LOCUS       NM_001105859            2432 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ST6 N-acetylgalactosaminide
            alpha-2,6-sialyltransferase 1 (St6galnac1), mRNA.
ACCESSION   NM_001105859 XM_001081728 XM_221248
VERSION     NM_001105859.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2432)
  AUTHORS   Yan X, Zhao R, Feng X, Mu J, Li Y, Chen Y, Li C, Yao Q, Cai L, Jin
            L, Han C and Zhang D.
  TITLE     Sialyltransferase7A promotes angiotensin II-induced cardiomyocyte
            hypertrophy via HIF-1alpha-TAK1 signalling pathway
  JOURNAL   Cardiovasc Res 116 (1), 114-126 (2020)
   PUBMED   30854566
  REMARK    GeneRIF: Sialyltransferase7A promotes angiotensin II-induced
            cardiomyocyte hypertrophy via HIF-1alpha-TAK1 signalling pathway.
REFERENCE   2  (bases 1 to 2432)
  AUTHORS   Harduin-Lepers A, Mollicone R, Delannoy P and Oriol R.
  TITLE     The animal sialyltransferases and sialyltransferase-related genes:
            a phylogenetic approach
  JOURNAL   Glycobiology 15 (8), 805-817 (2005)
   PUBMED   15843597
  REMARK    Erratum:[Glycobiology. 2005 Sep;15(9):21G]
REFERENCE   3  (bases 1 to 2432)
  AUTHORS   Kurosawa N, Takashima S, Kono M, Ikehara Y, Inoue M, Tachida Y,
            Narimatsu H and Tsuji S.
  TITLE     Molecular cloning and genomic analysis of mouse GalNAc alpha2,
            6-sialyltransferase (ST6GalNAc I)
  JOURNAL   J Biochem 127 (5), 845-854 (2000)
   PUBMED   10788794
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_221248.4, XM_001081728.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16093047,
                              SAMN16093048 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2432
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.2"
     gene            1..2432
                     /gene="St6galnac1"
                     /gene_synonym="Siat7A"
                     /note="ST6 N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 1"
                     /db_xref="GeneID:287920"
                     /db_xref="RGD:1562048"
     exon            1..214
                     /gene="St6galnac1"
                     /gene_synonym="Siat7A"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1661
                     /gene="St6galnac1"
                     /gene_synonym="Siat7A"
                     /EC_number="2.4.3.3"
                     /note="alpha-2,6-sialyltransferase ST6GalNAc I;
                     alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
                     1; ST6
                     (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,
                     3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1;
                     ST6GALNAC1, alpha-2,6-sialyltransferase 1; ST6 GalNAc
                     alpha-2,6-sialyltransferase 1; sialyltransferase 7
                     ((alpha-N-acetylneuraminyl
                     2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde
                     alpha-2,6-sialyltransferase) A"
                     /codon_start=1
                     /product="alpha-N-acetylgalactosaminide
                     alpha-2,6-sialyltransferase 1 precursor"
                     /protein_id="NP_001099329.1"
                     /db_xref="GeneID:287920"
                     /db_xref="RGD:1562048"
                     /translation="MENRCRGLSQGQTFLLLTGLMLLFILPSVVKEPSTRVSRYQFIE
                     DNESSLQGVPQKPAPQGPIVTLTPTVHNKKTTSVRTKWVELQKQDRATARGERGEGVE
                     KKLQAIRLAPENPKGKAEPEVKTPASKHLDKLPRATGALSTRKTQMATGAAPAKKKVV
                     QPTPTPASFPHLTTQRRQRLKASDFKSEPRWDFEEEYSLDGGSLQTTCPGSVKITASH
                     SPWLQNIFLPNITLFLDSGRFNQSEWYRLEHFTPPFGFMELNQSLVQKVVSRFPPVPQ
                     QQLLLASLPTRNLTCITCAVVGNGGILNNSRMGQEIDSHDYVFRLSGAVIKGYEQDVG
                     TRTSFYGFTAFSLVQSILNLGRQGFQHVPLGKDVRYLHFLEGTRDYEWLEAMFLNRTM
                     ANTKLYWFRHRPQEAFREALDLDRYFLVHPDFLRYMKNRFLRSKTLDTAHWRLYRPTT
                     GALLLLTALHLCDKVSAYGFITQGHERFSDHYYDTSWKRLIFYINHDFALERTVWKRL
                     HDEGIIQLYQRP"
     exon            215..716
                     /gene="St6galnac1"
                     /gene_synonym="Siat7A"
                     /inference="alignment:Splign:2.1.0"
     exon            717..885
                     /gene="St6galnac1"
                     /gene_synonym="Siat7A"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1057
                     /gene="St6galnac1"
                     /gene_synonym="Siat7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1196
                     /gene="St6galnac1"
                     /gene_synonym="Siat7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1300
                     /gene="St6galnac1"
                     /gene_synonym="Siat7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1390
                     /gene="St6galnac1"
                     /gene_synonym="Siat7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1490
                     /gene="St6galnac1"
                     /gene_synonym="Siat7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..2432
                     /gene="St6galnac1"
                     /gene_synonym="Siat7A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggtcaggg ctccctcact ctcatctgga caaggaggtg acctgctacc tcaggaggct
       61 cgctcatcac acgtgcgttt gggggccagc cgcccaccat ggagaaccgt tgtagagggc
      121 tttcccaggg gcaaactttc ctgcttctga ctgggttgat gttgctcttt atcctgccct
      181 ccgttgtcaa ggagccaagc acaagggttt ccaggtacca gtttatagag gacaatgaat
      241 caagtctgca gggggttcca caaaagcctg caccccaagg acccatcgtg accctgacac
      301 ccacagttca caacaagaag acaacctctg tcaggacaaa gtgggtggag ctgcagaaac
      361 aggacagagc gacagcccga ggagagcgag gagagggggt ggagaagaag ttgcaagcta
      421 taaggctagc accagagaat cctaagggca aggcagaacc tgaggtaaag acgcctgctt
      481 caaaacatct ggacaaacta ccaagagcta caggagcact gtcaacaagg aagacacaaa
      541 tggccacagg agctgcccca gccaagaaga aggtggtcca gcccacccca acccctgcct
      601 ctttcccaca cctcaccaca caaagacgcc aaaggttgaa ggcctccgac ttcaagtctg
      661 agcctcggtg ggattttgag gaggaatata gcttggatgg gggcagccta cagacgacct
      721 gccctggctc tgtgaagatc acggcttccc attcaccatg gctacaaaat atctttctgc
      781 ccaacatcac tctgttcctg gactctgggc gcttcaacca gagcgagtgg tacaggctag
      841 agcacttcac tccacccttc ggcttcatgg agctcaatca gtccctggta cagaaggtgg
      901 tgagccgctt ccctccggta ccccagcagc agctcctcct tgccagcctc cccactagga
      961 acttgacgtg tatcacctgt gctgtagtgg gcaacggagg catcctcaat aattcacgta
     1021 tgggccagga gatagacagc catgactacg tcttccgact gagtggagcc gttattaaag
     1081 gatatgaaca ggatgtgggg acccggacat ccttctatgg cttcactgcc ttctccctgg
     1141 tccagtctat cctcaatttg ggtcgtcaag gtttccagca tgtgcctctg gggaaggatg
     1201 tccgatatct acacttcctg gaaggcaccc gggactatga gtggctggaa gctatgttct
     1261 tgaatcggac catggcaaat actaaacttt actggttcag gcatagaccc caggaagcct
     1321 ttagagaggc cttggacttg gatcgatact ttctggtaca cccagacttt ctccgttaca
     1381 tgaagaacag gtttttgagg tcaaagaccc tggacactgc ccactggaga ctataccgcc
     1441 ccaccactgg tgccctcctg ctgcttacag cccttcatct ctgtgacaag gtgagcgcct
     1501 atggcttcat cacccagggc cacgagcgct tctctgatca ctactatgat acatcgtgga
     1561 aacggctcat cttttacata aaccatgact tcgcgttaga gagaacggtc tggaagaggc
     1621 tgcatgatga aggcatcatc cagctgtacc agcgcccgta gagtggcaaa gcaaagaact
     1681 gaccagggcc tggatcgagg ttcccctcaa tcacttacaa caggggtgta agggttcctc
     1741 aaatgctcct tcctgtctcc cagactcaaa cctgctccat gcccttccag agtcccaagg
     1801 aacaggtgtg catgacagag ggtttggagt cctttggaaa atcaccacag gctctgggca
     1861 tttcctgctc aaaccgcagc cttagaaaca gagccaaacc ccaaacaatt tagtccacct
     1921 tactttactt ttcaaacact gccttcagaa atttggcctc tggaacgcag agtatcagta
     1981 aagcccaaat cgaggtgctt attagtgggt ggaaggaaaa caaagcgaga taaaaaccaa
     2041 cttcatttag atttagtgcc cagtagggta ctatactgct tatgatttgc tcagactgca
     2101 gtagcgactc cggccggcag ggggcggcag ctgggcgctc gagagcagat tgacttttgc
     2161 tttgctggag cagcgcttct gcaaggtgga gccggcccag cactcagggt tcagggctga
     2221 gcaggatgaa gtccaggagg acgctgcaag ctgagcagga cacggatggc tcaggggtta
     2281 agagcacatg ctgctctagc agaggacctg agtttggatc ccagtggcta tgttacacaa
     2341 cgctcaactg cctgtacaca ggtgatgtcc tggctggttt taggtcaact tgacatagga
     2401 tagatatgag acttcaactg aaaaaaatat gc
//
