LOCUS       NM_031697               1207 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ST3 beta-galactoside alpha-2,3-sialyltransferase
            3 (St3gal3), mRNA.
ACCESSION   NM_031697
VERSION     NM_031697.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1207)
  AUTHORS   Perez-Garay,M., Arteta,B., Pages,L., de Llorens,R., de Bolos,C.,
            Vidal-Vanaclocha,F. and Peracaula,R.
  TITLE     alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer
            cell motility and adhesion in vitro and enhances its metastatic
            potential in vivo
  JOURNAL   PLoS One 5 (9), e12524 (2010)
   PUBMED   20824144
  REMARK    GeneRIF: St3gal3 modulates pancreatic cancer cell motility and
            adhesion and enhances metastatic potential.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1207)
  AUTHORS   Kono,M., Ohyama,Y., Lee,Y.C., Hamamoto,T., Kojima,N. and Tsuji,S.
  TITLE     Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of
            in vitro substrate specificities and tissue specific expression
  JOURNAL   Glycobiology 7 (4), 469-479 (1997)
   PUBMED   9184827
REFERENCE   3  (bases 1 to 1207)
  AUTHORS   Wen,D.X., Livingston,B.D., Medzihradszky,K.F., Kelm,S.,
            Burlingame,A.L. and Paulson,J.C.
  TITLE     Primary structure of Gal beta 1,3(4)GlcNAc alpha
            2,3-sialyltransferase determined by mass spectrometry sequence
            analysis and molecular cloning. Evidence for a protein motif in the
            sialyltransferase gene family
  JOURNAL   J Biol Chem 267 (29), 21011-21019 (1992)
   PUBMED   1400416
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M97754.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_031697.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M97754.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1207
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1207
                     /gene="St3gal3"
                     /gene_synonym="Siat6"
                     /note="ST3 beta-galactoside alpha-2,3-sialyltransferase 3"
                     /db_xref="GeneID:64445"
                     /db_xref="RGD:68414"
     exon            1..52
                     /gene="St3gal3"
                     /gene_synonym="Siat6"
                     /inference="alignment:Splign:2.1.0"
     exon            53..197
                     /gene="St3gal3"
                     /gene_synonym="Siat6"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1207
                     /gene="St3gal3"
                     /gene_synonym="Siat6"
                     /EC_number="2.4.3.6"
                     /note="N-acetyllacosaminide alpha 2,3-sialyltransferase;
                     ST3N; ST3GalIII; N-acetyllactosaminide
                     alpha-2,3-sialyltransferase; gal beta-1,3(4) GlcNAc
                     alpha-2,3 sialyltransferase; ST3Gal III; alpha 2,3-ST 3;
                     beta-galactoside alpha-2,3-sialyltransferase 3;
                     sialyltransferase (N-acetyllacosaminide alpha
                     23-sialyltransferase); sialyltransferase
                     6(N-acetyllacosaminide alpha 23-sialyltransferase);
                     sialyltransferase 6 (N-acetyllacosaminide alpha
                     2,3-sialyltransferase)"
                     /codon_start=1
                     /product="CMP-N-acetylneuraminate-beta-1,4-galactoside
                     alpha-2,3-sialyltransferase"
                     /protein_id="NP_113885.1"
                     /db_xref="GeneID:64445"
                     /db_xref="RGD:68414"
                     /translation="MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEDSNSLILS
                     LDSAGQTLGTEYDRLGFLLKLDSKLPAELATKYANFSEGACKPGYASAMMTAIFPRFS
                     KPAPMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLHCRRCI
                     IVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQ
                     YERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFI
                     QEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALDGCDEVAVAGFGYDMNTPNAPLHY
                     YETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSSGI"
     exon            198..245
                     /gene="St3gal3"
                     /gene_synonym="Siat6"
                     /inference="alignment:Splign:2.1.0"
     exon            246..288
                     /gene="St3gal3"
                     /gene_synonym="Siat6"
                     /inference="alignment:Splign:2.1.0"
     exon            289..381
                     /gene="St3gal3"
                     /gene_synonym="Siat6"
                     /inference="alignment:Splign:2.1.0"
     exon            382..476
                     /gene="St3gal3"
                     /gene_synonym="Siat6"
                     /inference="alignment:Splign:2.1.0"
     exon            477..540
                     /gene="St3gal3"
                     /gene_synonym="Siat6"
                     /inference="alignment:Splign:2.1.0"
     exon            541..636
                     /gene="St3gal3"
                     /gene_synonym="Siat6"
                     /inference="alignment:Splign:2.1.0"
     exon            637..823
                     /gene="St3gal3"
                     /gene_synonym="Siat6"
                     /inference="alignment:Splign:2.1.0"
     exon            824..970
                     /gene="St3gal3"
                     /gene_synonym="Siat6"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1117
                     /gene="St3gal3"
                     /gene_synonym="Siat6"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1207
                     /gene="St3gal3"
                     /gene_synonym="Siat6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcctttccc ggggccagat cctcttcgga gcgaccgggt cagtttgtca aagtcatgta
       61 ggaaattgtg ggtcatgtga agatgggact cttggtattt gtacgcaacc tgctgctagc
      121 cctctgcctc tttctggtcc tgggattttt gtattattct gcctggaagc tacacttact
      181 ccaatgggaa gactccaatt cactgattct ttcccttgac tccgctggac aaaccctagg
      241 cacagagtat gataggctgg gtttcctcct gaagctggac tctaaactgc ctgcagagct
      301 ggccaccaag tacgctaact tttccgaggg agcctgcaaa cccggctacg cttcagccat
      361 gatgactgcc atcttcccca ggttctccaa gccagcaccc atgttcctgg atgactcctt
      421 tcgcaaatgg gctaggattc gggagtttgt gccacccttt gggatcaaag gtcaagacaa
      481 tctgatcaaa gccatcttgt cagtcaccaa agaataccgc ctgacccctg ccttggacag
      541 cctccactgc cgccgctgca tcatcgtagg caatggaggg gtcctcgcca acaagtctct
      601 ggggtcacga attgacgact atgacattgt gatcagattg aactcagcac ctgtgaaggg
      661 ctttgagaag gacgtgggca gcaagaccac cctgcgcatc acctaccctg aaggtgccat
      721 gcagcggcct gagcaatatg aacgagactc tctctttgta ctagctggct tcaagtggca
      781 ggacttcaag tggctgaagt acatcgtcta caaggagaga gtgagcgcat ccgatggctt
      841 ctggaagtcc gtggccaccc gagtgcccaa ggagccccct gagatccgca tcctcaaccc
      901 gtacttcatc caggaggctg ccttcacgct catcggactg cccttcaaca atggcctcat
      961 gggcagaggg aacatcccaa cccttggcag tgtggcagtg accatggcac tcgatggctg
     1021 tgatgaagtg gcagtcgcgg gctttggcta tgacatgaac acacccaacg cccccctgca
     1081 ctactatgaa actgtgcgca tggcagccat caaagagtcc tggacacaca acatccagcg
     1141 agagaaagag tttctgcgga agctagtgaa agcacgcgtc atcactgact taagcagtgg
     1201 tatctga
//
