LOCUS       NM_053635               3174 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ST14 transmembrane serine protease matriptase
            (St14), mRNA.
ACCESSION   NM_053635 XM_346821
VERSION     NM_053635.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3174)
  AUTHORS   Inouye K, Tomoishi M, Yasumoto M, Miyake Y, Kojima K, Tsuzuki S and
            Fushiki T.
  TITLE     Roles of CUB and LDL receptor class A domain repeats of a
            transmembrane serine protease matriptase in its zymogen activation
  JOURNAL   J Biochem 153 (1), 51-61 (2013)
   PUBMED   23038671
  REMARK    GeneRIF: investigation of protein structure of matriptase and the
            structural effects on kinetics of proteolysis and zymogen
            activation
REFERENCE   2  (bases 1 to 3174)
  AUTHORS   Inouye K, Tsuzuki S, Yasumoto M, Kojima K, Mochida S and Fushiki T.
  TITLE     Identification of the matriptase second CUB domain as the secondary
            site for interaction with hepatocyte growth factor activator
            inhibitor type-1
  JOURNAL   J Biol Chem 285 (43), 33394-33403 (2010)
   PUBMED   20682770
  REMARK    GeneRIF: Identification of the matriptase second CUB domain as the
            secondary site for interaction with hepatocyte growth factor
            activator inhibitor type-1.
REFERENCE   3  (bases 1 to 3174)
  AUTHORS   Sales KU, Masedunskas A, Bey AL, Rasmussen AL, Weigert R, List K,
            Szabo R, Overbeek PA and Bugge TH.
  TITLE     Matriptase initiates activation of epidermal pro-kallikrein and
            disease onset in a mouse model of Netherton syndrome
  JOURNAL   Nat Genet 42 (8), 676-683 (2010)
   PUBMED   20657595
REFERENCE   4  (bases 1 to 3174)
  AUTHORS   Chen M, Chen LM, Lin CY and Chai KX.
  TITLE     Hepsin activates prostasin and cleaves the extracellular domain of
            the epidermal growth factor receptor
  JOURNAL   Mol Cell Biochem 337 (1-2), 259-266 (2010)
   PUBMED   19911255
REFERENCE   5  (bases 1 to 3174)
  AUTHORS   Tsuzuki S, Miyake Y, Inouye K and Fushiki T.
  TITLE     The occurrence of matriptase C-terminal fragments on the apical and
            basolateral sides of Madin-Darby canine kidney epithelial cells
  JOURNAL   Biosci Biotechnol Biochem 73 (11), 2538-2540 (2009)
   PUBMED   19897900
  REMARK    GeneRIF: Matriptase C-terminal fragments containing the catalytic
            serine protease domain were found to occur on the apical and
            basolateral sides of Madin-Darby canine kidney epithelial cells
            transfected with a cDNA encoding the protease.
REFERENCE   6  (bases 1 to 3174)
  AUTHORS   Jin JS, Hsieh DS, Loh SH, Chen A, Yao CW and Yen CY.
  TITLE     Increasing expression of serine protease matriptase in ovarian
            tumors: tissue microarray analysis of immunostaining score with
            clinicopathological parameters
  JOURNAL   Mod Pathol 19 (3), 447-452 (2006)
   PUBMED   16439987
REFERENCE   7  (bases 1 to 3174)
  AUTHORS   Tsuzuki S, Murai N, Miyake Y, Inouye K, Hirayasu H, Iwanaga T and
            Fushiki T.
  TITLE     Evidence for the occurrence of membrane-type serine protease
            1/matriptase on the basolateral sides of enterocytes
  JOURNAL   Biochem J 388 (Pt 2), 679-687 (2005)
   PUBMED   15669920
REFERENCE   8  (bases 1 to 3174)
  AUTHORS   Lee JW, Yong Song S, Choi JJ, Lee SJ, Kim BG, Park CS, Lee JH, Lin
            CY, Dickson RB and Bae DS.
  TITLE     Increased expression of matriptase is associated with
            histopathologic grades of cervical neoplasia
  JOURNAL   Hum Pathol 36 (6), 626-633 (2005)
   PUBMED   16021568
REFERENCE   9  (bases 1 to 3174)
  AUTHORS   Cho EG, Kim MG, Kim C, Kim SR, Seong IS, Chung C, Schwartz RH and
            Park D.
  TITLE     N-terminal processing is essential for release of epithin, a mouse
            type II membrane serine protease
  JOURNAL   J Biol Chem 276 (48), 44581-44589 (2001)
   PUBMED   11567025
REFERENCE   10 (bases 1 to 3174)
  AUTHORS   Satomi S, Yamasaki Y, Tsuzuki S, Hitomi Y, Iwanaga T and Fushiki T.
  TITLE     A role for membrane-type serine protease (MT-SP1) in intestinal
            epithelial turnover
  JOURNAL   Biochem Biophys Res Commun 287 (4), 995-1002 (2001)
   PUBMED   11573963
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB049189.1.
            
            On or before Dec 17, 2003 this sequence version replaced
            XM_346821.1, NM_053635.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB049189.1, AB037898.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3174
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3174
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /note="ST14 transmembrane serine protease matriptase"
                     /db_xref="GeneID:114093"
                     /db_xref="RGD:69288"
     exon            1..207
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2694
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /EC_number="3.4.21.109"
                     /note="suppression of tumorigenicity 14 (colon carcinoma,
                     matriptase, epithin); membrane-type serine protease;
                     suppression of tumorigenicity 14 (colon carcinoma)"
                     /codon_start=1
                     /product="suppressor of tumorigenicity 14 protein"
                     /protein_id="NP_446087.1"
                     /db_xref="GeneID:114093"
                     /db_xref="RGD:69288"
                     /translation="MGNNRGRKAGGGSQDFGAGLKYNSRLENMNGFEEGVEFLPVNNA
                     KQVEKRGPRRWVVMVAVVFSFLLLSLMAGLLVWHFHYRNVRIQKVFNGHLRITNENFL
                     DAYENSTSTEFISLASQVKEALKLMYSEVPVLGPYHKKSTVTAFSEGSVIAYYWSEFS
                     IPPHLEEEVDRAMAVERVVTLPPRARALKSFVLTSVVAFPIDPRMLQRTQDNSCSFAL
                     HARGRTVTRFTTPGFPNSPYPAHARCQWVLRGDADSVLSLTFRSFDVAPCDGHDSDLV
                     TVYDSLSPMEPHAVVRLCGTFSPSYNLTFLSSQNVFLVTLITNTDRRHPGFEATFFQL
                     PKMSSCGGLLSEAQGTFSSPYYPGHYPPNINCTWNIKVPNNRNVKVRFKLFYLVDPNI
                     PVGSCTKDYVEINGEKFCGERSQFVVSSNSSKITVHFHSDHSYTDTGFLAEYLSYDSN
                     DPCPGMFMCKTGRCIRKDLRCDGWADCPDYSDERHCRCNATHQFMCKNQFCKPLFWVC
                     DSVNDCGDGSDEEGCSCPAGSFKCSNGKCLPQSQQCNGKDDCGDGSDEASCDNVNAVS
                     CTKYTYRCQNGLCLNKGNPECDGKKDCSDGSDEKNCDCGLRSFTKQARVVGGTNADEG
                     EWPWQVSLHALGQGHLCGASLISPDWLVSAAHCFQDETIFKYSDHTMWTAFLGLLDQS
                     KRSASGVQEHKLKRIITHPSFNDFTFDYDIALLELEKPAEYSTVVRPICLPDNTHVFP
                     AGKAIWVTGWGHTKEGGTGALILQKGEIRVINQTTCEELLPQQITPRMMCVGFLSGGV
                     DSCQGDSGGPLSSVEKDGRIFQAGVVSWGEGCAQRNKPGVYTRIPEVRDWIKEQTGV"
     exon            208..367
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..495
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..566
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..724
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..760
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..1001
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1141
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1239
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1349
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1480
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1585
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1696
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1810
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1933
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2120
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2395
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2532
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..3157
                     /gene="St14"
                     /gene_synonym="MT-SP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggactgg gctcgtgcct cccctcacac ccttcgttcc tcgtgtcccc agcaccccgc
       61 gggtcatggt agtcggttgc cggcagagac cacgcgtctg agaccggcga tcgggccgcc
      121 gagaccatgg ggaacaatcg gggccgcaag gccggagggg gctcgcagga cttcggcgcc
      181 ggactcaagt acaactcccg gctagagaac atgaatggct ttgaggaggg tgtggagttc
      241 ctgcctgtga acaacgccaa gcaggtggag aagcgaggcc ccaggcgctg ggtggtgatg
      301 gtggccgtag tgttcagctt ccttttgctc tcgctcatgg ccggcttgct ggtgtggcac
      361 ttccattacc ggaatgtgag gatccaaaag gtcttcaatg gccatctgag gatcacgaat
      421 gagaactttc tggacgcgta tgagaactcc acctccacgg agttcatcag cctggccagt
      481 caggtgaagg aagcgctgaa gctgatgtac agtgaagtcc ctgtcctggg cccctaccac
      541 aagaaatcga ctgtaactgc cttcagtgag ggcagcgtca ttgcctacta ctggtcagag
      601 ttcagcatcc ccccacacct ggaggaagag gttgatcgcg ccatggctgt ggagcgagtt
      661 gtcacactgc caccccgagc acgggcactg aaatccttcg tgctgacctc tgtggtggcc
      721 ttccccattg accccagaat gctccagagg actcaggaca acagctgcag ttttgccctc
      781 catgcccgtg gcaggacagt gacacgtttc actacccctg gcttccctaa cagtccctac
      841 ccagctcatg cccgctgcca gtgggtcctg cggggggacg cggactctgt gctgagcctc
      901 accttccgaa gttttgatgt cgcgccctgt gatgggcatg acagtgacct ggtcacagtg
      961 tatgacagcc tgagccccat ggagccccat gctgtggtgc ggctgtgtgg caccttctcg
     1021 ccctcctaca acctgacttt cctctcctcc cagaacgtct tccttgttac gctgataacc
     1081 aacactgacc ggcgacatcc tggctttgag gccactttct tccagctgcc caagatgagc
     1141 agctgtggcg gccttttgag tgaagcccaa gggacgttta gcagccccta ctatccaggc
     1201 cattacccgc ccaacatcaa ctgcacatgg aatatcaagg tgcccaacaa ccggaacgtg
     1261 aaagtacgct tcaaactctt ctatctggtg gaccccaaca taccagtggg aagctgcacc
     1321 aaggactatg tggagatcaa cggggagaag ttctgcggtg agaggtccca gtttgtggtg
     1381 agcagcaaca gcagcaagat tacggtccac ttccattctg atcactcgta cacggacacc
     1441 gggttcctgg ctgagtatct ctcctacgac tccaatgacc catgcccagg gatgttcatg
     1501 tgtaagactg gacggtgcat ccgcaaggac ttgcgctgcg atggctgggc tgactgcccg
     1561 gactacagtg atgagcgtca ctgccgatgc aacgctaccc accagttcat gtgcaagaac
     1621 cagttctgca agcccctctt ctgggtctgt gacagtgtca acgactgtgg ggatggcagc
     1681 gatgaggagg gctgcagttg tcctgccggg agtttcaagt gttccaatgg gaagtgtctc
     1741 cctcagagcc agcagtgtaa tgggaaggac gactgtggag atgggtctga cgaggcctca
     1801 tgtgacaatg tgaatgccgt ctcttgcacc aaatatacct accgctgcca aaatggcctc
     1861 tgtctgaaca agggcaaccc tgagtgtgat gggaagaagg actgcagcga tggctcggat
     1921 gagaaaaact gtgactgtgg gctgcgatcc tttaccaaac aggctcgagt ggttggtggc
     1981 acgaatgcgg acgagggcga gtggccctgg caggtgagcc tccacgctct gggccagggc
     2041 cacttgtgtg gggcctcgct catctctcct gactggctgg tctctgcagc tcattgcttt
     2101 caggatgaga caattttcaa gtactcagac cacaccatgt ggacagcctt cctcggtctg
     2161 ctggaccaga gcaagcgcag tgcctctggg gtacaggagc acaagctcaa acgtatcatc
     2221 actcaccctt cctttaatga ctttaccttc gactatgaca ttgccttgct ggagctggag
     2281 aagccggcag agtacagcac tgtcgtgcgc cccatctgcc tgcctgataa tacccatgtc
     2341 tttcctgccg gcaaagccat ctgggtcaca ggctggggcc acacgaaaga aggaggaact
     2401 ggagcactga tcctgcagaa gggagagatc cgggtcatca accagaccac ctgtgaggaa
     2461 ctcttgccgc agcagatcac cccacgaatg atgtgtgtgg gtttcctcag tgggggtgtg
     2521 gactcctgcc agggtgattc cggtggcccc ttgtccagtg tggagaaaga tgggcgaatc
     2581 ttccaggctg gtgtggtgag ctggggtgaa ggctgcgctc agaggaacaa gccaggcgtg
     2641 tacacaagga tccctgaagt tcgggactgg atcaaagagc aaactggggt atagaagcat
     2701 ggacagacaa cccaccatga actcgcaaag ggatgccccc cacgcgtacc tggatacagc
     2761 agaggatcgc tgaggacatt tgtgctgtgg cctctccccc acatcccaga ctgtgaactg
     2821 cttccctagg actcagaatc cttccctgag cttccaaagt gggacccctc aggagttggc
     2881 cagagatctt ctgtgctggt ggcccagccc ggggtggggc aaggatttga tggcagcctt
     2941 cccctctaac cctgaactgg gtaaagacga tgctttcctg gagaactgct tccagactct
     3001 aaaggaaaac tatcgtcgcg ctcctggggg ccctatgggc agaggggctg cagggtcttt
     3061 caggaagctc cagccctagg gaccccagaa aagagtggca cctatggctg agtttgtttt
     3121 gctggtattt gagagtaaaa cattttattt ctttttaaaa aaaaaaaaaa aaaa
//
