LOCUS       NM_031122               1663 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ST13, Hsp70 interacting protein (St13), mRNA.
ACCESSION   NM_031122
VERSION     NM_031122.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1663)
  AUTHORS   Xilouri,M. and Stefanis,L.
  TITLE     Chaperone mediated autophagy to the rescue: A new-fangled target
            for the treatment of neurodegenerative diseases
  JOURNAL   Mol Cell Neurosci 66 (Pt A), 29-36 (2015)
   PUBMED   25724482
  REMARK    Review article
REFERENCE   2  (bases 1 to 1663)
  AUTHORS   Li,Z., Hartl,F.U. and Bracher,A.
  TITLE     Structure and function of Hip, an attenuator of the Hsp70 chaperone
            cycle
  JOURNAL   Nat Struct Mol Biol 20 (8), 929-935 (2013)
   PUBMED   23812373
  REMARK    GeneRIF: The tetratricopeptide repeat domain of rat Hip with the
            Hsp70 ATPase domain through an extensive interface, to form a
            bracket that locks ADP in the binding cleft.
REFERENCE   3  (bases 1 to 1663)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (bases 1 to 1663)
  AUTHORS   Zhang,Q.G., Han,D., Wang,R.M., Dong,Y., Yang,F., Vadlamudi,R.K. and
            Brann,D.W.
  TITLE     C terminus of Hsc70-interacting protein (CHIP)-mediated degradation
            of hippocampal estrogen receptor-alpha and the critical period
            hypothesis of estrogen neuroprotection
  JOURNAL   Proc Natl Acad Sci U S A 108 (35), E617-E624 (2011)
   PUBMED   21808025
REFERENCE   5  (bases 1 to 1663)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 1663)
  AUTHORS   Prescott,J. and Coetzee,G.A.
  TITLE     Molecular chaperones throughout the life cycle of the androgen
            receptor
  JOURNAL   Cancer Lett 231 (1), 12-19 (2006)
   PUBMED   16356826
  REMARK    Review article
REFERENCE   7  (bases 1 to 1663)
  AUTHORS   Demand,J., Luders,J. and Hohfeld,J.
  TITLE     The carboxy-terminal domain of Hsc70 provides binding sites for a
            distinct set of chaperone cofactors
  JOURNAL   Mol Cell Biol 18 (4), 2023-2028 (1998)
   PUBMED   9528774
REFERENCE   8  (bases 1 to 1663)
  AUTHORS   Bruce,B.D. and Churchich,J.
  TITLE     Characterization of the molecular-chaperone function of the
            heat-shock-cognate-70-interacting protein
  JOURNAL   Eur J Biochem 245 (3), 738-744 (1997)
   PUBMED   9183013
REFERENCE   9  (bases 1 to 1663)
  AUTHORS   Irmer,H. and Hohfeld,J.
  TITLE     Characterization of functional domains of the eukaryotic
            co-chaperone Hip
  JOURNAL   J Biol Chem 272 (4), 2230-2235 (1997)
   PUBMED   8999928
REFERENCE   10 (bases 1 to 1663)
  AUTHORS   Hohfeld,J., Minami,Y. and Hartl,F.U.
  TITLE     Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40
            reaction cycle
  JOURNAL   Cell 83 (4), 589-598 (1995)
   PUBMED   7585962
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031122.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X82021.1, FQ212434.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               JAXUCZ010000007.1  114805709-114805877 c
            170-227             JAXUCZ010000007.1  114798573-114798630 c
            228-300             JAXUCZ010000007.1  114796434-114796506 c
            301-371             JAXUCZ010000007.1  114795398-114795468 c
            372-438             JAXUCZ010000007.1  114788700-114788766 c
            439-523             JAXUCZ010000007.1  114783987-114784071 c
            524-634             JAXUCZ010000007.1  114783768-114783878 c
            635-737             JAXUCZ010000007.1  114781201-114781303 c
            738-854             JAXUCZ010000007.1  114777743-114777859 c
            855-903             JAXUCZ010000007.1  114775637-114775685 c
            904-1037            JAXUCZ010000007.1  114773179-114773312 c
            1038-1663           JAXUCZ010000007.1  114771156-114771781 c
FEATURES             Location/Qualifiers
     source          1..1663
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1663
                     /gene="St13"
                     /note="ST13, Hsp70 interacting protein"
                     /db_xref="GeneID:81800"
                     /db_xref="RGD:621312"
     exon            1..169
                     /gene="St13"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1166
                     /gene="St13"
                     /note="hip; protein ST13 homolog; suppression of
                     tumorigenicity 13 (colon carcinoma) Hsp70-interacting
                     protein"
                     /codon_start=1
                     /product="hsc70-interacting protein"
                     /protein_id="NP_112384.1"
                     /db_xref="GeneID:81800"
                     /db_xref="RGD:621312"
                     /translation="MDPRKVSELRAFVKMCRQDPSVLHTEEMRFLREWVESMGGKVPP
                     ATHKAKSEENTKEEKRDKTTEDNIKTEEPSSEESDLEIDNEGVIEADTDAPQEMGDEN
                     AEITEAMMDEANEKKGAAIDALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKL
                     QKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAARDLALACKLDYDEDASA
                     MLREVQPRAQKIAEHRRKYERKREEREIKERIERVKKAREEHEKAQREEEARRQSGSQ
                     FGSFPGGFPGGMPGNFPGGMPGMGGAMPGMAGMPGLNEILSDPEVLAAMQDPEVMVAF
                     QDVAQNPSNMSKYQNNPKVMNLISKLSAKFGGHS"
     exon            170..227
                     /gene="St13"
                     /inference="alignment:Splign:2.1.0"
     exon            228..300
                     /gene="St13"
                     /inference="alignment:Splign:2.1.0"
     exon            301..371
                     /gene="St13"
                     /inference="alignment:Splign:2.1.0"
     exon            372..438
                     /gene="St13"
                     /inference="alignment:Splign:2.1.0"
     exon            439..523
                     /gene="St13"
                     /inference="alignment:Splign:2.1.0"
     exon            524..634
                     /gene="St13"
                     /inference="alignment:Splign:2.1.0"
     exon            635..737
                     /gene="St13"
                     /inference="alignment:Splign:2.1.0"
     exon            738..854
                     /gene="St13"
                     /inference="alignment:Splign:2.1.0"
     exon            855..903
                     /gene="St13"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1037
                     /gene="St13"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1663
                     /gene="St13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcttggc atcgggcctc cgcagccgcc caccgccaga agcttccagc ctcaccacta
       61 tggatccccg caaagtgagc gagcttcggg ccttcgtgaa gatgtgtagg caggacccga
      121 gcgtcctgca caccgaggaa atgcgtttcc tgagggagtg ggtggagagc atggggggta
      181 aagtaccacc tgctactcat aaagcgaagt cagaagaaaa cactaaggaa gaaaaaagag
      241 acaagacgac agaggacaac ataaagacag aggagccatc gagtgaggag agcgatctag
      301 aaattgacaa tgaaggtgta attgaagcag acactgatgc tcctcaggaa atgggagatg
      361 aaaatgcaga gataactgag gcgatgatgg atgaagcaaa tgaaaagaag ggggctgcca
      421 tcgacgctct aaatgatggt gagctccaga aagccattga cttgttcaca gacgccatca
      481 agctaaaccc tcgcttggcc attctgtatg ccaagagagc cagtgttttc gtcaaattac
      541 agaagccaaa tgctgccatc cgagactgtg acagagctat tgaaataaac cctgattcag
      601 ctcagccata caaatggaga gggaaagcgc acagactcct gggtcactgg gaagaagcag
      661 ctcgcgatct tgccctggcc tgtaaattgg actatgatga ggacgccagt gcaatgctga
      721 gagaagtcca gcctcgggct caaaaaattg ctgaacatcg gagaaagtat gagcgaaaac
      781 gtgaagagcg agagataaaa gaacgaatag aaagggtgaa gaaggctcga gaagagcatg
      841 aaaaagccca aagggaagaa gaagccagaa gacaatctgg atctcagttt ggctcttttc
      901 caggtggttt tcctggggga atgcctggta attttcctgg aggaatgcct ggaatgggag
      961 gggccatgcc aggaatggca ggaatgcctg gactcaacga aatcctcagt gacccagagg
     1021 ttcttgcagc catgcaggat ccagaagtca tggtggcttt ccaggatgtg gcccagaacc
     1081 catcaaatat gtcaaaatat cagaacaacc caaaggttat gaatctcatc agtaaattgt
     1141 cagccaagtt tggaggtcac tcataatgtc aaagcccttg ctgaatgaag aacagcttag
     1201 ctcacttact ggatgttgca ataatacaaa ccagtgtacc tctgacctca ccagagagct
     1261 ggggcgcttc gaagataatc cctaccctct gcatcatatg cggctgaggc atattacagt
     1321 ggtttgccat tagagtgttc attcagataa tgttttccta ttaggaatta caaacttaaa
     1381 acatttttca accttaaaca tattttttaa aaatttaggg gatgtcaatt cctacatttt
     1441 tcgttactaa tctttttggg tttttccttt tgaattactg ggcaaggaag gtgaatgtgg
     1501 atgatttact gctttcatga atgaaataaa gatttgttag tgggaagcaa ataaaacaca
     1561 tttaagttga ttgagtcgga catacggtta ctgcaacatc ttgaattgtc tttaatgttt
     1621 tacttcacaa tgatctattt cagtaaatct tttgggacca cca
//
