LOCUS       NM_133522               3882 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus somatostatin receptor 3 (Sstr3), mRNA.
ACCESSION   NM_133522 XM_346802
VERSION     NM_133522.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3882)
  AUTHORS   Bai,J., Liu,X., Le Goff,L., Gargala,G., Francois,A., Ballet,J.J.,
            Ducrotte,P., Favennec,L. and Towledahong,L.
  TITLE     Octreotide modulates the expression of somatostatin receptor
            subtypes in inflamed rat jejunum induced by Cryptosporidium parvum
  JOURNAL   PLoS One 13 (3), e0194058 (2018)
   PUBMED   29522573
  REMARK    GeneRIF: In the jejunums of Cryptosporidium-parvum-infected rats,
            daily octreotide therapy increased mRNA levels of SSTR3 on day 50
            post-infection. Specific SSTRs may regulate the inflammatory
            pathway in the rat intestinal inflammation model.
            Erratum:[PLoS One. 2018 May 24;13(5):e0198377. doi:
            10.1371/journal.pone.0198377.. PMID: 29795701]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3882)
  AUTHORS   Yao,Q., Liu,Q., Xu,H., Wu,Z., Zhou,L., Gu,Z., Gong,P. and Shen,J.
  TITLE     Upregulated Expression of SSTR3 is Involved in Neuronal Apoptosis
            After Intracerebral Hemorrhage in Adult Rats
  JOURNAL   Cell Mol Neurobiol 37 (8), 1407-1416 (2017)
   PUBMED   28176050
  REMARK    GeneRIF: SSTR3 was significantly up-regulated after intracerebral
            hemorrhage, along with neuronal apoptosis.
REFERENCE   3  (bases 1 to 3882)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   4  (bases 1 to 3882)
  AUTHORS   Ludvigsen,E., Carlsson,C., Tiensuu Janson,E., Sandler,S. and
            Stridsberg,M.
  TITLE     Somatostatin receptor 1-5; expression profiles during rat
            development
  JOURNAL   Ups J Med Sci 120 (3), 157-168 (2015)
   PUBMED   25926390
  REMARK    GeneRIF: All SSTR1-5 proteins were observed at embryonal day 10 and
            increased with time in major structures, but the localization
            varied between the different subtypes. SSTR3-4 was co-localized
            with insulin and pancreatic polypeptide.
REFERENCE   5  (bases 1 to 3882)
  AUTHORS   Sun,X., Haley,J., Bulgakov,O.V., Cai,X., McGinnis,J. and Li,T.
  TITLE     Tubby is required for trafficking G protein-coupled receptors to
            neuronal cilia
  JOURNAL   Cilia 1 (1), 21 (2012)
   PUBMED   23351594
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3882)
  AUTHORS   Kumar,U., Laird,D., Srikant,C.B., Escher,E. and Patel,Y.C.
  TITLE     Expression of the five somatostatin receptor (SSTR1-5) subtypes in
            rat pituitary somatotrophes: quantitative analysis by double-layer
            immunofluorescence confocal microscopy
  JOURNAL   Endocrinology 138 (10), 4473-4476 (1997)
   PUBMED   9322965
REFERENCE   7  (bases 1 to 3882)
  AUTHORS   Roth,A., Kreienkamp,H.J., Meyerhof,W. and Richter,D.
  TITLE     Phosphorylation of four amino acid residues in the carboxyl
            terminus of the rat somatostatin receptor subtype 3 is crucial for
            its desensitization and internalization
  JOURNAL   J Biol Chem 272 (38), 23769-23774 (1997)
   PUBMED   9295322
REFERENCE   8  (bases 1 to 3882)
  AUTHORS   Viollet,C., Bodenant,C., Prunotto,C., Roosterman,D., Schaefer,J.,
            Meyerhof,W., Epelbaum,J., Vaudry,H. and Leroux,P.
  TITLE     Differential expression of multiple somatostatin receptors in the
            rat cerebellum during development
  JOURNAL   J Neurochem 68 (6), 2263-2272 (1997)
   PUBMED   9166718
REFERENCE   9  (bases 1 to 3882)
  AUTHORS   Bruno,J.F., Xu,Y., Song,J. and Berelowitz,M.
  TITLE     Pituitary and hypothalamic somatostatin receptor subtype messenger
            ribonucleic acid expression in the food-deprived and diabetic rat
  JOURNAL   Endocrinology 135 (5), 1787-1792 (1994)
   PUBMED   7956902
REFERENCE   10 (bases 1 to 3882)
  AUTHORS   Meyerhof,W., Wulfsen,I., Schonrock,C., Fehr,S. and Richter,D.
  TITLE     Molecular cloning of a somatostatin-28 receptor and comparison of
            its expression pattern with that of a somatostatin-14 receptor in
            rat brain
  JOURNAL   Proc Natl Acad Sci U S A 89 (21), 10267-10271 (1992)
   PUBMED   1279674
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133522.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X63574.1, SRR26360186.2338264.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-471               JAXUCZ010000007.1  111979780-111980250 c
            472-616             JAXUCZ010000007.1  111979451-111979595 c
            617-3882            JAXUCZ010000007.1  111973052-111976317 c
FEATURES             Location/Qualifiers
     source          1..3882
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3882
                     /gene="Sstr3"
                     /gene_synonym="Smstr28; SSTR"
                     /note="somatostatin receptor 3"
                     /db_xref="GeneID:171044"
                     /db_xref="RGD:620308"
     exon            1..471
                     /gene="Sstr3"
                     /gene_synonym="Smstr28; SSTR"
                     /inference="alignment:Splign:2.1.0"
     exon            472..616
                     /gene="Sstr3"
                     /gene_synonym="Smstr28; SSTR"
                     /inference="alignment:Splign:2.1.0"
     exon            617..3882
                     /gene="Sstr3"
                     /gene_synonym="Smstr28; SSTR"
                     /inference="alignment:Splign:2.1.0"
     CDS             657..1943
                     /gene="Sstr3"
                     /gene_synonym="Smstr28; SSTR"
                     /note="SS3R; SSR-28; SS3-R; SS-3-R; somatostatin receptor
                     28; somatostatin receptor subtype 3"
                     /codon_start=1
                     /product="somatostatin receptor type 3"
                     /protein_id="NP_598206.1"
                     /db_xref="GeneID:171044"
                     /db_xref="RGD:620308"
                     /translation="MAAVTYPSSVPTTLDPGNASSAWPLDTSLGNASAGTSLAGLAVS
                     GILISLVYLVVCVVGLLGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLA
                     AQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPV
                     ARMVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFG
                     PLLVICLCYLLIVVKVRSTTRRVRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFV
                     LCWMPFYLLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFR
                     RILLRPSRRVRSQEPGSGPPEKTEEEEDEEEEERREEEERRMQRGQEMNGRLSQIAQP
                     GPSGQQQRPCTGTAKEQQLLPQEATAGDKASTLSHL"
ORIGIN      
        1 caggcgtctc tccttactcc ccctcattct gcctttccgc ccacacactg tctcctctcc
       61 ctctcctctc tctctctcca cctccgaccc tccccctcct ttccttattt tcctcgggct
      121 tcttatgtcc cctgctatct cacatttctg tcatctttgg aagtgccttc tgccaccccc
      181 aactgggtgc catctgaaga ccccctatcc tgtgtccggc acccgccacg tgtcctggag
      241 atggggggtg acgtaccagg tgcgggtggc aagtcaggac cgaggaccag atgggagagg
      301 cgacgtgggc tgacgtggcc cccgaggacc taggaagggc ccaaccaagc ccacgagcgc
      361 tggaggagtg ggcactgtgt gtcaccccag ctggctgtgc tctggtggta cctggctgca
      421 gaaggttatc cagcctggcg actgcaaagg gaattcttgc cctgtgggca gaatcttgga
      481 acctccatgc agcagaatgt cagaactgga ccaaagagat gcaagctacc catggcttcc
      541 caggccttga gcaccccctc atgctggcag tggtgcatct gaagagtccc ttccaccttt
      601 gcagcaaccc cgtaaggttt gggctagttg gctgctgact gatcctcatc cctgccatgg
      661 ccgctgttac ctatccttca tccgtgccta cgaccttgga ccctgggaat gcatcctcag
      721 cctggcccct ggacacgtcc ctggggaatg catctgctgg cactagcctg gcaggactgg
      781 ctgtcagtgg catcttgatc tctctggtgt acctggtggt gtgcgtggtg ggtttgctgg
      841 gcaattcact ggtgatctac gtggttctgc ggcacacgtc cagcccatca gtgaccagtg
      901 tctatatcct caacctggca ctggctgacg aactcttcat gctggggcta cctttcctgg
      961 ctgctcagaa cgccctgtcc tactggcctt tcggctctct catgtgtcgt ctggtcatgg
     1021 ccgtggatgg catcaaccag ttcaccagca tcttctgcct caccgtcatg agtgtggacc
     1081 gctacctggc tgtggtgcac cccacacgct ctgcccgctg gcgcacggca cctgtggctc
     1141 gaatggtcag tgcagctgtc tgggtggcct cagctgtggt cgtgctgcct gtggttgtgt
     1201 tctcaggagt gccccgaggg atgagcacgt gccacatgca gtggccagag ccagcggctg
     1261 cctggcgaac agccttcatc atctatacgg ccgcactggg cttttttggg cccctgctgg
     1321 tcatctgctt atgctacctg cttattgtgg tgaaggtgcg gtcgaccaca cggcgggtgc
     1381 gggcgccctc gtgccagtgg gtacaggcac ccgcttgcca gcggcggcgg cgctctgagc
     1441 gcagggtgac acgcatggtg gtggctgtgg tggcactctt cgtcctctgc tggatgcctt
     1501 tctatttact caacatcgtt aatgtggtgt gcccgctgcc ggaggagccc gccttctttg
     1561 gcctctactt cctggtggtc gcgctgccct acgccaacag ctgcgcaaac cccatcctct
     1621 acggcttcct ctcctaccgc ttcaagcagg gcttccgcag gatcctgcta agaccttctc
     1681 ggcgagtacg gagccaggag ccagggtctg gccctccaga gaagacggag gaggaggagg
     1741 atgaagagga agaagagaga agggaagagg aagagcggag gatgcagaga gggcaggaga
     1801 tgaatgggag gctcagtcag atcgcacagc caggccccag tggacagcag caacggcctt
     1861 gcacagggac tgccaaggaa cagcagcttc taccccagga agccacagct ggggacaagg
     1921 ccagcacgct gagccatctg taagaacctt caaagagcca gcatgatcct gaagagagca
     1981 gaagctatgc ttgacctaag gcacgagtac cagacacatg gcagtgttct aagcaagcaa
     2041 cagctagagt gagcttattt acatggctgt cctggccctc tctggaccgt tgtggtacta
     2101 gggtccagtg atggaatgtc cataggcctg ggctctgtcc cactgtgcca gggcttgctg
     2161 tgtatacttt ggccagtcac tagccctctc tgggtcttgt tttcttcttt tgactcaggg
     2221 atgggtaaaa tgagccctgt cagaagaggg gtctggaatc cttattggga ttaatctcct
     2281 aatcagagcc caagttaaga atttgcgcag tctgaccaag aaacaagata tcttggggat
     2341 cagtctgtat cttggccctc aaggagatac accagggctt gggaaatcag agatgcagat
     2401 gacctggggg tgggtgcttg gctgaaacct aaaggaagtg ttagttggtg tggtgggatg
     2461 ccacggctta ggacccaagt gagccctttc catgctgctc tgtggcctca gccactctgt
     2521 tcatgtgcag gcctcctacc tcttctgcag ggcagtccgg gtgtcctaca gaccctcacc
     2581 ccagcgtctg agcattgggc cttctgtgct cctggacacc aggggaagaa cttcccagaa
     2641 ggcaggtgaa accaagtttc aggggttctt gctgcttggg cccccctggg acctacatgt
     2701 gactggtctt ctaattttgt attccttctc tggagggaag attgcacacc accaggctca
     2761 ggccacccgg agactgactc accctattca ggtcagctac ctagtcccca gggctatgca
     2821 gcagcctgag ggaaggagag ggagaaagga ggagagggag ctgaggcagt aagaagagga
     2881 gggggatggg atcggaggga gaagagaaca gaactttgtg gtgatcttga gtcaaccttc
     2941 tcccccttga gctaagctca gtttgcagca ctgatggttt caggaaggat ctgaaggaga
     3001 catgtgacca ggatcccctg gagagtgcat ggggctggtg agaggggcac aggtcatgat
     3061 ggagtcgtgg gaatgggctt ggctcctcag gagggatggt aagtcctttg tgtgggtcag
     3121 tcctcccatc ttctattccc agggctccag ctgatgtaga gactaacagg ctgtcatggg
     3181 gagtagccac tgtcccagct gggtcaggac ttcattcttc ccctcccaga gatggtcctt
     3241 ctggtcccag cagtgctggc cctggaaagg ttgaggcttc tgctcaaacc cccaccctac
     3301 cctgcagagg cagggttctc agggaaccca caaatccaga tgttgagaaa gctggatctt
     3361 ctattcacct caagcctctt ggccataccc tctgtctctg cgcctcagta tcctcatcat
     3421 agtgagaatg tgatccccca gttctccagt ctgttagaat ccaggaggga actgagtcat
     3481 gccaggcaag ctactgctca ccacaatggg gctgcgtaag gatacaaagc ggccgtgttg
     3541 tacctcaggc tcagcccaca ccttgccctt taagtgagtg gcttcggtgt cagctactgg
     3601 aggtgaaggt attcatgaga aatggagtgc aggaggtcag aagccaagga ccatggagaa
     3661 tgcaagccac cccagaagga ggaagtttgc aaacataggc atgtatgggg cctgaggccc
     3721 ggcccagggg ttcctctgag aaggagctgg gtcaggaagt aagcagtcca accttcctgg
     3781 atggggtagg tgagccacgt cttgcaaagg agtgggtgac cagttgagaa gttctttgct
     3841 gcttctgacc tgagctcctg tcaataaaga tagtgactaa ga
//
