LOCUS       NM_153310               3982 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus ST18 C2H2C-type zinc finger transcription factor
            (St18), mRNA.
ACCESSION   NM_153310
VERSION     NM_153310.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3982)
  AUTHORS   Henry,C., Close,A.F. and Buteau,J.
  TITLE     A critical role for the neural zinc factor ST18 in pancreatic
            beta-cell apoptosis
  JOURNAL   J Biol Chem 289 (12), 8413-8419 (2014)
   PUBMED   24509857
  REMARK    GeneRIF: ST18 expression and activity are increased in cytotoxic
            conditions in pancreatic beta-cells. Overexpression of ST18 causes
            apoptosis.
REFERENCE   2  (bases 1 to 3982)
  AUTHORS   Yang,J., Siqueira,M.F., Behl,Y., Alikhani,M. and Graves,D.T.
  TITLE     The transcription factor ST18 regulates proapoptotic and
            proinflammatory gene expression in fibroblasts
  JOURNAL   FASEB J 22 (11), 3956-3967 (2008)
   PUBMED   18676404
REFERENCE   3  (bases 1 to 3982)
  AUTHORS   Jandrig,B., Seitz,S., Hinzmann,B., Arnold,W., Micheel,B.,
            Koelble,K., Siebert,R., Schwartz,A., Ruecker,K., Schlag,P.M.,
            Scherneck,S. and Rosenthal,A.
  TITLE     ST18 is a breast cancer tumor suppressor gene at human chromosome
            8q11.2
  JOURNAL   Oncogene 23 (57), 9295-9302 (2004)
   PUBMED   15489893
REFERENCE   4  (bases 1 to 3982)
  AUTHORS   Yee,K.S. and Yu,V.C.
  TITLE     Isolation and characterization of a novel member of the neural zinc
            finger factor/myelin transcription factor family with
            transcriptional repression activity
  JOURNAL   J Biol Chem 273 (9), 5366-5374 (1998)
   PUBMED   9478997
REFERENCE   5  (bases 1 to 3982)
  AUTHORS   Bellefroid,E.J., Bourguignon,C., Hollemann,T., Ma,Q.,
            Anderson,D.J., Kintner,C. and Pieler,T.
  TITLE     X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory
            function in neuronal differentiation
  JOURNAL   Cell 87 (7), 1191-1202 (1996)
   PUBMED   8980226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U67080.1, AF031942.1 and CO394514.1.
            
            On Oct 13, 2005 this sequence version replaced NM_153310.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U67080.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               U67080.1           15-204
            191-195             AF031942.1         47-51
            196-645             U67080.1           209-658
            646-729             AF031942.1         470-553
            730-938             U67080.1           743-951
            939-3255            AF031942.1         763-3079
            3256-3351           U67080.1           3266-3361
            3352-3982           CO394514.1         22-652
FEATURES             Location/Qualifiers
     source          1..3982
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..3982
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /note="ST18 C2H2C-type zinc finger transcription factor"
                     /db_xref="GeneID:266680"
                     /db_xref="RGD:708566"
     exon            1..97
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            98..140
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..3275
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /note="suppression of tumorigenicity protein 18; NZF-3;
                     C2-HC type zinc finger protein r-MyT3; neural zinc finger
                     factor 3; ST18, C2H2C-type zinc finger"
                     /codon_start=1
                     /product="suppression of tumorigenicity 18 protein"
                     /protein_id="NP_695222.2"
                     /db_xref="GeneID:266680"
                     /db_xref="RGD:708566"
                     /translation="MDAEVEDKALHTLSKGTEVPMDSLIPELRVAYDCSMAKKRRAEE
                     QALGVPVNKRKSLLMKPRHYSPDMDCKENPDNRNEDDGLETNDHSTADEIVVKPMDKT
                     LHLPAQESSLPKEDQYACYPELMVKSLMHLGKFEESESVQTVGENLNGNGIQSLKAEC
                     DEANECFMVHSDDGRDKVHHSQPPFCSSGDSESDSDNTENGWGSGSNSSEDTDTHKGP
                     KRKLTYNRKDLLEVPEIKAEDDKFIPCENRCDSDTSGRDPQNSHMEPLAVKVQPSFPE
                     VEESESLATVIAESAEVEKAKGSLSLLEQAIALQAERGSVFHHTYKELDRFLLDHLAR
                     QRRQPKVTDASGRQIFNNKHSPRPERREAKCPIPGCDGTGHVTGLYPHHRSLSGCPHK
                     VRVPLEILAMHENVLKCPTPGCTGRGHVNSNRNTHRSLSGCPIAAAEKLAMTQDKSQL
                     DSSQTGQGPEQAHRVNLVKQIEFNFRSQAITSPRASASKEQEKFGKVPFDYASFDAQV
                     FGKRPLLQTGQGQKAPPFPESKHFSNPVKFSNGLPSAGAHTQSTVRASSYGHGQYSED
                     THIAAAAAILNLSTRCREATDILSNKPQSLRAKGAEIEVDENGTLDLSMKKHRILDKS
                     IPPTSSHTTIATPSSSPFKASSLLVNAAFYQALCDQEGWNVPINYSKSHGKTEEEKEK
                     DPVNSLENLEEKKFAGEASIPSPKPKLHTRDLKKELITCPTPGCDGSGHVTGNYASHR
                     SVSGCPLADKTLKSLMAANSQELKCPTPGCDGSGHVTGNYASHRSLSGCPRARKGGIK
                     MTPTKEEKEDSELRCPVIGCDGQGHISGKYTSHRTASGCPLAAKRQKENPLNGTPLSW
                     KLNKQELPHCPLPGCNGLGHVNNVFVTHRSLSGCPLNAQAIKKVKVSEELMTIKLKAT
                     GGIEGDEEIRHLDEEIKELNESNLKIEADMMKLQTQITSMESNLKTIEEENKLIEQSN
                     ESLLKELAGLSQALISSLADIQLPQMGPINEQNFEAYVNTLTDMYSNLERDYSPECKA
                     LLESIKQAVKGIHV"
     exon            141..195
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            196..226
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            227..414
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            415..1200
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1335
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1426
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1531
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1725
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1937
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2183
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2299
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2362
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2431
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2494
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2575
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2797
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2886
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2990
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3134
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3982
                     /gene="St18"
                     /gene_synonym="Nzf3; r-MyT3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcatatcatg gaaactacct ttcaaggcaa cagctttagt gtctcctgtc agcacaccag
       61 ggaggagaga aatagaaaag gaaacaaaca caaaaaacca tgacatctct tctgttcaaa
      121 ttcagtagct gctagaaaag atggatgcag aggttgaaga taaagcgttg catactctct
      181 caaaaggaac cgaagttcca atggattctc tgatcccaga gctcagggtt gcatatgatt
      241 gctctatggc gaagaagagg agagctgaag agcaggcatt gggagtgcca gttaacaaga
      301 ggaaatctct gttaatgaaa ccccggcact acagcccaga catggactgc aaggaaaacc
      361 cagacaacag gaatgaggat gatggcctag aaacgaatga ccactccact gcagatgaaa
      421 tcgtggtaaa acccatggat aagactcttc atttacctgc acaagaaagc tcactcccca
      481 aggaagacca atacgcgtgt tatccagagc tcatggtcaa atctctgatg catttaggta
      541 aatttgaaga aagtgagtct gtgcagaccg taggtgagaa cttaaatggc aacggcatcc
      601 agtctctaaa agcagagtgt gatgaagcaa atgaatgctt tatggttcat tctgatgatg
      661 gaagagacaa agtccaccat tcccagccac ctttctgctc ttccggtgac agtgagagtg
      721 actctgacaa tacagagaat gggtggggca gtggctccaa ctcttcagaa gacactgaca
      781 ctcacaaagg ccccaaacgc aagctgacat acaatagaaa ggacctgctg gaagtccctg
      841 agataaaagc agaagatgac aagtttatcc cttgcgagaa caggtgtgat tctgacacca
      901 gtgggagaga cccacagaac tctcacatgg aacccttggc tgtgaaagtc cagccttcct
      961 tcccagaggt tgaagagagt gagagcctgg ccacagtaat agcggagtct gctgaggtgg
     1021 agaaagcgaa ggggagcctg agtttgctgg aacaggctat tgccctacag gctgaacggg
     1081 gttccgtctt ccatcacacc tacaaagagc tggaccgatt tctcctggac cacctggcaa
     1141 ggcaacggag gcaacccaag gttactgatg ccagtggaag gcaaatcttt aataataaac
     1201 attcaccaag gcctgaaagg agggaggcta agtgccccat tcctggctgt gacggcacag
     1261 ggcacgtaac ggggctctac ccccaccacc gcagcctttc tgggtgcccc cacaaagtgc
     1321 gagttcctct ggaaattctt gccatgcatg agaacgtact caagtgtccc accccaggat
     1381 gcacaggaag gggacatgtg aacagcaatc gcaacactca cagaagtctt tctggttgtc
     1441 caattgctgc agctgaaaag ttggcaatga cccaggacaa aagtcaactt gattcttccc
     1501 agactgggca gggtcctgag caggctcaca gggtgaattt agtgaagcaa attgaattta
     1561 acttccgctc acaagccatc acctctccaa gagcctctgc atcaaaagaa caagagaagt
     1621 ttggcaaagt accatttgat tatgccagtt ttgatgcaca agtatttggt aaacgtccgc
     1681 tcctacaaac aggacaagga caaaaggcac caccatttcc tgaatcaaag catttttcaa
     1741 atccagtgaa attttctaat gggctgccta gtgctggcgc ccacacacag agcacagtcc
     1801 gtgccagctc ttatggccat ggtcagtaca gtgaagacac ccacatagca gcagctgctg
     1861 ctatcctgaa cctttccacc cgctgcaggg aagccacaga catcctctcc aacaaaccgc
     1921 aaagcctgcg tgccaaggga gctgagatag aagtggatga aaacggcacg ttggacttaa
     1981 gcatgaaaaa acatcgaatc ctcgacaagt ctataccccc gacttcctca cacactacaa
     2041 ttgcaacccc atcctcatcc ccattcaaag caagcagcct tctggtcaat gctgccttct
     2101 atcaggctct ctgtgaccaa gaaggctgga atgtgcctat caactatagc aaatcccacg
     2161 ggaagacaga ggaggagaaa gagaaagacc ctgtgaactc cctagaaaat ttagaggaaa
     2221 aaaagtttgc tggagaggcc tctattccaa gtccaaagcc caagctccac acacgagatc
     2281 tcaagaaaga attaatcacc tgccccacgc cagggtgtga tggaagcggc catgtcacag
     2341 gcaactatgc atctcaccgc agtgtctctg gatgtcctct agcagataag actctgaagt
     2401 ccctcatggc tgccaactct caagagctta agtgtccaac cccgggttgt gatggttctg
     2461 gtcacgtgac tggaaactat gcctcccata gaagcttgtc tggttgccct cgtgcaagga
     2521 aaggtggcat caaaatgacc ccaacaaagg aagaaaaaga agactctgag cttagatgtc
     2581 ctgtaatagg atgtgacggc caaggtcaca tatcaggtaa atacacatca caccgcacag
     2641 cttctggctg tcctctggct gccaagagac agaaggagaa tcccctcaat gggacccctc
     2701 tctcatggaa actgaacaag caagaacttc cccactgtcc tttgccagga tgcaatggtc
     2761 tgggtcatgt aaacaacgtt tttgtcaccc acaggagctt atccggatgc cctcttaatg
     2821 cacaagctat caaaaaagtc aaggtctctg aggaactaat gaccatcaag ctcaaagcaa
     2881 ctgggggtat tgagggtgat gaagaaatta ggcatctgga tgaagaaata aaggaactga
     2941 atgaatccaa ccttaaaatt gaagcagata tgatgaaact tcagacccag ataacatcta
     3001 tggagagcaa cttgaagacc atagaggagg agaacaagct tatagagcag agcaacgaga
     3061 gtctactgaa ggagctggca gggcttagcc aggctctcat ctccagtctt gctgacatcc
     3121 agcttccaca gatgggtcct atcaatgagc agaattttga agcatatgta aatactctca
     3181 cagacatgta cagcaatctg gaacgggact attccccaga atgcaaagct ctactggaaa
     3241 gcatcaagca ggcagtgaaa ggtatccatg tgtaggacaa cagtatgcag gaaacggagg
     3301 tcactacagc catgaactcc cacagatccg caggagacca atacccctgg agcctggagg
     3361 ctgtcccctg cgtttataat tgcaacattg cactaatttt tccccagttg acataaaaaa
     3421 gaaagaaaaa ctatgataaa ctctttggat taaaagcaat gcagtcaatt attagatctc
     3481 atttattttc atatcttttt cttttctttc ttcattgcac tctttatttt gtaaaatata
     3541 tgtaaaaata aatgtgacat tttatatttt atttattact aatcaaagag tttttttatc
     3601 ttttatctgc attttgaagt ctaccatatt tttacaggtg tgtttattaa tttatcttct
     3661 aataggattt aaatagaaat gctgttctca aatcaaatat ctttctgggt ttaaacgaga
     3721 aaaacaaaac aaaaaatgtg taagggaaat cccagtgtca ggactacact atggtcaagc
     3781 ttggtttcta ctgtgcactt ccatttcccc tttactggtt ttgtttttat aagtgatttt
     3841 tggtaatgtg agctgtgaag gattatgaag ataaatggcg cccactagtg ggaaatcagc
     3901 attcaaaagc acaggatgtt agctaacagt gcactcagaa cttgatagca ataattaaat
     3961 aaagtagtca gcatagtatt cc
//
