LOCUS       NM_012882               1372 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus somatostatin receptor 5 (Sstr5), mRNA.
ACCESSION   NM_012882
VERSION     NM_012882.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1372)
  AUTHORS   Zou,S., Somvanshi,R.K. and Kumar,U.
  TITLE     Somatostatin receptor 5 is a prominent regulator of signaling
            pathways in cells with coexpression of Cannabinoid receptors 1
  JOURNAL   Neuroscience 340, 218-231 (2017)
   PUBMED   27984180
  REMARK    GeneRIF: Results showed that CB1R and SSTR5 colocalized in rat
            brain cortex, striatum, and hippocampus. CB1R was expressed in
            SSTR5 immunoprecipitate prepared from the brain tissue lysate,
            indicating their association in a system where these receptors are
            endogenously expressed.
REFERENCE   2  (bases 1 to 1372)
  AUTHORS   Ludvigsen,E., Carlsson,C., Tiensuu Janson,E., Sandler,S. and
            Stridsberg,M.
  TITLE     Somatostatin receptor 1-5; expression profiles during rat
            development
  JOURNAL   Ups J Med Sci 120 (3), 157-168 (2015)
   PUBMED   25926390
  REMARK    GeneRIF: All SSTR1-5 proteins were observed at embryonal day 10 and
            increased with time in major structures, but the localization
            varied between the different subtypes. SSTR5 co-localized with
            glucagon and pancreatic polypeptide.
REFERENCE   3  (bases 1 to 1372)
  AUTHORS   Chen,W., Ke,J.B., Wu,H.J., Miao,Y., Li,F., Yang,X.L. and Wang,Z.
  TITLE     Somatostatin receptor-mediated suppression of gabaergic synaptic
            transmission in cultured rat retinal amacrine cells
  JOURNAL   Neuroscience 273, 118-127 (2014)
   PUBMED   24846611
  REMARK    GeneRIF: Results suggest that somatostatin suppresses GABA release
            from the amacrine cells by inhibiting presynaptic Ca2+ channels, in
            part through activating sst5/sst2 receptors, a process that is
            mediated by the intracellular cAMP-PKA signaling pathway
REFERENCE   4  (bases 1 to 1372)
  AUTHORS   Stathopoulos,S., Bishop,J.M. and O'Ryan,C.
  TITLE     Genetic signatures for enhanced olfaction in the African mole-rats
  JOURNAL   PLoS One 9 (4), e93336 (2014)
   PUBMED   24699281
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1372)
  AUTHORS   Park,S., Jiang,H., Zhang,H. and Smith,R.G.
  TITLE     Modification of ghrelin receptor signaling by somatostatin
            receptor-5 regulates insulin release
  JOURNAL   Proc Natl Acad Sci U S A 109 (46), 19003-19008 (2012)
   PUBMED   23112170
  REMARK    GeneRIF: Modification of ghrelin receptor signaling by somatostatin
            receptor-5 regulates insulin release.
REFERENCE   6  (bases 1 to 1372)
  AUTHORS   Nyegaard,M., Borglum,A.D., Bruun,T.G., Collier,D.A., Russ,C.,
            Mors,O., Ewald,H. and Kruse,T.A.
  TITLE     Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene
            associated with bipolar affective disorder
  JOURNAL   Mol Psychiatry 7 (7), 745-754 (2002)
   PUBMED   12192619
REFERENCE   7  (bases 1 to 1372)
  AUTHORS   Kumar,U., Laird,D., Srikant,C.B., Escher,E. and Patel,Y.C.
  TITLE     Expression of the five somatostatin receptor (SSTR1-5) subtypes in
            rat pituitary somatotrophes: quantitative analysis by double-layer
            immunofluorescence confocal microscopy
  JOURNAL   Endocrinology 138 (10), 4473-4476 (1997)
   PUBMED   9322965
REFERENCE   8  (bases 1 to 1372)
  AUTHORS   Bruno,J.F., Xu,Y., Song,J. and Berelowitz,M.
  TITLE     Pituitary and hypothalamic somatostatin receptor subtype messenger
            ribonucleic acid expression in the food-deprived and diabetic rat
  JOURNAL   Endocrinology 135 (5), 1787-1792 (1994)
   PUBMED   7956902
REFERENCE   9  (bases 1 to 1372)
  AUTHORS   Panetta,R., Greenwood,M.T., Warszynska,A., Demchyshyn,L.L., Day,R.,
            Niznik,H.B., Srikant,C.B. and Patel,Y.C.
  TITLE     Molecular cloning, functional characterization, and chromosomal
            localization of a human somatostatin receptor (somatostatin
            receptor type 5) with preferential affinity for somatostatin-28
  JOURNAL   Mol Pharmacol 45 (3), 417-427 (1994)
   PUBMED   7908405
REFERENCE   10 (bases 1 to 1372)
  AUTHORS   O'Carroll,A.M., Lolait,S.J., Konig,M. and Mahan,L.C.
  TITLE     Molecular cloning and expression of a pituitary somatostatin
            receptor with preferential affinity for somatostatin-28
  JOURNAL   Mol Pharmacol 42 (6), 939-946 (1992)
   PUBMED   1362243
  REMARK    Erratum:[Mol Pharmacol. 1993 Dec;44(6):1278. PMID: 8264565]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by NM_012882.3.
            
            On Oct 24, 2007 this sequence version replaced NM_012882.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L04535.1, SRR26360190.417523.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680422, SAMN06680439
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               JAXUCZ010000010.1  15017356-15017469   c
            115-1372            JAXUCZ010000010.1  15011391-15012648   c
FEATURES             Location/Qualifiers
     source          1..1372
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1372
                     /gene="Sstr5"
                     /gene_synonym="Smstr5; Somato"
                     /note="somatostatin receptor 5"
                     /db_xref="GeneID:25354"
                     /db_xref="RGD:3765"
     exon            1..114
                     /gene="Sstr5"
                     /gene_synonym="Smstr5; Somato"
                     /inference="alignment:Splign:2.1.0"
     exon            115..1372
                     /gene="Sstr5"
                     /gene_synonym="Smstr5; Somato"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1242
                     /gene="Sstr5"
                     /gene_synonym="Smstr5; Somato"
                     /note="SS5R; SS5-R; SS-5-R; Somatostatin receptor subtype
                     5"
                     /codon_start=1
                     /product="somatostatin receptor type 5"
                     /protein_id="NP_037014.2"
                     /db_xref="GeneID:25354"
                     /db_xref="RGD:3765"
                     /translation="MEPLSLASTPSWNASAASSGNHNWSLVGSASPMGARAVLVPVLY
                     LLVCTVGLSGNTLVIYVVLRHAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVSYW
                     PFGSFLCRLVMTLDGINQFTSIFCLMVMSVDRYLAVVHPLRSARWRRPRVAKMASAAV
                     WVFSLLMSLPLLVFADVQEGWGTCNLSWPEPVGLWGAAFITYTSVLGFFGPLLVICLC
                     YLLIVVKVKAAGMRVGSSRRRRSERKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLP
                     EEPTSAGLYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKVLCLRRGYGMEDADAIEP
                     RPDKSGRPQATLPTRSCEANGLMQTSRI"
ORIGIN      
        1 ccgacttcgt acagcaatcg agtgagcaca ctgctctttg agcccgagtg cgctgcctaa
       61 ctgcgaagta ccgccgccgt gcccgccccg gcgtgggcac cctgtcctgc acagagacac
      121 gcgtggtctg gcacccggcc tgaagctgac agcatggagc ccctctctct ggcctccaca
      181 ccaagctgga atgcctcggc tgcttccagt ggtaaccata actggtcact ggtgggctca
      241 gcatcgccaa tgggagcccg ggcagtatta gtgcctgtgc tctacctgtt ggtgtgcacc
      301 gtgggactga gtggaaatac actggtcatt tatgtggtgc tgcggcacgc caagatgaag
      361 acagttacta acgtgtacat cctgaacctg gccgtggctg acgtattatt tatgttggga
      421 cttcctttcc tggccacgca gaacgccgtc tcctactggc ccttcggctc cttcttgtgc
      481 cgcctggtca tgacactgga tggcatcaac cagttcacca gtatcttctg cctgatggtc
      541 atgagtgttg accgctacct ggccgtggtc caccctctcc gctcagcccg gtggcgtcgc
      601 ccacgggtag ccaagatggc cagcgcggcc gtctgggtct tttcgctgct catgtctctg
      661 ccgctcttgg tcttcgcgga tgtccaggag ggctggggca cctgcaacct gagctggcca
      721 gagcctgtgg ggctgtgggg tgcagccttc atcacctaca cgtctgtgtt gggcttcttt
      781 gggcccctgc tggtcatctg cttgtgctac ctgctcattg tggtcaaggt gaaggctgca
      841 ggcatgcgcg taggctcctc aaggcggagg cgctcggagc gcaaggtgac tcgcatggtg
      901 gtggtcgtgg tgctggtgtt tgtgggctgc tggctgcctt tcttcattgt caacatcgtc
      961 aacctggcct tcacactgcc cgaggaaccc acatctgccg gcctctattt ctttgtggtg
     1021 gtcctatctt atgccaatag ctgtgccaac cccctgctct acggctttct ctcggacaac
     1081 ttccgccaga gcttccggaa ggttctgtgc ctacgtagag gatacggtat ggaggatgcg
     1141 gacgccatag agccacggcc agacaagagt gggcggcctc aggccacact gcccacacgc
     1201 agctgcgagg ccaatgggct catgcagacc agcaggattt gaatgcccct gtaacaccct
     1261 gggggtcctc caggcctcca cggtgttgtc ttctgggatc tgagagtttg ctgagatgca
     1321 ttcaccccca ggcctacaag ttggactcct ctcggtggca gtgtgaagac ag
//
