LOCUS       NP_037014                362 aa            linear   ROD 13-DEC-2024
DEFINITION  somatostatin receptor type 5 [Rattus norvegicus].
ACCESSION   NP_037014
VERSION     NP_037014.2
DBSOURCE    REFSEQ: accession NM_012882.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 362)
  AUTHORS   Zou,S., Somvanshi,R.K. and Kumar,U.
  TITLE     Somatostatin receptor 5 is a prominent regulator of signaling
            pathways in cells with coexpression of Cannabinoid receptors 1
  JOURNAL   Neuroscience 340, 218-231 (2017)
   PUBMED   27984180
  REMARK    GeneRIF: Results showed that CB1R and SSTR5 colocalized in rat
            brain cortex, striatum, and hippocampus. CB1R was expressed in
            SSTR5 immunoprecipitate prepared from the brain tissue lysate,
            indicating their association in a system where these receptors are
            endogenously expressed.
REFERENCE   2  (residues 1 to 362)
  AUTHORS   Ludvigsen,E., Carlsson,C., Tiensuu Janson,E., Sandler,S. and
            Stridsberg,M.
  TITLE     Somatostatin receptor 1-5; expression profiles during rat
            development
  JOURNAL   Ups J Med Sci 120 (3), 157-168 (2015)
   PUBMED   25926390
  REMARK    GeneRIF: All SSTR1-5 proteins were observed at embryonal day 10 and
            increased with time in major structures, but the localization
            varied between the different subtypes. SSTR5 co-localized with
            glucagon and pancreatic polypeptide.
REFERENCE   3  (residues 1 to 362)
  AUTHORS   Chen,W., Ke,J.B., Wu,H.J., Miao,Y., Li,F., Yang,X.L. and Wang,Z.
  TITLE     Somatostatin receptor-mediated suppression of gabaergic synaptic
            transmission in cultured rat retinal amacrine cells
  JOURNAL   Neuroscience 273, 118-127 (2014)
   PUBMED   24846611
  REMARK    GeneRIF: Results suggest that somatostatin suppresses GABA release
            from the amacrine cells by inhibiting presynaptic Ca2+ channels, in
            part through activating sst5/sst2 receptors, a process that is
            mediated by the intracellular cAMP-PKA signaling pathway
REFERENCE   4  (residues 1 to 362)
  AUTHORS   Stathopoulos,S., Bishop,J.M. and O'Ryan,C.
  TITLE     Genetic signatures for enhanced olfaction in the African mole-rats
  JOURNAL   PLoS One 9 (4), e93336 (2014)
   PUBMED   24699281
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 362)
  AUTHORS   Park,S., Jiang,H., Zhang,H. and Smith,R.G.
  TITLE     Modification of ghrelin receptor signaling by somatostatin
            receptor-5 regulates insulin release
  JOURNAL   Proc Natl Acad Sci U S A 109 (46), 19003-19008 (2012)
   PUBMED   23112170
  REMARK    GeneRIF: Modification of ghrelin receptor signaling by somatostatin
            receptor-5 regulates insulin release.
REFERENCE   6  (residues 1 to 362)
  AUTHORS   Nyegaard,M., Borglum,A.D., Bruun,T.G., Collier,D.A., Russ,C.,
            Mors,O., Ewald,H. and Kruse,T.A.
  TITLE     Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene
            associated with bipolar affective disorder
  JOURNAL   Mol Psychiatry 7 (7), 745-754 (2002)
   PUBMED   12192619
REFERENCE   7  (residues 1 to 362)
  AUTHORS   Kumar,U., Laird,D., Srikant,C.B., Escher,E. and Patel,Y.C.
  TITLE     Expression of the five somatostatin receptor (SSTR1-5) subtypes in
            rat pituitary somatotrophes: quantitative analysis by double-layer
            immunofluorescence confocal microscopy
  JOURNAL   Endocrinology 138 (10), 4473-4476 (1997)
   PUBMED   9322965
REFERENCE   8  (residues 1 to 362)
  AUTHORS   Bruno,J.F., Xu,Y., Song,J. and Berelowitz,M.
  TITLE     Pituitary and hypothalamic somatostatin receptor subtype messenger
            ribonucleic acid expression in the food-deprived and diabetic rat
  JOURNAL   Endocrinology 135 (5), 1787-1792 (1994)
   PUBMED   7956902
REFERENCE   9  (residues 1 to 362)
  AUTHORS   Panetta,R., Greenwood,M.T., Warszynska,A., Demchyshyn,L.L., Day,R.,
            Niznik,H.B., Srikant,C.B. and Patel,Y.C.
  TITLE     Molecular cloning, functional characterization, and chromosomal
            localization of a human somatostatin receptor (somatostatin
            receptor type 5) with preferential affinity for somatostatin-28
  JOURNAL   Mol Pharmacol 45 (3), 417-427 (1994)
   PUBMED   7908405
REFERENCE   10 (residues 1 to 362)
  AUTHORS   O'Carroll,A.M., Lolait,S.J., Konig,M. and Mahan,L.C.
  TITLE     Molecular cloning and expression of a pituitary somatostatin
            receptor with preferential affinity for somatostatin-28
  JOURNAL   Mol Pharmacol 42 (6), 939-946 (1992)
   PUBMED   1362243
  REMARK    Erratum:[Mol Pharmacol. 1993 Dec;44(6):1278.. PMID: 8264565]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 24, 2007 this sequence version replaced NP_037014.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.230181.1,
                                           SRR26360194.325064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680422, SAMN06680439
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     Protein         1..362
                     /product="somatostatin receptor type 5"
                     /note="SS5R; SS5-R; SS-5-R; Somatostatin receptor subtype
                     5"
                     /calculated_mol_wt=39800
     Site            13
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P30938.2)"
     Site            23
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P30938.2)"
     Site            36..63
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30938.2)"
     Region          48..314
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          73..94
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Site            74..99
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30938.2)"
     Region          110..132
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Site            111..132
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30938.2)"
     Site            155..175
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30938.2)"
     Region          155..171
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Site            185
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P30938.2)"
     Site            196..220
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30938.2)"
     Region          197..220
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          246..268
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Site            247..272
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30938.2)"
     Region          282..307
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     Site            283..307
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30938.2)"
     Region          330..362
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P30938.2)"
     CDS             1..362
                     /gene="Sstr5"
                     /gene_synonym="Smstr5; Somato"
                     /coded_by="NM_012882.3:134..1222"
                     /db_xref="GeneID:25354"
                     /db_xref="RGD:3765"
ORIGIN      
        1 meplslastp swnasaassg nhnwslvgsa spmgaravlv pvlyllvctv glsgntlviy
       61 vvlrhakmkt vtnvyilnla vadvlfmlgl pflatqnavs ywpfgsflcr lvmtldginq
      121 ftsifclmvm svdrylavvh plrsarwrrp rvakmasaav wvfsllmslp llvfadvqeg
      181 wgtcnlswpe pvglwgaafi tytsvlgffg pllviclcyl livvkvkaag mrvgssrrrr
      241 serkvtrmvv vvvlvfvgcw lpffivnivn laftlpeept saglyffvvv lsyanscanp
      301 llygflsdnf rqsfrkvlcl rrgygmedad aieprpdksg rpqatlptrs ceanglmqts
      361 ri
//
