LOCUS       NM_001108179            5649 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus STAG1 cohesin complex component (Stag1), mRNA.
ACCESSION   NM_001108179 XM_001067112 XM_236609
VERSION     NM_001108179.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5649)
  AUTHORS   Remeseiro,S., Cuadrado,A., Kawauchi,S., Calof,A.L., Lander,A.D. and
            Losada,A.
  TITLE     Reduction of Nipbl impairs cohesin loading locally and affects
            transcription but not cohesion-dependent functions in a mouse model
            of Cornelia de Lange Syndrome
  JOURNAL   Biochim Biophys Acta 1832 (12), 2097-2102 (2013)
   PUBMED   23920377
REFERENCE   2  (bases 1 to 5649)
  AUTHORS   Faure,A.J., Schmidt,D., Watt,S., Schwalie,P.C., Wilson,M.D., Xu,H.,
            Ramsay,R.G., Odom,D.T. and Flicek,P.
  TITLE     Cohesin regulates tissue-specific expression by stabilizing highly
            occupied cis-regulatory modules
  JOURNAL   Genome Res 22 (11), 2163-2175 (2012)
   PUBMED   22780989
REFERENCE   3  (bases 1 to 5649)
  AUTHORS   Bermudez,V.P., Farina,A., Higashi,T.L., Du,F., Tappin,I.,
            Takahashi,T.S. and Hurwitz,J.
  TITLE     In vitro loading of human cohesin on DNA by the human Scc2-Scc4
            loader complex
  JOURNAL   Proc Natl Acad Sci U S A 109 (24), 9366-9371 (2012)
   PUBMED   22628566
REFERENCE   4  (bases 1 to 5649)
  AUTHORS   Remeseiro,S., Cuadrado,A., Gomez-Lopez,G., Pisano,D.G. and
            Losada,A.
  TITLE     A unique role of cohesin-SA1 in gene regulation and development
  JOURNAL   EMBO J 31 (9), 2090-2102 (2012)
   PUBMED   22415368
REFERENCE   5  (bases 1 to 5649)
  AUTHORS   Watrin,E., Schleiffer,A., Tanaka,K., Eisenhaber,F., Nasmyth,K. and
            Peters,J.M.
  TITLE     Human Scc4 is required for cohesin binding to chromatin,
            sister-chromatid cohesion, and mitotic progression
  JOURNAL   Curr Biol 16 (9), 863-874 (2006)
   PUBMED   16682347
REFERENCE   6  (bases 1 to 5649)
  AUTHORS   Gregson,H.C., Schmiesing,J.A., Kim,J.S., Kobayashi,T., Zhou,S. and
            Yokomori,K.
  TITLE     A potential role for human cohesin in mitotic spindle aster
            assembly
  JOURNAL   J Biol Chem 276 (50), 47575-47582 (2001)
   PUBMED   11590136
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            [WARNING] On Oct 8, 2024 this sequence was replaced by
            NM_001108179.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_236609.4, XM_001067112.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16093046
                              [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5649
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..5649
                     /gene="Stag1"
                     /note="STAG1 cohesin complex component"
                     /db_xref="GeneID:315958"
                     /db_xref="RGD:1310744"
     exon            1..222
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..324
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..3664
                     /gene="Stag1"
                     /note="stromal antigen 1"
                     /codon_start=1
                     /product="cohesin subunit SA-1"
                     /protein_id="NP_001101649.1"
                     /db_xref="GeneID:315958"
                     /db_xref="RGD:1310744"
                     /translation="MITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPP
                     STNKKPRKSPGEKSRIEAGIRGVGRGRANGHPQQNGEGDPVTLFEVVKLGKSAMQSVV
                     DDWIESYKQDRDIALLDLINFFIQCSGCRGTVRIEMFRNMQNAEIIRKMTEEFDEDSG
                     DYPLTMPGPQWKKFRSNFCEFIGVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAF
                     RHTSTLAAMKLMTALVNVALNLSIHQDNTQRQYEAERNKMIGKRANERLELLLQKRKE
                     LQENQDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKY
                     VGWTLHDRQGEVRLKCLKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVE
                     AIRLVTLILHGSEEALSNEDCENVYHLVYSAHRPVAVAAGEFLHKKLFSRHDPQAEEA
                     LAKRRGRNSPNGNLIRMLVLFFLESELHEHAAYLVDSLWESSQELLKDWECMTELLLE
                     EPVQGEEAMSDRQESALIELMVCTIRQAAEAHPPVGRGTGKRVLTAKERKTQIDDRNK
                     LTEHFIITLPMLLSKYSADAEKVANLLQIPQYFDLEIYSTGRMEKHLDALLKQIKFVV
                     EKHVESDVLEACSKTYSILCSEEYTIQNRVDIARSQLIDEFVDRFNHSVEDLLQEGEE
                     ADDDDIYNVLSTLKRLTSFHNAHDLTKWDLFGNCYRLLKTGIEHGAMPEQIVVQALQC
                     SHYSILWQLVKITDGSPSKYYNDYGDIIKETLSKTRQIDKIQCAKTLILSLQQLFNEL
                     VQEQGPNLDRTSAHVSGIKELARRFALTFGLDQIKTREAVATLHKDGIEFAFKYQNQK
                     GQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLTEQMMERREDVWLPLISYRN
                     SLVTGGEDDRMSVNSGSSSSKTSSVRSKKGRPPLHRKRAEDESLDNTWLNRTDTMIQT
                     PGPLPTPQLTSTVLRENSRPMGEQIQEPESEHGSEPDFLHNPQMQISWLGQPKLEDLN
                     RKDRTGMNYMKVRAGVRHAVRGLMEEDAEPIFEDVMMSSRSQLEDMNEEFEDTMVIDL
                     PPSRNRRERAELRPDFFDSAAIIEDDSGFGMPMF"
     exon            325..427
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..592
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..689
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..766
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..971
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1123
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1197
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1321
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1420
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1500
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1608
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1723
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1841
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1945
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2038
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2128
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2332
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2403
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2491
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2572
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2674
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2823
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2952
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3158
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3333
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..3444
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3559
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3640
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
     exon            3641..5649
                     /gene="Stag1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagagggc ggtcgggacc caagtctgca gcggcgccat tggcgtgtgg aaaatgccac
       61 cagatggcgg gttaggattg cagctccgtt gaaggcgcgg cccccgctcc cgaacccccg
      121 gcgaccaccc cgtaacaacc cccccacatc gggaataaca caccggagac ttttgggggg
      181 aaactaggtc gacggccgac agcgcccgga tgggcagctg aggtgtggct ttgaggttgt
      241 gtaacaagtt tgaattatcc agaactttct gtactgtggc atagtctctc ccgcaatgat
      301 tacttcagag ttaccagtgt tacaggattc aactaatgaa actactgccc attctgatgc
      361 tggcagcgaa cttgaagaaa cagaggtcaa aggaaagaga aaaaggggtc gtcctggccg
      421 gcctccatca acaaataaga aacctcgaaa atctccagga gaaaagagca gaattgaagc
      481 tggaattaga ggagtgggtc gcggaagagc taatgggcac cctcaacaga acggcgaagg
      541 ggatcccgtc accttatttg aggtggtgaa gctggggaag agtgcaatgc agtctgtggt
      601 ggatgactgg attgaatcat ataaacaaga ccgggacatc gcacttctgg atttaatcaa
      661 cttttttatc cagtgttcag gatgtcgagg tactgtcaga atagagatgt ttcgaaatat
      721 gcagaacgca gaaataatca gaaaaatgac tgaagaattt gatgaggaca gtggtgacta
      781 cccccttacc atgcctggtc ctcagtggaa aaaatttcgt tccaattttt gtgaatttat
      841 tggagtcctg attcgacagt gtcaatatag cataatttat gatgaatata tgatggacac
      901 cgtaatttcc cttttgactg gtttgtcaga ctcccaggtc agagctttta ggcatacaag
      961 tacccttgct gcaatgaagc tgatgactgc tctggtgaat gttgccttaa acctcagtat
     1021 tcatcaggat aatacacaga ggcaatacga agccgagaga aataaaatga ttgggaagag
     1081 agccaatgaa aggctggagt tactacttca gaaacgtaaa gagctacaag aaaatcaaga
     1141 tgaaattgaa aatatgatga actctatttt taagggtata tttgttcata gataccgtga
     1201 tgcaattgct gaaattcgag ccatctgtat tgaagaaatt ggagtatgga tgaaaatgta
     1261 tagcgatgcc ttcctcaatg acagttacct gaaatatgta ggatggactc ttcatgatag
     1321 gcaaggtgaa gtcagactga agtgtttgaa agctctacaa agcctgtata ccaatagaga
     1381 attattcccc aaattggagc tgtttactaa tcgattcaag gatcgcattg tatcaatgac
     1441 tcttgacaaa gaatatgatg ttgctgtgga agccatccgg ttggttactc tgatacttca
     1501 tggaagtgaa gaagctcttt ccaatgaaga ctgtgaaaac gtctaccatt tggtgtactc
     1561 agcacatcgc cctgttgctg tggcagctgg agagtttctg cacaaaaagc tgtttagcag
     1621 acatgaccca caagctgagg aagcattagc aaagagaaga ggaagaaaca gtccaaatgg
     1681 gaacctcatt aggatgcttg ttcttttctt tcttgaaagt gagttacatg aacatgcagc
     1741 ctacttggtg gacagcttgt gggagagctc tcaagaactg ttgaaagact gggaatgtat
     1801 gacagagtta ctattagaag aacctgttca aggagaggaa gccatgtctg accgtcagga
     1861 gagcgctctt atagagctaa tggtctgtac aattcgtcaa gcagctgagg cacatcctcc
     1921 agtgggaagg ggaaccggca agagagtgct aacagccaaa gaaaggaaaa ctcaaattga
     1981 tgatagaaat aaattaactg aacattttat cattacactt cctatgttac tatcaaagta
     2041 ttctgcagat gcagagaagg tagcgaactt gctgcagatt ccacagtatt ttgatctgga
     2101 aatctacagc acaggtcgga tggaaaagca cctggatgct ttattaaaac agattaagtt
     2161 tgttgtagag aaacatgtag agtcagatgt cctagaagcc tgcagtaaaa cctacagcat
     2221 tttatgcagt gaagagtaca ccattcaaaa tcgagtcgat attgctcgga gccagctcat
     2281 tgatgaattt gtagatcgat tcaatcattc tgtagaagac ctattgcaag agggtgaaga
     2341 agctgatgat gatgatatct acaatgttct ttccacctta aagcgtttaa cttcttttca
     2401 caatgctcat gatctcacta aatgggatct gtttggtaat tgctacagac tattgaagac
     2461 tggaattgaa catggagcta tgccagaaca gatagtcgta caagcactgc agtgttccca
     2521 ttactcaatt ctttggcagc tggtgaaaat tactgatggt tctccttcca aatattacaa
     2581 tgactatggt gatattatta aggaaaccct gagtaagacc aggcagattg ataagattca
     2641 gtgtgctaag actctcattc tcagtctaca acagttgttt aatgaacttg ttcaagaaca
     2701 aggtcctaat ctggatagga catcggccca tgtcagtgga attaaagaac tggcacgtcg
     2761 ttttgccctt acatttggat tggaccagat caagacccga gaagcagttg ccacacttca
     2821 caaggatgga atagagtttg cctttaaata ccagaatcag aaaggacaag agtatccacc
     2881 tcctaatctg gcttttcttg aagtactaag tgaattttct tctaaactcc ttcgacagga
     2941 caagaaaact gtccattcct atcttgaaaa attcctcact gagcagatga tggaaaggag
     3001 ggaggatgta tggcttccac tcatctcgta tagaaattcg ttagtcactg ggggtgaaga
     3061 cgacagaatg tctgtgaaca gtggaagtag cagcagtaaa acttcctcag tgcgcagtaa
     3121 gaaaggaaga cccccactgc acagaaaacg agcagaagat gaaagtctgg ataacacatg
     3181 gctaaatagg actgacacaa tgattcagac tcctggaccc ttgccaaccc cacagctcac
     3241 ctccactgta cttagagaga acagccgtcc catgggagag cagattcagg agcctgagtc
     3301 tgagcatggt tctgaaccag actttttaca caatccccag atgcagatct cttggttagg
     3361 ccagccgaag ttagaagact tgaatcggaa ggacagaaca ggaatgaact acatgaaagt
     3421 gagagctgga gtaaggcatg ctgttcgggg tctaatggag gaagatgctg agcccatctt
     3481 tgaagatgtg atgatgtcat cacggagcca gttagaagac atgaatgaag aatttgaaga
     3541 caccatggtt attgatttgc ccccatcaag aaatcggcga gagcgagctg agctaaggcc
     3601 agacttcttt gactctgcag ctatcataga agatgattca ggatttggaa tgcctatgtt
     3661 ctgaagtctg aagaaaattt acaaatctgg aactctatta tttagagcta gaggcctata
     3721 tactgtgata gcttgtatgg gggagaaaac acttttgatg tgatcttatt tgttttgtaa
     3781 tcaaatgatt aaaggttggt cccttttgca gtgacagagc agcatgtcag tcacccatgg
     3841 aaatatttgt gaatgtcacc tcggaaagac tgaccaaaaa aatcatttgt actctaatgt
     3901 tggacttatc tcagtacaga tgtgtgtgtg tttttctgaa aggaggaaga tattttaaat
     3961 ttttaaaaca actgtcaaaa taaacactgt tatacacctg ttttatgaaa attcagcatt
     4021 gagtaaaaaa aaaatatttt taactttatt ttcctgttgt acaatttaaa aaccgtttta
     4081 acattttgcc tttttatgtt ttaaaagcta accattttta ttaaactatg agtaagcagc
     4141 tcgttctaat cgccgaagag tgtttttgga gttcgctggg ttttcttgac cttgtaaagc
     4201 agacgttgaa ggaacagagc atggacaagc taaaatagag ttctaacatc gtgcatctct
     4261 gccaaaaacc acatgccctc tgtgggtgga tatgaatccc cagattttat atactcttga
     4321 ataaaaaggt ttatttttat ttataagtgg gcataaagtg cccatgcagc catttttcca
     4381 acagatgctg tacaccgttc attttctata ggatagtgag attcaaatac agtgcatttt
     4441 ctattggtct ttgttctgta catttttagc aacttctacc agcaaataaa gtattctcag
     4501 taaaacaaaa tggttctcaa gttatcggtc tcactgttgt taacacttgt ttcataccct
     4561 gccaaaagtc acgttacaca gacttccgtt ttcttagaat catgaaattt ttctttgtca
     4621 ttcagaagtt aattttaagg cgtgtaacgt aactgtcttc ttcccatgca ctcaataccc
     4681 cctcaacccg ctaattttgt gaaattgttt accaatcata gatgtatgtg ctgcatagaa
     4741 gtctgtgctt agagggtggc aattctgagc ttaccttgaa atacagctac atttcagtgt
     4801 taagtgtgca tattaagaga aattcttttg gagaaagaaa ttgactcttc gggacagtct
     4861 tcagtggctt agagttacac tccgcttatg tttatgactt gctattgttt aagagtccac
     4921 atagcttttc cctgatttta gtgtaggctt ccaaatttct aagccagtct gtccacaact
     4981 gtttctgggc tggtttttaa aatagctgcg acagaatcga gaggctttcc ctttttacca
     5041 aaaatgaaca ttttttaaaa atatatgaac tctatgatta tcttttgtgt ggaaaaataa
     5101 aacatgattt tattcatcct tttagtagac aagatttttc tcaacatttg tacagttcag
     5161 agatttaaaa aaacaaaaaa caaaccttgg tcaccaaaaa cgttttacct actaactcag
     5221 caagtcctag gctctggtta agacatctgg ggccccgctc tctcctagca atgtgggctt
     5281 cactggaact caagggcagg aatgaatgga ctatacacct cagccctgcc tcactgtagt
     5341 tctcggccag ggacccagct ttgaggagcc ctggaataag cacagataat cctttgactg
     5401 tcagtctcct gtgaacaaca catgctgatt taagggttac agactaccat gtaacaacaa
     5461 agacggctta atctctactc cagtgggttt ccaagttcag tttgaagtca atcaaatttt
     5521 tgtattttca gtgtctcctt gattggtttt gctagtaatt ctgtaaattg tacatttgca
     5581 atatgatgtt tttttttcct tttgtacaat ttgaaactga tgcttcacct ttcctttaat
     5641 aaactattc
//
