LOCUS       NM_031695               3221 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ST3 beta-galactoside alpha-2,3-sialyltransferase
            2 (St3gal2), mRNA.
ACCESSION   NM_031695
VERSION     NM_031695.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3221)
  AUTHORS   Chandrasekaran,E.V., Xue,J., Xia,J., Locke,R.D., Patil,S.A.,
            Neelamegham,S. and Matta,K.L.
  TITLE     Mammalian sialyltransferase ST3Gal-II: its exchange sialylation
            catalytic properties allow labeling of sialyl residues in
            mucin-type sialylated glycoproteins and specific gangliosides
  JOURNAL   Biochemistry 50 (44), 9475-9487 (2011)
   PUBMED   21913655
  REMARK    GeneRIF: Use of sialyl mucin core 2 compounds shows how ST3Gal-II
            exchanges sialyl residues between CMP-NeuAc and the
            NeuAcalpha2,3Galbeta1,3GalNAc unit, while also radiolabeling sialyl
            residues in gangliosides GD1a and GT1b, but not GM1.
REFERENCE   2  (bases 1 to 3221)
  AUTHORS   Giordanengo,V., Bannwarth,S., Laffont,C., Van Miegem,V.,
            Harduin-Lepers,A., Delannoy,P. and Lefebvre,J.C.
  TITLE     Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc
            alpha2,3-sialyltransferase from the CEM T-cell line
  JOURNAL   Eur J Biochem 247 (2), 558-566 (1997)
   PUBMED   9266697
REFERENCE   3  (bases 1 to 3221)
  AUTHORS   Kono,M., Ohyama,Y., Lee,Y.C., Hamamoto,T., Kojima,N. and Tsuji,S.
  TITLE     Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of
            in vitro substrate specificities and tissue specific expression
  JOURNAL   Glycobiology 7 (4), 469-479 (1997)
   PUBMED   9184827
REFERENCE   4  (bases 1 to 3221)
  AUTHORS   Lee,Y.C., Kojima,N., Wada,E., Kurosawa,N., Nakaoka,T., Hamamoto,T.
            and Tsuji,S.
  TITLE     Cloning and expression of cDNA for a new type of Gal beta 1,3GalNAc
            alpha 2,3-sialyltransferase
  JOURNAL   J Biol Chem 269 (13), 10028-10033 (1994)
   PUBMED   8144500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X76988.1, EV769154.1, CO404237.1 and JAXUCZ010000019.1.
            
            On Mar 6, 2008 this sequence version replaced NM_031695.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.53030.1,
                                           SRR21887620.1025618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               X76988.1           13-461
            450-825             EV769154.1         311-686
            826-1211            CO404237.1         216-601
            1212-3221           JAXUCZ010000019.1  55847217-55849226
FEATURES             Location/Qualifiers
     source          1..3221
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..3221
                     /gene="St3gal2"
                     /gene_synonym="Siat4b; Siat5"
                     /note="ST3 beta-galactoside alpha-2,3-sialyltransferase 2"
                     /db_xref="GeneID:64442"
                     /db_xref="RGD:68413"
     exon            1..407
                     /gene="St3gal2"
                     /gene_synonym="Siat4b; Siat5"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1121
                     /gene="St3gal2"
                     /gene_synonym="Siat4b; Siat5"
                     /EC_number="2.4.3.4"
                     /EC_number="2.4.3.2"
                     /note="monosialoganglioside sialyltransferase; SIAT4-B;
                     ST3GALA.2; ST3Gal II; gal-NAc6S;
                     gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; ST3GalII;
                     alpha 2,3-ST 2; beta-galactoside
                     alpha-2,3-sialyltransferase 2; sialyltransferase 5;
                     sialyltransferase 4B (beta-galactoside
                     alpha-2,3-sialyltransferase)"
                     /codon_start=1
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 2"
                     /protein_id="NP_113883.2"
                     /db_xref="GeneID:64442"
                     /db_xref="RGD:68413"
                     /translation="MKCSLRVWFLSMAFLLVFIMSLLFTYSHHSMATLPYLDSGTLGG
                     THRVKLVPGYTGQQRLVKEGLSGKSCTCSRCMGDAGTSEWFDSHFDSNISPVWTRDNM
                     NLTPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPQQCRRCAVVGNSGN
                     LRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVP
                     FKALDLMWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRY
                     PSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHI
                     IDMLAKASKIEVYRGN"
     exon            408..601
                     /gene="St3gal2"
                     /gene_synonym="Siat4b; Siat5"
                     /inference="alignment:Splign:2.1.0"
     exon            602..781
                     /gene="St3gal2"
                     /gene_synonym="Siat4b; Siat5"
                     /inference="alignment:Splign:2.1.0"
     exon            782..827
                     /gene="St3gal2"
                     /gene_synonym="Siat4b; Siat5"
                     /inference="alignment:Splign:2.1.0"
     exon            828..947
                     /gene="St3gal2"
                     /gene_synonym="Siat4b; Siat5"
                     /inference="alignment:Splign:2.1.0"
     exon            948..3221
                     /gene="St3gal2"
                     /gene_synonym="Siat4b; Siat5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgtggctgg ccccacagtg ggctgggaaa ggattggcca cggtgacagc cgccccgtgg
       61 ccagcacaat gaagtgctcc cttcgagtgt ggttcctctc tatggccttc ctgctggtgt
      121 tcattatgtc tctgctcttc acgtactcac accacagcat ggctaccttg ccctacctgg
      181 actcggggac tctgggcgga acacaccgag tgaagctggt accgggctat actgggcaac
      241 agcgccttgt caaggagggg ctttcgggga aaagttgtac ctgcagtcgc tgcatgggtg
      301 atgccggcac ctctgagtgg tttgacagcc actttgacag taacatctca cctgtctgga
      361 cgagagataa catgaacctc accccggatg tccagcggtg gtggatgatg ctgcaacccc
      421 aattcaagtc acacaacacc aatgaagtgt tggagaagct cttccagatc gtgcccggtg
      481 agaaccccta ccgcttccgg gacccccagc agtgccggcg ctgtgctgtg gtcgggaact
      541 caggcaacct tcggggctct ggctatgggc aagaagtgga cagccacaac tttatcatga
      601 ggatgaatca ggcaccgact gtaggctttg agaaggatgt tggcagccga acaactcacc
      661 atttcatgta cccggagagt gccaagaacc tgcctgccaa cgtgagcttt gtgctggtgc
      721 ccttcaaggc cctggacctg atgtggattg ccagcgccct ctccacagga cagatccgat
      781 tcacctatgc tccagtgaag tccttccttc gagtggacaa agagaaggtc cagatttaca
      841 acccagcctt cttcaagtac atccatgaca ggtggaccga gcaccatggc cgctacccct
      901 ccacaggaat gctggtgctc ttctttgcac tacacgtgtg tgatgaggtg aacgtgtatg
      961 ggttcggggc cgacagccgt ggcaactggc accactactg ggagaacaac cggtacgcgg
     1021 gcgagttccg gaagacaggc gtgcatgatg ccgacttcga agcccacatc attgacatgc
     1081 tggccaaggc cagcaagatt gaagtctacc gagggaactg agcagcctca ggcgccttca
     1141 gaaccagtca cttcagggtc tggcaagcgc cggttgccgc ccaccaatca gactgcgccg
     1201 tccccagcaa ccaatcagtg ctgcagttgg gaggagcttc tttcttagcc aatcacacaa
     1261 ctcaaggaga acttccggcg ccgccgtctc caccaatcat ggccttggga ggcggcgggc
     1321 ctggaccccc tcccccaacc cccaaccccg ctttggatga gaatttttct gctttttaag
     1381 aggccggtct gggtctggga gggagcacct tgaactgctc atttccagct tagtcccgat
     1441 gggtgagtga agcccgccaa agaaatgtgg tcccggcgag atactttcca gggcattctg
     1501 tggctcacca gctagtaggg ggttgtattc actccctagt tgggttgacc tccctagggc
     1561 ctcattagtg tcaggaacgg gtaggaagct ccaccgggtc acatgcaagg tgcttctctc
     1621 acgtgtgccc tcactcctgt tccccaccac cttctcagcg tctgtcctta ggtcctgggt
     1681 ctcctctcca gctcacctgt tgatttggag acaaaatgag accaccggga ctccgctgct
     1741 tgtgctctca cacacgcggc ccaagtcttt agccctaagg cgagagcagc agggttggac
     1801 agtaggctgg aaaggagtgc cctgtgcatg tatctttttc tttcattgtc accccaaaga
     1861 ggagcaggca gcctcttgct tgggtgttgg atttgctttg gattcatact ttagttaccc
     1921 tccagctgcc agggatggct atccaaccaa gatcgcttga cagttgtttg caggccttgc
     1981 agatggctcg gagctttgct ggggaggagc agattggtat ctgccatgca tggctcctcc
     2041 tgtccgcccc tttaccatgc ttactcgcct gttctaacct actttccagc tcctaaaggg
     2101 ctggtgagtc aagaatcggg ttacaactgg aagctatttg catgacttga cccaggtcaa
     2161 agttgaggtt catttgggag aaagggcttc agtgaatgcc tcaggcccca gaaaacactt
     2221 cccttcagtg tccacataat aatttcccat tcttaatgag ttgacattaa caagcagctt
     2281 cctggttggg ggacagtcac acgtaaggag tgtgttaaag tttggtatga ggcaaatacc
     2341 cctaaaaact aatatatgaa gaactttgct tgaatttgtt ccttccaagt ttcaaaagca
     2401 ggggtagaga aaaagggagt ataccgagaa gggctgtagc ggaacctctc agggctctaa
     2461 tcatcgtgca gtcactgtac cagtggccgt tcttgcctgt ctccgctctc ccaagaagct
     2521 gctgtgatga gaagtgggaa agtactgcga ttacgacaaa cagtattgag aagaagaatt
     2581 tatttttcct ccttttgttt tgcttaaacc atgagtcacc attctagaaa aggtaggtcc
     2641 cagcacccac atcctttttc ttctacagtt atttaaacat tcaatttttc cctctgtttc
     2701 ttttcctgaa ttaaaaagaa cgaagtccat agagttactc atctgttctg aactgtaccc
     2761 ctcataggtg attctgagga ggtaaagatg tttgggggaa caaggcaact ctgataacct
     2821 cttacacctg agaagccttt tcatgggctc tgcactccga agtcccccca cagagggctg
     2881 agtattatgg tttagaaaaa tcaatttatt atgccaggca tggtggtatg tgcctttaat
     2941 cctagcagtt aggagtctgc agcaggaaag taagttaaag gctagcctca gctatatggt
     3001 aactttcaaa ctaacctggg ctatatgaga ccctttctca aggggaaaaa agggaacaaa
     3061 aaaaaaaaaa tccattgtcc cctcttcaga ttcctctaaa agagtaatgc cttgggaaga
     3121 atttctggtt cacctgaaat ggccttttgt aaatacaggg tctttattac agactcatgt
     3181 tggtttatct cagcacccat aaagcggtcc tcttcctgtg a
//
