LOCUS       NM_213624               3534 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ST8 alpha-N-acetyl-neuraminide
            alpha-2,8-sialyltransferase 6 (St8sia6), mRNA.
ACCESSION   NM_213624 XM_225584
VERSION     NM_213624.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3534)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3534)
  AUTHORS   Harduin-Lepers,A., Mollicone,R., Delannoy,P. and Oriol,R.
  TITLE     The animal sialyltransferases and sialyltransferase-related genes:
            a phylogenetic approach
  JOURNAL   Glycobiology 15 (8), 805-817 (2005)
   PUBMED   15843597
  REMARK    Erratum:[Glycobiology. 2005 Sep;15(9):21G]
REFERENCE   3  (bases 1 to 3534)
  AUTHORS   Takashima,S., Ishida,H.K., Inazu,T., Ando,T., Ishida,H., Kiso,M.,
            Tsuji,S. and Tsujimoto,M.
  TITLE     Molecular cloning and expression of a sixth type of alpha
            2,8-sialyltransferase (ST8Sia VI) that sialylates O-glycans
  JOURNAL   J Biol Chem 277 (27), 24030-24038 (2002)
   PUBMED   11980897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Sep 28, 2022 this sequence version replaced NM_213624.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.58245.1,
                                           SRR26643292.58534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               JAXUCZ010000017.1  81792220-81792732   c
            514-612             JAXUCZ010000017.1  81791627-81791725   c
            613-702             JAXUCZ010000017.1  81726843-81726932   c
            703-789             JAXUCZ010000017.1  81697528-81697614   c
            790-934             JAXUCZ010000017.1  81664539-81664683   c
            935-1047            JAXUCZ010000017.1  81660316-81660428   c
            1048-1140           JAXUCZ010000017.1  81657255-81657347   c
            1141-3534           JAXUCZ010000017.1  81653687-81656080   c
FEATURES             Location/Qualifiers
     source          1..3534
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..3534
                     /gene="St8sia6"
                     /gene_synonym="Siat8f"
                     /note="ST8 alpha-N-acetyl-neuraminide
                     alpha-2,8-sialyltransferase 6"
                     /db_xref="GeneID:291325"
                     /db_xref="RGD:1303161"
     exon            1..513
                     /gene="St8sia6"
                     /gene_synonym="Siat8f"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..1609
                     /gene="St8sia6"
                     /gene_synonym="Siat8f"
                     /function="adds sialic acid to another sialic acid"
                     /note="alpha 2,8-sialyltransferase; sialyltransferase 8F
                     (alpha-2, 8-sialyltransferase); ST8
                     alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 6"
                     /codon_start=1
                     /product="alpha-2,8-sialyltransferase 8F"
                     /protein_id="NP_998789.1"
                     /db_xref="GeneID:291325"
                     /db_xref="RGD:1303161"
                     /translation="MRPGGTLFALVGSLMLLLLLRLFWCPADAPARSRMLGEESREET
                     GGTSAALKTLWSPTTPVPRTRNSTYLDEKTPETAEKCKGLKYSLDSLANKTRRYSEDD
                     YLQIVTNIQRCPWKRQAEEYENFRAKLASCCDAIQDFVVSQNNTPVGSNMTYEVESKK
                     QIPIRENIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGAEIDKSDFVFRCNLPPI
                     TGSASQDVGSKTNLVTVNPSIITLKYKNLKEKKARFLEDISAYGDAFLLLPAFSYRVN
                     TGISFKVYQTLKESKVRQKVLFFHPRYLRHLALFWRTKGVTAYRLSTGLMIASIAVEL
                     CENVTLYGFWPFSKTVEEIPLSHHYYDNKLPKHGFHQMPKEYSQMLQLHMKGILKLQF
                     SKCEAA"
     exon            514..612
                     /gene="St8sia6"
                     /gene_synonym="Siat8f"
                     /inference="alignment:Splign:2.1.0"
     exon            613..702
                     /gene="St8sia6"
                     /gene_synonym="Siat8f"
                     /inference="alignment:Splign:2.1.0"
     exon            703..789
                     /gene="St8sia6"
                     /gene_synonym="Siat8f"
                     /inference="alignment:Splign:2.1.0"
     exon            790..934
                     /gene="St8sia6"
                     /gene_synonym="Siat8f"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1047
                     /gene="St8sia6"
                     /gene_synonym="Siat8f"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1140
                     /gene="St8sia6"
                     /gene_synonym="Siat8f"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..3534
                     /gene="St8sia6"
                     /gene_synonym="Siat8f"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcggcgg cggcagcagt aggcagaggc agcggcagtg gtagcggcgg ctgcagcgac
       61 cagagcccgc agcggctccg agcgcctccg gcaggacaag aggcgagctc ggaggatcgt
      121 catctgctag ctgtccacca gcttcggcag ccaggggctg gcttgaaaga agcgggcgag
      181 cccggaggct gcttgcttcc ttggctccgt acccggcaac actgttgcag gctgggctcc
      241 gggcagcccc cagagtgcgg gcccgcgcca ccgcctttga acgctggggg tgtgcgtggc
      301 agcggccgcg gtggcggcgg cggcggcggc ggtgaccgga gcggcgagtc ggtgccgccc
      361 gggctgcgct tcgcctcggc agctttggcg gcgagggcgc ccgtggctca ggatgcgacc
      421 cgggggtacg ctgttcgccc tggtaggcag cctgatgctg ctgctccttc tgcgtctgtt
      481 ctggtgccca gccgacgcgc ccgcccgctc caggatgttg ggggaggaaa gcagagagga
      541 gaccggcggt acctcggctg cactgaagac gctctggagc cctacgaccc cagtgccacg
      601 caccaggaac agcacatatc tggacgagaa gacacccgag actgcagaga aatgcaaagg
      661 cctgaaatat agcttggact ctttagctaa caaaacgaga cggtactctg aggatgacta
      721 cctccagatc gtcacaaaca ttcagagatg cccgtggaaa cgccaagcag aagaatatga
      781 aaattttaga gcaaaactag cttcctgttg cgatgccatt caagacttcg tggtttccca
      841 gaacaacact ccagtgggaa gtaacatgac ctacgaggtg gaaagcaaga aacaaatccc
      901 cattcgagag aacattttcc acatgtttcc agtgtcacag ccttttgtgg actatcccta
      961 caaccagtgt gcagtggttg gcaatggggg aattctgaac aagtctctct gtggagcaga
     1021 aattgacaag tctgacttcg tcttcaggtg taacctcccc cccatcacag ggagtgctag
     1081 tcaagatgtt ggaagcaaaa cgaatcttgt gactgtcaat cccagcatca taaccctgaa
     1141 atacaagaat ttgaaggaga agaaagcacg gtttctggag gatatttccg cctatgggga
     1201 cgcattcctc cttttgccag ccttttccta tcgggtcaac accggcatct cttttaaagt
     1261 ctaccaaaca ctcaaagagt ctaaagtgag gcaaaaggtt ctcttcttcc accccaggta
     1321 cctgagacac ctcgctcttt tctggagaac taaaggggtg actgcgtacc gcttgtccac
     1381 gggcttgatg atcgcgagca tcgcggtgga actgtgtgaa aatgtcacgc tctacggatt
     1441 ctggccgttc tctaagaccg tcgaagaaat tcctctgagc caccactact atgacaacaa
     1501 gctacctaag cacggtttcc accagatgcc taaggaatac agccaaatgc tccagctcca
     1561 tatgaaaggg atcctcaaac tgcagttcag caaatgtgaa gccgcttagc gtttcttaaa
     1621 gtgcgaacca tttcagtagg tggagtgggt gcatcgcagt gtctccaaac gtggatggag
     1681 aaaggcacag aacatggagg attgcacaag agctccccga cttggctaga ccaaagcccg
     1741 cccccgcccc cgctaccttt gcagccccca cgagtcactc attctaacct tcaatgttct
     1801 ttctctgaga atggaggtca cgatatcaga ctccgacaag taaaatgaga tcatgtttaa
     1861 atcggccata ggatttgatc tgaggcagcg actcgaggag tgcttcctcg ttcctattcg
     1921 tggtagccat tcccgccatt atcagagtgg tgacgaaact gtgcaactgt gccaaagagc
     1981 ccttctgaag agaatgtccg catcatgagg gtgcaccgag ctctccctca cagcccttcc
     2041 tttatcaata acctttccac tatcctcccc ctcccaaatg agtaccgaaa caaaacaccc
     2101 ttgatgattc aggaagaaaa cccttttcta cttagcaatg tgcctgcttc tgactcggtt
     2161 cacttgtgat gtaatctgcg ctgaggtgtt ggtgggattt ggggcgtttc ctcgcctctt
     2221 tcgtcaatac tttgcctacc tttatcagtt tgtgctagag cttccttctc tggggttctc
     2281 ttctttgggg ttctgctccc cctccacaca caccgacagg atccactcaa tgacataaag
     2341 tagttccagt atctgctact tctcacaggt tatcatatcc aggaagttac ccggccgact
     2401 tttttttttt aatagtaaac atctattgga tatcagacct ggggactgtt ggaggatatg
     2461 aagagattgt cactggcaga agagcgagtg tgtaccatta attgataaga cacggtagca
     2521 ggcgccatcg tgacagttat gagcacagtg ctggaaggat cataggcagg aacagttaaa
     2581 tctgattcca gtagaatcaa tgccaatatg tctatttcag ggaagagttg atttcacaat
     2641 taaaactaga aaacgaacca attcttagca agttaagtgg attcggggta aaaaaaaaaa
     2701 aatggaacaa gaggagaagg cggtttcctc gactatgatt ttccaaatga gtatgctgat
     2761 agtagactgt gaggttgcct gacacactct gtgttaggag agagtacagg gcatgggggt
     2821 ggtagctttt tgtccacact ggtgaagaag tgtgagtaat tcagagccaa tcacttcaca
     2881 aggaaggctt aggatagcag cgcctgacac attactccag ggaaagatga acgttttcat
     2941 gaaaaattgc actcattggc taagcatcag tcttgagtaa aatttgaata gatgttaaat
     3001 atgagcaatt tacacccctt acgtcccagg gatacccctt aatgtaagca catttcttag
     3061 gttatttgac ttattacata tttatgtgtg tacattcttg ttcatccacg gatgttccca
     3121 agaactagga gtctaggaga tgcggtccac ttgccaagaa aactataaat tttactcttt
     3181 acctctcacc tgagccagcg cattattcac tgatactttc ttgaaggaag attaccctgt
     3241 gaattcttca ttctgataca gtgtcacctt gtatttgaca tttgtaacgt gtcaagtttg
     3301 cttctctttc gttcttttat agccaatcaa acttgttagc tttagaaata tatcagaagt
     3361 tcatatataa atattttgca aagggtaaaa aggctttttg ttaaataaaa tcaaatgtat
     3421 ttattacctt cttctggtga atagaggttc ttttatgctg ctgctaatgg gtttaattag
     3481 ctttaaataa tctcctagca acattggtca tgtttcaatc ccactatttg caaa
//
