LOCUS       NM_053914               5428 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus ST8 alpha-N-acetyl-neuraminide
            alpha-2,8-sialyltransferase 4 (St8sia4), mRNA.
ACCESSION   NM_053914 XM_001071501 XM_346078
VERSION     NM_053914.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5428)
  AUTHORS   Mione,J., Manrique,C., Duhoo,Y., Roman,F.S. and Guiraudie-Capraz,G.
  TITLE     Expression of polysialyltransferases (STX and PST) in adult rat
            olfactory bulb after an olfactory associative discrimination task
  JOURNAL   Neurobiol Learn Mem 130, 52-60 (2016)
   PUBMED   26844880
  REMARK    GeneRIF: After learning an olfactory discrimination task, no
            changes in the expression level of St8sia4 were observed in the
            olfactory bulb.
REFERENCE   2  (bases 1 to 5428)
  AUTHORS   Manrique,C., Migliorati,M., Gilbert,V., Brezun,J.M., Chaillan,F.A.,
            Truchet,B., Khrestchatisky,M., Guiraudie-Capraz,G. and Roman,F.S.
  TITLE     Dynamic expression of the polysialyltransferase in adult rat
            hippocampus performing an olfactory associative task
  JOURNAL   Hippocampus 24 (8), 979-989 (2014)
   PUBMED   24753009
  REMARK    GeneRIF: Results suggest that sialyltransferase-X is probably
            involved in the proliferation of neural progenitor cells;
            polysialyltransferase may play a key role in synaptic plasticity of
            mature neural networks
REFERENCE   3  (bases 1 to 5428)
  AUTHORS   Harduin-Lepers,A., Petit,D., Mollicone,R., Delannoy,P., Petit,J.M.
            and Oriol,R.
  TITLE     Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia)
            gene family: tandem duplications in early deuterostomes explain
            most of the diversity found in the vertebrate ST8Sia genes
  JOURNAL   BMC Evol Biol 8, 258 (2008)
   PUBMED   18811928
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5428)
  AUTHORS   Wang,B., Hu,H. and Yu,B.
  TITLE     Molecular characterization of pig ST8Sia IV--a critical gene for
            the formation of neural cell adhesion molecule and its response to
            sialic acid supplement in piglets
  JOURNAL   Nutr Neurosci 9 (3-4), 147-154 (2006)
   PUBMED   17176637
REFERENCE   5  (bases 1 to 5428)
  AUTHORS   Angata,K., Suzuki,M., McAuliffe,J., Ding,Y., Hindsgaul,O. and
            Fukuda,M.
  TITLE     Differential biosynthesis of polysialic acid on neural cell
            adhesion molecule (NCAM) and oligosaccharide acceptors by three
            distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II
            (STX), and ST8Sia III
  JOURNAL   J Biol Chem 275 (24), 18594-18601 (2000)
   PUBMED   10766765
REFERENCE   6  (bases 1 to 5428)
  AUTHORS   Phillips,G.R., Krushel,L.A. and Crossin,K.L.
  TITLE     Developmental expression of two rat sialyltransferases that modify
            the neural cell adhesion molecule, N-CAM
  JOURNAL   Brain Res Dev Brain Res 102 (2), 143-155 (1997)
   PUBMED   9352097
REFERENCE   7  (bases 1 to 5428)
  AUTHORS   Yoshida,Y., Kojima,N. and Tsuji,S.
  TITLE     Molecular cloning and characterization of a third type of N-glycan
            alpha 2,8-sialyltransferase from mouse lung
  JOURNAL   J Biochem 118 (3), 658-664 (1995)
   PUBMED   8690732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Oct 12, 2022 this sequence version replaced NM_053914.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.50318.1,
                                           SRR26643289.26559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676806 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-442               JAXUCZ010000009.1  103531567-103532008 c
            443-574             JAXUCZ010000009.1  103525209-103525340 c
            575-832             JAXUCZ010000009.1  103517691-103517948 c
            833-1126            JAXUCZ010000009.1  103480612-103480905 c
            1127-5428           JAXUCZ010000009.1  103437479-103441780 c
FEATURES             Location/Qualifiers
     source          1..5428
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..5428
                     /gene="St8sia4"
                     /gene_synonym="Siat8d"
                     /note="ST8 alpha-N-acetyl-neuraminide
                     alpha-2,8-sialyltransferase 4"
                     /db_xref="GeneID:116696"
                     /db_xref="RGD:621845"
     exon            1..442
                     /gene="St8sia4"
                     /gene_synonym="Siat8d"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..1409
                     /gene="St8sia4"
                     /gene_synonym="Siat8d"
                     /note="sialyltransferase 8 (alpha-2,
                     8-polysialyltransferase) D; sialyltransferase 8 (alpha-2,
                     8-polysialytransferase) D; sialyltransferase 8 (alpha-2,
                     8-sialytransferase) D; ST8 alpha-N-acetylneuraminate
                     alpha-2,8-sialyltransferase 4;
                     CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase"
                     /codon_start=1
                     /product="CMP-N-acetylneuraminate-poly-alpha-2,
                     8-sialyltransferase precursor"
                     /protein_id="NP_446366.2"
                     /db_xref="GeneID:116696"
                     /db_xref="RGD:621845"
                     /translation="MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELCL
                     SRSLVNNSDKITRKAGSTIFQHSVQGWKINSSLVLEIRKNILRFLDAERDVSVVKSSF
                     KPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEI
                     DSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSML
                     NDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIK
                     RPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMP
                     LEFKTLNVLHNRGALKLTTGKCMKQ"
     exon            443..574
                     /gene="St8sia4"
                     /gene_synonym="Siat8d"
                     /inference="alignment:Splign:2.1.0"
     exon            575..832
                     /gene="St8sia4"
                     /gene_synonym="Siat8d"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1126
                     /gene="St8sia4"
                     /gene_synonym="Siat8d"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..5428
                     /gene="St8sia4"
                     /gene_synonym="Siat8d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgacgccc ccgagcccag ctgcagaagc aaccgccacc tccgatgcac aaggtgtcac
       61 atttgaaaag aaacccgagc cccagggagg cggcacagag cgaccccagc ccggctagcg
      121 caaactgcgc ggcagggcgc tgggcagcgc tggagaaccg ggagagctcc accgctgaac
      181 gtcctagcga cctgattctg ggatctcggc tccacgctcc cttcgcaaat ttcagatttc
      241 tcccccttga ttatttcccc aaaacggagc ctttatacca ggagaaggtg cctgagctgg
      301 gacaacctgg actttcccgg gcacccaaga tgcgctccat tagaaaacgg tggaccatct
      361 gcactataag tctactcctg atcttttata agacaaaaga aatagccagg actgaggagc
      421 accaagagac gcaactcatc ggagatggtg aattatgctt gagcagatca cttgtcaaca
      481 actctgataa aatcactcgg aaggctggtt ccaccatctt ccaacattcc gtacaaggct
      541 ggaaaatcaa ttcttcttta gtcctggaga taaggaagaa tattctccgt ttcctagacg
      601 cagaacgtga cgtgtcggtg gtcaagagca gtttcaagcc tggtgatgtc atacactatg
      661 tgctggacag acgccggaca ctaaatattt cccacgatct gcatagcctc ctgcctgaag
      721 tttcaccaat gaaaaaccgc aggtttaaga cctgtgctgt tgttggaaat tccggcattc
      781 tactagacag tggatgtgga aaggagatcg acagccacaa ctttgtcata aggtgtaatc
      841 tagctcccgt ggtggagttc gctgcggatg tggggactaa gtcagatttc attaccatga
      901 atccatcagt tgtgcaaaga gcattcggag gctttcggaa tgagagtgac agagaaaaat
      961 ttgtgcacag actctccatg ctgaatgaca gcgtcctttg gattcctgcc ttcatggtca
     1021 aaggaggaga gaagcacgtg gaatgggtta atgcattaat ccttaagaat aaactgaaag
     1081 tgaggactgc ctatccatca ctgagactca ttcatgcggt cagaggttac tggctgacca
     1141 acaaagttcc tatcaaaaga cccagcactg gtctcctcat gtacaccctt gccaccagat
     1201 tctgtgacga aattcacctg tatggattct ggccatttcc taaggatctg aacggaaaag
     1261 ctgtcaaata tcattactat gatgacttga aatatagata cttttccaac gcaagtcctc
     1321 acagaatgcc actggaattc aaaacattga atgtgctgca caatagagga gctctaaaac
     1381 tgaccacagg gaagtgcatg aagcaataag gcgcagcggg aaggataaaa actgaacaca
     1441 aactttttct aaagatgctt ctggagattt agaaacagga tccaaaacga ggctgggttt
     1501 cagcacccac cacttgactg agtcgctgaa atggaagtct gtgcgagtcc accaccagct
     1561 gatgaaaaac ctgcaaagtg ctctaaccat aaaatatcct gacttcaagg gtcctagcaa
     1621 gtgccacttc catgaagaat acagtttgaa tgtattatcc gtcgtgttta caagatccaa
     1681 cagtgcactc atcgtcagtt agcagagcaa acgtgttcgt cactgtgggg cagccactgt
     1741 aatgccaagc acactggaag aggaacccaa gagcaccact cggcccttgg gaagtaaaaa
     1801 cgtccttgat agcagaaatg aagaagaaga gagttcaagc agtgaaatcc aggacaggaa
     1861 gcagcgtgag ggaatgcttt cagtcaggac gccgagaatg gccgtgttta cgttttgttt
     1921 atattcttgt ttgtcttctg acgtttagtt tgggtttggg tttggggtgc ttaaaaattc
     1981 atttgagaaa cagaagtggg aaacacatat gaatgagaaa aataaacatc aaatggtcct
     2041 ttttaaagtt cttatgtttt ttaaaacaac aatcacacca aatttttgct tgcttgtttg
     2101 ttttcctttg cacaacttta aatctctgga ttacagatca atggtgtatg tagcaggtac
     2161 cagccaaact ataccacccg gtagtaataa actattaatg aaggagtgag atttgaaaca
     2221 cggtaaaatt agcagaaaaa cttcactctt ggtaccaaag attatatcat gttcctacac
     2281 agtaagccac tgtccttaaa gaatatattc ttagcatgaa tgattctata tgctgctaat
     2341 atgaaactta gctctacata gttaaacatt ttcaaaatca aacactggtt ttaatgtatt
     2401 tctttgaaat ttcatgataa ttttgtggag acacatattt gtgaagagct aatgttggct
     2461 tgatgcagct gaaatgagac ttcccattca gtaaaatcat ctcagctatc cgggtgcaga
     2521 gatcaatatg gcgctcgtag tgttatttta aaatttctcc ctacaaataa cacgattaac
     2581 ggagccttgt tttcataaca gacgagtgat tcaaagcagt ttaacaatac cacatcagca
     2641 ttgtgcgttt cagatgaatt caatggacat ggatctttcg gtagttgagt acagttctgt
     2701 tattacagca tttttaaagg aacatgaact tactcataga gtgacttgct aacttactta
     2761 tgtgactgga ctgactggtg gcccggcttt ctgtttcttt tgaaagcaga actacattct
     2821 cacttctgct tttgtctgca gcagcttaac atgacttcct gtttctcaga gaagtcagag
     2881 gaaagcagaa acagcatgaa aaatgtgcac gttttgtttt tcaaagtcag gcaatctaaa
     2941 atgaagaaag agcacagcat agttacacat atatgttata tatgtactca cattatggac
     3001 aaggatagtc atacagtaca gttaccaaat ttttaataac agttgcaata tttttttaga
     3061 aaagttgact gaacctcagg ataaaaataa catttttttc tgagaatcca tgtatccatc
     3121 agaaaggaaa agagaatgcc tatgggagtt tcctaactgg caatgaatta ttatctcact
     3181 ctacctttac catcaaattc cttttctatt tgaaaaattg aaagtgttaa atacatgtta
     3241 tataaatgtt taattgagag tctaatatac tggatatgtg aacattgggt aatatatgaa
     3301 acttattttg aactctatgc agatcagtgt tcccaccaac agctaacatg aattccacag
     3361 aaatccagaa gccacaagta aattattata agtaaatact accttggcac tcattcacag
     3421 tatgtatttg aaagcagcag cataccgttt tgactgaaat tttaagggga aaaaatgtgt
     3481 ttaaaaccac actttgcccg cagccagcac agctcagccg tccactgttt catgcattgg
     3541 tgtctaactc ttacacgcat tgggtagtgc cttttaacat cgctgcatgg attcttcacc
     3601 ctctgctttg cgttttctaa atacttgccc agttagggaa atgctcagta tcctaagggc
     3661 ttcagatttg agaggcaact acttttgttc atctcaggga tctttgagta cataagaatg
     3721 aattccatta aagacattta gtgctccaag aagaaacctt gtgtgaggcc atttctttct
     3781 ctctcacaca catacacgct ttcatttgcc atcagagctc aatccctgtc atggccttcc
     3841 cacaggaaga aggcaaggag agaattgagg agtgacagca gggaacagag ttacgacttg
     3901 acacgcatga tggcataaca tgaagggatc acaacaaaat caaattacaa gtacatactt
     3961 gaactatctg tgttttcctt aatacggtat gctcgcagct ttacttgttt tatttctttt
     4021 ttttttacga tttaatcatg gacctggggg ggtgcccagg cagatgactg tgaaatatcc
     4081 cagtcactga ggtaacgtga ttgccactgt gcttttgaca ggagccgacc atgggaatat
     4141 tctcatggga atattgttac tcagcataaa cgacacccaa caacaagtcg ttgaaagaaa
     4201 atatgaatca atactaggtt ttcagggcaa atctagtgat tgcgctcaca ggaacaatgg
     4261 aagcactgtg gaagtttttc tcgctgggag aaggcgctgg gcattcgaat gtcctcatgt
     4321 aatgtatacc acatgaactg cacatcgatc gttaatgaaa atctccacat atatccttac
     4381 agaaatgctt tatttaagaa atactaagag tagtgtacag ccaagtgagt tacccagtta
     4441 ctactcaagg aagggcaagc aaagtaattt atttatagtt gtgccaatta gtcatgatac
     4501 atattacgtg atatttggtt cacagagttg tcttcatgtg attattataa ggactatcta
     4561 tagttgtgga agggggctgg aaaacgttgt gtatagttag ctggtatctc tacaagtttg
     4621 agagtttccc cattaaatgt tatcagtata cagaggtttt aatttaaaaa aaaaaacaag
     4681 taagggtaat tatttgtatt tgaaaaacaa actccaaata caacccatct agaaatagat
     4741 attatatatg tgctataaat atatctatat agtacaaata gacatgtgtg atgcatatat
     4801 accatgttat atatgtatat ctgtgtgtac actctgattc tgtaatatgt gcacaactag
     4861 atgtgtgtga tattgacatc ttcagggtct gcactgtgga cttccctgga gatcgtgacc
     4921 actttaaaaa cagaagttct tttgaaactt cacttactac tctgctttaa gaaagaccca
     4981 cttcgtagct gaattatatg ttctttccta gagaaatagt cagcaactag tctgttcaag
     5041 cctttcaaaa caaaagtaaa gggaaaaaaa ttaccttcaa gctggcgatg tatttaaatt
     5101 gcggttttct gactgtgggt ctaggctgtg tgtttctcct ttatgtagcg ccttttacag
     5161 aatactgttt tgtttgtgtt ggtgaaagca caagagtttt agatgtacat agccaggaga
     5221 agaaaagcaa aacagagttt acagatcgct ttgctgcata ggataattgc tgtgtctttc
     5281 ttctaccatc cgtagaaagg aaggatgaag ctcactctgt aggttctttc tggtcaacaa
     5341 tgtcttctgt tgtttgtgca tagcaatgag ctattcctgc tttatcattt gtacaattgt
     5401 aaaataaatt aaattccttg tttttcaa
//
