LOCUS       NM_001413108            2005 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ST8 alpha-N-acetyl-neuraminide
            alpha-2,8-sialyltransferase 5 (St8sia5), transcript variant 1,
            mRNA.
ACCESSION   NM_001413108 XM_006254968
VERSION     NM_001413108.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2005)
  AUTHORS   Bailey,M.J., Coon,S.L., Carter,D.A., Humphries,A., Kim,J.S.,
            Shi,Q., Gaildrat,P., Morin,F., Ganguly,S., Hogenesch,J.B.,
            Weller,J.L., Rath,M.F., Moller,M., Baler,R., Sugden,D.,
            Rangel,Z.G., Munson,P.J. and Klein,D.C.
  TITLE     Night/day changes in pineal expression of >600 genes: central role
            of adrenergic/cAMP signaling
  JOURNAL   J Biol Chem 284 (12), 7606-7622 (2009)
   PUBMED   19103603
  REMARK    GeneRIF: Expression of St8sia5 increases over 15 fold at night in
            the rat pineal gland.
REFERENCE   2  (bases 1 to 2005)
  AUTHORS   Harduin-Lepers,A., Mollicone,R., Delannoy,P. and Oriol,R.
  TITLE     The animal sialyltransferases and sialyltransferase-related genes:
            a phylogenetic approach
  JOURNAL   Glycobiology 15 (8), 805-817 (2005)
   PUBMED   15843597
  REMARK    Erratum:[Glycobiology. 2005 Sep;15(9):21G]
REFERENCE   3  (bases 1 to 2005)
  AUTHORS   Kono,M., Yoshida,Y., Kojima,N. and Tsuji,S.
  TITLE     Molecular cloning and expression of a fifth type of
            alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is
            similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and
            GT3
  JOURNAL   J Biol Chem 271 (46), 29366-29371 (1996)
   PUBMED   8910600
REFERENCE   4  (bases 1 to 2005)
  AUTHORS   Iber,H., Zacharias,C. and Sandhoff,K.
  TITLE     The c-series gangliosides GT3, GT2 and GP1c are formed in rat liver
            Golgi by the same set of glycosyltransferases that catalyse the
            biosynthesis of asialo-, a- and b-series gangliosides
  JOURNAL   Glycobiology 2 (2), 137-142 (1992)
   PUBMED   1606358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Oct 25, 2022 this sequence version replaced XM_006254968.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.38127.1,
                                           SRR26643295.56879.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-401               JAXUCZ010000018.1  73011587-73011987
            402-509             JAXUCZ010000018.1  73032873-73032980
            510-602             JAXUCZ010000018.1  73051134-73051226
            603-689             JAXUCZ010000018.1  73058833-73058919
            690-834             JAXUCZ010000018.1  73063207-73063351
            835-947             JAXUCZ010000018.1  73066251-73066363
            948-1040            JAXUCZ010000018.1  73070665-73070757
            1041-2005           JAXUCZ010000018.1  73072020-73072984
FEATURES             Location/Qualifiers
     source          1..2005
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..2005
                     /gene="St8sia5"
                     /gene_synonym="SATV; SIAT8-E; SIAT8E; ST8SiaV"
                     /note="ST8 alpha-N-acetyl-neuraminide
                     alpha-2,8-sialyltransferase 5"
                     /db_xref="GeneID:364901"
                     /db_xref="RGD:1302934"
     exon            1..401
                     /gene="St8sia5"
                     /gene_synonym="SATV; SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1509
                     /gene="St8sia5"
                     /gene_synonym="SATV; SIAT8-E; SIAT8E; ST8SiaV"
                     /EC_number="2.4.99.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-2,8-sialyltransferase 8E; ST8
                     alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 5;
                     sialyltransferase St8Sia V"
                     /codon_start=1
                     /product="alpha-2,8-sialyltransferase 8E isoform 1"
                     /protein_id="NP_001400037.1"
                     /db_xref="GeneID:364901"
                     /db_xref="RGD:1302934"
                     /translation="MRYADPSANRDLLGNRTLLFIFICAFALVTLLQQILYSKSYIKR
                     GFQFGWQRGDQQANWTGLFNASGSLTEQNISDSSSRYFEFYKEPLEFNSTRCLELRQE
                     ILEVKVLSMVKQSELFERWKSLQICKWAMDASEASLFKSTLSRCCNAPNFLFTTQKNT
                     PVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEI
                     NSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYE
                     NASVLLPAFYNVRNTLVSFRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARR
                     ISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVKPKPGFHAMPSEIFT
                     FLRMHSRGILRVHTGTCNCC"
     exon            402..509
                     /gene="St8sia5"
                     /gene_synonym="SATV; SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            510..602
                     /gene="St8sia5"
                     /gene_synonym="SATV; SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            603..689
                     /gene="St8sia5"
                     /gene_synonym="SATV; SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            690..834
                     /gene="St8sia5"
                     /gene_synonym="SATV; SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            835..947
                     /gene="St8sia5"
                     /gene_synonym="SATV; SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1040
                     /gene="St8sia5"
                     /gene_synonym="SATV; SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..2005
                     /gene="St8sia5"
                     /gene_synonym="SATV; SIAT8-E; SIAT8E; ST8SiaV"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgggcagat tggcggctgc gggacaccgg cgcccagaag ccgcagcacg agagggcagg
       61 cctgaggctc atccgacctc cacgcggcgg gccctgtcct tttgctgccg cggccgcgac
      121 tgcgcccacg ggaaactttg ccccaccaag tcctctgccc tcctggccac gccgtggcag
      181 ttcgcctaag ggcccccggg ggccccccgc acaacgcgcg tgattgccgc cccgccccgc
      241 acagtgcgtc cgcggcgccc ggccgccagg atgcgctacg cagacccctc ggccaacagg
      301 gatttgttgg ggaaccgaac tttgctcttc atcttcatct gcgccttcgc cttggtgacc
      361 ttgctccagc agatcctgta cagcaagagc tacatcaaga gaggcttcca gtttggttgg
      421 cagaggggcg accaacaggc caattggact gggctcttta atgccagcgg cagcctaaca
      481 gagcagaaca tcagtgactc cagctccagg tacttcgaat tttacaagga acctttagaa
      541 tttaactcca cgagatgcct ggagctgagg caggagatcc tggaggtgaa ggtgctgtcc
      601 atggtgaagc agtctgaact gttcgaaagg tggaagagcc tccagatatg caaatgggcg
      661 atggacgcct cggaagccag cctcttcaag tccaccttgt ccaggtgttg caatgccccc
      721 aactttctct tcaccaccca gaagaacacc ccggttgaga cgaatctcag gtatgaggtg
      781 gagtccagtg gcttgtatca catcgaccaa gagatcttca aaatgtttcc caaggaaatg
      841 ccctactacc gctctcagtt taagaagtgt gctgtggtgg gcaatggcgg catcttgaag
      901 aacagcggct gcgggaagga gatcaacagc gctgacttcg tcttccggtg caatctgccc
      961 cctatctcag ggatatatac cacagatgtg ggagagaaga cagatgtggt caccgtgaat
     1021 cccagcatca taattgacag gttccacaag ttggagaagt ggcggcggcc cttcttcagc
     1081 gtgctgcaga ggtacgagaa cgcctcggtg ctgctgccgg ccttctacaa tgtgcgcaac
     1141 accctcgtgt ccttccgagt caagtacatg ctggacgact tccagtcgcg gcagcccgtc
     1201 tacttcttcc atcctcagta cctgagcagc gtgtcgcgct actggctcag cctgggcgtg
     1261 cgcgcacggc gcatcagcac cggcctcatc ctggtcactg cggccctgga gctctgcgag
     1321 gaggtgcacc tgttcggttt ctgggccttc cccatgaacc cctccggctt cttcatcacg
     1381 caccactact atgacaatgt caagcccaag cccggctttc atgctatgcc ctcggagatc
     1441 ttcaccttcc tgcgcatgca cagccgcggc atcctccgcg tgcacacagg cacctgcaat
     1501 tgctgctgaa aaacaggccc accacgggtg tttcagctcc tgtcctcctc cccgaaggat
     1561 cccctgtccc tgccattatg gctgttgtca ctccctaagg atttagggtt tgtgtttggg
     1621 tcctggggag ggaggcaggg agacattcat ttaacaggat agagcacaga tccaggtctc
     1681 attcagacct ttggctgccc gagtttcata cggggaactc agccataaag caccatcttg
     1741 aaactcacgg cctgggtgcc agcccttcca gggaacaaac agtatgagtg tcctagtcac
     1801 accacctggc tgagctcaaa agacttcagg gatatctaat caaaacccgt gttagcatat
     1861 ccccacgagt ccaggagctg agagccatgc cctttaaaac agctcttgga cacacacagc
     1921 cttggtgcct ctaggttcca gcctgcattt aacctttgac aagaaggaaa taaaccagac
     1981 cagccatttg cactaagatc ttcaa
//
