNTQRQYEAERNKMIGKRANERLELLLQKRKELQE
                     NQDEIENMMNAIFKGVFVHRYRDAIAEIRAICIEEIGIWMKMYSDAFLNDSYLKYVGW
                     TMHDKQGEVRLKCLTALQGLYYNKELNSKLELFTSRFKDRIVSMTLDKEYDVAVQAIK
                     LLTLVLQSSEEVLTAEDCENVYHLVYSAHRPVAVAAGEFLYKKLFSRRDPEEDGIMKR
                     RGRQGPNANLVKTLVFFFLESELHEHAAYLVDSMWDCATELLKDWECMNSLLLEEPLS
                     GEEALTDRQESALIEIMLCTIRQAAECHPPVGRGTGKRVLTAKEKKTQLDDRTRITEL
                     FAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIYTTGRLEKHLDALLRQIRNIVEKHT
                     DTDVLEACSKTYHALCNEEFTIFNRVDISRSQLIDELADKFNRLLEDFLQEGEEPDED
                     DAYQVLSTLKRITAFHNAHDLSKWDLFACNYKLLKTGIENGDMPEQIVIHALQCAHYV
                     ILWQLAKITESTSTKEDLLRLKKQMRVFCQICQHYLTNVNTTVKEQAFTILCDILMIF
                     SHQIMSGGRDMLEPLVYTPDSSLQSELLSFILDHVFIEQDDDSNSADGQQEDEASKIE
                     ALHKRRNLLAAFCKLIVYTVVEMNTAADIFKQYMKYYNDYGDIIKETMSKTRQIDKIQ
                     CAKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIKELARRFALTFGLDQLKTREAIAM
                     LHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSKLLRQDKRTVYVYLEKFMTFQM
                     SLRREDVWLPLMSYRNSLLAGGDDDTMSVISGMSSRGSTVRSKKSKPSTGKRKVLEGM
                     QLALPEESSSSDSMWLSREQTLHTPVMMQTPQLTSTIMREPKRLRPEDSFMSVYPMQT
                     EHHQTPLDYNQRGTSIMEDDEEPIVEDVMMSSEGRIEDLNEGMDFDTMDIDLPPSKNR
                     RERTELKPDFFDPASIMDESVLGVSMF"
     exon            501..579
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            580..744
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            745..841
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            842..918
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1123
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1275
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1349
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1473
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1572
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1652
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1760
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1872
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1990
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2094
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2187
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2277
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2481
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2552
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2640
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2721
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2814
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2989
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3129
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3231
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3380
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            3381..3509
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            3510..3733
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3923
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            3924..4050
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            4051..4128
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
     exon            4129..6122
                     /gene="Stag2"
                     /gene_synonym="RGD1562042"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcgaaca ccccaaacaa tcccgaagcg ccaccaaaaa aaaaaaaaaa aaaaaaagaa
       61 aagaaaaaag agaaaagaaa aaagaaaaaa agaaaagaaa aaaatagaaa aaaagaaaag
      121 agaaaaaaac aggaaaaaaa aagcaccctg ccggatccga ccgccacttt caaccccccc
      181 ccccccacgg ctctagaccc gcgggagctt ccgtccctca gtagaattca agggtgtaaa
      241 gaagaggaag ggggaaaaaa tcttgtacca gcccaggggc gaagaagccc ccggcctgag
      301 aaagaaggag tgggggaggc caacagtctc ctcgctgcct ctgtagacgc tgagggggga
      361 ggaactgtct ttcttagagg aagcacactg tcttttattc acataaatat atgaatatat
      421 ttctgacatt ggggtgatcc agaagatgat aaagaaatga tagcagctcc agaaatacca
      481 actgatttta atctactgca ggagtcagaa acacattttt cttctgacac agattttgaa
      541 gacattgaag gaaaaaatca gaagcaaggc aaaggcaaaa cttgtaaaaa aggcaagaag
      601 ggtccagcag agaagggtaa aagtggaaat ggaggaggaa aacctccttc tggtccaaac
      661 cgaatgaatg gtcatcatca gcagaatgga gttgaaaaca tgatgttgtt tgaagttgta
      721 aaaatgggca agagtgctat gcagtcggtg gtagatgatt ggatagaatc atacaagcat
      781 gaccgagata tagcacttct tgaccttatc aactttttta ttcagtgttc aggctgcaaa
      841 ggagtcgtca cagcagagat gtttagacat atgcagaact ctgagataat tcgaaaaatg
      901 acagaagaat tcgacgagga tagtggggat tacccactaa ccatggctgg tcctcagtgg
      961 aagaagttca agtccagctt ctgtgagttc attggtgtat tagtacggca atgtcaatat
     1021 agtatcatat atgatgagta catgatggac actgtcattt cacttcttac tggattgtct
     1081 gactcccaag tcagagcatt tcgacataca agcaccctgg cagctatgaa gttgatgact
     1141 gctttggtaa atgtggcact aaatcttagc attaatatgg ataacacaca aagacagtat
     1201 gaggcagaac ggaataaaat gattggaaaa cgagccaatg aaaggctaga actcctgtta
     1261 caaaagcgta aagagcttca ggaaaatcaa gatgaaatag aaaatatgat gaatgcaata
     1321 tttaaaggag tgtttgtaca tagatacagg gatgcaatag ctgaaatcag agctatatgc
     1381 attgaagaga ttggcatttg gatgaagatg tatagtgatg ccttccttaa tgacagctat
     1441 ttaaaatatg ttggttggac tatgcatgat aagcaaggtg aggtaagact caagtgtctt
     1501 actgctttac aagggcttta ctataacaaa gagcttaact ccaaactgga actgtttacc
     1561 agtcggttca aggatagaat tgtgtctatg acccttgaca aagaatatga tgttgcagta
     1621 caagcaataa agttactcac tcttgtttta cagagtagtg aagaagttct aactgcagaa
     1681 gactgtgaaa atgtctatca tctggtttat tcagctcacc ggccagtagc agttgcagct
     1741 ggagaatttc tctacaaaaa gctcttcagc cgtagagatc cagaagagga tggaataatg
     1801 aaaagaaggg gaagacaagg tccaaatgcc aatcttgtca agactttggt gtttttcttc
     1861 ttggaaagtg agttacatga acatgcagca taccttgtgg atagcatgtg ggattgtgct
     1921 actgagctac tgaaagactg ggaatgtatg aatagcttgt tattagagga gcctctcagt
     1981 ggagaggaag ctctaacaga cagacaagag agtgctttga ttgaaataat gctttgtact
     2041 attagacaag cagctgaatg tcatccgcct gtgggaagag ggacaggaaa aagggtgcta
     2101 acagcaaagg agaagaagac acagttggat gacagaacaa gaatcactga gctgtttgct
     2161 gtggcccttc cacaattatt agcaaaatac tctgtagatg cagaaaaggt gaccaatttg
     2221 ttgcagttac ctcaatactt tgacttggag atctacacca ctggacgatt ggaaaagcac
     2281 ttggatgcct tattgcgtca gatccgaaat attgtagaga agcacacaga cacagatgtt
     2341 ttggaagcat gttctaaaac ttaccatgca ttatgtaatg aagagttcac gatcttcaac
     2401 agagtagata tttcaagaag tcagctgata gatgaactgg cagataaatt taaccggctt
     2461 ctggaagatt ttctgcaaga gggagaagaa cctgacgaag atgatgcata tcaggtattg
     2521 tcaacattga agaggatcac tgcttttcat aatgcccatg atctttcaaa gtgggatttg
     2581 tttgcttgta attacaaact cttgaaaacc ggaattgaaa atggagatat gcctgagcag
     2641 atcgttattc acgcactgca gtgtgctcac tatgtaatcc tttggcagct tgctaagatc
     2701 actgaaagca cttctacaaa ggaggacttg ctgcgtttaa agaaacagat gagggtattt
     2761 tgccagatat gtcaacatta cttaaccaac gtgaatacta ctgttaagga acaggccttc
     2821 actattctgt gtgatatttt gatgatcttc agtcaccaga ttatgtctgg agggcgtgac
     2881 atgttagagc cattagttta tactcctgat tcttcattgc agtctgagtt gctcagcttt
     2941 attttggatc atgtcttcat tgaacaggat gatgatagta atagtgcaga tggtcagcag
     3001 gaggatgaag ccagtaaaat tgaagctttg cataagagga gaaatttact tgcagcattt
     3061 tgtaagctaa ttgtatatac agtggtggag atgaacacag ctgcggatat cttcaagcag
     3121 tatatgaagt attataacga ttatggcgat atcatcaaag aaacaatgag taaaacaagg
     3181 cagattgaca aaattcagtg tgccaagact cttattctca gtttgcagca gctttttaat
     3241 gagatgatac aagaaaatgg ctataacttt gatagatcat cctcaacatt tagcggcata
     3301 aaagaacttg ctcgacgttt tgctttaact tttggacttg atcagttgaa aaccagagaa
     3361 gccattgcca tgctgcacaa agatggcata gaatttgctt ttaaggagcc taatccacaa
     3421 ggggagagcc atccaccttt aaatttggca tttcttgata ttctcagtga attttcttct
     3481 aaactgctcc gacaagataa aagaacagtg tatgtttatt tggaaaagtt catgaccttt
     3541 cagatgtcac tccgaagaga agatgtatgg cttcctctga tgtcttaccg aaattctttg
     3601 ctagctggtg gtgatgatga caccatgtca gtcattagtg gaatgagcag tcggggatca
     3661 actgtacgga gtaaaaaatc aaaaccatct acagggaaac ggaaagtgct tgaaggcatg
     3721 caactagcac tccctgaaga aagcagtagc agtgacagta tgtggttgag cagagagcag
     3781 acactgcaca cccctgttat gatgcagaca ccgcagctca cctccactat tatgagagaa
     3841 ccgaaaaggt tacggcctga agatagcttc atgagtgtct atccgatgca gacagaacac
     3901 catcaaactc ctctggatta caatcagcgt ggtacaagca taatggagga tgacgaagag
     3961 ccgattgttg aagatgttat gatgtcctca gaaggaagga ttgaggatct taatgaggga
     4021 atggactttg acaccatgga tatagacctg ccaccatcaa agaatagaag agagagaaca
     4081 gaactgaagc ctgatttctt tgatcctgct tcaattatgg atgaatcagt tcttggcgtg
     4141 tcaatgtttt aataccagta cacattaaat ctgtgatgaa gtcattttct aagtggaaga
     4201 ggaaatttta aaataaagtg tggtagatac agtgaaattc tgtacagatt tttctctaag
     4261 gagaatataa catgcttatg cttaccaaga tgaagtgcat tgaggggcag ttttgtttgc
     4321 ctgaaaaaat aaaggacaag taaacaattt gatgataagc tacagttttt cttagaaagt
     4381 aaatatttta tttatgcgct gttagttggc ttttaaagga attatttcat gcttttttaa
     4441 aaaaaaatat aacaatctga agaagtattt ggtacagata agaatcttct cacatttatt
     4501 tactggttgt actaaataat gatgacctct gctggatttc tgtttacatc catgaaacaa
     4561 aagttaagga tggatttatt ccctgaccct gaaattgtag gatagaattg tttttagcat
     4621 tctaaattta aatgcttaaa acatcaatca acaaaccttt gttttaaatg ttgtaattgt
     4681 ggaaaaaagt taaacttata agcagaactt ttacaatttt ttcatctaaa atgtatttta
     4741 agatattttt aaaatccaag agcttctgta tacttttcag aaatatccag atgcagtgaa
     4801 ctgccagaag gtaaccagtc tcgaacacgc ttatcccaca gcagcccgaa agtttgcttg
     4861 tcctttaaga taaaacgtaa cgttgtgatg ttccttccag tagtgccact gtattttgtc
     4921 tccaaataaa gaagcttatt gtagtatgtt tgcagaaaat ttaaacaaaa attatacagc
     4981 ttattagagt gtgggaatag ggatctaaat tttaaataaa attatatata tatataaatt
     5041 ggtgctgatt ttataattgc gcagtttgtt tagttttttc ttacttttaa attccaactt
     5101 aaaattatga ggtttcagaa atatattgaa agtttaacaa tgtttaaaaa tagaaaagca
     5161 tgactgttca tgctttaaaa tgatttttaa atttgtattt tatattgttt tatctatctg
     5221 tctttgcaag cagtcttcag gttaaagata cttctaacag gttacagtac atttcctctg
     5281 tatgtaaatt agatgggata atagaattca taacccataa tattctttga aagctaagct
     5341 ttaaacttca ttttatgtcc tttcacaagt gaattagttt aaaacagaaa gtggccactt
     5401 gccattttga catcaactca ttttgcgagg cttaggcagc tagacatcgt ttaaaacaaa
     5461 atattaactt atattacatg tatatctatc ttttgtcagt cgtctctcag ttcttgaggt
     5521 atattatttt aatcattcca tgccttaata tgcttgcaat acaagaatat cttcagatgt
     5581 gtgaatacca aaaggtttct ggtttttcaa gtcaggaaat caacaagcat tgggctgtgg
     5641 tagccaaaaa accataggtt aaatgaaaga ccacaaaata catttatttt attaattcat
     5701 ggttaacaaa taaaaccaga cctgtctaac atactttcca tcaacaaaca ttgttatgtg
     5761 caaacgtatt gcatatgttc ttttacacac cactgcattt cctacaactg ctgagaggac
     5821 tgtatatatg atttgaaacc taagttgatt tttttctcac tcttgaaagg agtatttctt
     5881 tgtgaaagca gttcttccag ctttgttttg aaccagctaa aatgttttct ctattactct
     5941 aacctgttgt cctccacatt ctattgtcct aattgtactg tttgctgatt tgtatttatg
     6001 tcttgagaca gtaacttttt gaataaaaat aaacctacgg tatgttgtat gctttatctc
     6061 ttgtaatcaa aaggggaggg tggttctaaa tgctttatga attatattta ttatcacact
     6121 tt
//
