LOCUS       NM_001398944            2385 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ST6 N-acetylgalactosaminide
            alpha-2,6-sialyltransferase 6 (St6galnac6), mRNA.
ACCESSION   NM_001398944 XM_039105641
VERSION     NM_001398944.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2385)
  AUTHORS   Senda,M., Ito,A., Tsuchida,A., Hagiwara,T., Kaneda,T., Nakamura,Y.,
            Kasama,K., Kiso,M., Yoshikawa,K., Katagiri,Y., Ono,Y., Ogiso,M.,
            Urano,T., Furukawa,K., Oshima,S. and Furukawa,K.
  TITLE     Identification and expression of a sialyltransferase responsible
            for the synthesis of disialylgalactosylgloboside in normal and
            malignant kidney cells: downregulation of ST6GalNAc VI in renal
            cancers
  JOURNAL   Biochem J 402 (3), 459-470 (2007)
   PUBMED   17123352
REFERENCE   2  (bases 1 to 2385)
  AUTHORS   Harduin-Lepers,A., Mollicone,R., Delannoy,P. and Oriol,R.
  TITLE     The animal sialyltransferases and sialyltransferase-related genes:
            a phylogenetic approach
  JOURNAL   Glycobiology 15 (8), 805-817 (2005)
   PUBMED   15843597
  REMARK    Erratum:[Glycobiology. 2005 Sep;15(9):21G]
REFERENCE   3  (bases 1 to 2385)
  AUTHORS   Tsuchida,A., Okajima,T., Furukawa,K., Ando,T., Ishida,H.,
            Yoshida,A., Nakamura,Y., Kannagi,R., Kiso,M. and Furukawa,K.
  TITLE     Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer
            cell lines by a sialyltransferase, ST6GalNAc VI, responsible for
            the synthesis of alpha-series gangliosides
  JOURNAL   J Biol Chem 278 (25), 22787-22794 (2003)
   PUBMED   12668675
REFERENCE   4  (bases 1 to 2385)
  AUTHORS   Okajima,T., Chen,H.H., Ito,H., Kiso,M., Tai,T., Furukawa,K.,
            Urano,T. and Furukawa,K.
  TITLE     Molecular cloning and expression of mouse
            GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene
  JOURNAL   J Biol Chem 275 (10), 6717-6723 (2000)
   PUBMED   10702226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 28, 2021 this sequence version replaced XM_039105641.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.845394.1,
                                           SRR26360176.1127702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               JAXUCZ010000003.1  36291996-36292146
            152-206             JAXUCZ010000003.1  36293071-36293125
            207-297             JAXUCZ010000003.1  36294261-36294351
            298-477             JAXUCZ010000003.1  36297206-36297385
            478-884             JAXUCZ010000003.1  36299621-36300027
            885-992             JAXUCZ010000003.1  36303093-36303200
            993-2385            JAXUCZ010000003.1  36303825-36305217
FEATURES             Location/Qualifiers
     source          1..2385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..2385
                     /gene="St6galnac6"
                     /gene_synonym="Siat7F"
                     /note="ST6 N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 6"
                     /db_xref="GeneID:407765"
                     /db_xref="RGD:1303196"
     exon            1..151
                     /gene="St6galnac6"
                     /gene_synonym="Siat7F"
                     /inference="alignment:Splign:2.1.0"
     exon            152..206
                     /gene="St6galnac6"
                     /gene_synonym="Siat7F"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1182
                     /gene="St6galnac6"
                     /gene_synonym="Siat7F"
                     /note="alpha-2,6-sialyltransferase ST6GalNAc VI;
                     sialyltransferase 7F; ST6
                     (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6;
                     ST6 GalNAc alpha-2,6-sialyltransferase 6"
                     /codon_start=1
                     /product="alpha-N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 6"
                     /protein_id="NP_001385873.1"
                     /db_xref="GeneID:407765"
                     /db_xref="RGD:1303196"
                     /translation="MACSRPPSQCDPTTLPPGPPAGRWPLPFSRRRREMSSNKEQRSA
                     VFVVLFALITILILYSSNSANEVFHYGSLRGRSRRPVNLKKWSFSNAYFPILGNKTLP
                     SRCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSS
                     VFRVLRKPQEFVNRTPETVFIFWGPPNKMQKPQGSLLRVIQRAGLAFPNMEAYAVSQA
                     RMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPDYCSQRPRL
                     QRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHPSWT"
     exon            207..297
                     /gene="St6galnac6"
                     /gene_synonym="Siat7F"
                     /inference="alignment:Splign:2.1.0"
     exon            298..477
                     /gene="St6galnac6"
                     /gene_synonym="Siat7F"
                     /inference="alignment:Splign:2.1.0"
     exon            478..884
                     /gene="St6galnac6"
                     /gene_synonym="Siat7F"
                     /inference="alignment:Splign:2.1.0"
     exon            885..992
                     /gene="St6galnac6"
                     /gene_synonym="Siat7F"
                     /inference="alignment:Splign:2.1.0"
     exon            993..2385
                     /gene="St6galnac6"
                     /gene_synonym="Siat7F"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaccggtctg tgagcgtcgg cgctaggacc cggcgggcca gagctgcagc ggggcctggg
       61 cggccagagc agcgcggacc ccggttctcg gctcccggcg ccatgtgacg gggtgcgggg
      121 gccgcggggg gccgggcgct ccccggcgga gatgaggaaa ctgaggctca gagaggtcac
      181 atggcttgct cgaggccccc cagccagtgt gaccccacaa ccttgccccc cgggccacct
      241 gcaggacgct ggcctctacc cttcagcaga cgccgccgag agatgagtag caacaaagag
      301 cagcggtcag cagtgtttgt ggtcctcttt gctctcatca ccatcctcat cctctacagc
      361 tccaacagtg ccaacgaggt cttccactac ggctccctgc ggggccgctc gcggcggcca
      421 gtcaacctca agaagtggag tttctccaac gcctacttcc ctatcctcgg caacaagacg
      481 ctgccgtccc ggtgcaacca gtgtgtgatc gtcaccagct ccagccacct gctgggcacc
      541 aaactgggcc ctgagattga gcgggccgag tgcaccatcc gcatgaacga tgctcccacc
      601 actggctact cggccgacgt cggcaacaaa accaccttcc gcgtagtggc tcattccagt
      661 gtgttccggg tgctgcggaa gccccaggaa tttgtcaaca ggacccctga aactgtgttc
      721 atcttctggg gccccccaaa caagatgcag aagccccagg gcagcctcct gcgcgtcatc
      781 cagcgggcgg gccttgcgtt ccctaacatg gaggcctatg ccgtctctca agcccgcatg
      841 cagcagtttg acgacctctt ccggggtgag acaggcaagg acagggaaaa gtcccactcg
      901 tggttgagca caggctggtt taccatggtg attgcggtgg agttgtgtga ccatgtgcac
      961 gtgtatggca tggtccctcc cgactactgc agccagcggc cccgcctgca gcggatgccg
     1021 taccactact atgaacccaa ggggccagat gaatgtgtca cctacatcca gaacgagcac
     1081 agccgtaagg gcaatcacca ccgcttcatc actgagaaga gggtcttctc atcctgggct
     1141 caactctacg gtatcacctt ctcccacccc tcctggacct aaccatcctg tccacagacc
     1201 tcggacagat acaagtgaag tggctctggg cccagccatt tgaccacggc catcttccag
     1261 ccagttcaga ctggctggag tatttcccag ccaatcaaat cagggccttg atgagggttt
     1321 tttcctccag ccaactgggg ctggggttat ctcttggcca atcagggatt tggaattctg
     1381 tatggattaa tcgggtgtcg gggtctttct cgtctagtca gggtctgagt gtaatctatc
     1441 agggtatagg ggtctttctg agtcagtctg aagcttagga catgtcttta ccaataaggt
     1501 tttgcttcag agccccagga atgggtcccc aaatcactcc ctccttagct gggacaatga
     1561 ggtccctgtc ctaaggatct ggggacttgg tgttgcccca cagttgccag aatcagctgt
     1621 actgtatcag ggagaagctg cgaggaggcc aggcccgaga atctgtggag ttctaggaat
     1681 ggtagggagg cccagggagt aggagacggc gtcccgctct ggtttcttcc tgagtgatct
     1741 tggacaggct ctcttgtctt tctggcacgc tgtggtgaca gatctcggtg tgcagacaga
     1801 gaccctcact ctccattata tgtaagtgtg aattccccaa cttccattcc tccctgggga
     1861 ctcagctccc tggggatggg gagcctgggg tacccttccc tgcctccttc tagaaacttt
     1921 agggtatttt tgtgcaagta ccctgacaga aatggggcaa acatgaagtt gttttcctaa
     1981 cccctcagtc cagctgccat taacctggct ctagaaaagc caggatctct tcctaccctc
     2041 ctactggaga gtgttcccta ctgtccaaag gagcttttgg ggccgaggaa gggataatcc
     2101 cagccacccc agggctttgt ctggagatgt tgaggacttt ggggagaagg atctttcccc
     2161 caagtttggg atgagaatag agatgggggc tgggttctgt tcctcgctta agcactttat
     2221 taagggcggg actgtgtagg gtgtaaagag gctgtggact gggggttggg agagactggc
     2281 cagcagtgag cccttccaca ccgaggtaat gggtggggag ggcagtgaca gccccagatc
     2341 tggttttgta atgatttata cagaaataaa catgcctaag cccca
//
