LOCUS       NM_012813               1471 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus ST8 alpha-N-acetyl-neuraminide
            alpha-2,8-sialyltransferase 1 (St8sia1), mRNA.
ACCESSION   NM_012813
VERSION     NM_012813.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1471)
  AUTHORS   Fujimoto,M., Oshima,K., Shinkawa,T., Wang,B.B., Inouye,S.,
            Hayashida,N., Takii,R. and Nakai,A.
  TITLE     Analysis of HSF4 binding regions reveals its necessity for gene
            regulation during development and heat shock response in mouse
            lenses
  JOURNAL   J Biol Chem 283 (44), 29961-29970 (2008)
   PUBMED   18755693
REFERENCE   2  (bases 1 to 1471)
  AUTHORS   Yamada,A., Fukumoto,E., Kamasaki,Y., Ida-Yonemochi,H., Saku,T.,
            Fujiwara,T. and Fukumoto,S.
  TITLE     GD3 synthase gene found expressed in dental epithelium and shown to
            regulate cell proliferation
  JOURNAL   Arch Oral Biol 50 (4), 393-399 (2005)
   PUBMED   15748692
REFERENCE   3  (bases 1 to 1471)
  AUTHORS   Kamimura,Y., Furukawa,K., Kittaka,D., Nishio,M., Hamamura,K.,
            Fukumoto,S. and Furukawa,K.
  TITLE     Differential enhancing effects of alpha2,8-sialyltransferase on the
            cell proliferation and mobility
  JOURNAL   Int J Oncol 26 (2), 337-344 (2005)
   PUBMED   15645117
  REMARK    GeneRIF: alpha2,8-sialyltransferase has roles in cell proliferation
            and mobility
REFERENCE   4  (bases 1 to 1471)
  AUTHORS   Copani,A., Melchiorri,D., Caricasole,A., Martini,F., Sale,P.,
            Carnevale,R., Gradini,R., Sortino,M.A., Lenti,L., De Maria,R. and
            Nicoletti,F.
  TITLE     Beta-amyloid-induced synthesis of the ganglioside GD3 is a
            requisite for cell cycle reactivation and apoptosis in neurons
  JOURNAL   J Neurosci 22 (10), 3963-3968 (2002)
   PUBMED   12019315
REFERENCE   5  (bases 1 to 1471)
  AUTHORS   Watanabe,Y., Nara,K., Takahashi,H., Nagai,Y. and Sanai,Y.
  TITLE     The molecular cloning and expression of alpha 2,8-sialyltransferase
            (GD3 synthase) in a rat brain
  JOURNAL   J Biochem 120 (5), 1020-1027 (1996)
   PUBMED   8982871
REFERENCE   6  (bases 1 to 1471)
  AUTHORS   Zeng,G., Gao,L., Ariga,T. and Yu,R.K.
  TITLE     Molecular cloning of cDNA for rat brain GD3-synthase
  JOURNAL   Biochem Biophys Res Commun 226 (2), 319-323 (1996)
   PUBMED   8806633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012813.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U53883.1, SRR26643429.18389.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-533               JAXUCZ010000004.1  177651021-177651553 c
            534-678             JAXUCZ010000004.1  177600538-177600682 c
            679-788             JAXUCZ010000004.1  177570895-177571004 c
            789-881             JAXUCZ010000004.1  177562188-177562280 c
            882-1471            JAXUCZ010000004.1  177520926-177521515 c
FEATURES             Location/Qualifiers
     source          1..1471
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..1471
                     /gene="St8sia1"
                     /gene_synonym="Siat8; Siat8a"
                     /note="ST8 alpha-N-acetyl-neuraminide
                     alpha-2,8-sialyltransferase 1"
                     /db_xref="GeneID:25280"
                     /db_xref="RGD:3679"
     exon            1..533
                     /gene="St8sia1"
                     /gene_synonym="Siat8; Siat8a"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1371
                     /gene="St8sia1"
                     /gene_synonym="Siat8; Siat8a"
                     /EC_number="2.4.3.8"
                     /note="alpha-N-acetylneuraminate:
                     alpha-2,8-sialytransferase; alpha-2, 8-sialytransferase;
                     alpha-2,8-sialyltransferase; sialyltransferase 8 (alpha-2
                     8-sialytransferase) A; Sialyltransferase 8
                     (alpha-N-acetylneuraminate: alpha-28-sialytransferase GD3
                     synthase); Sialyltransferase 8 A
                     (alpha-N-acetylneuraminate: alpha-28-sialytransferase GD3
                     synthase) GenBank no: U53883; ST8
                     alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1"
                     /codon_start=1
                     /product="alpha-N-acetylneuraminide
                     alpha-2,8-sialyltransferase"
                     /protein_id="NP_036945.2"
                     /db_xref="GeneID:25280"
                     /db_xref="RGD:3679"
                     /translation="MSPCGRALHTSRGAMAMLARKFPRTRLPVGASALCVVVLCWLYV
                     FPVYRLPNEKEIVQGVLAQRTAWRRNQTSARLFRKQMEDCCNPAHLFAMTKVNSPMGK
                     SLWYDGEFLYSLTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGCGRQIDEANF
                     VMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIY
                     MPAFSMKTGTEPSLRVYYTLKDAGANQTVLFANPNFLRNIGKFWKGRGIHAKRLSTGL
                     FLVSAALGLCEEVSIYGFWPFSVNMQGEPISHHYYDNVLPFSGFHAMPEEFLQLWYLH
                     KMGALRMQLDPCEEPSPPQPTS"
     exon            534..678
                     /gene="St8sia1"
                     /gene_synonym="Siat8; Siat8a"
                     /inference="alignment:Splign:2.1.0"
     exon            679..788
                     /gene="St8sia1"
                     /gene_synonym="Siat8; Siat8a"
                     /inference="alignment:Splign:2.1.0"
     exon            789..881
                     /gene="St8sia1"
                     /gene_synonym="Siat8; Siat8a"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1471
                     /gene="St8sia1"
                     /gene_synonym="Siat8; Siat8a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccccactg ctctcagacc ccttcagcgc ccactgtctg cagggaaaga gaccaaggct
       61 cgtgatttgc ccggaggcca cttcctctag caagacatcc cagtaaaagt tgcattggcg
      121 aagatccttg tagctgacct ctgaagccgt ggcgtggggg ttccccagtc gtgcgtgtgc
      181 gagctggaaa gccaaaggtg tgtgtgcatg gggggccagc cactggggca ttctccgctg
      241 ccactttgcc cggcgttgtg ctgaggctgc caccactgac cctgggacac cgaggctgcg
      301 atgagcccct gcgggcgggc cctacataca tccagagggg ccatggccat gctggcgcgg
      361 aaattcccgc gtacccggct acccgtggga gccagtgccc tctgtgtggt ggtcctctgt
      421 tggctctatg tcttccctgt ctaccggctg cccaacgaga aggagatcgt gcaaggagtg
      481 ctggcgcagc gcacagcttg gaggaggaac cagacgtcag ccaggctctt caggaaacaa
      541 atggaagact gctgcaaccc cgcccatctc tttgcaatga cgaaggtgaa ctcccccatg
      601 gggaagagcc tgtggtatga cggggagttt ctatactcgc tcaccatcga caactccacg
      661 tactccctct tcccccaggc aacccccttc cagctgccat tgaagaaatg tgcggtggtg
      721 ggaaacggtg ggattctgaa gatgagtggc tgtggccgtc aaatagatga agcaaatttt
      781 gtcatgcggt gtaaccttcc tcccttgtca agtgaataca ccagagatgt gggttccaag
      841 actcagttgg tgacagctaa ccccagcata attcgccaga gatttgaaaa cctgctgtgg
      901 tccagaaaga agtttgtgga caacatgaag atctataacc acagttacat atacatgcct
      961 gccttttcta tgaagacggg aacagagccg tctctccgtg tgtactacac cctgaaagac
     1021 gctggagcca atcaaacagt gctttttgct aaccccaact ttcttcgaaa cattggaaag
     1081 ttctggaagg gtagggggat ccatgccaag cgcctgtcta caggactctt tttggtgagt
     1141 gcagccttgg gcctttgtga ggaggtgtcc atctacggct tctggccctt ctccgtgaac
     1201 atgcaagggg aacctatcag ccaccattac tatgacaacg tcttgccctt ctcaggcttc
     1261 catgccatgc ccgaggagtt tcttcaactc tggtatcttc ataaaatggg tgcactgagg
     1321 atgcaactgg acccatgtga ggagccgtcg ccgccacagc ccacttccta gggactgcag
     1381 aagaggaaaa gactggatgg gggtattttt ttgctagatt ttttttatgt gactttcaaa
     1441 aggagctgcc aaagtgtgtc atggattggc g
//
