LOCUS       NM_175597               2547 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SSX family member 2 interacting protein (Ssx2ip),
            mRNA.
ACCESSION   NM_175597
VERSION     NM_175597.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2547)
  AUTHORS   Saito,K., Shiino,T., Kurihara,H., Harita,Y., Hattori,S. and Ohta,Y.
  TITLE     Afadin regulates RhoA/Rho-associated protein kinase signaling to
            control formation of actin stress fibers in kidney podocytes
  JOURNAL   Cytoskeleton (Hoboken) 72 (3), 146-156 (2015)
   PUBMED   25712270
  REMARK    GeneRIF: afadin mediates RhoA/ROCK signaling and contributes to the
            formation of actin stress fibers in podocyte cells
REFERENCE   2  (bases 1 to 2547)
  AUTHORS   Klinger,M., Wang,W., Kuhns,S., Barenz,F., Drager-Meurer,S.,
            Pereira,G. and Gruss,O.J.
  TITLE     The novel centriolar satellite protein SSX2IP targets Cep290 to the
            ciliary transition zone
  JOURNAL   Mol Biol Cell 25 (4), 495-507 (2014)
   PUBMED   24356449
REFERENCE   3  (bases 1 to 2547)
  AUTHORS   Barenz,F., Inoue,D., Yokoyama,H., Tegha-Dunghu,J., Freiss,S.,
            Draeger,S., Mayilo,D., Cado,I., Merker,S., Klinger,M.,
            Hoeckendorf,B., Pilz,S., Hupfeld,K., Steinbeisser,H., Lorenz,H.,
            Ruppert,T., Wittbrodt,J. and Gruss,O.J.
  TITLE     The centriolar satellite protein SSX2IP promotes centrosome
            maturation
  JOURNAL   J Cell Biol 202 (1), 81-95 (2013)
   PUBMED   23816619
REFERENCE   4  (bases 1 to 2547)
  AUTHORS   Fukumoto,Y., Kurita,S., Takai,Y. and Ogita,H.
  TITLE     Role of scaffold protein afadin dilute domain-interacting protein
            (ADIP) in platelet-derived growth factor-induced cell movement by
            activating Rac protein through Vav2 protein
  JOURNAL   J Biol Chem 286 (50), 43537-43548 (2011)
   PUBMED   22027834
REFERENCE   5  (bases 1 to 2547)
  AUTHORS   Asada,M., Irie,K., Yamada,A. and Takai,Y.
  TITLE     Afadin- and alpha-actinin-binding protein ADIP directly binds
            beta'-COP, a subunit of the coatomer complex
  JOURNAL   Biochem Biophys Res Commun 321 (2), 350-354 (2004)
   PUBMED   15358183
  REMARK    GeneRIF: ADIP is involved in vesicle trafficking from the Golgi to
            the endoplasmic reticulum
REFERENCE   6  (bases 1 to 2547)
  AUTHORS   Asada,M., Irie,K., Morimoto,K., Yamada,A., Ikeda,W., Takeuchi,M.
            and Takai,Y.
  TITLE     ADIP, a novel Afadin- and alpha-actinin-binding protein localized
            at cell-cell adherens junctions
  JOURNAL   J Biol Chem 278 (6), 4103-4111 (2003)
   PUBMED   12446711
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078687.1.
            
            On Jun 3, 2007 this sequence version replaced NM_175597.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132297, SAMD00132305
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2547
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..2547
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /note="SSX family member 2 interacting protein"
                     /db_xref="GeneID:308023"
                     /db_xref="RGD:708490"
     exon            1..109
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            110..276
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            277..408
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..2207
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /note="afadin DIL domain-interacting protein; afadin- and
                     alpha-actinin-binding protein ADIP; synovial sarcoma, X
                     breakpoint 2 interacting protein; afadin- and
                     alpha-actinin-binding protein-like"
                     /codon_start=1
                     /product="afadin- and alpha-actinin-binding protein"
                     /protein_id="NP_783187.1"
                     /db_xref="GeneID:308023"
                     /db_xref="RGD:708490"
                     /translation="MGDWMTVTDPVLCTENKNLSQYTSETKMSPSSLYSQQVLCSATP
                     LSKNVHGVFSAFCTGENIEQSISYLDQELTTFGFPSLYEESKSKEAKRELSIVALLNC
                     MNELLVLQRKNLLAQESVETQNLKLGSDMDHLQSCYAKLKEQLEASRREMISLQERDR
                     QLQCKNRNLHQLLKNEKEEVQKLQNIIASRATQYNHDVKRKEREYNKLKERLHQLVMN
                     KKDKNIAMDVLNYVGRVDGKRGSWRTDKTEARNEDEMYKILLNDYEYRQKQILLENAE
                     LKKVLQQMKKEMISLLSPQKKKPRERAEDSTGTVVISDVEDDAGELSRDGVWSLSCDT
                     VREQLTNSIRKQWRILKSHVEKLDNQASKVHSEGFHEEDVISRQDHEQETEKLELEIE
                     RCKEMIKAQQQLLQQQLATACDDDTTSLLRDCYLLEEKERLKEEWSLFKEQKKNFERE
                     RRSFTEAAIRLGLERKAFEEERASWVKQQFLNMTTFDHQNSENVKLFSAFSGSSDPDN
                     LIVHPRPRQKKPHSVANGVPACTSKLAKSLPTSPSDFCPSRSCVSEHSPVSALTVTPE
                     ETKPNEVGRESTDQKWSVVSRPSSREGCYGGCSSAYTSSHVERDDLP"
     exon            409..578
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            579..791
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            792..902
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1038
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1114
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1295
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1446
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1583
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1757
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1872
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2032
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2522
                     /gene="Ssx2ip"
                     /gene_synonym="ADIP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggctggac gtgggcgcat gcacccgggc cggcactggg cgggctcgtc gcggccgttg
       61 cagcggttgg agagcgttgc tgccagccgc ctgcagcggg aagtgtgagc tgtacaggga
      121 agataatagg cccagggatt aagtaaccag gctgaagcag cttggagata actgcagaag
      181 ctgggtcact ccaggatgaa acgtgaagct tactccatga cacattgagc cttgtgacaa
      241 gacctgttaa gtccatagca tcctcgactt gctcaggaga tgctcacgta ggagagtgac
      301 aggagctgtt gtgcatgccc cagcactgaa ctgccttctc agggaccctg gctctgggac
      361 tggctatggg agattggatg actgttacag atccagttct gtgtacagaa aacaaaaatc
      421 tctctcaata tacctcagaa acaaagatgt ctccgtcaag tttatactcg cagcaagtac
      481 tgtgctctgc aacaccttta tccaagaatg tgcatggtgt tttcagtgcc ttctgcacag
      541 gagagaacat cgaacagagt atttcgtatc ttgatcagga actgactacc ttcggtttcc
      601 cttccttgta tgaagaatcc aaaagtaagg aggcgaagcg agagttaagt atagttgctc
      661 ttctgaactg catgaatgag ctgcttgtgc ttcagcggaa gaacctcctg gcccaagaaa
      721 gcgtggagac acagaatctg aagctgggca gtgacatgga ccacctgcag agctgctacg
      781 ccaaacttaa ggaacagttg gaggcctcca ggcgagagat gatcagcctt caggagagag
      841 acagacagct acagtgcaaa aacaggaatt tgcatcagct cctgaaaaac gagaaagaag
      901 aggtacaaaa attacaaaat atcatagcca gtcgggctac tcagtataat catgatgtga
      961 agagaaagga gcgggagtac aataaactga aggagcgtct gcatcagctt gttatgaaca
     1021 agaaggataa aaatatagcc atggacgttt taaattacgt gggccgagtg gatggaaagc
     1081 gaggctcctg gaggactgat aaaacagaag ccaggaatga agatgaaatg tacaaaattc
     1141 tgctgaatga ttatgagtac cgccagaagc agatcctgct ggagaatgcg gagctgaaga
     1201 aggtcctcca gcagatgaag aaagagatga tctctctcct ttctcctcaa aagaagaaac
     1261 ccagagaaag agcagaggac agcacaggca ctgttgtcat ctccgatgta gaagacgacg
     1321 ctggggagct gagcagagat ggtgtgtgga gcctttcctg tgacactgtc agggagcagc
     1381 ttacaaacag catcaggaag cagtggagaa ttctgaaaag ccatgtggaa aaacttgata
     1441 accaagcttc aaaggtacac tcagagggct ttcatgaaga ggacgtcatc tcacgacaag
     1501 accatgagca agagactgag aaactggagc tggagattga gcggtgtaaa gagatgatca
     1561 aggctcagca gcagctctta cagcaacagc tggccactgc gtgtgatgac gacaccacct
     1621 cactgttgcg agactgttac ttgcttgaag aaaaggaacg ccttaaagaa gagtggtccc
     1681 tttttaaaga gcaaaaaaag aattttgaga gagaaagacg aagctttaca gaagctgcta
     1741 ttcgcttggg gttggagaga aaggcgtttg aggaagagcg agccagctgg gtgaagcagc
     1801 agtttttaaa catgacgacc tttgatcacc agaactcaga aaatgtgaaa cttttcagtg
     1861 ccttttcagg aagttctgat ccagacaatc ttatagtcca cccacggcca cggcaaaaga
     1921 agccacacag tgtcgctaat ggggtaccag cttgcacatc caaactggct aagtctcttc
     1981 cgacctcacc ttcagacttc tgcccgtctc gctcatgtgt gtctgagcac agtcccgtca
     2041 gtgcgctgac tgtgactcct gaagaaacca aaccgaatga ggttggaaga gaaagtacgg
     2101 accagaagtg gagcgtggtg tccagaccca gctcccggga gggttgctac ggtggatgct
     2161 cctcggccta cacaagctcc cacgtggaac gagatgactt accataggtg ctcgggctgc
     2221 agcgctgtcc tggagtgcat gagaggaatt gacacggggt gtagcataaa gtcagccatc
     2281 taccttaaga tgtcggagtt gtttgtttgg acttcccagt ctttccccaa agagctgaaa
     2341 cgctttagag gatgcgaaag ctttggctgt gtgttagtaa cagaagcctc tggctctgtg
     2401 agtaaaggaa tgtatggtgt ttggtgggaa acaaaagcac gagaatgatt tcctcttccg
     2461 ggtactgaga atagcacttt tagggactga ttcttgtaaa cattaaattt ttgtcccaag
     2521 taaaaaaaaa aaaaaaaaaa aaaaaaa
//
