LOCUS       NM_013036               1864 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus somatostatin receptor 4 (Sstr4), mRNA.
ACCESSION   NM_013036
VERSION     NM_013036.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1864)
  AUTHORS   Faron-Gorecka,A., Kusmider,M., Solich,J., Kolasa,M., Gruca,P.,
            Pabian,P., Szlachta,M. and Dziedzicka-Wasylewska,M.
  TITLE     Behavioral response to imipramine under chronic mild stress
            corresponds with increase of mRNA encoding somatostatin receptors
            sst2 and sst4 expression in medial habenular nucleus
  JOURNAL   Neurochem Int 121, 108-113 (2018)
   PUBMED   30291955
  REMARK    GeneRIF: There is an increase in sst4 and sst2 expression in the
            habenula, following imipramine administration in a chronic stress
            model.
REFERENCE   2  (bases 1 to 1864)
  AUTHORS   Ludvigsen,E., Carlsson,C., Tiensuu Janson,E., Sandler,S. and
            Stridsberg,M.
  TITLE     Somatostatin receptor 1-5; expression profiles during rat
            development
  JOURNAL   Ups J Med Sci 120 (3), 157-168 (2015)
   PUBMED   25926390
  REMARK    GeneRIF: All SSTR1-5 proteins were observed at embryonal day 10 and
            increased with time in major structures, but the localization
            varied between the different subtypes. SSTR3-4 was co-localized
            with insulin and pancreatic polypeptide.
REFERENCE   3  (bases 1 to 1864)
  AUTHORS   Gorham,L., Just,S. and Doods,H.
  TITLE     Somatostatin 4 receptor activation modulates G-protein coupled
            inward rectifying potassium channels and voltage stimulated calcium
            signals in dorsal root ganglion neurons
  JOURNAL   Eur J Pharmacol 736, 101-106 (2014)
   PUBMED   24769416
  REMARK    GeneRIF: sstr4 activation modulates G-protein coupled inward
            rectifying potassium channels and voltage stimulated calcium
            signals in dorsal root ganglion neurons, mechanisms thought to
            contribute to the analgesic propoerties sstr4 agonists
REFERENCE   4  (bases 1 to 1864)
  AUTHORS   Hou,Z.H. and Yu,X.
  TITLE     Activity-regulated somatostatin expression reduces dendritic spine
            density and lowers excitatory synaptic transmission via
            postsynaptic somatostatin receptor 4
  JOURNAL   J Biol Chem 288 (4), 2501-2509 (2013)
   PUBMED   23233668
  REMARK    GeneRIF: Activity-regulated somatostatin expression reduces
            dendritic spine density and lowers excitatory synaptic transmission
            via postsynaptic somatostatin receptor 4
REFERENCE   5  (bases 1 to 1864)
  AUTHORS   Jung,Y., Oh,S.H., Witek,R.P. and Petersen,B.E.
  TITLE     Somatostatin stimulates the migration of hepatic oval cells in the
            injured rat liver
  JOURNAL   Liver Int 32 (2), 312-320 (2012)
   PUBMED   22098068
  REMARK    GeneRIF: Somatostatin stimulates the migration of hepatic oval
            cells within injured liver through SSTR4, and this action appears
            to be mediated by the PI3K pathway.
REFERENCE   6  (bases 1 to 1864)
  AUTHORS   Kumar,U., Laird,D., Srikant,C.B., Escher,E. and Patel,Y.C.
  TITLE     Expression of the five somatostatin receptor (SSTR1-5) subtypes in
            rat pituitary somatotrophes: quantitative analysis by double-layer
            immunofluorescence confocal microscopy
  JOURNAL   Endocrinology 138 (10), 4473-4476 (1997)
   PUBMED   9322965
REFERENCE   7  (bases 1 to 1864)
  AUTHORS   Bito,H., Mori,M., Sakanaka,C., Takano,T., Honda,Z., Gotoh,Y.,
            Nishida,E. and Shimizu,T.
  TITLE     Functional coupling of SSTR4, a major hippocampal somatostatin
            receptor, to adenylate cyclase inhibition, arachidonate release and
            activation of the mitogen-activated protein kinase cascade
  JOURNAL   J Biol Chem 269 (17), 12722-12730 (1994)
   PUBMED   8175684
REFERENCE   8  (bases 1 to 1864)
  AUTHORS   Kubota,A., Yamada,Y., Kagimoto,S., Shimatsu,A., Imamura,M.,
            Tsuda,K., Imura,H., Seino,S. and Seino,Y.
  TITLE     Identification of somatostatin receptor subtypes and an implication
            for the efficacy of somatostatin analogue SMS 201-995 in treatment
            of human endocrine tumors
  JOURNAL   J Clin Invest 93 (3), 1321-1325 (1994)
   PUBMED   8132773
REFERENCE   9  (bases 1 to 1864)
  AUTHORS   Bruno,J.F., Xu,Y., Song,J. and Berelowitz,M.
  TITLE     Molecular cloning and functional expression of a brain-specific
            somatostatin receptor
  JOURNAL   Proc Natl Acad Sci U S A 89 (23), 11151-11155 (1992)
   PUBMED   1360663
REFERENCE   10 (bases 1 to 1864)
  AUTHORS   O'Carroll,A.M., Lolait,S.J., Konig,M. and Mahan,L.C.
  TITLE     Molecular cloning and expression of a pituitary somatostatin
            receptor with preferential affinity for somatostatin-28
  JOURNAL   Mol Pharmacol 42 (6), 939-946 (1992)
   PUBMED   1362243
  REMARK    Erratum:[Mol Pharmacol. 1993 Dec;44(6):1278.. PMID: 8264565]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013036.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: U04738.1, SRR26360176.1006960.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1864              JAXUCZ010000003.1  156307992-156309855
FEATURES             Location/Qualifiers
     source          1..1864
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1864
                     /gene="Sstr4"
                     /gene_synonym="Smstr4"
                     /note="somatostatin receptor 4"
                     /db_xref="GeneID:25555"
                     /db_xref="RGD:3764"
     exon            1..1864
                     /gene="Sstr4"
                     /gene_synonym="Smstr4"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1213
                     /gene="Sstr4"
                     /gene_synonym="Smstr4"
                     /note="Somatostatin receptor subtype 4 Rattus norvegicus
                     Sprague-Dawley major hippocampal somatostatin receptor
                     (SSTR4) mRNA; SS4R; SS4-R; SS-4-R"
                     /codon_start=1
                     /product="somatostatin receptor type 4"
                     /protein_id="NP_037168.1"
                     /db_xref="GeneID:25555"
                     /db_xref="RGD:3764"
                     /translation="MNTPATLPLGGEDTTWTPGINASWAPDEEEDAVRSDGTGTAGMV
                     TIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASA
                     AALRHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAK
                     LINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVFVIYTFLLGFLL
                     PVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQL
                     LNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLETTGG
                     AEEEPLDYYATALKSRGGPGCICPPLPCQQEPMQAEPACKRVPFTKTTTF"
ORIGIN      
        1 gttcagcgtt cggctgctct ccacggcaat ccgctgcccc gggtgggcac cccgaagcat
       61 gaacacgcct gcaactctgc ccctgggggg cgaggacacc acctggaccc ctgggatcaa
      121 cgccagctgg gctccggatg aggaggagga tgcagtgcgg tccgacggca cggggacagc
      181 gggcatggta actatccagt gcatctatgc gctcgtgtgt ctggtgggcc tggtaggaaa
      241 cgccctggtc atattcgtga tcctacgcta tgccaaaatg aagacagcca ccaacatcta
      301 cctgctcaac ctggccgtcg ctgatgagct cttcatgctc agtgtgccat ttgtggcctc
      361 ggcggctgcc ctgcgccact ggccgttcgg ggcggtgctg tgccgcgcag tgcttagtgt
      421 ggacggcctt aacatgttca cgagtgtctt ctgcctcaca gtgctcagcg tggatcgcta
      481 tgtggctgta gtgcaccctc tgcgagctgc cacctaccgg cggcccagcg tggccaagct
      541 aatcaacctg ggagtgtggc tagcatcctt gctggtcacc ctgcccatcg cagtcttcgc
      601 tgacactagg ccagctcgtg ggggtgaggc agtagcttgc aacctgcact ggcctcaccc
      661 ggcctggtct gcagtctttg tgatctatac ttttttgctg ggcttcctac tcccggttct
      721 ggctatcgga ttatgttacc tgcttatcgt gggcaagatg cgtgctgtgg ccctgcgggc
      781 tggctggcaa caacggaggc gctcagagaa gaagatcact aggctcgtgc taatggtggt
      841 gactgtcttt gtgctatgct ggatgccatt ctatgtagtg cagcttctga atctgtttgt
      901 caccagcctc gatgccactg tcaaccatgt gtccctcatc ctcagctatg ccaacagctg
      961 tgccaacccg attctctatg gtttcctctc agacaacttc cgacgctctt tccagcgggt
     1021 tctgtgcctg cgctgctgtc tcctggaaac aactggaggt gctgaggaag agcccctgga
     1081 ctactatgct actgctctca aaagcagagg tggcccagga tgcatatgcc ctccattgcc
     1141 ctgccagcag gagcccatgc aagcagaacc tgcctgcaag cgagtccctt tcaccaagac
     1201 cactactttc tgaaaaccat ttcaccctcc ctcagcccac ctgcaagcag gtctgcacca
     1261 cactctcaag ccagcaactt caagaaaact cctgttgtca ctaagccagg ccctttcagc
     1321 agcctgtgtt ctgtccctag gagcctcagg actcctgcta gcccctgcct ctcctaggac
     1381 tgactggctc caaggacaac tccgtggggg taggacttct ctgggttttg ggctagagta
     1441 ccatccatcc tttcctggac ctctagcaat ttttcaagag gcaggaagca ggtggtggtc
     1501 agaaagggat gcctaccctt gtgtgacttg tgacagtgac tgcttggaag agcgctggga
     1561 gggtgaggta ggcagagcta ggctctctgc tgtgtggtag catagggcat acggtgatac
     1621 aggggagaag atatgatacc tccaagtgtt ttccctctgt gtctgtctga gtctcttgtt
     1681 gctaaatgag atgtctacgc aacagctgaa agcatttgct ttcccaaggc aaatgtttcc
     1741 cagttgtcaa agggccagta gcagacttcc tgcgaatgca aatgtttaaa gaaggatggt
     1801 gtggggcgtt ttttgaaaaa aaaaataatt ctgatttctg gtcaggaatt aaaaggcaga
     1861 aagg
//
