LOCUS       NM_001130558            1546 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SH3 and cysteine rich domain 3 (Stac3), mRNA.
ACCESSION   NM_001130558 XM_001056439 XM_343222
VERSION     NM_001130558.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1546)
  AUTHORS   Bi,X., Liu,J., Xu,S., Wang,Y. and Wu,X.
  TITLE     Testicular STAC3 regulates Leydig cell steroidogenesis through
            potentiating mitochondrial membrane potential and StAR processing
  JOURNAL   Cell Tissue Res 384 (1), 195-209 (2021)
   PUBMED   33409656
  REMARK    GeneRIF: Testicular STAC3 regulates Leydig cell steroidogenesis
            through potentiating mitochondrial membrane potential and StAR
            processing.
REFERENCE   2  (bases 1 to 1546)
  AUTHORS   Polster,A., Nelson,B.R., Papadopoulos,S., Olson,E.N. and Beam,K.G.
  TITLE     Stac proteins associate with the critical domain for
            excitation-contraction coupling in the II-III loop of CaV1.1
  JOURNAL   J Gen Physiol 150 (4), 613-624 (2018)
   PUBMED   29467163
REFERENCE   3  (bases 1 to 1546)
  AUTHORS   Campiglio,M. and Flucher,B.E.
  TITLE     STAC3 stably interacts through its C1 domain with CaV1.1 in
            skeletal muscle triads
  JOURNAL   Sci Rep 7, 41003 (2017)
   PUBMED   28112192
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1546)
  AUTHORS   Polster,A., Nelson,B.R., Olson,E.N. and Beam,K.G.
  TITLE     Stac3 has a direct role in skeletal muscle-type
            excitation-contraction coupling that is disrupted by a
            myopathy-causing mutation
  JOURNAL   Proc Natl Acad Sci U S A 113 (39), 10986-10991 (2016)
   PUBMED   27621462
REFERENCE   5  (bases 1 to 1546)
  AUTHORS   Reinholt,B.M., Ge,X., Cong,X., Gerrard,D.E. and Jiang,H.
  TITLE     Stac3 is a novel regulator of skeletal muscle development in mice
  JOURNAL   PLoS One 8 (4), e62760 (2013)
   PUBMED   23626854
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1546)
  AUTHORS   Horstick,E.J., Linsley,J.W., Dowling,J.J., Hauser,M.A.,
            McDonald,K.K., Ashley-Koch,A., Saint-Amant,L., Satish,A., Cui,W.W.,
            Zhou,W., Sprague,S.M., Stamm,D.S., Powell,C.M., Speer,M.C.,
            Franzini-Armstrong,C., Hirata,H. and Kuwada,J.Y.
  TITLE     Stac3 is a component of the excitation-contraction coupling
            machinery and mutated in Native American myopathy
  JOURNAL   Nat Commun 4, 1952 (2013)
   PUBMED   23736855
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 28, 2008 this sequence version replaced
            XM_001056439.1, XM_343222.3.
FEATURES             Location/Qualifiers
     source          1..1546
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1546
                     /gene="Stac3"
                     /note="SH3 and cysteine rich domain 3"
                     /db_xref="GeneID:362895"
                     /db_xref="RGD:1308964"
     exon            1..39
                     /gene="Stac3"
                     /inference="alignment:Splign:2.1.0"
     exon            40..201
                     /gene="Stac3"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1221
                     /gene="Stac3"
                     /codon_start=1
                     /product="SH3 and cysteine-rich domain-containing protein
                     3"
                     /protein_id="NP_001124030.1"
                     /db_xref="GeneID:362895"
                     /db_xref="RGD:1308964"
                     /translation="MTEKEVVESPQPPFPGETPQSGLQRLKQLFKKGSPETTEMEPPP
                     EPQANGEAVGAGGGPIYYIYEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFC
                     DVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQKCFGKIPPGFHRAYSSPLYSNQQ
                     YACVSAANRNDPVFETLRVGVIMANKERKKGQADKKNPLAAMMEEEPESARPEEGKSQ
                     DGNDAEKDKKAEKKTPDDKNKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDD
                     SNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQK
                     GDEAGGYVKVYTGRKVGLFPTDFLEEI"
     exon            202..466
                     /gene="Stac3"
                     /inference="alignment:Splign:2.1.0"
     exon            467..564
                     /gene="Stac3"
                     /inference="alignment:Splign:2.1.0"
     exon            565..628
                     /gene="Stac3"
                     /inference="alignment:Splign:2.1.0"
     exon            629..726
                     /gene="Stac3"
                     /inference="alignment:Splign:2.1.0"
     exon            727..793
                     /gene="Stac3"
                     /inference="alignment:Splign:2.1.0"
     exon            794..846
                     /gene="Stac3"
                     /inference="alignment:Splign:2.1.0"
     exon            847..932
                     /gene="Stac3"
                     /inference="alignment:Splign:2.1.0"
     exon            933..984
                     /gene="Stac3"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1122
                     /gene="Stac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1546
                     /gene="Stac3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtcctcc aactctgtca cttcagctct accaccacgt ttctcccaaa ccctcccctt
       61 caagggccac cctactgtgc ggcaggaaca ctgggataga attagatctc atagtggggt
      121 ccaacctctt gtaggatgac agaaaaggag gtggtggagt cccctcagcc cccctttcca
      181 ggagagactc cgcaaagtgg gctacagcga ctgaagcaat tattcaagaa gggctctcca
      241 gagacaaccg agatggagcc tcccccagag ccccaggcca atggagaagc cgtgggggct
      301 gggggtggcc ccatctacta tatctatgag gaagaagaag aggaggagga agaggaagaa
      361 ccacccccag aacctcctaa gcttgtcaat gacaagcccc acaagttcaa agatcatttc
      421 ttcaagaagc ccaagttctg tgatgtctgt gcccggatga ttgtgctcaa taacaagttt
      481 ggactccgct gtaagaactg caaaaccaac atccatgaac actgtcagtc ctacgtggag
      541 atgcagaaat gcttcggcaa gatcccacct ggtttccatc gggcctatag ctccccactc
      601 tacagcaacc agcagtatgc ttgtgtctct gctgccaatc gcaatgaccc tgtgtttgaa
      661 accctacgcg tcggggtgat catggcaaac aaggaacgga agaaggggca ggcagataag
      721 aaaaatcctc tggcagccat gatggaggag gagccagagt cagccaggcc agaggagggc
      781 aagtcacagg atggaaacga tgcagaaaag gacaagaagg ctgagaagaa aacacctgat
      841 gataaaaaca agcaacctgg tttccagcag tctcattact ttgtggctct ctatcggttc
      901 aaagccctgg agaaggatga tctggatttc ccaccagggg agaagatcac agtcattgat
      961 gactccaatg aggagtggtg gcgggggaaa atcggagaga aggtgggatt cttccctcca
     1021 aacttcatca ttcgggtccg ggctggagaa cgtgtgcacc gtgtaaccag atcctttgtg
     1081 ggaaaccgcg agattgggca gatcactctc aagaaggacc agatcgtagt gcagaaagga
     1141 gatgaagctg gtggctacgt caaggtctac accggccgca aggtggggct gtttcccacc
     1201 gacttcctgg aggagattta ggtgtactgg cgcctgctgg cgggagacac ccacgccccg
     1261 ttctgggcgg ggcccagtgc gggctgggga gggaaggggc agggggacga ggagggtcgg
     1321 aaaggcccac cagagcataa tgacgtttct ggggagggtc tggctcctac ctctcccctg
     1381 cctagggctt cggatacctg gtgcgctgag catcctgcac cgataaggcc cacacttcag
     1441 gtccatccaa acctcaagag ctttggggtg agggtgggga agcatctcca taaggagggg
     1501 cagagctgtc aaatgtttgg aatttattaa agttttgaca aaagtt
//
