LOCUS       NM_001393863            2187 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ST3 beta-galactoside alpha-2,3-sialyltransferase
            4 (St3gal4), transcript variant 2, mRNA.
ACCESSION   NM_001393863 XM_006242789
VERSION     NM_001393863.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2187)
  AUTHORS   Swaminathan,S., Huentelman,M.J., Corneveaux,J.J., Myers,A.J.,
            Faber,K.M., Foroud,T., Mayeux,R., Shen,L., Kim,S., Turk,M.,
            Hardy,J., Reiman,E.M. and Saykin,A.J.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative  and  NIA-LOAD/NCRAD
            Family Study Group
  TITLE     Analysis of copy number variation in Alzheimer's disease in a
            cohort of clinically characterized and neuropathologically verified
            individuals
  JOURNAL   PLoS One 7 (12), e50640 (2012)
   PUBMED   23227193
REFERENCE   2  (bases 1 to 2187)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2187)
  AUTHORS   Harduin-Lepers,A., Mollicone,R., Delannoy,P. and Oriol,R.
  TITLE     The animal sialyltransferases and sialyltransferase-related genes:
            a phylogenetic approach
  JOURNAL   Glycobiology 15 (8), 805-817 (2005)
   PUBMED   15843597
  REMARK    Erratum:[Glycobiology. 2005 Sep;15(9):21G]
REFERENCE   4  (bases 1 to 2187)
  AUTHORS   Kono,M., Ohyama,Y., Lee,Y.C., Hamamoto,T., Kojima,N. and Tsuji,S.
  TITLE     Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of
            in vitro substrate specificities and tissue specific expression
  JOURNAL   Glycobiology 7 (4), 469-479 (1997)
   PUBMED   9184827
REFERENCE   5  (bases 1 to 2187)
  AUTHORS   Gao,L., Gu,X.B., Yu,D.S., Yu,R.K. and Zeng,G.
  TITLE     Association of a 14-3-3 protein with CMP-NeuAc:GM1 alpha
            2,3-sialyltransferase
  JOURNAL   Biochem Biophys Res Commun 224 (1), 103-107 (1996)
   PUBMED   8694795
REFERENCE   6  (bases 1 to 2187)
  AUTHORS   Chang,M.L., Eddy,R.L., Shows,T.B. and Lau,J.T.
  TITLE     Three genes that encode human beta-galactoside alpha
            2,3-sialyltransferases. Structural analysis and chromosomal mapping
            studies
  JOURNAL   Glycobiology 5 (3), 319-325 (1995)
   PUBMED   7655169
REFERENCE   7  (bases 1 to 2187)
  AUTHORS   Kitagawa,H. and Paulson,J.C.
  TITLE     Cloning of a novel alpha 2,3-sialyltransferase that sialylates
            glycoprotein and glycolipid carbohydrate groups
  JOURNAL   J Biol Chem 269 (2), 1394-1401 (1994)
   PUBMED   8288606
REFERENCE   8  (bases 1 to 2187)
  AUTHORS   Gu,T.J., Gu,X.B., Ariga,T. and Yu,R.K.
  TITLE     Purification and characterization of CMP-NeuAc:GM1 (Gal beta
            1-4GalNAc) alpha 2-3 sialyltransferase from rat brain
  JOURNAL   FEBS Lett 275 (1-2), 83-86 (1990)
   PUBMED   2262006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 19, 2021 this sequence version replaced XM_006242789.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.754155.1,
                                           SRR26360194.2076315.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               JAXUCZ010000008.1  41722154-41722347   c
            195-295             JAXUCZ010000008.1  41721467-41721567   c
            296-371             JAXUCZ010000008.1  41682607-41682682   c
            372-456             JAXUCZ010000008.1  41682244-41682328   c
            457-537             JAXUCZ010000008.1  41681746-41681826   c
            538-635             JAXUCZ010000008.1  41681472-41681569   c
            636-696             JAXUCZ010000008.1  41681098-41681158   c
            697-792             JAXUCZ010000008.1  41680334-41680429   c
            793-982             JAXUCZ010000008.1  41680040-41680229   c
            983-1126            JAXUCZ010000008.1  41679179-41679322   c
            1127-1270           JAXUCZ010000008.1  41674722-41674865   c
            1271-2187           JAXUCZ010000008.1  41673510-41674426   c
FEATURES             Location/Qualifiers
     source          1..2187
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q21"
     gene            1..2187
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; siat4c; ST3GalIV"
                     /note="ST3 beta-galactoside alpha-2,3-sialyltransferase 4"
                     /db_xref="GeneID:363040"
                     /db_xref="RGD:1303068"
     exon            1..194
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; siat4c; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            195..295
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; siat4c; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            296..371
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; siat4c; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..1357
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; siat4c; ST3GalIV"
                     /EC_number="2.4.3.4"
                     /EC_number="2.4.3.6"
                     /EC_number="2.4.3.2"
                     /note="isoform 1 is encoded by transcript variant 2;
                     alpha-2,3-sialyltransferase ST3Gal IV;
                     CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
                     3-sialyltransferase 4; alpha 2,3-sialyltransferase IV;
                     sialyltransferase 4C; beta-galactoside
                     alpha-2,3-sialyltransferase 4;
                     gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase;
                     gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase;
                     gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase;
                     N-acetyllactosaminide alpha-2,3-sialyltransferase"
                     /codon_start=1
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 4 isoform 1"
                     /protein_id="NP_001380792.1"
                     /db_xref="GeneID:363040"
                     /db_xref="RGD:1303068"
                     /translation="MTSKSHWKLLALALVLVVVMVWYSISREDRYIEFFYFPVSEKKE
                     PCFQGEAERQASKIFGNHSREQPIFLQLKDYFWVKTPSAYELPFGTKGSEDLLLRVLA
                     ITSYSIPESIQSLECRRCVVVGNGHRLKNSSLGGVINKYDVVIRLNNAPVAGYEGDVG
                     SKTTIRLFYPESAHFDPKIENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQP
                     PLIWDVNPKQIRILNPFFMEIAADKLLSLPIQQPRKIKQKPTTGLLAITLALHLCDLV
                     HIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEAVAIKRMLEMGAVKNLTYF"
     exon            372..456
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; siat4c; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            457..537
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; siat4c; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            538..635
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; siat4c; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            636..696
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; siat4c; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            697..792
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; siat4c; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            793..982
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; siat4c; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1126
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; siat4c; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1270
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; siat4c; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..2187
                     /gene="St3gal4"
                     /gene_synonym="SIAT4-C; siat4c; ST3GalIV"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgcccccc gcccaagccc tggcccccgc ctccccttca ggcggacttg cccgctccca
       61 ggccggcccc gctccgggga cagggaccgg gccgagcgga gccactacgc cagtgctgcc
      121 ccgccagtcg gggcgcctaa cggatcggag ctgcgcgcgg atttacctcg ccccgccccg
      181 ttccacccgc gagggtgcct ctctgagacc cttgctggct ggcacctgtg ggcagctccg
      241 agatgccaac gtgtcttgta ccactgccat tcccagtcgg aggagtagac ttctggtggc
      301 ccgaggcagc cgggatgaca cttctcccca ggaacccttc tatctgctga gaaacatgac
      361 cagcaaatct cactggaagc tcctggcctt ggctctggtc cttgttgttg tcatggtgtg
      421 gtattccatc tcccgagaag acaggtacat tgagttcttt tattttcccg tctccgagaa
      481 gaaagagcca tgcttccagg gtgaggcaga gaggcaggcc tctaaaattt tcggcaacca
      541 ttctagggaa cagcccatct ttctgcagct taaggattat ttctgggtaa agacaccatc
      601 cgcctatgag ttgccctttg ggactaaagg aagtgaagat cttcttctcc gggtgttggc
      661 catcaccagc tactctatac ccgagagcat acagagcctc gagtgtcgtc ggtgtgttgt
      721 ggtggggaat gggcaccggt taaagaacag ctcactggga ggtgttatca acaagtacga
      781 tgtggtcatc agattaaaca atgctcctgt agccggttat gagggagacg tgggctccaa
      841 gaccaccata cgtctcttct atcctgagtc ggcccacttc gaccctaaga tagaaaacaa
      901 cccagacacg ctcttggtcc tggtagcttt caaggcgatg gacttccact ggattgagac
      961 catcttgagc gataagaagc gggtgcgaaa aggtttctgg aagcagcctc ccctcatctg
     1021 ggatgtcaac cccaaacaga tccggattct aaaccccttc tttatggaga ttgccgcgga
     1081 caagctcctg agcctgccca tacaacagcc tcgaaagatc aagcagaagc caaccacggg
     1141 tctgctagcc atcaccttgg ccctacacct ctgcgacttg gtgcacatcg ccggcttcgg
     1201 ctatccagat gcctacaaca agaagcagac catccactac tatgaacaga tcacactcaa
     1261 gtctatggcg ggctcaggcc acaatgtctc ccaagaggct gtagccatca agcggatgct
     1321 agagatggga gctgtcaaga acctcacata cttctgactt ggatgagagc tgcgttccct
     1381 actttgctat ttgagttggc cctgtccaca gctttggggt gcctggtgcc agtacaaccc
     1441 aattgacctc accctcaatg gagagggtgt tctgggactg gccaggtctc aggagaggct
     1501 atgcccctgg ctaatttggt ggatttcaaa tccagacagg gtggacatac tgaggctacg
     1561 gggcaaggta gcagggagcc tgttactgtg gcatcccctc tctgccagca caaagaattt
     1621 ttgttttgtt ttgttttgga atgttggtgg tggctggttg gttcttctgt ttgtttgttt
     1681 agtttgtttg tttttgtttg ttttgttttg ttcttgagac agggtcttaa ctgtgaagcc
     1741 ctggctaatc tggaactcac tatgtagacc aggctggtct tgaactcaca gagatccaac
     1801 tgcctctgcc tcccacaggt tggggattaa aggcgtgtac tacgacgcct gaccccagca
     1861 ccaagacatt atttaacata ctatttaatt aaggggtagg aaaatgaatg ggctggtccc
     1921 aggacattca caaaaggaac acaatacagt gttctgccca ctttttaata aaatttacat
     1981 acgattggcc tgttaaggcc caattctaga gctggcctcc cagaaagacg gaggcatcaa
     2041 gagtgggagg gtgtcctcca gagaggggtt gctacttccc agcgggcatg gggggagcgt
     2101 tgacaaaggg gttctaccta gaaggggcct caccttgaaa agaggttgca aaagaccatt
     2161 aaaatatttt tttttcctaa aacggaa
//
