LOCUS       NM_019123               2960 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ST6 N-acetylgalactosaminide
            alpha-2,6-sialyltransferase 3 (St6galnac3), mRNA.
ACCESSION   NM_019123 XM_579418
VERSION     NM_019123.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2960)
  AUTHORS   Senda,M., Ito,A., Tsuchida,A., Hagiwara,T., Kaneda,T., Nakamura,Y.,
            Kasama,K., Kiso,M., Yoshikawa,K., Katagiri,Y., Ono,Y., Ogiso,M.,
            Urano,T., Furukawa,K., Oshima,S. and Furukawa,K.
  TITLE     Identification and expression of a sialyltransferase responsible
            for the synthesis of disialylgalactosylgloboside in normal and
            malignant kidney cells: downregulation of ST6GalNAc VI in renal
            cancers
  JOURNAL   Biochem J 402 (3), 459-470 (2007)
   PUBMED   17123352
REFERENCE   2  (bases 1 to 2960)
  AUTHORS   Sjoberg,E.R., Kitagawa,H., Glushka,J., van Halbeek,H. and
            Paulson,J.C.
  TITLE     Molecular cloning of a developmentally regulated
            N-acetylgalactosamine alpha2,6-sialyltransferase specific for
            sialylated glycoconjugates
  JOURNAL   J Biol Chem 271 (13), 7450-7459 (1996)
   PUBMED   8631773
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019123.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072501.1, SRR26643293.15052.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               JAXUCZ010000002.1  245304839-245304945 c
            108-302             JAXUCZ010000002.1  245094248-245094442 c
            303-712             JAXUCZ010000002.1  245002102-245002511 c
            713-820             JAXUCZ010000002.1  244792778-244792885 c
            821-2960            JAXUCZ010000002.1  244789627-244791766 c
FEATURES             Location/Qualifiers
     source          1..2960
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..2960
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /note="ST6 N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 3"
                     /db_xref="GeneID:29758"
                     /db_xref="RGD:3677"
     exon            1..107
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1007
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /EC_number="2.4.3.7"
                     /note="((alpha-N-acetylneuraminyl
                     2,3-betagalactosyl-1,3)-N-acetyl galactosaminide
                     alpha-2,6-sialyltransferase) C; STY; ST6GalNAc III; galNAc
                     alpha-2,6-sialyltransferase III; SIAT7-C; ST6GalNAcIII;
                     sialyltransferase 7 ((alpha-N-acetylneuraminyl
                     23-betagalactosyl-13)-N-acetyl galactosaminide
                     alpha-26-sialyltransferase) C; ST6
                     (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3;
                     ST6 GalNAc alpha-2,6-sialyltransferase 3;
                     sialyltransferase 7c"
                     /codon_start=1
                     /product="alpha-N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 3"
                     /protein_id="NP_061996.2"
                     /db_xref="GeneID:29758"
                     /db_xref="RGD:3677"
                     /translation="MACILKRKPALAVSFIALCILLLAMRLANDVTFPLLLNCFGQPK
                     TKWIPLSYTLRQPLQTHYGYINVRTQEPLQLNCNHCAVVSNSGQMVGQKVGEEIDRAS
                     CIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASTTIYVIWGPFRN
                     MRKDGNGIVYNMLKKTVDTYPDAQIYVTTEQRMTYCDGVFKDETGKDRVQSGSYLSTG
                     WFTFILAMDACYSIHVYGMINETYCTTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGG
                     HRFITEKKVFAKWAKKHRIVFTHPNWTVS"
     exon            108..302
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /inference="alignment:Splign:2.1.0"
     exon            303..712
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /inference="alignment:Splign:2.1.0"
     exon            713..820
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /inference="alignment:Splign:2.1.0"
     exon            821..2960
                     /gene="St6galnac3"
                     /gene_synonym="Siat7c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcccggct cgctctgcgg gaatgtgggc tggagtggtc cagctgcggg gccgaggtgc
       61 agcgagccac agggtcgatc catagcgcca tggcctgcat cctcaagagg aagcctgcgc
      121 ttgcggtgag cttcatagcc ctgtgcatct tgctgctagc catgcgcctt gccaatgacg
      181 tgactttccc tttgctcctg aactgctttg gacaacctaa aaccaaatgg atccctttgt
      241 cctacacact caggcagcct cttcaaactc actatggata cataaacgtg aggacccaag
      301 agcctttgca gctgaactgt aaccattgtg ccgtcgtgtc gaactcgggt cagatggttg
      361 gacagaaggt gggggaagag atagaccgtg cgtcctgcat ctggagaatg aacaatgccc
      421 ccaccaaggg tttcgaggaa gatgtcggct acatgacgat ggtccgagtg gtgtcacaca
      481 ccagcgtccc tctcttgctg aaaaacccgg actatttttt caaggaggcg agcacaacca
      541 tttacgtcat ctggggccct ttccgcaaca tgaggaagga cgggaacggg atcgtgtaca
      601 acatgctaaa gaagacggtc gacacctacc cagacgcgca gatctacgtg accacggagc
      661 agcggatgac gtactgcgac ggggtgttta aggatgaaac tgggaaagac agagtccagt
      721 ctggctccta tctcagcacc gggtggttca cctttatcct ggccatggac gcctgctaca
      781 gtatccacgt ctacgggatg ataaatgaga cctactgcac gacagaaggg tatagaaaag
      841 tcccctatca ttactatgaa caagggaagg acgagtgtaa cgagtatctt ctccatgaac
      901 atgccccata cgggggacac aggttcatca ccgagaagaa agtgtttgcc aagtgggcca
      961 agaaacacag aatagtattt acacacccaa actggacagt gtcctgatgc tgtgcttcct
     1021 gaccgtgaca ctgcagctgt gaggaagaga ggttgatggt ggtgacagtg cgggcaggat
     1081 gctcatggtg accatggtcc tggacattct ctgtggggac actgactctg ctagtaattt
     1141 gaactttggc attctgtggg agggggtcat gttcattctg gtccttctgg tggttcagcc
     1201 ctgcgaattg cactttaaaa cttacctaca actgaaatga aggctgtgac taaagaaaac
     1261 acgaagatta cctttcaaga tggctgctca gaattcttta acagaggctt ccaggactca
     1321 cgattcagcc tgctcaggca aggttactga gtgcatgggc tgctccccat cttggaaaac
     1381 ggtggactgt cataatacac tgtccccaag caattctttc agggtagaga tatcttgcca
     1441 ccgttaccag ttaccctgat agaggggagg tatctctttc tgctctgcca tctttcttcc
     1501 atatgtctct catctaaagc ctcaggccac ctaactaaat gtagcaatga aggcattctg
     1561 taattcctgc atatcaggat tgctggactg tctcagagac ttaattcaaa atgtatcaaa
     1621 tagcaaatat tgacaatttt tcacttggac agctgtgctc tcactactca aaacaatgta
     1681 actaaacata ttactacaat tacctacatt aatgtttagt tatttttggt tgagtgctaa
     1741 acattaacag gttagatata ctgctacact gtaataacac atactgtgaa agcatttctt
     1801 gaaaataacc aaagggttcc tcactcttct tcaacactca gtaccaagaa atgagatgct
     1861 ctttgaaacc acaaaacagg ggaaagcaag acatattttt gcatcaattt gtatcctatc
     1921 atattcataa tatatatttt taaattcaaa tttctatttt ataagctgaa ggtgtacctc
     1981 tctccatata cattatcaat gtcaagtgcc aaacggtaga tatggaacct tctttatatc
     2041 atcaaaccca gcccaagctt ttgccttcat agggctgatt gtcccttagg ttgccgtatg
     2101 ttctgctaga aaagtaaaat ggtcatgagc ttcattccca aagtgcttcg ctatgcttca
     2161 cataggctat gtaccacgtg acgcccatgg ccacctccct ggactattgc ctgcacattc
     2221 tgccatcccc agcagctgat ctgcattgtt ggctgtgttc atgtgtccca ggtcgctcta
     2281 gttcagaata taggtataga atagcatttg tgtaaatcag taaacgactg agttctctgc
     2341 caagcacagc atagcatacc gagattatgc aaaatggcca caaggacggc cgtgtcatag
     2401 atcagtaccc tataagctta gataccttca atgtttttgc ttctgttcgt ggctctctgt
     2461 tccagagctc ggggacaatg gctaggaatg gtagcagaga aatacagttt ccaggtctag
     2521 acctgagaca gctttcttct ctgtagactc aatgatcctt aaatattaga ggttgatttt
     2581 ctgagacact tccaagcatc cataaatatc ttggcacaat gattcaaaag ctaaaaccaa
     2641 gctgcattga gtgttttaga gctggaaatg acaaaacacc tcacctgtgc cacctcgaca
     2701 gggctttcct acgattaagg gctatgctaa ctcattaaga tgtgcatctt tcctaccctc
     2761 tgcacccatt ttgatatccc acaccccgac ccataagctt tgcccagccc catcttcacc
     2821 gctggagagg agtggtcatt ctgttgtttg cttgtgtgat tttttagtta tgaatgttag
     2881 ttcctataga gctgatagtg gatccaagtg cccacttaaa ggaaagtaaa taaaataaat
     2941 catagcaatg ttaaaatttc
//
