LOCUS       NM_001399483            3067 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SH3 and cysteine rich domain 2 (Stac2), mRNA.
ACCESSION   NM_001399483 XM_006247383
VERSION     NM_001399483.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3067)
  AUTHORS   Polster,A., Dittmer,P.J., Perni,S., Bichraoui,H., Sather,W.A. and
            Beam,K.G.
  TITLE     Stac Proteins Suppress Ca2+-Dependent Inactivation of Neuronal
            l-type Ca2+ Channels
  JOURNAL   J Neurosci 38 (43), 9215-9227 (2018)
   PUBMED   30201773
  REMARK    GeneRIF: There is a large postnatal increase in Stac2 expression in
            forebrain and cerebellum.
REFERENCE   2  (bases 1 to 3067)
  AUTHORS   Polster,A., Nelson,B.R., Papadopoulos,S., Olson,E.N. and Beam,K.G.
  TITLE     Stac proteins associate with the critical domain for
            excitation-contraction coupling in the II-III loop of CaV1.1
  JOURNAL   J Gen Physiol 150 (4), 613-624 (2018)
   PUBMED   29467163
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jan 10, 2022 this sequence version replaced XM_006247383.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1408953.1, AM903074.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-570               JAXUCZ010000010.1  83544014-83544583   c
            571-877             JAXUCZ010000010.1  83536144-83536450   c
            878-975             JAXUCZ010000010.1  83535060-83535157   c
            976-1066            JAXUCZ010000010.1  83534820-83534910   c
            1067-1179           JAXUCZ010000010.1  83534176-83534288   c
            1180-1252           JAXUCZ010000010.1  83534018-83534090   c
            1253-1314           JAXUCZ010000010.1  83533864-83533925   c
            1315-1412           JAXUCZ010000010.1  83533322-83533419   c
            1413-1464           JAXUCZ010000010.1  83532998-83533049   c
            1465-1602           JAXUCZ010000010.1  83532605-83532742   c
            1603-3067           JAXUCZ010000010.1  83528741-83530205   c
FEATURES             Location/Qualifiers
     source          1..3067
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..3067
                     /gene="Stac2"
                     /note="SH3 and cysteine rich domain 2"
                     /db_xref="GeneID:363674"
                     /db_xref="RGD:1305548"
     exon            1..570
                     /gene="Stac2"
                     /inference="alignment:Splign:2.1.0"
     CDS             481..1707
                     /gene="Stac2"
                     /codon_start=1
                     /product="SH3 and cysteine-rich domain-containing protein
                     2"
                     /protein_id="NP_001386412.1"
                     /db_xref="GeneID:363674"
                     /db_xref="RGD:1305548"
                     /translation="MTEMSEKENEPDDAATHTPPGTVSTLQETKLQRFKRSLSLKTIL
                     RSKSVENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPASTDRGLPTPTPSPCPVPRPL
                     APLKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKTCKVSVHLWCSEEISHQQ
                     CPGKTSTSFRRNFSSPLLVHEPPPACAMSKESPPTGTSGKVDPVYETLRYGTSLALMN
                     RSSFSSTSESPTRSLSERDELTEDGEGSIRSSEEGPGDSVFTAPVESEGSGAEEKSPG
                     QQPPKLPVRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDR
                     VGFFPANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVSRSKDSDGFIRVS
                     SGKKRGLVPVDSLAEI"
     exon            571..877
                     /gene="Stac2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..975
                     /gene="Stac2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1066
                     /gene="Stac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1179
                     /gene="Stac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1252
                     /gene="Stac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1314
                     /gene="Stac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1412
                     /gene="Stac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1464
                     /gene="Stac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1602
                     /gene="Stac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..3067
                     /gene="Stac2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgacctc ctaaatcaaa gttgggaggc taggactggg cggaggggcc gccgggtgca
       61 aggctggggc ccgcgcgggg agggggaggg agatgggggg cgggcgcaga ggacggcgga
      121 gccggccgga ctcggacagc tcggtcgctc cctgtctctg cacatccgcg catccctact
      181 tccctcctcc tcccgcggag cgcagcatcc tctgcagacc cttggtcctc acaccccggg
      241 tcgtcccgct ccggcggctc ggtgtaattg ccgccctctc ccctgccaca ccgacaactt
      301 tcttccctgg tgcctggggt tagggggctg ctttgcctgg gagggtttct cctagggtca
      361 ctggagagca gaccctggag aaaggcttga gagtcccaaa gagacgcccg ccactcacag
      421 cctgcccccg gcgggcctgc cgtcgggtct ccgtaccttc tcttccttta taccccaacc
      481 atgaccgaaa tgagcgagaa ggagaatgaa ccggatgacg cggccaccca tactccccca
      541 gggaccgtct ccaccctcca agaaaccaag ctccagcgat ttaagcgttc cctctccctc
      601 aaaactatcc ttcgaagtaa gagtgtggag aacttcttcc tccgctcagg ctctgagctg
      661 aagtgcccaa cagaggtgct gctgacacca ccaaccccac tgcctcctcc ttctccacca
      721 cctgcctcca cagacagggg tctacccacc ccgaccccct ctccgtgccc agtccctcgc
      781 cccttggcac cactcaaacc agtgaggctg cacagcttcc aggaacacgt cttcaagaga
      841 gccagccctt gtgagctgtg ccaccagctc attgtgggaa actccaagca gggcttgcgg
      901 tgtaagacat gcaaggtcag cgttcacctc tggtgctccg aggagatctc tcaccagcaa
      961 tgcccgggca agacatccac atcttttcga cgcaacttca gctccccact cctggtgcac
     1021 gagccgccac cagcctgtgc catgagcaaa gagtccccac ctaccgggac cagcgggaag
     1081 gtggacccag tttatgagac cctgcgctac ggcacctccc tggcactgat gaaccggtct
     1141 agcttcagca gcacgtctga gtcccccaca cggagcctga gtgagcgtga tgagctaaca
     1201 gaagatgggg aaggcagcat ccgcagctca gaagagggac ctggtgacag tgtattcaca
     1261 gccccagtgg agagtgaagg ctcaggagca gaggagaaga gccctggaca gcagccccca
     1321 aagttgcccg tgcggaagga tgtggggccc atgtactcct atgttgccct ctacaagttc
     1381 ctgccccagg agaacaatga cctggcactg cagcccggag atcggatcat gctggtggat
     1441 gactctaacg aagactggtg gaagggcaag atcggcgacc gggttggctt cttcccggcc
     1501 aattttgtgc agcgggtgag gccgggagag aatgtttggc gatgctgtca gcccttctct
     1561 ggaaacaagg agcaaggtta catgagtctc aaggagaatc agatttgcgt gggcgtgagc
     1621 agaagcaagg atagtgatgg cttcatccgc gtcagcagtg gcaagaagcg gggtttggtg
     1681 ccagtcgact ccttggcaga gatctgacag aaaccgagag aacccagatg ctacccctgc
     1741 ccatgcctgg ctcttgcttc tggcctgaga aggaagcggg catcctggcc acacccttcc
     1801 tctccgcgtc tctctcctca gcgtcaccca ccccccactt aggagccttc tgcactgagg
     1861 aaggttttat ttcttgggtg gggtatcctg aatggggtga tcttctgggg cttggggaag
     1921 ggagtccaaa gtgggaagaa atgaggaagc tacagtaggt ccacccagag cccgagtacc
     1981 acctagtcgg gttgccgtag cgagtcccac cctagggagt aattagcctg ctgtctttca
     2041 gagactacct gcccatactg cctttgcatg cctgactcct ctctgcccac agcctttgct
     2101 tgggtctgcg tatccaccca cccctttgca agtggggcct tgagagagga tcttcagtgt
     2161 tcctcagccc tcctctctgg cttgagaaga cactgaggac tatgggagag ccctaagcta
     2221 accacccgtc accccttcaa ttctcaggaa agttcaggaa tctttccaat tacttgaaac
     2281 ctgtgcgaca gagcagggtc agggttgagg tctggaaggg gatgtaaccg gtagaggagt
     2341 ctgttccctt gaggacggtc cccacagaac agtctgattc tcctttatct acacgaaatc
     2401 tgtgtccaaa aggagcccgg acaaagaccc agtggagaag aagacactgg accctgtgtg
     2461 gtcaaaacct ttcactgtta gggctccaga aatccctatc accagaagca gacagctggg
     2521 ggttgtgagg tttgctttct ctgaaagccc tgccctcaga tggaccaact taccttctca
     2581 ctgggctcta tatggcgcat ccctgggagg aatgcctcgg gagatggagg aaggatatgc
     2641 aaagttcttt ttggccacag tcaaatggtg gtctaggaac ccttaaccct ccagggcagg
     2701 accaatgtcc ccttcctcaa aggctgcttt ttattcctgg tgccagcccc cctccttcca
     2761 agctccagac ccttcttttg agccctaatc ctgtcagcca atgccgccgc cccctccccc
     2821 gaccccgttc tgggtacagt cctgcctacc atacagtgag aggacaccaa ttctctaccc
     2881 aacacacctt gccccacttt ttcccctaaa aggggactaa agccacactg ccctgtttgc
     2941 tgccatgagg gcccccccag caaaatcccc ggggcgggcc caatgcccac tgtacatgag
     3001 gctgcatgat gggtctgtgg gggcgttgct gagcccccag gcccataatt aaatgtttct
     3061 tgtctca
//
