LOCUS       NM_057156               5390 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ST8 alpha-N-acetyl-neuraminide
            alpha-2,8-sialyltransferase 2 (St8sia2), mRNA.
ACCESSION   NM_057156 XM_346544
VERSION     NM_057156.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5390)
  AUTHORS   Mione,J., Manrique,C., Duhoo,Y., Roman,F.S. and Guiraudie-Capraz,G.
  TITLE     Expression of polysialyltransferases (STX and PST) in adult rat
            olfactory bulb after an olfactory associative discrimination task
  JOURNAL   Neurobiol Learn Mem 130, 52-60 (2016)
   PUBMED   26844880
  REMARK    GeneRIF: After learning an olfactory discrimination task, no
            changes in STX gene expression level were observed in the olfactory
            bulb.
REFERENCE   2  (bases 1 to 5390)
  AUTHORS   Manrique,C., Migliorati,M., Gilbert,V., Brezun,J.M., Chaillan,F.A.,
            Truchet,B., Khrestchatisky,M., Guiraudie-Capraz,G. and Roman,F.S.
  TITLE     Dynamic expression of the polysialyltransferase in adult rat
            hippocampus performing an olfactory associative task
  JOURNAL   Hippocampus 24 (8), 979-989 (2014)
   PUBMED   24753009
  REMARK    GeneRIF: Results suggest that sialyltransferase-X is probably
            involved in the proliferation of neural progenitor cells;
            polysialyltransferase may play a key role in synaptic plasticity of
            mature neural networks
REFERENCE   3  (bases 1 to 5390)
  AUTHORS   Deane,E.C., Ilie,A.E., Sizdahkhani,S., Das Gupta,M., Orlowski,J.
            and McKinney,R.A.
  TITLE     Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into
            Dendritic spines of hippocampal pyramidal neurons during NMDA
            receptor-dependent long-term potentiation
  JOURNAL   J Neurosci 33 (2), 595-610 (2013)
   PUBMED   23303939
REFERENCE   4  (bases 1 to 5390)
  AUTHORS   Mackowiak,M., Mordalska,P., Dudys,D., Korostynski,M., Bator,E. and
            Wedzony,K.
  TITLE     Cocaine enhances ST8SiaII mRNA expression and neural cell adhesion
            molecule polysialylation in the rat medial prefrontal cortex
  JOURNAL   Neuroscience 186, 21-31 (2011)
   PUBMED   21536109
REFERENCE   5  (bases 1 to 5390)
  AUTHORS   Brocco,M.A. and Frasch,A.C.
  TITLE     Interfering polysialyltransferase ST8SiaII/STX mRNA inhibits
            neurite growth during early hippocampal development
  JOURNAL   FEBS Lett 580 (19), 4723-4726 (2006)
   PUBMED   16887122
  REMARK    GeneRIF: ST8SiaII/STX expression is essential to allow a correct
            neuritic development at initial stages of hippocampus ontogeny
REFERENCE   6  (bases 1 to 5390)
  AUTHORS   Brocco,M., Pollevick,G.D. and Frasch,A.C.
  TITLE     Differential regulation of polysialyltransferase expression during
            hippocampus development: Implications for neuronal survival
  JOURNAL   J Neurosci Res 74 (5), 744-753 (2003)
   PUBMED   14635225
REFERENCE   7  (bases 1 to 5390)
  AUTHORS   Angata,K., Suzuki,M., McAuliffe,J., Ding,Y., Hindsgaul,O. and
            Fukuda,M.
  TITLE     Differential biosynthesis of polysialic acid on neural cell
            adhesion molecule (NCAM) and oligosaccharide acceptors by three
            distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II
            (STX), and ST8Sia III
  JOURNAL   J Biol Chem 275 (24), 18594-18601 (2000)
   PUBMED   10766765
REFERENCE   8  (bases 1 to 5390)
  AUTHORS   Kojima,N., Kono,M., Yoshida,Y., Tachida,Y., Nakafuku,M. and
            Tsuji,S.
  TITLE     Biosynthesis and expression of polysialic acid on the neural cell
            adhesion molecule is predominantly directed by ST8Sia II/STX during
            in vitro neuronal differentiation
  JOURNAL   J Biol Chem 271 (36), 22058-22062 (1996)
   PUBMED   8703013
REFERENCE   9  (bases 1 to 5390)
  AUTHORS   Kojima,N., Yoshida,Y., Kurosawa,N., Lee,Y.C. and Tsuji,S.
  TITLE     Enzymatic activity of a developmentally regulated member of the
            sialyltransferase family (STX): evidence for alpha
            2,8-sialyltransferase activity toward N-linked oligosaccharides
  JOURNAL   FEBS Lett 360 (1), 1-4 (1995)
   PUBMED   7875291
REFERENCE   10 (bases 1 to 5390)
  AUTHORS   Livingston,B.D. and Paulson,J.C.
  TITLE     Polymerase chain reaction cloning of a developmentally regulated
            member of the sialyltransferase gene family
  JOURNAL   J Biol Chem 268 (16), 11504-11507 (1993)
   PUBMED   7685014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 7, 2022 this sequence version replaced NM_057156.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.3604.1,
                                           SRR21887623.1749615.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               JAXUCZ010000001.1  137247490-137247753 c
            265-327             JAXUCZ010000001.1  137209484-137209546 c
            328-456             JAXUCZ010000001.1  137205223-137205351 c
            457-714             JAXUCZ010000001.1  137200265-137200522 c
            715-1008            JAXUCZ010000001.1  137194685-137194978 c
            1009-5390           JAXUCZ010000001.1  137172354-137176735 c
FEATURES             Location/Qualifiers
     source          1..5390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..5390
                     /gene="St8sia2"
                     /gene_synonym="SIAT8-B; Siat8b; STX"
                     /note="ST8 alpha-N-acetyl-neuraminide
                     alpha-2,8-sialyltransferase 2"
                     /db_xref="GeneID:117523"
                     /db_xref="RGD:621843"
     exon            1..264
                     /gene="St8sia2"
                     /gene_synonym="SIAT8-B; Siat8b; STX"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1294
                     /gene="St8sia2"
                     /gene_synonym="SIAT8-B; Siat8b; STX"
                     /note="sialyltransferase 8 (alpha-2, 8-sialytransferase)
                     B; alpha-2,8-sialyltransferase 8B; ST8Sia II;
                     sialyltransferase X; ST8SiaII; sialytransferase St8Sia II;
                     sialyltransferase 8 (alpha-2, 8-sialyltransferase) B;
                     sialyltransferase St8Sia II; ST8 alpha-N-acetylneuraminate
                     alpha-2,8-sialyltransferase 2"
                     /codon_start=1
                     /product="alpha-2,8-sialyltransferase 8B precursor"
                     /protein_id="NP_476497.1"
                     /db_xref="GeneID:117523"
                     /db_xref="RGD:621843"
                     /translation="MQLQFRSWMLAALTLLVVFLIFADISEIEEEIGNSGGRGTIRSA
                     VNSLHSKSNRAEVVINGSSLPAVADRSNESLKHSIQPASSKWRHNQTLSLRIRKQILK
                     FLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYELLPRTSPLKNKHFQTCAIV
                     GNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYARDVGLKTDLVTMNPSVIQRAFEDLV
                     NATWREKLLQRLHGLNGSILWIPAFMARGGKERVEWVNALILKHHVNVRTAYPSLRLL
                     HAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDS
                     LKYGYTSQASPHTMPLEFKALKSLHEQGALKLTVGQCDGAT"
     exon            265..327
                     /gene="St8sia2"
                     /gene_synonym="SIAT8-B; Siat8b; STX"
                     /inference="alignment:Splign:2.1.0"
     exon            328..456
                     /gene="St8sia2"
                     /gene_synonym="SIAT8-B; Siat8b; STX"
                     /inference="alignment:Splign:2.1.0"
     exon            457..714
                     /gene="St8sia2"
                     /gene_synonym="SIAT8-B; Siat8b; STX"
                     /inference="alignment:Splign:2.1.0"
     exon            715..1008
                     /gene="St8sia2"
                     /gene_synonym="SIAT8-B; Siat8b; STX"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..5390
                     /gene="St8sia2"
                     /gene_synonym="SIAT8-B; Siat8b; STX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcaaccc ttgtctgttg ctgctgctgt cgccttggcc gccgccggcc cggactcgcc
       61 cggagcgcag ggtgtgtgcc ccgctgcgcg tggagcgcgg aggctcctcc agccccagct
      121 cctcgccccg gcccgcgcgc gggtcccgga gggcaccgac cccaccatgc agctgcagtt
      181 ccggagctgg atgctggccg cgctcacgct gctcgtggtc ttcctcatct tcgcagacat
      241 ctcagagatc gaagaagaaa tcgggaattc tggaggcaga ggtacaatca gatcagctgt
      301 gaacagctta catagcaaat ctaatagagc tgaagttgta ataaatggct cttcactacc
      361 agccgttgct gacagaagta atgaaagcct taagcacagc atccagccag cctcatccaa
      421 gtggagacac aaccagacgc tctctctgag gatcaggaag caaattttaa agttcctgga
      481 tgcagagaag gatatttctg tccttaaggg gaccctgaag cctggagaca ttattcatta
      541 tatctttgat cgagacagca caatgaacgt gtcccagaac ctctatgaac tcctccccag
      601 aacctcacct ctgaagaata agcatttcca gacttgtgcc atcgtgggca actcaggagt
      661 cttgctcaac agcggctgtg ggcaggagat tgacacacac agctttgtca taaggtgcaa
      721 cctggctcca gttcaggagt atgcccggga tgtgggcctc aagactgacc tagtgaccat
      781 gaacccctca gtcatccagc gggcctttga ggacctagtg aatgccacgt ggcgggagaa
      841 gctactgcag cgactgcatg gcctcaatgg gagcatactg tggatacctg ccttcatggc
      901 ccggggtggc aaggagcgtg tggagtgggt caatgctctc atcctgaagc accatgtcaa
      961 cgtacgcaca gcttaccctt ccctgcgcct gctgcacgca gtccgaggat attggctgac
     1021 caacaaagtc cacatcaaaa gaccaaccac tggcctcctg atgtacaccc tggccacacg
     1081 cttctgcaat cagatctacc tttatggctt ctggcccttc ccattggatc agaatcagaa
     1141 ccccgtcaag taccactatt atgacagcct caagtatggc tacacctccc aggccagccc
     1201 ccacaccatg cccttggaat tcaaggccct caagagccta catgaacagg gggcattgaa
     1261 actgactgtc ggccagtgtg acggggctac gtaaggaggg cagcccatgg gactcagtgg
     1321 ctcactttcc tgccagctac accataggca gatgggagtc ggggtggcac aaacaataga
     1381 acaagcaggc tagtggtttt ctttgttaaa gtgtaaaaca gtgaccagaa tatatatatc
     1441 tatacctgca tatatatatt gacctgagta tttataactg tgtggtgttc atctagcatt
     1501 aggcagataa gccacaggaa gaaggtgtgg agaacccacc tggaccagat ggagactcag
     1561 tccatctttg ggggcagaag gacttgacac gaaaagaagc cagtcccatg actttggatg
     1621 acaacccact tcctgggctg gatggatctt tgggctcatg gatgaatgga gagccacctg
     1681 ttgtcagctt ccccgaacct ccaagtgaag tagattctgg gtagcccaga cccagagatg
     1741 acagcttgga ccagtctaaa gaggtgcagt tcatggagga gagacttgaa gagttccact
     1801 gggcaaagag gcacaaggag accaagcagc actggtcaca acagagctga gggctttgtt
     1861 catgaacttg agagtgcagc tgcccaaagg acaagtacgg atggcgtccc agacaagcct
     1921 tcccagttat ggagaaaggc tggaggaagc tcaatgacag ccccaaattc tggttagaca
     1981 agtaccacct gggacttagt agggcaggac ttagtaagac gtggccctaa agaggtagat
     2041 tgttgtaaat catggtttta gaaacttgac atcttctagg agtttgctcc acctcagaaa
     2101 aggacaaaag agtgtacaaa ttaggattgt ttttgttggg tgaggcccac tgaggcagaa
     2161 gtgaccctag aacttcaact tccaggttag cttttatccc atcctcttag aatgtcacat
     2221 gaaggaactc tactgtccca tctaccacca gaaagacaca gcaggtgctt gaaagagcat
     2281 ggtcacagta ggtgtcatct tgttcaaaac atatacagtc agctttctag gcacctcaca
     2341 gggccctaga actgggcacc tggaaggctg tgacacatct acccctgggt ctctacagtc
     2401 attccatgtt tgctttctgc atcctgcact ctgagagtcc cctgcagcca gcctgctgtg
     2461 tcaatgtcac cttgtcactt tcccattttg agtcatccct gcccacacca agctcttctg
     2521 ggagaggttc cagtgtccac cctacatccc tccccaccct cacaccccta caccaccaac
     2581 cactgcagag tttttgcaaa agccttctcc cctctgttag ggctcccact taagacttgt
     2641 ttttcttgta aaaagcccaa agccaaacac aggtccaaac actggacata atctccaggg
     2701 gaaatctggg cttgatgcca acaacttagg ggttggactt acaggtcaca cagtgcaaag
     2761 cattagccag cttgatgtgt tagatgcaat tccctaattc cctcgcctga taaataatgg
     2821 tgttttaaaa catatttgaa agataaatgt aaaaaaaaac aaaacaaaac actattatct
     2881 tgaaggtgaa gagagttaaa aaaaaaaagt aatcaagatc ctctcccaag cgtatgaggc
     2941 ctgacgtaat taatcaacag ccattcagaa cacgatgctt gctctaaatt aatggctgat
     3001 gggaagtgag caaagacaat ggagggatac cctagaacca ttaaccctgc gtacagtccc
     3061 tccagcccca cgcaggctga ggactgtata tctctatgtt tctctctttg ttcttgttgc
     3121 agtatgaagc ttgtgatttg ggatttgcgt cataaaatga atattttaaa aagtaacagc
     3181 cataacagcc tccctgggag ctgagtggtt cagcctcctc atgagcagcg gagataatta
     3241 gtatcatatt ttacatgtgt ccagagcttt ccatctgaag gctctcaacg gctctagaag
     3301 acacttaatt tccaaagtct gcggtgtcct ggaggaatag gtacaatcac caccagggct
     3361 ctgcattagg aaagcccttg gatgtcagaa caccccacgt ggagtcatac agaaggctgc
     3421 agaggtcagg tactggacat gaccatgagc accacccagc atcctctctg tgaagagtta
     3481 gagggccatt tgtctaactg ggcttacaca ggctataacc tgatgggaaa aggcagaggt
     3541 cccaggacca cccatatatg ccctttccct aacttagcag acctggccta ttagaatgat
     3601 ctgggcatgt aactgcaaga tctctatggg ccttggtttt ccctcttgcc attcttctcc
     3661 aatcagcagc caagtgtcct ctactactta ctgagaactc acttggggct gggttctatt
     3721 gaagtctttt aacataaact ggttgacttt ggctggcctt ggggagacac agccttcact
     3781 cttaaactca tagctgccac gtaacatcac agcagcctca gccagtcccc tctactgttg
     3841 gctatcagta acctcctcag tctgcccgcc taagcctgcc agacctccat ttactctgaa
     3901 cccccagtgg ccccaccctc agcctctgct atcaccaaaa aaaggccatt tgacatcaga
     3961 ccttttctca tattctcttg gcctctccct cccacttaac cttcattctt ccacaagtga
     4021 ggcttctcct gtaggcaagt agtctttcct ctcctgccct cagacttttc ccagcccctc
     4081 ttgcattcac cctgattcct agagcctctc cacttaactc ctctaccacc agaccttggc
     4141 agcatctgca gtccctactg ccaccaatcc cccgtaccac accttaatgt tccctcctag
     4201 cctactccta ggaccagcat ctatagccac ctccatgtgc taaattgaaa ggcctctctc
     4261 attgcaaagc cctatggtga attctcctgg gcaaaacact atgttcttaa gatttttacc
     4321 cctcccatcc caacctccat gaccacgtat ttatatattt atttatgtat ttatgaggta
     4381 tttattggca ttcctacctt gagctgaaag gagccaagga agatctgccc attttcccct
     4441 ctcttctccc ggtaccacaa agtaaccatt ccttccaaca aggtcctccc tgaagtccta
     4501 taagccatgc atccatagtt gcatgctttc cttcagaccc aactgccact acccaaagaa
     4561 taccctcaac tccccttagc tgtttagctc cactagaagc tcccagttcc aagaagatac
     4621 actgcttgtt aagcatactt aatctgctct gacatcttga gctcaagaca tctgaagcta
     4681 agtagaccat ctatcttccc agcatgatcc cctattttct ggttggaata ccaatgattc
     4741 tttcaacaca gtctgggtcc ctaagatagc cactgactca tccatgtatt ccctcattac
     4801 tctttccaac tagtcccaac ctcacctcta cttgtccgtt ggaccacctg agtagtggtc
     4861 tcctctccca gacctccctg agcatgctca atggtatgta actccagctc ttcgtgaact
     4921 ttgctaagat ctcctggccc acaaaaatgt gcctgtcttt atcctgacat tacacccaat
     4981 caggtccctt cataccctgc aatggtcaat ccagaagagt tgtcagtatt ggaaaagcac
     5041 cgtgtttcct ggccccgtgc ctttggcctt gcagtttgca tcttctggat cattcttgag
     5101 tttcttccaa ggcgcatgca gagaccacat cctccatgaa gccctcccca gtccatcaat
     5161 gctgggacct ctccccccac agaaccacca cagcacttta tttctccctt tctcacggca
     5221 cttaccatat tctgccttgt attatagcta cttgtgcact tgtcctatgt ctgttcgtag
     5281 actgtaaccc tgccaagggc aggcactgtt ttattcatct gtatccatca cagcattagg
     5341 cgtggtgcat agcacacaac agttgctcaa taaatgtttg ttggatcaaa
//
