LOCUS       NM_001013219            5584 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ST3 beta-galactoside alpha-2,3-sialyltransferase
            1 (St3gal1), mRNA.
ACCESSION   NM_001013219 XM_006241709 XM_343254
VERSION     NM_001013219.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5584)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 5584)
  AUTHORS   Rao,F.V., Rich,J.R., Rakic,B., Buddai,S., Schwartz,M.F.,
            Johnson,K., Bowe,C., Wakarchuk,W.W., Defrees,S., Withers,S.G. and
            Strynadka,N.C.
  TITLE     Structural insight into mammalian sialyltransferases
  JOURNAL   Nat Struct Mol Biol 16 (11), 1186-1188 (2009)
   PUBMED   19820709
REFERENCE   3  (bases 1 to 5584)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 5584)
  AUTHORS   Harduin-Lepers,A., Mollicone,R., Delannoy,P. and Oriol,R.
  TITLE     The animal sialyltransferases and sialyltransferase-related genes:
            a phylogenetic approach
  JOURNAL   Glycobiology 15 (8), 805-817 (2005)
   PUBMED   15843597
  REMARK    Erratum:[Glycobiology. 2005 Sep;15(9):21G]
REFERENCE   5  (bases 1 to 5584)
  AUTHORS   Jeanneau,C., Chazalet,V., Auge,C., Soumpasis,D.M.,
            Harduin-Lepers,A., Delannoy,P., Imberty,A. and Breton,C.
  TITLE     Structure-function analysis of the human sialyltransferase ST3Gal
            I: role of n-glycosylation and a novel conserved sialylmotif
  JOURNAL   J Biol Chem 279 (14), 13461-13468 (2004)
   PUBMED   14722111
REFERENCE   6  (bases 1 to 5584)
  AUTHORS   Martin,L.T., Marth,J.D., Varki,A. and Varki,N.M.
  TITLE     Genetically altered mice with different sialyltransferase
            deficiencies show tissue-specific alterations in sialylation and
            sialic acid 9-O-acetylation
  JOURNAL   J Biol Chem 277 (36), 32930-32938 (2002)
   PUBMED   12068010
REFERENCE   7  (bases 1 to 5584)
  AUTHORS   Kono,M., Ohyama,Y., Lee,Y.C., Hamamoto,T., Kojima,N. and Tsuji,S.
  TITLE     Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of
            in vitro substrate specificities and tissue specific expression
  JOURNAL   Glycobiology 7 (4), 469-479 (1997)
   PUBMED   9184827
REFERENCE   8  (bases 1 to 5584)
  AUTHORS   Lee,Y.C., Kurosawa,N., Hamamoto,T., Nakaoka,T. and Tsuji,S.
  TITLE     Molecular cloning and expression of Gal beta 1,3GalNAc alpha
            2,3-sialyltransferase from mouse brain
  JOURNAL   Eur J Biochem 216 (2), 377-385 (1993)
   PUBMED   8375377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Oct 13, 2022 this sequence version replaced
            XM_006241709.4, NM_001013219.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.20919.1,
                                           SRR26643292.30363.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760475,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000007.1  100802190-100802285 c
            97-234              JAXUCZ010000007.1  100784307-100784444 c
            235-289             JAXUCZ010000007.1  100757197-100757251 c
            290-1151            JAXUCZ010000007.1  100744378-100745239 c
            1152-1348           JAXUCZ010000007.1  100743422-100743618 c
            1349-1528           JAXUCZ010000007.1  100742219-100742398 c
            1529-1574           JAXUCZ010000007.1  100741006-100741051 c
            1575-1694           JAXUCZ010000007.1  100739551-100739670 c
            1695-5584           JAXUCZ010000007.1  100734300-100738189 c
FEATURES             Location/Qualifiers
     source          1..5584
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..5584
                     /gene="St3gal1"
                     /gene_synonym="Siat4a"
                     /note="ST3 beta-galactoside alpha-2,3-sialyltransferase 1"
                     /db_xref="GeneID:362924"
                     /db_xref="RGD:1309373"
     exon            1..96
                     /gene="St3gal1"
                     /gene_synonym="Siat4a"
                     /inference="alignment:Splign:2.1.0"
     exon            97..234
                     /gene="St3gal1"
                     /gene_synonym="Siat4a"
                     /inference="alignment:Splign:2.1.0"
     exon            235..289
                     /gene="St3gal1"
                     /gene_synonym="Siat4a"
                     /inference="alignment:Splign:2.1.0"
     exon            290..1151
                     /gene="St3gal1"
                     /gene_synonym="Siat4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             846..1868
                     /gene="St3gal1"
                     /gene_synonym="Siat4a"
                     /EC_number="2.4.3.4"
                     /function="adds sialic acid in alpha2,3 linkage to
                     galactose"
                     /note="sialyltransferase ST3Gal-I; sialyltransferase 4A
                     (beta-galactoside alpha-2,3-sialytransferase)"
                     /codon_start=1
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 1 precursor"
                     /protein_id="NP_001013237.2"
                     /db_xref="GeneID:362924"
                     /db_xref="RGD:1309373"
                     /translation="MVNMRKRTLKYLTFFLLFIFLTSFVLNYSNSGVPSAWFPKQMVL
                     EFSENFRKFIKSQPCTCRHCISQGKVSYWFDQRFNKTMQPLLTAHNALMEEDTYRWWL
                     RLQRERKPNNLSDTVKELFRLVPGNVDPMLNKRLVGCRRCAVVGNSGNLKDSSYGPEI
                     DSHDFVLRMNRAPTVGFEADVGSRTTHHLVYPESFRELGENVNMVLVPFKITDLQWVI
                     SATTTGTITHTYVPVPPKIKVKQEKILIYHPAFIKYVFDNWLQGHGRYPSTGILSVIF
                     SIHICDEVDLYGFGADSKGNWHHYWENNPSAGAFRKTGVHDGDFEYNVTTTLAAINKI
                     RIFKGR"
     exon            1152..1348
                     /gene="St3gal1"
                     /gene_synonym="Siat4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1528
                     /gene="St3gal1"
                     /gene_synonym="Siat4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1574
                     /gene="St3gal1"
                     /gene_synonym="Siat4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1694
                     /gene="St3gal1"
                     /gene_synonym="Siat4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..5584
                     /gene="St3gal1"
                     /gene_synonym="Siat4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacactttc gacactttgc aaagacaaag agccctagac cggagggaga agagaggagg
       61 agacagagga ggaccgtgag gtgtgagctg actggggctt gactttgctg agttagcaat
      121 gccatcaagg agcaactggc actttgttgg gtctgtgctg agcaaggctc agagctctgc
      181 ggccagacag ctgtatcagt gagccagagg cagacagtgg ctcaacttcc tgagatgaag
      241 aaactgagac ctaaagaggt taagggactc cactgatgtg gcacttccga tgttcggcaa
      301 cccctgcgcc ttccgggaga catcctggaa gtccccattc ctggtgacag cctcggagac
      361 acagctctaa ttaaggactg tccttagcca cacttcccag aggaaggtgg ccaagcagtt
      421 tcacatcctg tgccaagacc cttttccaga tgatccaggg agtcacccag gctgaggatt
      481 aactaactaa acttaatccc ttttgaactg gggagaacat cgctcttccc aggtttcgct
      541 aaagcatcat caaaccacat tcttgacttt gcttgggatg cagaagacgt agaccacgct
      601 gtccaccaat aaggccagga ctgcattgca caggctctcc tcatgcgcca cccagggatg
      661 tccagaacac agtcctagat gtatctccga caggctgaag tttgccctag ctgcatctga
      721 gacctccctg cagattccct tccctgccgc ctgctcctgt gtctctgaga tttctgctca
      781 actctaggag gggtctcctc tcttccaccc ttccgtcaac acagaggtcc cagcaaaggg
      841 tggagatggt gaacatgagg aagaggaccc tcaagtacct caccttcttc ctgctcttca
      901 tcttcctcac ttcctttgtc ctgaactact ccaactcggg agtgcccagt gcctggttcc
      961 ccaagcagat ggtcctggag ttctcagaga acttccgcaa gtttatcaag tcacagccgt
     1021 gcacctgcag acactgcatc agccagggca aagtctcata ttggttcgac cagcgcttca
     1081 acaagaccat gcagccactg ctgacagccc acaatgctct gatggaggag gacacatatc
     1141 ggtggtggct gaggctccag cgggagagga aacccaataa cctgagcgac accgtcaagg
     1201 aactgtttcg cctggtacct gggaatgtgg accccatgtt gaacaagagg ttggtgggtt
     1261 gccgacgctg tgcagttgtt ggaaactctg gtaacctgaa agactcctcg tatgggcctg
     1321 agatcgacag ccatgacttt gtgctgagga tgaacagggc acccacagtg ggctttgagg
     1381 cagatgttgg gagcaggacc acccaccatc ttgtgtatcc tgagagcttc cgggagctgg
     1441 gagagaatgt caacatggtc ctggtcccct tcaagatcac cgacctgcaa tgggtgatca
     1501 gtgccaccac cacaggcacc atcactcaca cctacgtccc tgtgcccccg aagatcaaag
     1561 tgaaacaaga gaagatcctg atctaccacc cagccttcat caagtatgtc tttgacaact
     1621 ggcttcaggg ccacgggcgg tatccatcga ccggcatcct ctcggtcatc ttctccattc
     1681 atatctgtga tgaggtggac ttatatggct ttggggcaga cagcaaagga aattggcacc
     1741 attactggga gaacaaccca tcagcaggtg cattccgaaa gacgggggtt catgatggcg
     1801 acttcgagta caatgtcaca actaccctgg cagccatcaa caaaatccgc atcttcaagg
     1861 ggagatgatg ctgcaaccta gtaaggatgg acacaacata tcacacctct caacttgcag
     1921 ccccagcatc tccctagagc cactgtgttc cagaagttcc cagggctgaa ctcagggtgt
     1981 ttccaggctt tctggcagcc tcttgcaccc tcattttggt atcatctaca tagcaaagtt
     2041 gttcaactct cccaggatac agagcaggtc tcaggcctgc ccacagtagg agcacttccc
     2101 cactgcagtc ccctaactgg gaaaaagtga gcagatacca agaaaggcct agcctccaaa
     2161 caacaacagt tattttggct tctgggttgg attggagggt agagatgggg aaaacaaaat
     2221 cctgaaggtt ctgtgttcaa aagagtgaac atttccagga agtcatttag aggctaccac
     2281 tgaactgtgg acctcatgct caactcagac tctggctagg gatgtttggg acagtcatct
     2341 gcagagcaga accacactag gttacaccag cagaggagca agatgccgtt ctcctttgca
     2401 tgaagcctca cctgtctctt gatatgacat ccccattgtc cctttcttca aaaaggtcac
     2461 tgatgatggc taggcaaagc ttctgtctct agagttcttc catggaaacc aggccatgta
     2521 atgctgacag cagtgaaacc ctcgtcacca ttctgtgatc ccccatctgt agtgatactg
     2581 atggccagag caggtctgac tacttccacg tgcctttgaa cttgagaaga aaaaaaaacg
     2641 catgcattgg ctgacatgaa gtaaaatccc caactggaga aaggggacct ccaccagcac
     2701 cccgctttgc tgcatagctc aaaatctttt cagatgatac tctgtaccac acagagtata
     2761 ccaggattgg gatgggtgtt cacttcttca gactgctggg ttcaggatca ctaactacca
     2821 gcattcttcc ctggtcctga acactgagcc aagtccctag cagccacctt cctggactcg
     2881 tttggggtcg cactggggac attctaggac tacaattgaa atgcatgtac ctcttttcca
     2941 gagttctgtc tgttcttcct ccttcctcta cagaaatcct gattatttat tgatttgtta
     3001 attcagctga ccctgtgcat actcttcccc acagctgctc acagtgtgtt ttgttgcttt
     3061 gcctgtgtcg tgtgagagca ggagcttgaa gggagaacac ccaaatgtac gtgtttagac
     3121 atctggactc ggggcttgct ggtgggcaga tcctgtggca ctgacaatcc ttggtagaat
     3181 ccgtgtcacc tccctttcta gtacaagtga tgctttcttc ctcattgcag aagggaggac
     3241 agtaggcact tggagataac tgtctcctcc ctacagatat tcaggaagag aaacctgttc
     3301 ctgttgaaaa atattcccta aagatcacaa caacttcatc aaggcagata atgagagagg
     3361 tgtcttgaag gtttggggtg atctcccctt gctcaggttc ctctctgcaa gtaagagccc
     3421 agggacccca ctcaacttta ggccattcac aggcatcacc aaagagcaga caccaagatt
     3481 gccattttct aggagtgtgt cctgtgagtg gctttggcgt tgcttttgtt taattttcag
     3541 cgactcagaa ttcaggcgtt taatgaggga gcaatatggt ttcactttta aaatctctct
     3601 gacataaaat ccttggctga agaggctgga ctcctgcgag gtccttgcag tggaggggcc
     3661 tcctcaaagg tcccagtttg aggaactcag cagatgtttg tgggtcaaca ggtcagtccc
     3721 taagacaaat caaaagtagt ggacattggc ttagggggtg acagttcagg tgtagctggg
     3781 ttctactgta tgagagcaag tgcctgcatc gggagtgtag ccatttctag ctgagtgctg
     3841 ctgctctgaa gcgcttctgt ctctgttggc tcctcccact cctcttccca acccccactg
     3901 gggcctcctg cctccctacc tcgctgcctt cctctctccc tccctccctc cctctgtccc
     3961 tcctccagcc aaggagccaa tggttctctg tcccataatc ctcatccttc ccctgtgttt
     4021 cactggctca gtagtgggcc cttaactgaa taaaatacag tcagttgtgg ccagaattat
     4081 gtgcagcaat tagtttaacg taaccggagc tttccttggg tgtgggaggc tgagtacagg
     4141 aagaggcttc cccaaagaga ctgggctggt tgacagaaaa gctggtcctg ggcaccaggc
     4201 agagagcaaa gagctggctt ccagtgcaca ggaatctact aaatctaagg gaattggggt
     4261 gtgtgggttc tcatcagcac ccaagactac taatctaaag tgaaccagga ggctggtgtt
     4321 tcttgcactg gttgcaatct tccactcctc tcagcctctg ttaggggaga gagaatcaga
     4381 tctgtagcct ttggttcctg gaagtgacaa gccgaagagg aaagtcttga tttcaatgtc
     4441 tttaggatgg cttttgggca tcagacatca tccaataagc catgtgggcg tggttagtgg
     4501 aacacacccc aaaacagtgt agaatgggga ggccaccagc cactatccag gagcttgacg
     4561 atctgaaggt ctagagacca aaggagggag gatacagttg gtgttgcagt ctccgctgtg
     4621 gccacacggg tctgctaaag gcccatcaca cttcctggga atgtggcctc cctgtcagag
     4681 gtgggaaggc ttcacctgtg cctctcaaag tagctcccaa catgcagggt gagggaggcc
     4741 cagaggatag agtgacagct gtataccctc agaacctggc agctggagcc acaggtgcca
     4801 tcatagtcag gtgagaaaga ttggctccta ggcagctcag ccaccaaggc ctgactagcc
     4861 aattttcaga taagatcatc tctcctcttt gtcaccctct cctgtgcccc aggtgttacc
     4921 taatacctgg aaaaagcagg catggggaag aaagcaagca gagaccagca gagcagtgcc
     4981 cctaagcctt ctgcctcaga atatagtaaa tgcatcatca gccaggctag gcctggagcc
     5041 tgcttctccc tgctgaaccc catccttacc tccctaaccc ttctgctcat ttagcttgtt
     5101 ccttgactct tcctgcccag agtctgcctc atggcaacag ctttaaccct ttctccagag
     5161 tctaatccgg atcttgcaca ccctactggg tgaacatggg taactcctgc ctccacccca
     5221 gacccttgca caatcacttt aactatttcc caagagcctg atcaaaccac cctagtaggt
     5281 agatgtgggt ccctcctgca cctccaggca caatcagttt agccatttcc caagtctcct
     5341 tcagagccaa agttttccaa gcactttctg cccaaaagct tttccttcct tgcctcctgt
     5401 ggcccagcat tgcccattta aactttgctt tctcctgccc acatcttatc atcctcctga
     5461 ttggtctgaa cgcatttcca atgatgttag caaatctgcc ttcctcagcc actgctgttt
     5521 tatttattgt tgaatatttc caatgatttg aatcaaagta aataaaaaga gttattttat
     5581 tgtt
//
